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Journal Articles

Molecular Classification of Relapsed DLBCL Reveals Novel Biologic Subgroups

Kerstin Wenzl, Matthew E Stokes, Joseph P. Novak, Allison M. Bock, Melissa A. Hopper, Jordan Krull, Abigail R. Dropik, Janek S. Walker, Miranda S. Laverty, Vivekananda Sarangi, Raphael Mwangi, Maria Ortiz, Nicholas Stong, C. Chris Huang, Matthew J. Maurer, Lisa M. Rimsza, Brian K. Link, Rebecca King, Stephen M Ansell, Thomas M. Habermann, Thomas E. Witzig, Grzegorz S. Nowakowski, James R. Cerhan, Anita K. Gandhi, Anne J. Novak
Journal: Blood
Blood (2023) 142 (Supplement 1): 2770.
https://doi.org/10.1182/blood-2023-180949
Published: 2023
Journal Articles

RRMM and Post-BCMA Treated Subjects from the CC-220-MM-001 Study Show Increased Genomic Aberrations Associated with High-Risk and Significant Dysfunction in CD4+ T-Cell Compartment Compared to NDMM Subjects

Michael Amatangelo, Erin Flynt, Nicholas Stong, Maria Ortiz, Pradipta Ray, Maria Wang, Niels W.C.J. van de Donk, Sagar Lonial, Aparna Raval, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4665.
https://doi.org/10.1182/blood-2023-178912
Published: 2023
Journal Articles

Differential Chromatin Organization between t(4;14) and Non-t(4;14) Multiple Myeloma Driven By the Histone Methyltransferase NSD2

Chad C. Bjorklund, Junfei Zhao, Gaurav Jain, Natasha Shtraizent, Maria Ortiz, Sambuddo Mukherjee, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3295.
https://doi.org/10.1182/blood-2023-190137
Published: 2023
Journal Articles

A Single Cell Atlas of Diffuse Large B Cell Lymphomas Reveals Distinct Cellular States Predictive of Outcomes

Sabrina Baaklini, Alexandre Sarrabay, Camille Barthelemy, Laila Dahbi, Laurine Gil, Noushin Mossadegh-Keller, Jean-Marc Navarro, Caroline Huber, Romain Fenouil, Bertrand Escaliere, Romane Trombetta, Marine Pujol, Philippe Gaulard, Benjamin Riviere, Peggy Dartigues, Francesco Llamas Gutierrez, Celine Pangault, Fabrice Jardin, Francois Lemonnier, Gabriel Brisou, Corinne Haioun, Pauline Gravelle, Camille Laurent, Lionel Spinelli, C Chris Huang, Matthew E Stokes, Sahil Seth, Maria Ortiz, Anita K. Gandhi, Bertrand Nadel, Pierre Milpied, Sandrine Roulland
Journal: Blood
Blood (2023) 142 (Supplement 1): 848.
https://doi.org/10.1182/blood-2023-173929
Published: 2023
Journal Articles

Mezigdomide Reverses T-Cell Exhaustion through Degradation of Aiolos/Ikaros and Reinvigoration of Cytokine Production Pathways

Hsiling Chiu, Junfei Zhao, Maria Ortiz Estevez, Patrick R Hagner, Anita K. Gandhi
Journal: Blood
Blood (2023) 142 (Supplement 1): 335.
https://doi.org/10.1182/blood-2023-189445
Published: 2023
Journal Articles

The location of the t(4;14) translocation breakpoint within the NSD2 gene identifies a subset of patients with high-risk NDMM

Clinical Trials & Observations
Nicholas Stong, María Ortiz-Estévez, Fadi Towfic, Mehmet Samur, Amit Agarwal, Jill Corre, Erin Flynt, Nikhil Munshi, Hervé Avet-Loiseau, Anjan Thakurta
Journal: Blood
Blood (2023) 141 (13): 1574–1583.
https://doi.org/10.1182/blood.2022016212
Published: 2023
Includes: Supplemental data
Journal Articles

Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma

Naser Ansari-Pour, Mehmet Samur, Erin Flynt, Sarah Gooding, Fadi Towfic, Nicholas Stong, Maria Ortiz Estevez, Konstantinos Mavrommatis, Brian Walker, Gareth Morgan, Nikhil Munshi, Herve Avet-Loiseau, Anjan Thakurta
Journal: Blood
Blood (2023) 141 (6): 620–633.
https://doi.org/10.1182/blood.2022017010
Published: 2023
Includes: Supplemental data
Journal Articles

Integrative Genomics Identifies a High-Risk Metabolic and TME Depleted Signature That Predicts Early Clinical Failure in DLBCL

Kerstin Wenzl, Matthew E Stokes, Joseph P. Novak, Sana Khan, Melissa A. Hopper, Jordan E. Krull, Abigail Dropik, Vivekananda Sarangi, Raphael Mwangi, Maria Ortiz, Nicholas Stong, C. Chris Huang, Matthew J. Maurer, Lisa M. Rimsza, Brian K. Link, Susan L. Slager, Yan Asmann, Patrizia Mondello, Ryan D. Morin, Stephen M. Ansell, Thomas M. Habermann, Andrew L. Feldman, Rebecca L. King, Grzegorz S. Nowakowski, James R. Cerhan, Anita K. Gandhi, Anne J. Novak
Journal: Blood
Blood (2022) 140 (Supplement 1): 1742–1744.
https://doi.org/10.1182/blood-2022-159620
Published: 2022
Journal Articles

Biological Features of a High-Risk Transcriptional Molecular Subtype in Diffuse Large B-Cell Lymphoma

Matthew E Stokes, Kerstin Wenzl, C. Chris Huang, Maria Ortiz Estevez, Matthew J. Maurer, Nicholas Stong, Patrick Hagner, Yumi Nakayama, Chih-Chao Hsu, Samuel A Danziger, Fadi Towfic, Rebecca L. King, Joel S. Parker, Brian K. Link, Susan L. Slager, Vivekananda Sarangi, Yan Asmann, Joseph P. Novak, Akshay Sudhindra, Stephen M. Ansell, Thomas M. Habermann, Grzegorz S. Nowakowski, James R. Cerhan, Anne J. Novak, Anita K. Gandhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 3548–3550.
https://doi.org/10.1182/blood-2022-170228
Published: 2022
Journal Articles

Molecular Landscape of Primary Refractory DLBCL

Allison M. Bock, Kerstin Wenzl, Matthew E. Stokes, Joseph P. Novak, Melissa A. Hopper, Jordan E. Krull, Abigail Dropik, Vivekananda Sarangi, Maria Ortiz, Nicholas Stong, C. Chris Huang, Matthew J. Maurer, Rebecca L. King, Richard Curtis Godby, Umar Farooq, Yucai Wang, Stephen M. Ansell, Thomas M. Habermann, James R. Cerhan, Anita K. Gandhi, Grzegorz (Greg) Nowakowski, Anne J. Novak
Journal: Blood
Blood (2022) 140 (Supplement 1): 9221–9223.
https://doi.org/10.1182/blood-2022-156497
Published: 2022
Journal Articles

Loss of COP9 signalosome genes at 2q37 is associated with IMiD resistance in multiple myeloma

Brief Report
Sarah Gooding, Naser Ansari-Pour, Mohammad Kazeroun, Kubra Karagoz, Ann Polonskaia, Mirian Salazar, Evie Fitzsimons, Korsuk Sirinukunwattana, Selina Chavda, Maria Ortiz Estevez, Fadi Towfic, Erin Flynt, William Pierceall, Daniel Royston, Kwee Yong, Karthik Ramasamy, Paresh Vyas, Anjan Thakurta
Journal: Blood
Blood (2022) 140 (16): 1816–1821.
https://doi.org/10.1182/blood.2022015909
Published: 2022
Includes: Supplemental data
Journal Articles

Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination

Aarif Ahsan, Ann Polonskaia, Chih-Chao Hsu, Chad C Bjorklund, Maria Ortiz Estevez, Fadi Towfic, Nizar J. Bahlis, Michael Pourdehnad, Erin Flynt, Aarif Ahsan, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 2658.
https://doi.org/10.1182/blood-2021-150641
Published: 2021
Journal Articles

Location of the t(4;14) Translocation Breakpoint Identifies a Subset of Newly-Diagnosed Multiple Myeloma Patients with Poor Prognosis

Nicholas Stong, Maria Ortiz, Fadi Towfic, William Pierceall, Erin Flynt, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 2681.
https://doi.org/10.1182/blood-2021-151094
Published: 2021
Journal Articles

Loss of COP9 Signalosome Gene-Containing 2q Region Is Associated with Lenalidomide and Pomalidomide Resistance in Myeloma Patients

Sarah Gooding, Naser Ansari-Pour, Mohammad H Kazeroun, Kubra Karagoz, Mirian Angulo Salazar, Evelyn Fitzsimons, Maria Ortiz Estevez, Fadi Towfic, Erin Flynt, William E. Pierceall, Kwee Yong, Paresh Vyas, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 458.
https://doi.org/10.1182/blood-2021-150166
Published: 2021
Journal Articles

Multiple cereblon genetic changes are associated with acquired resistance to lenalidomide or pomalidomide in multiple myeloma

Clinical Trials & Observations Brief Report
Sarah Gooding, Naser Ansari-Pour, Fadi Towfic, María Ortiz Estévez, Philip P. Chamberlain, Kao-Tai Tsai, Erin Flynt, Marissa Hirst, Dan Rozelle, Paula Dhiman, Paola Neri, Karthik Ramasamy, Nizar Bahlis, Paresh Vyas, Anjan Thakurta
Journal: Blood
Blood (2021) 137 (2): 232–237.
https://doi.org/10.1182/blood.2020007081
Published: 2021
Includes: Supplemental data
Journal Articles

Large-Scale Analysis of Relapsed/Refractory Multiple Myeloma Genome Reveals Increased Prevalence of High-Risk Molecular Features and Oncogenic Drivers

Fadi Towfic, PhD, Naser Ansari-Pour, PhD, Maria Ortiz, Sarah Gooding, MD PhD, Dan Rozelle, PhD, Victoria Zadorozhny, Konstantinos Mavrommatis, PhD, Sneh Lata, PhD, Nicholas Stong, PhD, Sitharthan Kamalakaran, PhD, Kao-Tai Tsai, Erin Flynt, Anjan Thakurta
Journal: Blood
Blood (2019) 134 (Supplement_1): 365.
https://doi.org/10.1182/blood-2019-124939
Published: 2019
Journal Articles

Gene Expression and Genomic Markers Identify a Subpopulation of Poor Prognosis t(4;14) Patients in Newly Diagnosed Multiple Myeloma

Maria Ortiz, Fadi Towfic, PhD, Erin Flynt, Nicholas Stong, PhD, Sneh Lata, PhD, Dharanya Sampath, Dan Rozelle, PhD, Matthew Trotter, PhD, Jill Corre, PharmD, PhD, Hervé Avet-Loiseau, MD PhD, Anjan Thakurta
Journal: Blood
Blood (2019) 134 (Supplement_1): 366.
https://doi.org/10.1182/blood-2019-128907
Published: 2019
Journal Articles

Interactome of Aiolos/Ikaros in Diffuse Large B-Cell Lymphoma (DLBCL) Reveals Novel Combination of Cereblon Modulators (CELMoD) and Histone Deacetylase (HDAC) Inhibitors

Patrick R. Hagner, PhD, Hsiling Chiu, MS, Vivek S. Chopra, PhD, Martino S. Colombo, PhD, Nisha Patel, PhD, Maria Ortiz, Remco S. Loos, PhD, Fadi Towfic, PhD, Michelle Waldman, MS, Anita K Gandhi
Journal: Blood
Blood (2019) 134 (Supplement_1): 306.
https://doi.org/10.1182/blood-2019-126681
Published: 2019
Journal Articles

Crowdsourced High-Risk Classifiers for Multiple Myeloma Patients Commonly Identify PHF19 As a Robust Progression Biomarker

Michael J Mason, PhD, Carolina D. Schinke, MD, Christine Eng, PhD, Fadi Towfic, PhD, Fred Gruber, PhD, Brian S. White, Yi Cui, PhD, Bailiang Li, PhD, Thomas Yu, BS, William S. Dalton, PhDMD, Hartmut Goldschmidt, MD, Herve Avet-Loiseau, MD PhD, Mehmet Samur, PhD, Maria Ortiz, Matthew Trotter, PhD, Boris Hayete, PhD, Andrew Dervan, Erin Flynt, Hongyue Dai, PhD, Douglas Bassett, PhD, Pieter Sonneveld, Kenneth H. Shain, MD PhD, Nikhil C. Munshi, MD, Daniel Auclair, Dirk Hose, MD, Gareth Morgan, MDPhDFRCP, Jonathan Göke, PhD, Brian A Walker, PhD, Anjan Thakurta, Justin Guinney, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4370.
https://doi.org/10.1182/blood-2019-127362
Published: 2019
Journal Articles

Genetic and Transcript Changesin Cereblon in IMiD-Treated Myeloma Patients

Sarah Gooding, FRCPath,MRCP,MBBChir, Naser Ansari-Pour, PhD, Fadi Towfic, PhD, Maria Ortiz, Dan Rozelle, PhD, Victoria Zadorozhny, Michael Amatangelo, Erin Flynt, Kao-Tai Tsai, Paola Neri, MD PhD, Nizar Bahlis, MD, Paresh Vyas, MD PhD, Anjan Thakurta
Journal: Blood
Blood (2019) 134 (Supplement_1): 1793.
https://doi.org/10.1182/blood-2019-126828
Published: 2019