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Aarif Ahsan
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Journal Articles

GDF11/SMAD Regulated Splicing of GATA1 Is Associated with Response to Luspatercept in Lower-Risk Myelodysplastic Syndromes (LR-MDS)

Srinivas Aluri, Ellen Fraint, Samarpana Chakraborty, Aarif Ahsan, Gowri Poigailwar, Rongbao Zhao, Kith Pradhan, Kimo Bachiashvili, Anjali Budhathoki, Beamon Agarwal, Shanisha Gordon Mitchell, Milagros Carbajal, Srabani Sahu, Jacqueline Boultwood, Andrea Pellagatti, Ulrich Steidl, Amittha Wickrema, Satish Nandakumar, Aditi Shastri, Teresa Bowman, Sadanand Vodala, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 318.
https://doi.org/10.1182/blood-2023-179131
Published: 2023
Journal Articles

Bivalent BCMA Binding and Low Affinity CD3 T-Cell Engagement By Abbv-383 Drives Sustained Activation with Reduced T-Cell Exhaustion in Preclinical Models of Multiple Myeloma

David Sharon, Valerie Robinson, Claudie Hecquet, Kelly Calabrese, Cormac Cosgrove, Christine Mantis, Orlando Bueno, Aarif Ahsan, Adam Chervin, PK Epling-Burnette, Jeremy A Ross
Journal: Blood
Blood (2023) 142 (Supplement 1): 4666.
https://doi.org/10.1182/blood-2023-179039
Published: 2023
Journal Articles

Updated Safety and Efficacy Results of Abbv-383, a BCMA x CD3 Bispecific T-Cell Redirecting Antibody, in a First-in-Human Phase 1 Study in Patients with Relapsed/Refractory Multiple Myeloma

Ravi Vij, Shaji Kunnathu Kumar, Anita D'Souza, John T Mckay, Peter M. Voorhees, Alfred Chung, Sascha Alexander Tuchman, Neha Korde, Katja Weisel, Raphael Teipel, Orlando Bueno, Zhongling Feng, Tanya S Rosenberg, Rajvineeth Kumar Pothacamury, Akshanth R Polepally, Shane Lee, Ziyi Jin, Jeremy A Ross, Aarif Ahsan, Chetasi Talati, Cesar Rodriguez
Journal: Blood
Blood (2023) 142 (Supplement 1): 3378.
https://doi.org/10.1182/blood-2023-182388
Published: 2023
Journal Articles

Luspatercept Modulates Inflammation in the Bone Marrow, Restores Effective Erythropoiesis/Hematopoiesis, and Provides Sustained Clinical Benefit Versus Epoetin Alfa (EA): Biomarker Analysis from the Phase 3 COMMANDS Study

Sheida Hayati, Amer M. Zeidan, Guillermo Garcia-Manero, Uwe Platzbecker, Aarif Ahsan, Amit K. Verma, Srinivas Aluri, Manuel Ugidos Guerrero, Anita K. Gandhi, Rajasekhar N.V.S. Suragani, Sadanand Vodala
Journal: Blood
Blood (2023) 142 (Supplement 1): 1845.
https://doi.org/10.1182/blood-2023-178674
Published: 2023
Journal Articles

Investigations into the Mechanisms and Clinical Implications of Modulation of Hepcidin Levels By Luspatercept in TD MDS and TD b-Thalassemia

Aarif Ahsan, Wei Fang, Manuel Ugidos, Danny V Jeyaraju, Pierre Fenaux, Uwe Platzbecker, Olivier Hermine, John B. Porter, Rajasekhar N.V.S. Suragani, Sadanand Vodala, Anita K. Gandhi
Journal: Blood
Blood (2022) 140 (Supplement 1): 8188–8189.
https://doi.org/10.1182/blood-2022-166559
Published: 2022
Journal Articles

Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination

Aarif Ahsan, Ann Polonskaia, Chih-Chao Hsu, Chad C Bjorklund, Maria Ortiz Estevez, Fadi Towfic, Nizar J. Bahlis, Michael Pourdehnad, Erin Flynt, Aarif Ahsan, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 2658.
https://doi.org/10.1182/blood-2021-150641
Published: 2021
Journal Articles

A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma

Parvathi Sudha, Aarif Ahsan, Akhil Khera, Mohammad H Kazeroun, Tasneem Kausar, Lin Wang, Mirian Angulo Salazar, Evelyn Fitzsimons, Outi Salminen, Timothy Cody Ashby, Patrick Blaney, Magdalena Czader, Gail Vance, Jon Williams, Mohammad Issam Abu Zaid, Karthik Ramasamy, Kwee Yong, Gareth J. Morgan, Frits van Rhee, Rafat Abonour, Erin Flynt, Naser Ansari-Pour, Sarah Gooding, Anjan Thakurta, Brian A Walker
Journal: Blood
Blood (2021) 138 (Supplement 1): 2676.
https://doi.org/10.1182/blood-2021-148692
Published: 2021
Journal Articles

Low Exposure Extended Dosing Mimicking Clinical Exposures of the Oral Formulation of Azacitidine Results in a Sustained Hypomethylation and Targets Leukemic Stem Cells

Danny V Jeyaraju, Maryam Alapa, Ann Polonskaia, Alberto Risueño, Aarif Ahsan, Chao Wang, Prakash Subramanyam, Jammula Sriganesh, Amit Anand, Gaurav Jain, Madhusudhan Reddy, Kaushik Ghosh, Charalampos Kyriakopoulos, Nathalie Lailler, Christopher Hartl, Daniel Lopes de Menezes, Patrick Hagner, Anjan Thakurta
Journal: Blood
Blood (2021) 138 (Supplement 1): 3355.
https://doi.org/10.1182/blood-2021-153523
Published: 2021
Journal Articles

Modeling Tumor Microenvironment Interactions of Imid Sensitive and Resistant Cells in 3D Organotypic Culture Models

Aarif Ahsan, PhD, Danny Jeyaraju, Kamlesh Bisht, Patrick R. Hagner, PhD, Chad C. Bjorklund, William E Pierceall, Anjan Thakurta, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5622.
https://doi.org/10.1182/blood-2018-99-118885
Published: 2018