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Patrick Blaney
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Journal Articles

The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma

Anthony M. Cirrincione, Alexandra M. Poos, Bachisio Ziccheddu, Marcella Kaddoura, Marc-Andrea Bärtsch, Kylee Maclachlan, Monika Chojnacka, Benjamin Diamond, Lukas John, Philipp Reichert, Stefanie Huhn, Patrick Blaney, Dylan Gagler, Karsten Rippe, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Faith Davies, Hartmut Goldschmidt, Roland Fenk, Katja C. Weisel, Elias K. Mai, Neha Korde, Gareth J. Morgan, Saad Usmani, Ola Landgren, Marc S. Raab, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (7): 771–783.
https://doi.org/10.1182/blood.2024024299
Published: 2024
Includes: Supplemental data
Journal Articles

Somatic Hypermutation in Enhancer Regions Shapes Non-Coding Myeloma Genome, Generating DNA Breaks and Driving Etiology through Mutation and Structural Variation

Patrick Blaney, Brian A. Walker, Aneta Mikulasova, Dylan Gagler, Bachisio Ziccheddu, Benjamin Diamond, Yubao Wang, Liming Hou, Sanxiong Liu, Alexandra Maria Poos, Anthony Cirrincione, Kylee H Maclachlan, Elias K. Mai, Hartmut Goldschmidt, Saad Z Usmani, Marc S. Raab, Niels Weinhold, Ola Landgren, Faith E. Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1401.
https://doi.org/10.1182/blood-2023-190473
Published: 2023
Journal Articles

Revealing Novel Mechanisms Underlying Inactivation of Tumor Suppressor Genes on Duplicated Chromosomes in Multiple Myeloma

Anthony Cirrincione, Marcella Kaddoura, Alexandra Maria Poos, Bachisio Ziccheddu, Kylee H Maclachlan, Monika Chojnacka, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Yanming Zhang, Ahmet Dogan, Alexander Lesokhin, Faith E. Davies, Hartmut Goldschmidt, Katja Weisel, Roland Fenk, Elias K. Mai, Neha Korde, Gareth J. Morgan, Marc S. Raab, Saad Z Usmani, Ola Landgren, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2023) 142 (Supplement 1): 874.
https://doi.org/10.1182/blood-2023-186802
Published: 2023
Journal Articles

Genomic Profiling to Interpret the Outcomes of Early Intervention for High-Risk Smoldering Myeloma

Benjamin Diamond, Dickran Kazandjian, Marios Papadimitriou, Bachisio Ziccheddu, Patrick Blaney, Monika Chojnacka, Michael Durante, Elizabeth Hill, Romanos Sklavenitis-Pistofidis, Kylee H Maclachlan, Ryan M. Young, Saad Z Usmani, Faith E. Davies, Gad Getz, Irene M. Ghobrial, Gareth J. Morgan, Francesco Maura, Ola Landgren
Journal: Blood
Blood (2023) 142 (Supplement 1): 757.
https://doi.org/10.1182/blood-2023-181817
Published: 2023
Journal Articles

Whole-Genome Sequencing Identifies Structural Variation As a Key Driver of Disease Relapse and Aggressive Clinical Behavior in Multiple Myeloma

Marc Braunstein, Patrick Blaney, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 2773.
https://doi.org/10.1182/blood-2023-191008
Published: 2023
Journal Articles

Single Cell Analysis of Bone Marrow Stromal Cells Shows That a Pro-Inflammatory and Stress Response Together with Polarized Differentiation of Stromal Elements Characterize the Bone Marrow Microenvironment during Multiple Myeloma Development

Hussein Ghamlouch, Dylan Gagler, Patrick Blaney, Eileen Boyle, Yubao Wang, Liming Hou, Ola Landgren, Francesco Maura, Aristotelis Tsirigos, Gareth J. Morgan, Faith E. Davies
Journal: Blood
Blood (2023) 142 (Supplement 1): 332.
https://doi.org/10.1182/blood-2023-182968
Published: 2023
Journal Articles

Whole-Genome Sequencing Reveals Distinct Mutational Signatures in Multiple Myeloma Patients with African Ancestry Compared with Those of Non-African Ancestry

Kylee H Maclachlan, Patrick Blaney, Anthony Cirrincione, Timothy R. Chu, Alexandra Maria Poos, Elizabeth E. Brown, Elisabet E. Manasanch, Antje Hoering, Liming Hou, Dylan Gagler, Yubao Wang, Sanxiong Liu, Benjamin Diamond, Bachisio Ziccheddu, Marc S. Raab, Niels Weinhold, Ola Landgren, Nicolas Robine, Faith E. Davies, Alexander Lesokhin, Saad Z Usmani, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2023) 142 (Supplement 1): 3764.
https://doi.org/10.1182/blood-2023-190882
Published: 2023
Journal Articles

Tracking the Earliest Genomic Events in Multiple Myeloma Life-History

Anthony Cirrincione, Bachisio Ziccheddu, Kylee H Maclachlan, Alexandra M. Poos, Monika Chojnacka, Benjamin Diamond, Eileen M Boyle, Patrick Blaney, Dylan Gagler, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Faith E. Davies, Neha Korde, Marc S Raab, Niels Weinhold, Saad Usmani, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2022) 140 (Supplement 1): 1553–1555.
https://doi.org/10.1182/blood-2022-164742
Published: 2022
Journal Articles

Genomic Determinants of Resistance in Newly Diagnosed Multiple Myeloma Treated with Targeted-Immunotherapy

Francesco Maura, Eileen Boyle, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Bachisio Ziccheddu, Hussein Ghamlouch, Yubao Wang, James E. Hoffman, Dickran Kazandjian, Hani Hassoun, Emily Guzman, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A. Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E. Davies, Saad Usmani, Neha Korde, Gareth J. Morgan, Ola Landgren
Journal: Blood
Blood (2022) 140 (Supplement 1): 1137–1139.
https://doi.org/10.1182/blood-2022-160308
Published: 2022
Journal Articles

Structural Heterogeneity of Chromosome 1q Drives Outcome in Newly Diagnoses Myeloma

Eileen M Boyle, Patrick Blaney, James Stoeckle, Yubao Wang, Hussein Ghamlouch, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, David Kaminetzsky, Marc Braunstein, Lydia Montes, Jill Corre, Even H Rustad, Ola Landgren, Francesco Maura, Benedetto Bruno, Aristotelis Tsirigos, Brian A. Walker, Faith E Davies, Dylan Gagler, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 4253–4254.
https://doi.org/10.1182/blood-2022-165467
Published: 2022
Journal Articles

Variability in Pattern of Mutational Signatures in Multiple Myeloma As a Function of Racial Origin

Patrick Blaney, Eileen M Boyle, Kylee H Maclachlan, Louis S. Williams, Dylan Gagler, Parvathi Sudha, Alexandra M Poos, Yubao Wang, Hussein Ghamlouch, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, David Kaminetzsky, Marc Braunstein, David Coffey, Benjamin Diamond, Bachisio Ziccheddu, Dickran Kazandjian, Urvi A Shah, Elizabeth E. Brown, Elisabet E. Manasanch, Alexander M Lesokhin, Niels Weinhold, Brian A. Walker, Saad Usmani, Ola Landgren, Faith E Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 430–432.
https://doi.org/10.1182/blood-2022-167390
Published: 2022
Journal Articles

Impact of Rare Structural Variant Events in Newly Diagnosed Multiple Myeloma

Monika Chojnacka, Benjamin Diamond, Bachisio Ziccheddu, Even Rustad, Eileen Boyle, Kylee H Maclachlan, Patrick Blaney, Saad Usmani, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2022) 140 (Supplement 1): 1542–1543.
https://doi.org/10.1182/blood-2022-160311
Published: 2022
Journal Articles

Fc-Mediated Antibody Effector Function, Inflammation Resolution and Oligoclonality on TCR Rearrangements Predict Sustained MRD Negativity in Newly Diagnosed Multiple Myeloma Treated with Immunotherapy Regimens

Eileen M Boyle, Francesco Maura, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Hussein Ghamlouch, Dylan Gagler, Patrick Blaney, Bachisio Ziccheddu, Yubao Wang, Emily Guzman, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, James E Hoffman, Dickran Kazandjian, Hani Hassoun, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E Davies, Saad Usmani, Neha Korde, Ola Landgren, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 249–251.
https://doi.org/10.1182/blood-2022-165500
Published: 2022
Journal Articles

Multiomic Mapping of Copy Number and Structural Variation on Chromosome 1 (Chr1) Highlights Multiple Recurrent Disease Drivers

Patrick Blaney, Eileen M Boyle, Yubao Wang, Hussein Ghamlouch, Jinyoung Choi, Louis Williams, Stoeckle James, Ariel Siegel, Beatrice Razzo, Marc Braunstein, David Kaminetzky, Arnaldo A Arbini, Benedetto Bruno, Jill Corre, Lydia Montes, Daniel Auclair, Faith E. Davies, Aristotelis Tsirigos, Even H Rustad, Francesco Maura, Ola Landgren, Michael A Bauer, Brian Walker, Gareth Morgan
Journal: Blood
Blood (2021) 138 (Supplement 1): 721.
https://doi.org/10.1182/blood-2021-148439
Published: 2021
Journal Articles

Hispanic or Latin American Ancestry Is Associated with a Similar Genomic Profile and a Trend Toward Inferior Outcomes in Newly Diagnosed Multiple Myeloma As Compared to Non-Hispanic White Patients in the Multiple Myeloma Research Foundation (MMRF) CoMMpassstudy

Louis Williams, Patrick Blaney, Eileen M Boyle, Hussein Ghamlouch, Yubao Wang, Jinyoung Choi, Michael A Bauer, Ariel Siegel, James Stoeckle, Beatrice Razzo, Daniel Auclair, David Kaminetzky, Marc Braunstein, Benedetto Bruno, Arnaldo A. Arbini, Brian A Walker, Faith E. Davies, Gareth J Morgan
Journal: Blood
Blood (2021) 138 (Supplement 1): 4117.
https://doi.org/10.1182/blood-2021-148854
Published: 2021
Journal Articles

A Clinically Validated Targeted Capture Panel to Identify Translocations, Copy Number Abnormalities, and Mutations in Multiple Myeloma

Parvathi Sudha, Aarif Ahsan, Akhil Khera, Mohammad H Kazeroun, Tasneem Kausar, Lin Wang, Mirian Angulo Salazar, Evelyn Fitzsimons, Outi Salminen, Timothy Cody Ashby, Patrick Blaney, Magdalena Czader, Gail Vance, Jon Williams, Mohammad Issam Abu Zaid, Karthik Ramasamy, Kwee Yong, Gareth J. Morgan, Frits van Rhee, Rafat Abonour, Erin Flynt, Naser Ansari-Pour, Sarah Gooding, Anjan Thakurta, Brian A Walker
Journal: Blood
Blood (2021) 138 (Supplement 1): 2676.
https://doi.org/10.1182/blood-2021-148692
Published: 2021
Journal Articles

Unifying the Definition of High-Risk in Multiple Myeloma

Ariel Siegel, Eileen M Boyle, Patrick Blaney, Yubao Wang, Hussein Ghamlouch, Jinyoung Choi, Jessica Caro, Louis Williams, Beatrice Razzo, Arnaldo A. Arbini, Marc Braunstein, David Kaminetzky, Daniel Auclair, Charlotte Pawlyn, David Cairns, Graham Jackson, Brian Walker, Benedetto Bruno, Gareth J. Morgan, Faith E. Davies
Journal: Blood
Blood (2021) 138 (Supplement 1): 2714.
https://doi.org/10.1182/blood-2021-148502
Published: 2021
Journal Articles

Genomic and Immune Signatures Predict Sustained MRD Negativity in Newly Diagnosed Multiple Myeloma Patients Treated with Daratumumab, Carfilzomib, Lenalidomide, and Dexamethasone (D-KRd)

Francesco Maura, Eileen M Boyle, Benjamin Diamond, Patrick Blaney, Hussein Ghamlouch, Bachisio Ziccheddu, Yubao Wang, Kylee H Maclachlan, James E. Hoffman, Hani Hassoun, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Dickran Kazandjian, Gunjan L Shah, Heather J Landau, David J. Chung, Sergio Giralt, Benedetto Bruno, Yanming Zhang, Arnaldo A Arbini, Ahmet Dogan, Alexander Lesokhin, Faith E Davies, Neha Korde, Gareth J Morgan, Ola Landgren
Journal: Blood
Blood (2021) 138 (Supplement 1): 325.
https://doi.org/10.1182/blood-2021-149112
Published: 2021
Journal Articles

Influence of Aging Processes on the Biology and Outcome of Multiple Myeloma

Eileen M Boyle, MDMSc, Louis Williams, MD MBA, Patrick Blaney, Cody Ashby, PhD, Michael A Bauer, PhD, Brian A Walker, PhD, Jinyoung Choi, PhD, Jessica Caro, MD, Beatrice Razzo, MD, Arnaldo A. Arbini, MD, David Kaminetzky, MD, Marc Braunstein, MDPhD, Francesco Maura, MD, Yubao Wang, PhD, Ola Landgren, MD PhD, James Stoeckle, MD, Kylee H Maclachlan, MBChB, PhD, Rachel Litke, Faith E. Davies, Gareth Morgan, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 8–9.
https://doi.org/10.1182/blood-2020-138787
Published: 2020