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Alexander M Lesokhin
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Journal Articles

The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma

Anthony M. Cirrincione, Alexandra M. Poos, Bachisio Ziccheddu, Marcella Kaddoura, Marc-Andrea Bärtsch, Kylee Maclachlan, Monika Chojnacka, Benjamin Diamond, Lukas John, Philipp Reichert, Stefanie Huhn, Patrick Blaney, Dylan Gagler, Karsten Rippe, Yanming Zhang, Ahmet Dogan, Alexander M. Lesokhin, Faith Davies, Hartmut Goldschmidt, Roland Fenk, Katja C. Weisel, Elias K. Mai, Neha Korde, Gareth J. Morgan, Saad Usmani, Ola Landgren, Marc S. Raab, Niels Weinhold, Francesco Maura
Journal: Blood
Blood (2024) 144 (7): 771–783.
https://doi.org/10.1182/blood.2024024299
Published: 2024
Includes: Supplemental data
Journal Articles

Antigen escape as a shared mechanism of resistance to BCMA-directed therapies in multiple myeloma

Brief Report
Ross S. Firestone, Nicholas D. Socci, Tala Shekarkhand, Menglei Zhu, Wei Ge Qin, Malin Hultcrantz, Sham Mailankody, Carlyn Rose Tan, Neha Korde, Alexander M. Lesokhin, Hani Hassoun, Urvi Shah, Kylee H. Maclachlan, Sridevi Rajeeve, Heather J. Landau, Michael Scordo, Gunjan L. Shah, Oscar B. Lahoud, Sergio Giralt, Kazunori Murata, Saad Z. Usmani, David J. Chung
Journal: Blood
Blood (2024) 144 (4): 402–407.
https://doi.org/10.1182/blood.2023023557
Published: 2024
Includes: Supplemental data
Journal Articles

Fc-Mediated Antibody Effector Function, Inflammation Resolution and Oligoclonality on TCR Rearrangements Predict Sustained MRD Negativity in Newly Diagnosed Multiple Myeloma Treated with Immunotherapy Regimens

Eileen M Boyle, Francesco Maura, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Hussein Ghamlouch, Dylan Gagler, Patrick Blaney, Bachisio Ziccheddu, Yubao Wang, Emily Guzman, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, James E Hoffman, Dickran Kazandjian, Hani Hassoun, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E Davies, Saad Usmani, Neha Korde, Ola Landgren, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 249–251.
https://doi.org/10.1182/blood-2022-165500
Published: 2022
Journal Articles

A Phase 2 Trial of Colesevelam for Lenalidomide-Associated Diarrhea

Malin Hultcrantz, Hani Hassoun, Neha Korde, Sham Mailankody, Tala Shekarkhand, Miranda Burge, Kylee H Maclachlan, Dhwani Patel, Urvi A Shah, David J. Chung, Michael Scordo, Kelly Barnett, Jenna Blaslov, Meghan Salcedo, Julia Caple, Linh Tran, Selena Hamid, Oscar B Lahoud, Heather Landau, Gunjan L. Shah, Sergio A Giralt, Andriy Derkach, Carlyn Tan, Cody Peer, William D. Figg, Sr., Saad Usmani, Ola Landgren, Alexander M Lesokhin
Journal: Blood
Blood (2022) 140 (Supplement 1): 4454–4456.
https://doi.org/10.1182/blood-2022-164851
Published: 2022
Journal Articles

Enduring Responses after 1-Year, Fixed-Duration Cevostamab Therapy in Patients with Relapsed/Refractory Multiple Myeloma: Early Experience from a Phase I Study

Alexander M Lesokhin, Joshua Richter, Suzanne Trudel, Adam D Cohen, Andrew Spencer, Peter A Forsberg, Jacob P Laubach, Sheeba K Thomas, Nizar J. Bahlis, Luciano J. Costa, Paula Rodriguez Otero, Maria-Victoria Mateos, Jesus G Berdeja, Rayan Kaedbey, Amrita Y. Krishnan, Rafael Fonseca, Voleak Choeurng, James Cooper, Teiko Sumiyoshi, Chihunt Wong, Simon J Harrison
Journal: Blood
Blood (2022) 140 (Supplement 1): 4415–4417.
https://doi.org/10.1182/blood-2022-157547
Published: 2022
Journal Articles

Stem Cell Autograft Minimal Residual Disease Negativity Improves Outcomes after Autotransplant for Multiple Myeloma

Noriko Nishimura, Samantha Brown, Sean M. Devlin, Parastoo B. Dahi, Heather Landau, Oscar B Lahoud, Michael Scordo, Gunjan L. Shah, Hani Hassoun, Malin Hultcrantz, Neha Korde, Alexander M Lesokhin, Sham Mailankody, Urvi A Shah, Carlyn Tan, Saad Usmani, Sergio A. Giralt, David J. Chung, Gaurav Gupta, Elena Maryamchik, Evangelos Ntrivalas, Mikhail Roshal
Journal: Blood
Blood (2022) 140 (Supplement 1): 620–622.
https://doi.org/10.1182/blood-2022-160271
Published: 2022
Journal Articles

A Randomized Placebo Controlled Study of a Plant-Based Dietary Versus Supplement Versus Placebo Intervention in Patients with Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM) - the Nutrition Prevention (NUTRIVENTION-3) Study

Urvi A. Shah, Francesca Castro, Aishwarya Anuraj, Eliana Schach, Andriy Derkach, Nisha S. Joseph, Peter A. Adintori, Laura Guttentag, Jenna Blaslov, Justin R. Cross, Kylee H. Maclachlan, Sham Mailankody, Neha Korde, Carlyn Tan, Malin Hultcrantz, Hani Hassoun, Oscar B. Lahoud, Gunjan L. Shah, Michael Scordo, Jonathan U. Peled, David J. Chung, Heather Landau, Jun J. Mao, Neil M. Iyengar, Saad Usmani, Sergio A. Giralt, Marcel R.M. van den Brink, Alexander M. Lesokhin
Journal: Blood
Blood (2022) 140 (Supplement 1): 5052–5055.
https://doi.org/10.1182/blood-2022-159794
Published: 2022
Journal Articles

Tracking the Evolution of Therapy-Related Myeloid Neoplasms Using Chemotherapy Signatures

Bachisio Ziccheddu, Benjamin Diamond, Kylee H Maclachlan, Justin Taylor, Eileen M Boyle, Juan E. Arango Ossa, Jahn Jacob, Maurizio Affer, Tulasigeri M Totiger, David Coffey, Justin Watts, Sydney X. Lu, Niccolo Bolli, Kelly L Bolton, Jae H Park, Heather Landau, Karuna Ganesh, Andrew McPherson, Mikkael A. Sekeres, Alexander M Lesokhin, David J. Chung, Yanming Zhang, Caleb Ho, Mikhail Roshal, Jeffrey W. Tyner, Stephen D Nimer, Elli Papaemmanuil, Saad Usmani, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2022) 140 (Supplement 1): 2088–2090.
https://doi.org/10.1182/blood-2022-158992
Published: 2022
Journal Articles

Variability in Pattern of Mutational Signatures in Multiple Myeloma As a Function of Racial Origin

Patrick Blaney, Eileen M Boyle, Kylee H Maclachlan, Louis S. Williams, Dylan Gagler, Parvathi Sudha, Alexandra M Poos, Yubao Wang, Hussein Ghamlouch, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, David Kaminetzsky, Marc Braunstein, David Coffey, Benjamin Diamond, Bachisio Ziccheddu, Dickran Kazandjian, Urvi A Shah, Elizabeth E. Brown, Elisabet E. Manasanch, Alexander M Lesokhin, Niels Weinhold, Brian A. Walker, Saad Usmani, Ola Landgren, Faith E Davies, Francesco Maura, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 430–432.
https://doi.org/10.1182/blood-2022-167390
Published: 2022
Journal Articles

Elranatamab, a BCMA Targeted T-Cell Engaging Bispecific Antibody, Induces Durable Clinical and Molecular Responses for Patients with Relapsed or Refractory Multiple Myeloma

Noopur Raje, Nizar Jacques Bahlis, Caitlin Costello, Bhagirathbhai Dholaria, Melhem Solh, Moshe Yair Levy, Michael H Tomasson, Michael A. Damore, Sibo Jiang, Cynthia Basu, Athanasia Skoura, Edward M Chan, Suzanne Trudel, Andrzej Jakubowiak, Michael P Chu, Cristina J. Gasparetto, Andrew P. Dalovisio, Michael Sebag, Alexander M Lesokhin
Journal: Blood
Blood (2022) 140 (Supplement 1): 388–390.
https://doi.org/10.1182/blood-2022-166494
Published: 2022
Journal Articles

Tracking the Earliest Genomic Events in Multiple Myeloma Life-History

Anthony Cirrincione, Bachisio Ziccheddu, Kylee H Maclachlan, Alexandra M. Poos, Monika Chojnacka, Benjamin Diamond, Eileen M Boyle, Patrick Blaney, Dylan Gagler, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Faith E. Davies, Neha Korde, Marc S Raab, Niels Weinhold, Saad Usmani, Gareth J. Morgan, Ola Landgren, Francesco Maura
Journal: Blood
Blood (2022) 140 (Supplement 1): 1553–1555.
https://doi.org/10.1182/blood-2022-164742
Published: 2022
Journal Articles

Carfilzomib, Lenalidomide and Dexamethasone (KRd) Vs Bortezomib, Lenalidomide, and Dexamethasone (VRd) As Induction Therapy in Newly Diagnosed High-Risk Multiple Myeloma

Carlyn Tan, David Nemirovsky, Andriy Derkach, Malin Hultcrantz, Hani Hassoun, Sham Mailankody, Urvi A Shah, Dhwani Patel, Kylee H Maclachlan, Oscar B Lahoud, Gunjan L. Shah, Michael Scordo, David J. Chung, Heather Landau, Sergio A Giralt, Alexander M Lesokhin, Neha Korde, Saad Usmani
Journal: Blood
Blood (2022) 140 (Supplement 1): 1817–1819.
https://doi.org/10.1182/blood-2022-169161
Published: 2022
Journal Articles

A Pilot Plant Based Dietary Intervention in MGUS and SMM Patients with Elevated BMI Is Feasible and Associated with Improvements in Metabolic and Microbiome Biomarkers of Progression

Urvi A. Shah, Andriy Derkach, Francesca Castro, Aishwarya Anuraj, Jenna Blaslov, Linh Tran, Peter A. Adintori, Miranda Burge, Sharon Funkhouser, Kinga Hosszu, Justin R. Cross, Michael N. Pollak, Devin P. McAvoy, David Nemirovsky, Kylee H. Maclachlan, Sham Mailankody, Neha Korde, Carlyn Tan, Malin Hultcrantz, Dhwani Patel, Hani Hassoun, Gunjan L. Shah, Michael Scordo, Oscar B. Lahoud, David J. Chung, Marius E. Mayerhoefer, Jonathan U. Peled, Heather Landau, Anita D'Souza, Ola Landgren, Sergio A. Giralt, Neil M. Iyengar, Saad Usmani, Marcel R.M. van den Brink, Alexander M. Lesokhin
Journal: Blood
Blood (2022) 140 (Supplement 1): 5066–5069.
https://doi.org/10.1182/blood-2022-163281
Published: 2022
Journal Articles

Efficacy and Safety of Elranatamab in Patients with Relapsed/Refractory Multiple Myeloma Naïve to B-Cell Maturation Antigen (BCMA)-Directed Therapies: Results from Cohort a of the Magnetismm-3 Study

Nizar Jacques Bahlis, Michael H. Tomasson, Mohamad Mohty, Ruben Niesvizky, Ajay K. Nooka, Salomon Manier, Christopher Maisel, Yogesh Jethava, Joaquin Martinez-Lopez, H Miles Prince, Bertrand Arnulf, Paula Rodriguez Otero, Guenther Koehne, Cyrille Touzeau, Noopur Raje, Shinsuke Iida, Marc-Steffen Raab, Eric Leip, Sharon Sullivan, Umberto Conte, Andrea Viqueira, Alexander M Lesokhin
Journal: Blood
Blood (2022) 140 (Supplement 1): 391–393.
https://doi.org/10.1182/blood-2022-162440
Published: 2022
Journal Articles

Microbial Changes in Response to a Plant-Based Diet and/or Supplements in SMM Patients: A National Multi-Arm Randomized Prospective Telehealth Study Via Healthtree: The Nutrition Prevention (NUTRIVENTION-2) Study

Francesca Castro, Nathan W. Sweeney, Andriy Derkach, Kadiatou Traore, Aishwarya Anuraj, Laura Guttentag, Jenna Blaslov, Ana Sahagun, Jay Hydren, Cynthia Chmielewski, Terry Golombick, Justin R Cross, Jun J Mao, Marcel R M van den Brink, Saad Usmani, Jennifer M. Ahlstrom, Alexander M Lesokhin, Urvi A Shah
Journal: Blood
Blood (2022) 140 (Supplement 1): 13079–13081.
https://doi.org/10.1182/blood-2022-160241
Published: 2022
Journal Articles

Low Intake of Fruits and Vegetables and High Intake of Processed Meats and Juices Are Associated with Risk of MGUS in the National Health and Nutrition Examination Survey (NHANES) Database

Janine M. Joseph, Li Tang, Jens Hillengass, Kirsten Moysich, Ola Landgren, Saad Usmani, Alexander M Lesokhin, Susan E McCann, Urvi A Shah
Journal: Blood
Blood (2022) 140 (Supplement 1): 12556–12558.
https://doi.org/10.1182/blood-2022-167423
Published: 2022
Journal Articles

Genomic Determinants of Resistance in Newly Diagnosed Multiple Myeloma Treated with Targeted-Immunotherapy

Francesco Maura, Eileen Boyle, David Coffey, Kylee H Maclachlan, Benjamin Diamond, Patrick Blaney, Dylan Gagler, Bachisio Ziccheddu, Hussein Ghamlouch, Yubao Wang, James E. Hoffman, Dickran Kazandjian, Hani Hassoun, Emily Guzman, Sham Mailankody, Urvi A Shah, Carlyn Tan, Malin Hultcrantz, Michael Scordo, Gunjan L. Shah, Heather Landau, David J. Chung, Sergio A. Giralt, Yanming Zhang, Ahmet Dogan, Alexander M Lesokhin, Dennis Verducci, Faith E. Davies, Saad Usmani, Neha Korde, Gareth J. Morgan, Ola Landgren
Journal: Blood
Blood (2022) 140 (Supplement 1): 1137–1139.
https://doi.org/10.1182/blood-2022-160308
Published: 2022
Journal Articles

Initial Results of Dose Escalation of ISB 1342, a Novel CD3xCD38 Bispecific Antibody, in Patients with Relapsed / Refractory Multiple Myeloma (RRMM)

Sanjay R Mohan, Cristiana Costa Chase, Jesus G Berdeja, Lionel Karlin, Karim Belhadj, Aurore Perrot, Philippe Moreau, Cyrille Touzeau, Thomas Chalopin, Alexander M Lesokhin, Carol Ann Huff, David H. Vesole, Joshua Richter, Jeffrey V. Matous, Igor Proscurshim, Eileen Wolff, Girish Gudi, Andrew Garton, Vinu Menon, Sunitha Gn, Yacine Salhi, Eric J. Feldman, Mohamad Mohty
Journal: Blood
Blood (2022) 140 (Supplement 1): 7264–7266.
https://doi.org/10.1182/blood-2022-157525
Published: 2022
Journal Articles

Belantamab Mafodotin in Patients with Relapsed/Refractory Multiple Myeloma, a Real-World Single Center Experience

Malin Hultcrantz, Andriy Derkach, Hani Hassoun, Neha Korde, Kylee H Maclachlan, Sham Mailankody, Dhwani Patel, Urvi A Shah, Carlyn Tan, Theresia Akhlaghi, Issam S. Hamadeh, David J. Chung, Oscar B Lahoud, Heather Landau, Michael Scordo, Gunjan L. Shah, Sergio A. Giralt, Alexander M Lesokhin, Saad Usmani
Journal: Blood
Blood (2022) 140 (Supplement 1): 7246–7248.
https://doi.org/10.1182/blood-2022-171077
Published: 2022
Journal Articles

Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study

Niloufer Khan, Sarah Lindner, Antonio L. C. Gomes, Sean M. Devlin, Gunjan L. Shah, Anthony D. Sung, Craig S. Sauter, Heather J. Landau, Parastoo B. Dahi, Miguel-Angel Perales, David J. Chung, Alexander M. Lesokhin, Anqi Dai, Annelie Clurman, John B. Slingerland, Ann E. Slingerland, Daniel G. Brereton, Paul A. Giardina, Molly Maloy, Gabriel K. Armijo, Carlos Rondon-Clavo, Emily Fontana, Lauren Bohannon, Sendhilnathan Ramalingam, Amy T. Bush, Meagan V. Lew, Julia A. Messina, Eric Littmann, Ying Taur, Robert R. Jenq, Nelson J. Chao, Sergio Giralt, Kate A. Markey, Eric G. Pamer, Marcel R. M. van den Brink, Jonathan U. Peled
Journal: Blood
Blood (2021) 137 (11): 1527–1537.
https://doi.org/10.1182/blood.2020006923
Published: 2021
Includes: Supplemental data