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Aristotelis Tsirigos
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Journal Articles

Single Cell Analysis of Bone Marrow Stromal Cells Shows That a Pro-Inflammatory and Stress Response Together with Polarized Differentiation of Stromal Elements Characterize the Bone Marrow Microenvironment during Multiple Myeloma Development

Hussein Ghamlouch, Dylan Gagler, Patrick Blaney, Eileen Boyle, Yubao Wang, Liming Hou, Ola Landgren, Francesco Maura, Aristotelis Tsirigos, Gareth J. Morgan, Faith E. Davies
Journal: Blood
Blood (2023) 142 (Supplement 1): 332.
https://doi.org/10.1182/blood-2023-182968
Published: 2023
Journal Articles

The Genomic and Transcriptomic Landscape of Myeloid Sarcoma and Associated Acute Myeloid Leukemia

Bettina Nadorp, Audrey Lasry, Sanam Loghavi, Ravi Patel, Ben Kelly, Christopher J. Walker, Stephanie LaHaye, Jill Buss, Isaiah Boateng, Karen Nahmod, Adrienne Heyrosa, Helee Desai, Andrea Langanson, Hasan Abaza, Linda Procell, Tejas Patel, Benjamin Kaffenberger, Saranga Wijeratne, Maria Guillamot Ruano, Anna Yeaton, Geraldine Cayanan, Maria Velegraki, Zihai Li, Kieran D Sahasrabudhe, Lynne V. Abruzzo, Daniel Pollyea, Christine M. McMahon, Arwa Shana'Ah, John C. Byrd, Aristotelis Tsirigos, Elaine R Mardis, Alice Mims, Iannis Aifantis, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2023) 142 (Supplement 1): 292.
https://doi.org/10.1182/blood-2023-182967
Published: 2023
Journal Articles

Integrated Genomic Analysis Identifies a Downstream Regulatory Element Oncogenically Activating Hematopoietically Expressed Homeobox ( HHEX ) in ETP-ALL

Utpal P. Davé, Justin Layer, Bernhard Maier, Bryan Venters, Neal Copeland, Nancy Jenkins, Aristotelis Tsirigos, Javier Rodriguez Hernaez, Mircea Ivan
Journal: Blood
Blood (2023) 142 (Supplement 1): 1403.
https://doi.org/10.1182/blood-2023-182950
Published: 2023
Journal Articles

Haplodeficiency of the 9p21 tumor suppressor locus causes myeloid disorders driven by the bone marrow microenvironment

Jue Feng, Pei-Feng Hsu, Eduardo Esteva, Rossella Labella, Yueyang Wang, Alireza Khodadadi-Jamayran, Joseph Pucella, Cynthia Z. Liu, Arnaldo A. Arbini, Aristotelis Tsirigos, Stavroula Kousteni, Boris Reizis
Journal: Blood
Blood (2023) 142 (5): 460–476.
https://doi.org/10.1182/blood.2022018512
Published: 2023
Includes: Supplemental data
Journal Articles

Structural Heterogeneity of Chromosome 1q Drives Outcome in Newly Diagnoses Myeloma

Eileen M Boyle, Patrick Blaney, James Stoeckle, Yubao Wang, Hussein Ghamlouch, Avital Tenenbaum, Ariel Siegel, Xiaoyi Chen, Gaurav Varma, David Kaminetzsky, Marc Braunstein, Lydia Montes, Jill Corre, Even H Rustad, Ola Landgren, Francesco Maura, Benedetto Bruno, Aristotelis Tsirigos, Brian A. Walker, Faith E Davies, Dylan Gagler, Gareth J. Morgan
Journal: Blood
Blood (2022) 140 (Supplement 1): 4253–4254.
https://doi.org/10.1182/blood-2022-165467
Published: 2022
Journal Articles

The Role of Relapse Specific over-Expression of S100A8/A9 B Leukemic Cells in Promoting Chemoresistance

Clemence Aldebert, Emily Duan, Sylwia Jasinski, Talia H Ostrow, Isaiah Gonzalez, Aristotelis Tsirigos, Elizabeth A. Raetz, Nikki Ann Evensen, William L. Carroll
Journal: Blood
Blood (2022) 140 (Supplement 1): 6337–6338.
https://doi.org/10.1182/blood-2022-169273
Published: 2022
Journal Articles

Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens

Giuseppina Astone, Luca Vincenzo Cappelli, William Chiu, Clarisse Kayembe, Rui Wang, Bin Yang, Kirti Sharma, Joyoti Dey, Rahul Karnik, Lara Brambilla, David Levy, Liron Yoffe, Francesco Boccalatte, Javier Rodriguez Hernaez, Aristotelis Tsirigos, Paul Zumbo, Doron Betel, Akanksha Verma, Olivier Elemento, Michela Cumerlato, Roberto Piva, Steven M. Horwitz, Zachary D. Epstein-Peterson, Jared Gollob, Chris DeSavi, Phillip CC Liu, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 865.
https://doi.org/10.1182/blood-2021-153995
Published: 2021
Journal Articles

Multiomic Mapping of Copy Number and Structural Variation on Chromosome 1 (Chr1) Highlights Multiple Recurrent Disease Drivers

Patrick Blaney, Eileen M Boyle, Yubao Wang, Hussein Ghamlouch, Jinyoung Choi, Louis Williams, Stoeckle James, Ariel Siegel, Beatrice Razzo, Marc Braunstein, David Kaminetzky, Arnaldo A Arbini, Benedetto Bruno, Jill Corre, Lydia Montes, Daniel Auclair, Faith E. Davies, Aristotelis Tsirigos, Even H Rustad, Francesco Maura, Ola Landgren, Michael A Bauer, Brian Walker, Gareth Morgan
Journal: Blood
Blood (2021) 138 (Supplement 1): 721.
https://doi.org/10.1182/blood-2021-148439
Published: 2021
Journal Articles

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

Nevin Yusufova, Matthew R Teater, PhD, Alexey Soshnev, Andreas Kloetgen, Adewola Osunsade, Joseph Conway, Ashley Doane, Arthur Skoultchi, Aristotelis Tsirigos, PhD, Yael David, C. David Allis, PhD, Ethel Cesarman, MD PhD, Ari Melnick, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 23.
https://doi.org/10.1182/blood-2019-127774
Published: 2019
Journal Articles

Identification of a Whole Blood Signature for Venous Thromboembolism

Marie Hogan, MD, Hua Zhou, Tenzin Lhakhang, MD, Tessa Jo Barrett, PhD, Deirdre O'Reilly, Nathaniel Smilowitz, MD, Adriana Heguy, PhD, Thomas Maldonado, MD, Aristotelis Tsirigos, PhD, Jeffrey Berger, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3809.
https://doi.org/10.1182/blood-2018-99-110225
Published: 2018
Journal Articles

Genomic and Epigenetic Effects of DNA Methyltransferase Inhibition in Acute Lymphoblastic Leukemia

Shella Saint Fleur-Lominy, MDPhD, Teena Bhatla, MD, Stephen Kelly, MS, Varshini Vasudevaraja, MS, Aristotelis Tsirigos, PhD, William L. Carroll, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2479.
https://doi.org/10.1182/blood.V130.Suppl_1.2479.2479
Published: 2017
Journal Articles

An Oncogene-Regulated Epigenetic Switch in T Cell Acute Lymphoblastic Leukemia

Panagiotis Ntziachristos, PhD, Aristotelis Tsirigos, Grant Welstead, Thomas Trimarchi, Linda Holmfeldt, PhD, Takashi Satoh, Elisabeth M. Paietta, PhD, Martin S. Tallman, MD, Jacob M. Rowe, MD, Giovanni Tonon, MDPhD, Jared Becksfort, MS, Laurens Kruidenier, Rab K Prinjha, Pieter Van Vlierberghe, Rudolph Jaenisch, PhD, Adolfo A. Ferrando, MD PhD, Charles G. Mullighan, MBBS, MSc, MD, Iannis Aifantis
Journal: Blood
Blood (2014) 124 (21): 56.
https://doi.org/10.1182/blood.V124.21.56.56
Published: 2014