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Jared Gollob
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Journal Articles

Preliminary Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of KT-333, a Targeted Protein Degrader of STAT3, in Patients with Relapsed or Refractory Lymphomas, Large Granular Lymphocytic Leukemia, and Solid Tumors

Aditi Shastri, Eric J Feldman, Alexander N Starodub, Tatyana Feldman, Cristina P Rodriguez, Zachary D. Epstein-Peterson, Don A. Stevens, Adam J Olszewski, Auris O Huen, Pierluigi Porcu, John C Reneau, Stefan K. Barta, Enrica Marchi, Ahmad H Mattour, Lauren C. Pinter-Brown, Rachelle Perea, Sean Donohue, Joyoti Dey, Sagar Agarwal, Rahul Karnik, Ashwin Gollerkeri, Jared Gollob, Stephen D Smith
Journal: Blood
Blood (2023) 142 (Supplement 1): 3081.
https://doi.org/10.1182/blood-2023-181130
Published: 2023
Journal Articles

A STAT3 Degrader Demonstrates Pre-Clinical Efficacy in Venetoclax Resistant Acute Myeloid Leukemia

Samarpana Chakraborty, Claudia Morganti, Joyoti Dey, Hui Zhang, Srinivas Aluri, Nadege Gitego, Kith Pradhan, Bianca Rivera, Yogesh Chutake, Anna Skwarska, Ioannis Mantzaris, Mendel Goldfinger, Eric J Feldman, Gaurav S Choudhary, Stefan Hubner, Yihua Qiu, Brandon D. Brown, Amit Verma, Evripidis Gavathiotis, Marina Y. Konopleva, Steven M. Kornblau, Jared Gollob, Keisuke Ito, Aditi Shastri
Journal: Blood
Blood (2023) 142 (Supplement 1): 2787.
https://doi.org/10.1182/blood-2023-186947
Published: 2023
Journal Articles

Phase 1 Study of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates, in Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Jennifer Kimberly Lue, Don A. Stevens, Michael E. Williams, Jason Westin, Reggie Ewesuedo, Alice McDonald, Sagar Agarwal, Patrick Henrick, Rachelle Perea, Jared Gollob
Journal: Blood
Blood (2022) 140 (Supplement 1): 12143–12144.
https://doi.org/10.1182/blood-2022-170151
Published: 2022
Journal Articles

Leveraging Pre-Clinical Animal Model of CTCL to Explore Therapeutic Potential of a Novel STAT3 Degrader

Ellie Ivanova, Cosmin A Tegla, Ekaterina Novikova, Alberto M Herrera, Briana Mullins, Jo-Ann Latkowski, Kenneth B. Hymes, Joyoti Dey, Bin Yang, Ashwin Gollerkeri, Jared Gollob, Sergei B. Koralov
Journal: Blood
Blood (2022) 140 (Supplement 1): 3557–3558.
https://doi.org/10.1182/blood-2022-156816
Published: 2022
Journal Articles

Precision Targeting of MYD88 Mutant DLBCL Using the Novel Combination of Irakimids and BCL2 Inhibition

Andre M. Grilo, Christine Klaus, Alice McDonald, Jared Gollob, Matt Weiss, Owen A. O'Connor, Gilles Salles, Jayanta Chaudhuri, Jennifer Kimberly Lue
Journal: Blood
Blood (2022) 140 (Supplement 1): 8862–8864.
https://doi.org/10.1182/blood-2022-159567
Published: 2022
Journal Articles

A Phase 1 Study of KT-333, a Targeted Protein Degrader of STAT3, in Patients with Relapsed or Refractory Lymphomas, Large Granular Lymphocytic Leukemia, and Solid Tumors

Stephen D Smith, Alexander Starodub, Don A. Stevens, Aditi Shastri, Pierluigi Porcu, Tatyana Feldman, Reggie Ewesuedo, Chris DeSavi, Joyoti Dey, Sagar Agarwal, Sean Donohue, Rachelle Perea, Christine Klaus, Jared Gollob
Journal: Blood
Blood (2022) 140 (Supplement 1): 12024–12025.
https://doi.org/10.1182/blood-2022-169514
Published: 2022
Journal Articles

A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers

Phillip CC Liu, Vaishali Dixit, Michele Mayo, Joyoti Dey, Karen Yuan, Rahul Karnik, Dirk Walther, Yatao Shi, Kirti Sharma, Haojing Rong, Bin Yang, Ashwin Gollerkeri, Jared Gollob, Chris DeSavi
Journal: Blood
Blood (2021) 138 (Supplement 1): 1865.
https://doi.org/10.1182/blood-2021-151125
Published: 2021
Journal Articles

Selective STAT3 Degraders Dissect Peripheral T-Cell Lymphomas Vulnerabilities Empowering Personalized Regimens

Giuseppina Astone, Luca Vincenzo Cappelli, William Chiu, Clarisse Kayembe, Rui Wang, Bin Yang, Kirti Sharma, Joyoti Dey, Rahul Karnik, Lara Brambilla, David Levy, Liron Yoffe, Francesco Boccalatte, Javier Rodriguez Hernaez, Aristotelis Tsirigos, Paul Zumbo, Doron Betel, Akanksha Verma, Olivier Elemento, Michela Cumerlato, Roberto Piva, Steven M. Horwitz, Zachary D. Epstein-Peterson, Jared Gollob, Chris DeSavi, Phillip CC Liu, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 865.
https://doi.org/10.1182/blood-2021-153995
Published: 2021
Journal Articles

Targeting MYD88-Mutant DLBCL with IRAKIMiDs: A Comparison to IRAK4 Kinase Inhibition and Evaluation of Synergy with Rational Combinations

Jennifer Kimberly Lue, MD, John S Manavalan, MD, Christine Klaus, BS, Rahul Kanik, PhD, Andre M. Grilo, PhD, Alice McDonald, PhD, Jared Gollob, PhD MD, Duncan Walker, PhD, Owen A. O'Connor, MD PhD, Nello Mainolfi, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12.
https://doi.org/10.1182/blood-2020-135898
Published: 2020
Journal Articles

Ktx-120, a Novel Irakimid Degrader of IRAK4 and IMiD Substrates Shows Preferential Activity and Induces Regressions in MYD88-Mutant DLBCL CDX and PDX Models

Duncan Walker, PhD, Michele Mayo, Christine Klaus, BS, Dapeng Chen, PhD, Samyabrata Bhaduri, PhD, Kirti Sharma, Scott Rusin, Alice McDonald, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD, Matt Weiss, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41.
https://doi.org/10.1182/blood-2020-137750
Published: 2020
Journal Articles

Mechanisms of the Anti-Tumor Activity of STAT3 Degraders in Lymphoma

Haojing Rong, PhD, Kirti Sharma, Fred Csibi, Bin Yang, Scott Rusin, Yatao Shi, PhD, Joyoti Dey, PhD, Rahul Karnik, Michele Mayo, Karen Yuan, Yogesh Chutake, Alice McDonald, PhD, Sean Zhu, PhD, Nan Ji, PhD, Phillip Liu, PhD, Henry Li, PhD, Duncan Walker, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD, Chris Desavi
Journal: Blood
Blood (2020) 136 (Supplement 1): 42.
https://doi.org/10.1182/blood-2020-137778
Published: 2020
Journal Articles

Small Molecule-Induced, Selective STAT3 Degradation Leads to Anti-Tumor Activity in STAT3-Dependent Heme Malignancies

Fred Csibi, Nan Ji, PhD, Bin Yang, Karen Yuan, Michele Mayo, Haojing Rong, PhD, Scott Rusin, Kirti Sharma, Christine Loh, PhD, Henry Li, PhD, Sharon Townson, Jesse Chen, PhD, Hari Kamadurai, PhD, Duncan Walker, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3803.
https://doi.org/10.1182/blood-2019-128981
Published: 2019