1-14 of 14
Alice McDonald
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Phase 1 Study of KT-413, a Targeted Protein Degrader of IRAK4 and IMiD Substrates, in Adult Patients with Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

Jennifer Kimberly Lue, Don A. Stevens, Michael E. Williams, Jason Westin, Reggie Ewesuedo, Alice McDonald, Sagar Agarwal, Patrick Henrick, Rachelle Perea, Jared Gollob
Journal: Blood
Blood (2022) 140 (Supplement 1): 12143–12144.
https://doi.org/10.1182/blood-2022-170151
Published: 2022
Journal Articles

Development of KT-253, a Highly Potent and Selective Heterobifunctional MDM2 Degrader for the Treatment of Acute Myeloid Leukemia

Michele Mayo, Yogesh Chutake, Rahul Karnik, Alice McDonald, Patricia S. Cho, Jessica Filiatrault, Dapeng Chen, Vaishali Dixit, William Proctor, Susanne Breitkopf, Frank Qi, Kan-Nian Hu, Kirti Sharma, Reggie Ewesuedo, Matt Weiss, Joseph D. Growney, Juliet Williams, Stefanie S Schalm
Journal: Blood
Blood (2022) 140 (Supplement 1): 6239–6240.
https://doi.org/10.1182/blood-2022-169021
Published: 2022
Journal Articles

Precision Targeting of MYD88 Mutant DLBCL Using the Novel Combination of Irakimids and BCL2 Inhibition

Andre M. Grilo, Christine Klaus, Alice McDonald, Jared Gollob, Matt Weiss, Owen A. O'Connor, Gilles Salles, Jayanta Chaudhuri, Jennifer Kimberly Lue
Journal: Blood
Blood (2022) 140 (Supplement 1): 8862–8864.
https://doi.org/10.1182/blood-2022-159567
Published: 2022
Journal Articles

Targeting MYD88-Mutant DLBCL with IRAKIMiDs: A Comparison to IRAK4 Kinase Inhibition and Evaluation of Synergy with Rational Combinations

Jennifer Kimberly Lue, MD, John S Manavalan, MD, Christine Klaus, BS, Rahul Kanik, PhD, Andre M. Grilo, PhD, Alice McDonald, PhD, Jared Gollob, PhD MD, Duncan Walker, PhD, Owen A. O'Connor, MD PhD, Nello Mainolfi, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12.
https://doi.org/10.1182/blood-2020-135898
Published: 2020
Journal Articles

Ktx-120, a Novel Irakimid Degrader of IRAK4 and IMiD Substrates Shows Preferential Activity and Induces Regressions in MYD88-Mutant DLBCL CDX and PDX Models

Duncan Walker, PhD, Michele Mayo, Christine Klaus, BS, Dapeng Chen, PhD, Samyabrata Bhaduri, PhD, Kirti Sharma, Scott Rusin, Alice McDonald, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD, Matt Weiss, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41.
https://doi.org/10.1182/blood-2020-137750
Published: 2020
Journal Articles

Mechanisms of the Anti-Tumor Activity of STAT3 Degraders in Lymphoma

Haojing Rong, PhD, Kirti Sharma, Fred Csibi, Bin Yang, Scott Rusin, Yatao Shi, PhD, Joyoti Dey, PhD, Rahul Karnik, Michele Mayo, Karen Yuan, Yogesh Chutake, Alice McDonald, PhD, Sean Zhu, PhD, Nan Ji, PhD, Phillip Liu, PhD, Henry Li, PhD, Duncan Walker, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD, Chris Desavi
Journal: Blood
Blood (2020) 136 (Supplement 1): 42.
https://doi.org/10.1182/blood-2020-137778
Published: 2020
Journal Articles

Updated Report on Identification of Molecular Predictors of Tazemetostat Response in an Ongoing NHL Phase 2 Study

Alice McDonald, Elizabeth Thomas, Scott Daigle, Franck Morschhauser, Gilles Salles, MD PhD, Vincent Ribrag, Pamela McKay, MD, Herve Tilly, MD, Anna Schmitt, Connie Lee Batlevi, MD, Christophe Fruchart, Peter Johnson, MD, Michael Dickinson, MD, Stephen Opat, Wojciech Jurczak, Guillaume Cartron, Thierry Lamy, Pier Luigi Zinzani, MD, Sarit Assouline, John Radford, MD FRCP, John G. Gribben, Corinne Haioun, MD, Aristeidis Chaidos, MD PhD, Steven Le Gouill, MD PhD, Alicia Clawson, John Larus, Stephen J Blakemore
Journal: Blood
Blood (2018) 132 (Supplement 1): 4097.
https://doi.org/10.1182/blood-2018-99-115132
Published: 2018
Journal Articles

Phase 1 Study of Tazemetostat (EPZ-6438), an Inhibitor of Enhancer of Zeste-Homolog 2 (EZH2): Preliminary Safety and Activity in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) Patients

Vincent Ribrag, Jean-Charles Soria, Professor, Jean-Marie Michot, Anna Schmitt, MD, Sophie Postel-Vinay, MD, Fontanet Bijou, MD, Blythe Thomson, MD, Heike Keilhack, PhD, Stephen J. Blakemore, PhD, Larisa Reyderman, PhD, Pavan Kumar, PhD, Greg Fine, MS, Alice McDonald, Peter T Ho, PhD MD, Antoine Italiano, MD
Journal: Blood
Blood (2015) 126 (23): 473.
https://doi.org/10.1182/blood.V126.23.473.473
Published: 2015
Journal Articles

The DOT1L Inhibitor EPZ-5676: Safety and Activity in Relapsed/Refractory Patients with MLL-Rearranged Leukemia

Eytan M. Stein, Guillermo Garcia-Manero, MD, David A. Rizzieri, MD, Michael Savona, MD, Raoul Tibes, MD, Jessica K Altman, Mojca Jongen-Lavrencic, MD PhD, Hartmut Döhner, Prof., Scott Armstrong, MD PhD, Roy M Pollock, PhD, Nigel J Waters, PhD, Michelle Legler, MSHS, Blythe Thomson, MD, Scott Daigle, Alice McDonald, Carly Campbell, Ed Olhava, Eric E Hedrick, MD, Bob Lowenberg, MDPhD, Robert A Copeland, PhD, Martin S. Tallman, MD
Journal: Blood
Blood (2014) 124 (21): 387.
https://doi.org/10.1182/blood.V124.21.387.387
Published: 2014
Journal Articles

Phase 1 Dose-Escalation Study of MLN4924, a Novel NAE Inhibitor, in Patients with Multiple Myeloma and Non-Hodgkin Lymphoma.

Jatin J Shah, Andrzej J Jakubowiak, Owen A O’Connor, Robert Z Orlowski, Molly Patterson, Donald Harvey, Allison J Berger, Alice McDonald, George Mulligan, Lilli Petruzzelli, Michael D Pickard, Peter G Smith, Karthik Venkatakrishnan, Sagar Lonial
Journal: Blood
Blood (2009) 114 (22): 1854.
https://doi.org/10.1182/blood.V114.22.1854.1854
Published: 2009
Journal Articles

Immunohistochemical Analyses for Potential Biomarkers of Bortezomib Activity in Mantle Cell Lymphoma from the PINNACLE Phase 2 Trial.

Andre Goy, Steven H. Bernstein, Alice McDonald, Michael D. Pickard, Mark D. Fleming, Barb Bryant, William Trepicchio, Richard I. Fisher, Anthony Boral, George Mulligan
Journal: Blood
Blood (2007) 110 (11): 2573.
https://doi.org/10.1182/blood.V110.11.2573.2573
Published: 2007
Journal Articles

Pre-Treatment p27 and Bcl-6 Staining Levels Correlate with Response to Bortezomib in Non-Hodgkin Lymphoma: Results from a Tissue Microarray Analysis

John Gerecitano, Sivaraman Gounder, Julie Feldstein, Shahiba Ogilvie, Dorothy Lin, Junting Zheng, Zhigang Zhang, Alice McDonald, George Mulligan, Owen A. O’Connor
Journal: Blood
Blood (2007) 110 (11): 1294.
https://doi.org/10.1182/blood.V110.11.1294.1294
Published: 2007
Journal Articles

The Steap proteins are metalloreductases

Robert S. Ohgami, Dean R. Campagna, Alice McDonald, Mark D. Fleming
Journal: Blood
Blood (2006) 108 (4): 1388–1394.
https://doi.org/10.1182/blood-2006-02-003681
Published: 2006
Includes: Supplemental data
Journal Articles

Selective Rapid B-Cell Depletion In Vivo by Pharmacologic IKK2 Inhibition.

Christopher C. Fraser, Ph.D., Kumiko Nagashima, M.Sc., Vito Sasseville, Ph.D., Jim Deeds, M.Sc., Alice McDonald, M.Sc., Chris Simpson, M.Sc., Yajun Xu, Ph.D
Journal: Blood
Blood (2004) 104 (11): 2481.
https://doi.org/10.1182/blood.V104.11.2481.2481
Published: 2004