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Christopher Walker
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Journal Articles

Selinexor alone and in combination with JAK inhibitors suppresses pro-inflammatory cytokine secretion from primary myelofibrosis cells ex vivo

Free
Trinayan Kashyap, Christopher Walker, Andrea Ellero, John Mascarenhas, Raajit Rampal, Pankit Vachhani, Yair Levy, Zhanet Grudeva-Popova, Pietro Taverna
Journal: Blood
Blood (2025) 146 (Supplement 1): 5537.
https://doi.org/10.1182/blood-2025-5537
Published: 2025
Journal Articles

XPO1 inhibition by selinexor blocks nucleo-cytoplasmic trafficking of multiple members of the NF-kb family in MPN cell lines and primary myelofibrosis cells

Free
Anthony Pomicter, Kristin Starr, Yurong Ouyang, Josh Monts, James Marvin, Andrea Ellero, Christopher Walker, Srinivas Tantravahi
Journal: Blood
Blood (2025) 146 (Supplement 1): 7275.
https://doi.org/10.1182/blood-2025-7275
Published: 2025
Journal Articles

Exploiting RAS pathway addiction as a therapeutic vulnerability in myeloid sarcoma

Free
Audrey Lasry, Bettina Nadorp, Sanam Loghavi, Ravi Patel, Hager Mansour, Ben Kelly, Christopher Walker, Jill Buss, Isaiah Boateng, Wafa Al-Santli, Zoe Ciantra, Rebecca Austin, Adrienne Heyrosa, Helee Desai, Andrea Laganson, Hasan Abaza, Linda Procell, Tejas Patel, Benjamin Kaffenberger, Saranga Wijeratne, Maria Guillamot, Maria Velegraki, Luis Chiriboga, Zihai Li, Lynne Abruzzo, Daniel Pollyea, Christine McMahon, Arwa Shana'Ah, John Byrd, Alan Shih, Ross Levine, Eirini Papapetrou, Aristotelis Tsirigos, Elaine Mardis, Alice Mims, Iannis Aifantis, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2025) 146 (Supplement 1): 220.
https://doi.org/10.1182/blood-2025-220
Published: 2025
Journal Articles

Phip Is a Potent Leukemia Oncogene Identified in Acute Myeloid Leukemia (AML) Patients of African Ancestry

Free
Bailee N. Kain, Sidharth Sen, Deedra Nicolet, Sierra N. Bennett, David Bernardicius, Yueh-Chiang Hu, Christopher Walker, Ann-Kathrin Eisfeld, Nathan Salomonis, H. Leighton Grimes
Journal: Blood
Blood (2024) 144 (Supplement 1): 327.
https://doi.org/10.1182/blood-2024-210463
Published: 2024
Journal Articles

BCR-ABL1 Kinase Activity but Not Its Expression Is Dispensable for Ph+ Quiescent Stem Cell Survival Which Depends on the PP2A-Controlled Jak2 Activation and Is Sensitive to FTY720 Treatment

Free
Paolo Neviani, Ph.D, Jason G Harb, Ph.D, Joshua J Oaks, B.S., Christopher Walker, B.S., Ramasamy Santhanam, Ph.D, Carolyn Paisie, B.S., Anna Eiring, Ph.D, Bin Zhang, Ph.D, Bastianella Perazzona, Ph.D, Y. Ma, Charlene Mao, Guido Marcucci, MD, Tessa L. Holyoake, PhD, FRCP, FRCPath, Stefano Volinia, MD, Jorge E. Cortes, MD, Michael A. Caligiuri, MD, Claudia Huettner, Ph.D, Robert Bittman, Ph.D, Ching-Shih Chen, Ph.D, Ralph B. Arlinghaus, PhD, Peter Hokland, MD, DMSC, Denis-Claude Roy, MD, FRCPC, Ravi Bhatia, MD, Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 515.
https://doi.org/10.1182/blood.V116.21.515.515
Published: 2010
Journal Articles

PP2A Activating Drugs (PAD): Anti-Leukemic and Non-Toxic Activity of Two Novel and Non-Immunosuppressive FTY720 Derivatives

Free
Christopher Walker, B.S., Joshua J Oaks, B.S., Paolo Neviani, Ph.D, Jason G Harb, Ph.D., Ramasamy Santhanam, Ph.D, Y. Ma, Guido Marcucci, MD, James Van Brocklyn, Ph.D, Ching-Shih Chen, Ph.D, Robert Bittman, Ph.D, Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 2901.
https://doi.org/10.1182/blood.V116.21.2901.2901
Published: 2010
Journal Articles

Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders

Free
Joshua J Oaks, A. Mukhopadhyay, Ramasamy Santhanam, S. A Saddoughi, Christopher Walker, Paolo Neviani, Jason G Harb, Y. Ma, Srdan Verstovsek, MD, PhD, Guido Marcucci, MD, Roger Briesewitz, Robert Bittman, Ching-Shih Chen, Alfonso Quintas-Cardama, MD, Besim Ogretmen, Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 775.
https://doi.org/10.1182/blood.V116.21.775.775
Published: 2010
Journal Articles

Ex Vivo Multiplexed Signal Pathway Inhibitor Treatment Reveals Differential Sensitivity of Myeloma and Non-Myeloma Bone Marrow Cell Populations.

Free
Virginia Espina, MS, Alessandra Romano, MD, Amy VanMeter, BS, Gregory Orloff, MD, Alexander I. Spira, MD, PhD, Dipti Patel, MD, Christopher Walker, BS, Emanuel F Petricoin, III, PhD, Lance A Liotta, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2860.
https://doi.org/10.1182/blood.V114.22.2860.2860
Published: 2009