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Journal Articles

Mitophagy As a Novel Cell-Protective Mechanism Against Mitochondrial Ferroptosis in Acute Myeloid Leukemia

Hiroki Akiyama, Matthew Tcheng, Priyanka Sharma, Ran Zhao, Lauren B. Ostermann, Samar Yazdani, Arman Moayed, Zdzislaw Szulc, Natalia Oleinik, Po Yee Mak, Vivian Ruvolo, Bing Z. Carter, Besim Ogretmen, Gautam Borthakur, Aaron D. Schimmer, Michael Andreeff, Jo Ishizawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 2804.
https://doi.org/10.1182/blood-2023-181410
Published: 2023
Journal Articles

Inhibition of Sphingosine Kinase 2 Enhances Immunotherapy in Mouse Model of Multiple Myeloma

Yubin Kang, Xiaobei Wang, Jian Wu, Shaima Jabbar, Chongming Tom Jiang, Xiling Shen, Besim Ogretmen
Journal: Blood
Blood (2023) 142 (Supplement 1): 876.
https://doi.org/10.1182/blood-2023-186965
Published: 2023
Journal Articles

S1P/S1PR1 Signalis Required for Optimal T-Cell Pathogenicity to Induce Gvhd By RegulatingDrp1/mTOR Axis

Linlu Tian, Yongxia Wu, Hee-Jin Choi, Xiaohui Sui, Mohammed Hanief Sofi, Mohamed Faisal Kassir, Paul J Martin, Shikhar Mehrotra, Besim Ogretmen, Xue-Zhong Yu
Journal: Blood
Blood (2021) 138 (Supplement 1): 643.
https://doi.org/10.1182/blood-2021-149660
Published: 2021
Journal Articles

Complement Promotes Gvhd through Suppressing Autophagy in Recipient Dendritic Cells after Allogeneic Hematopoietic Cell Transplantation in Mice

Hung D Nguyen, PhD, David Bastian, Sandeepkumar Kuril, MD, Mohammmed Dany, David Fairlie, PhD, Carl Atkinson, PhD, Besim Ogretmen, PhD, Stephen Tomlinson, PhD, Xue-Zhong Yu, MD MS
Journal: Blood
Blood (2017) 130 (Supplement 1): 1904.
https://doi.org/10.1182/blood.V130.Suppl_1.1904.1904
Published: 2017
Journal Articles

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

Mohammed Dany, Salih Gencer, Rose Nganga, Raquela J. Thomas, Natalia Oleinik, Kyla D. Baron, Zdzislaw M. Szulc, Peter Ruvolo, Steven Kornblau, Michael Andreeff, Besim Ogretmen
Journal: Blood
Blood (2016) 128 (15): 1944–1958.
https://doi.org/10.1182/blood-2016-04-708750
Published: 2016
Includes: Supplemental data
Journal Articles

Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma

Jagadish Kummetha Venkata, Ningfei An, Robert Stuart, Luciano J. Costa, Houjian Cai, Woodrow Coker, Jin H. Song, Kiwana Gibbs, Terri Matson, Elizabeth Garrett-Mayer, Zhuang Wan, Besim Ogretmen, Charles Smith, Yubin Kang
Journal: Blood
Blood (2014) 124 (12): 1915–1925.
https://doi.org/10.1182/blood-2014-03-559385
Published: 2014
Includes: Supplemental data
Journal Articles

Targeting Sphingosine Kinase Induces Apoptosis and Regression Of Virus-Associated Lymphoma In Vivo

Zhiqiang Qin, Lu Dai, Karlie Plaisance-Bonstaff, Can Senkal, Wenxue Wang, Thomas M. Reske, MD, Luis Del Valle, Christina Voelkel-Johnson, Erik Flemington, Besim Ogretmen, Charles D Smith, Chris Parsons
Journal: Blood
Blood (2013) 122 (21): 4414.
https://doi.org/10.1182/blood.V122.21.4414.4414
Published: 2013
Journal Articles

Antagonistic activities of the immunomodulator and PP2A-activating drug FTY720 (Fingolimod, Gilenya) in Jak2-driven hematologic malignancies

Joshua J. Oaks, Ramasamy Santhanam, Christopher J. Walker, Steve Roof, Jason G. Harb, Greg Ferenchak, Ann-Kathrin Eisfeld, James R. Van Brocklyn, Roger Briesewitz, Sahar A. Saddoughi, Kyosuke Nagata, Robert Bittman, Michael A. Caligiuri, Omar Abdel-Wahab, Ross Levine, Ralph B. Arlinghaus, Alfonso Quintas-Cardama, John M. Goldman, Jane Apperley, Alistair Reid, Dragana Milojkovic, Mark T. Ziolo, Guido Marcucci, Besim Ogretmen, Paolo Neviani, Danilo Perrotti
Journal: Blood
Blood (2013) 122 (11): 1923–1934.
https://doi.org/10.1182/blood-2013-03-492181
Published: 2013
Includes: Supplemental data
Journal Articles

FTY720 Restores PP2A Tumor Suppressor Activity in Polycythemia Vera CD34 + Progenitors Through Inhibition of Jak2 V617F- and PI-3Kγ-Dependent SET Serine Phosphorylation and Enhancement of NOS-Dependent PP2A Tyrosine Nitration

Joshua J Oaks, A. Mukhopadhyay, Ramasamy Santhanam, PhD, S. A Saddoughi, Paolo Neviani, PhD, Jason G Harb, Ph.D, Besim Ogretmen, PhD, Robert Bittman, Ph.D, Ross L Levine, MD, Alfonso Quintás-Cardama, MD, Guido Marcucci, MD, Danilo Perrotti, MD, Ph.D
Journal: Blood
Blood (2011) 118 (21): 2494.
https://doi.org/10.1182/blood.V118.21.2494.2494
Published: 2011
Journal Articles

Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A

Arelis Salas, Suriyan Ponnusamy, Can E. Senkal, Marisa Meyers-Needham, Shanmugam Panneer Selvam, Sahar A. Saddoughi, Elif Apohan, R. David Sentelle, Charles Smith, Christopher R. Gault, Lina M. Obeid, Hesham M. El-Shewy, Joshua Oaks, Ramasamy Santhanam, Guido Marcucci, Yusuf Baran, Sandeep Mahajan, Daniel Fernandes, Robert Stuart, Danilo Perrotti, Besim Ogretmen
Journal: Blood
Blood (2011) 117 (22): 5941–5952.
https://doi.org/10.1182/blood-2010-08-300772
Published: 2011
Includes: Supplemental data
Journal Articles

Pharmacologic Restoration of PP2A Activity and Interference with the SET-PP2A Interplay by FTY720 and Its Non-Immunosuppressive Derivative as a Novel and Efficient Therapy for Ph-Negative Myeloproliferative Disorders

Joshua J Oaks, A. Mukhopadhyay, Ramasamy Santhanam, S. A Saddoughi, Christopher Walker, Paolo Neviani, Jason G Harb, Y. Ma, Srdan Verstovsek, MD, PhD, Guido Marcucci, MD, Roger Briesewitz, Robert Bittman, Ching-Shih Chen, Alfonso Quintas-Cardama, MD, Besim Ogretmen, Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 775.
https://doi.org/10.1182/blood.V116.21.775.775
Published: 2010
Journal Articles

FTY720 but Not Its Immunosuppressive Phosphorylated Form FTY720-P Exerts Anti-Leukemic Activity towards Ph(+) and Ph(−) Myeloproliferative Disorders through Reactivation of the PP2A Tumor Suppressor.

Joshua Oaks, BS, Paolo Neviani, PhD, A. Mukhopadhyay, Ramasamy Santhanam, PhD, Y. Ma, Charlene Mao, Guido Marcucci, MD, Ching-Shih Chen, Jorge Cortes, MD, Michael A. Caligiuri, M.D., Peter Hokland, Sr., Claudia Huettner, PhD, Steffen Koschmieder, MD, Jose Cancelas, MD, PhD, Roger Briesewitz, PhD, Ravi Bhatia, MD, Denis-Claude Roy, MD, Besim Ogretmen, PhD, Danilo Perrotti, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3259.
https://doi.org/10.1182/blood.V114.22.3259.3259
Published: 2009