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Journal Articles

Calibrated Release IL15 Bivalent CD33 and/or FLT3 and NOT Emcn Logic Gated Gene Circuit CAR-NK Cell Therapy (SENTI-202) in Venetoclax Resistant Patient Derived Xenograft Acute Myeloid Leukemia Models

Muharrem Muftuoglu, Mahesh Basyal, Li Li, Jiangxing Lv, Lauren B. Ostermann, Ran Zhao, Baozhen Ke, Hiroki Akiyama, Po Yee Mak, Bing Z. Carter, Han Deng, Yongshuai Li, Brian S. Garrison, Kanya L. Rajangam, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 4831.
https://doi.org/10.1182/blood-2023-191127
Published: 2023
Journal Articles

Selective Targeting of TP53-Y220C Mutant AML By PC14586 Results in TP53 Wild-Type Conformation and Synergistical Apoptosis Induction By Concomitant Inhibition of Xpo-1, MDM2, or Bcl-2

Bing Z. Carter, Po Yee Mak, Baozhen Ke, Yuki Nishida, Steffen Boettcher, Andrea Bedoy, Lauren B. Ostermann, Courtney D. DiNardo, Anna Puzio-Kuter, Arnold Levine, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 2261.
https://doi.org/10.1182/blood-2023-181186
Published: 2023
Journal Articles

Mitophagy As a Novel Cell-Protective Mechanism Against Mitochondrial Ferroptosis in Acute Myeloid Leukemia

Hiroki Akiyama, Matthew Tcheng, Priyanka Sharma, Ran Zhao, Lauren B. Ostermann, Samar Yazdani, Arman Moayed, Zdzislaw Szulc, Natalia Oleinik, Po Yee Mak, Vivian Ruvolo, Bing Z. Carter, Besim Ogretmen, Gautam Borthakur, Aaron D. Schimmer, Michael Andreeff, Jo Ishizawa
Journal: Blood
Blood (2023) 142 (Supplement 1): 2804.
https://doi.org/10.1182/blood-2023-181410
Published: 2023
Journal Articles

ERK1/2 Inhibition Overcomes Resistance to Venetoclax in AML By Inhibiting Drp1 Dependent Mitochondrial Fission

Priyanka Sharma, Lauren B. Ostermann, Sujan Piya, Baozhen Ke, Natalia Baran, Anudishi Tyagi, Muharrem Muftuoglu, Mahesh Basyal, Qi Zhang, Joanne Munck, Kim-Hien Dao, Martin Sims, Bing Z. Carter, Venkata Lokesh Battula, Michael Andreeff, Gautam Borthakur
Journal: Blood
Blood (2023) 142 (Supplement 1): 412.
https://doi.org/10.1182/blood-2023-185700
Published: 2023
Journal Articles

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Yuki Nishida, Edward Ayoub, Darah Scruggs, Shayaun Khazaei, Faryal Munir, Lauren B. Ostermann, Po Yee Mak, Ke Baozhen, Bing Z. Carter, Natalia Baran, Abhishek Maiti, Vakul Mohanty, Ken Chen, Nicholas Navin, Torsten Haferlach, Zhihua Ren, Youzhi Tong, Dong Chen, Ghayas C. Issa, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 583.
https://doi.org/10.1182/blood-2023-174938
Published: 2023
Journal Articles

TP53 Y220C Mutations in Patients with Myeloid Malignancies

Georgina Gener-Ricos, Jan Philipp Bewersdorf, Sanam Loghavi, Aaron D. Goldberg, Christopher Famulare, Ghayas C. Issa, Gautam Borthakur, Tapan M. Kadia, Bing Z. Carter, Keyur P. Patel, Michael Andreeff, Eytan M. Stein, Courtney D. DiNardo
Journal: Blood
Blood (2023) 142 (Supplement 1): 1477.
https://doi.org/10.1182/blood-2023-189343
Published: 2023
Journal Articles

Novel Hypomethylating Agent Ntx-301 Exhibits Anti-Leukemia Activity in Venetoclax-Resistant and TP53-Mutant AML

Bing Z. Carter, Po Yee Mak, Baozhen Ke, Andrea Bedoy, Steffen Boettcher, Lauren B. Ostermann, Elizabeth J. Shpall, Michael Andreeff
Journal: Blood
Blood (2023) 142 (Supplement 1): 4158.
https://doi.org/10.1182/blood-2023-180051
Published: 2023
Journal Articles

Epichaperome inhibition targets TP53- mutant AML and AML stem/progenitor cells

Bing Z. Carter, Po Yee Mak, Muharrem Muftuoglu, Wenjing Tao, Baozhen Ke, Jingqi Pei, Andrea D. Bedoy, Lauren B. Ostermann, Yuki Nishida, Sevinj Isgandarova, Mary Sobieski, Nghi Nguyen, Reid T. Powell, Margarita Martinez-Moczygemba, Clifford Stephan, Mahesh Basyal, Naveen Pemmaraju, Steffen Boettcher, Benjamin L. Ebert, Elizabeth J. Shpall, Barbara Wallner, Robert A. Morgan, Georgios I. Karras, Ute M. Moll, Michael Andreeff
Journal: Blood
Blood (2023) 142 (12): 1056–1070.
https://doi.org/10.1182/blood.2022019047
Published: 2023
Includes: Supplemental data
Journal Articles

Epichaperome Inhibition Targets Kinase and TP53 Mutant Therapy Resistant AML

Bing Z Carter, Po Yee Mak, Wenjing Tao, Lauren B Ostermann, Yuki Nishida, Naveen Pemmaraju, Steffen Boettcher, Elizabeth J Shpall, Gabriela Chiosis, Georgios Karras, Barbara Wallner, Robert A Morgan, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 5930–5931.
https://doi.org/10.1182/blood-2022-158547
Published: 2022
Journal Articles

Inhibition of Menin, BCL-2, and FLT3 Combined with a Hypomethylating Agent Cures NPM1/FLT3 -ITD/-TKD Mutant AML in a PDX Model

Bing Z Carter, Po Yee Mak, Wenjing Tao, Lauren B Ostermann, Duncan Mak, Boazhen Ke, Peter Ordentlich, Gerard M. McGeehan, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 3063–3064.
https://doi.org/10.1182/blood-2022-158570
Published: 2022
Journal Articles

Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia

Hiroki Akiyama, Ran Zhao, Yuki Nishida, Natalia Baran, Ziyi Li, Lauren B Ostermann, Po Yee Mak, Edward Ayoub, Sujan Piya, Bing Z Carter, Michael Andreeff, Jo Ishizawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 8785–8786.
https://doi.org/10.1182/blood-2022-162354
Published: 2022
Journal Articles

C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53 -Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Yuki Nishida, Darah A Scruggs, Edward Ayoub, Tallie Patsilevas, Vivian Ruvolo, Po Yee Mak, Bing Z Carter, Steffen Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff
Journal: Blood
Blood (2022) 140 (Supplement 1): 483–484.
https://doi.org/10.1182/blood-2022-164968
Published: 2022
Journal Articles

Enhanced p53 Activation By Dual Inhibition of MDM2 and XPO1 Disrupts MYC Transcriptional Program and Restores Sensitivity to BCL-2 Inhibition in Ven/HMA Resistant AML

Yuki Nishida, Jo Ishizawa, Edward Ayoub, Tallie Patsilevas, Lauren Ostermann, Rafael Heinz Montoya, Muharrem Muftuoglu, Vivian Ruvolo, Po Yee Mak, Wenjing Tao, Bing Z Carter, Kensuke Kojima, Naval Daver, Arnaud Lesegretain, Takahiko Seki, Sharon Shacham, Marina Konopleva, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 505.
https://doi.org/10.1182/blood-2021-149260
Published: 2021
Journal Articles

Combined Inhibition of Bcl-2 and Mcl-1 Circumvents Resistance of TP53 Deficient/Mutant AML to BH3 Mimetics

Bing Z Carter, Po Yee Mak, Wenjing Tao, Lauren B Ostermann, Steffen Boettcher, Yuki Nishida, Edward Ayoub, Vivian Ruvolo, Elias J. Jabbour, Paul Hughes, PK Morrow, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 2239.
https://doi.org/10.1182/blood-2021-148014
Published: 2021
Journal Articles

Co-Targeting E-Selectin/CXCR4 with GMI-1359 Facilitates AML Stem Cell Mobilization and Protects BM Niches from Anti-Leukemia Therapy

Kyung Hee Chang, Tomasz Zal, Mahesh Basyal, Lauren Ostermann, Muharrem Muftuoglu, Po Yee Mak, Yannan Jia, Wenjing Tao, Malgorzata Anna Zal, William E. Fogler, John L. Magnani, Weiguo Zhang, Bing Z Carter, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 3348.
https://doi.org/10.1182/blood-2021-153661
Published: 2021
Journal Articles

Co-Targeting Intrinsic and Extrinsic Apoptosis to Maximize Cell Death Induction in Venetoclax-Resistant AML Cells

Bing Z Carter, Wenjing Tao, Lauren B Ostermann, Hong Mu-Mosley, Po Yee Mak, Steffen Boettcher, Yuki Nishida, Ran Tao, Eric Lang, Yifan Zhai, Dajun Yang, Michael Andreeff
Journal: Blood
Blood (2021) 138 (Supplement 1): 3332.
https://doi.org/10.1182/blood-2021-148127
Published: 2021
Journal Articles

Menin inhibition decreases Bcl-2 and synergizes with venetoclax in NPM1/FLT3-mutated AML

Bing Z. Carter, Wenjing Tao, Po Yee Mak, Lauren B. Ostermann, Duncan Mak, Gerard McGeehan, Peter Ordentlich, Michael Andreeff
Journal: Blood
Blood (2021) 138 (17): 1637–1641.
https://doi.org/10.1182/blood.2021011917
Published: 2021
Includes: Supplemental data
Journal Articles

High-Dimensional Single-Cell Proteomic Analysis Reveals Therapeutic Vulnerabilities in Relapsed/Refractory AML By Concomitant Analysis of Cell Surface Antigens, Signaling Pathways and Anti-Apoptotic Proteins

Muharrem Muftuoglu, MD, Zoe Alaniz, BS, Duncan Mak, BSc, MPhil, Angelique J. Lin, MS, Jared K. Burks, PhD, Bing Z Carter, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 26.
https://doi.org/10.1182/blood-2020-143432
Published: 2020
Journal Articles

Low-Dose Triptolide Promotes MDM2 Inhibitor Nutlin3a to Induce Acute Myeloid Leukemia Cell Death Via p53-Dependent and -Independent Mechanisms

Qinwei Chen, MD PhD, Suqi Deng, MS, Zhijuan Lin, MD PhD, Manman Deng, MD PhD, Lihong Ding, MS, Jie Zha, MD PhD, Yong Zhou, MS, Yuelong Jiang, MS, Bing Z Carter, PhD, Bing Xu, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24.
https://doi.org/10.1182/blood-2020-141315
Published: 2020
Journal Articles

Co-Targeting MCL-1 and BCL-2 Is Highly Synergistic in BH3 Mimetic- and Venetoclax/Hypomethylating Agent-Resistant and TP53 Mutated AML

Bing Z Carter, PhD, Po Yee Mak, Wenjing Tao, Vivian Ruvolo, MS, Xuan Zhang, PhD, Yuki Nishida, MD PhD, Steven M. Kornblau, MD, Paul Hughes, Xiaoyue Chen, PK Morrow, Michael Andreeff, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7.
https://doi.org/10.1182/blood-2020-141417
Published: 2020