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Journal Articles

Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia

Shayaun Khazaei, Shreya Nair, Lauren Ostermann, Hideaki Mizuno, Po Yee Mak, Bing Carter, Steffen Boettcher, Liandong Ma, Miriam Garcia, Branko Cuglievan, Alexandra McLean Stevens, Michael Andreeff, Yuki Nishida

Blood (2025) 146 (Supplement 1): 1510.

https://doi.org/10.1182/blood-2025-1510

Published: 2025

Journal Articles

Dichotomy of TP53 mutant AML MRD microenvironment: Spatially segregated immunosuppressive mechanisms and niche-specific structural support

Hideaki Mizuno, Yuki Nishida, Edward Ayoub, Andrea Bedoy, Akshay Basi, Danielle L Stolley, Xuehong Gui, Jared Burks, Rashmi Kanagal-Shamanna, Michael Andreeff

Blood (2025) 146 (Supplement 1): 6714.

https://doi.org/10.1182/blood-2025-6714

Published: 2025

Journal Articles

Protein degradation of MYC/GSPT1 is a novel treatment modality for aggressive T-cell acute lymphoblastic leukemias

Mikaela Garza, Shayaun Khazaei, Faryal Munir, Phoebe Calkins, Darah Threat, Hideaki Mizuno, Lauren Ostermann, Branko Cuglievan, Miriam Garcia, Liandong Ma, Michael Andreeff, Yuki Nishida

Blood (2025) 146 (Supplement 1): 1539.

https://doi.org/10.1182/blood-2025-1539

Published: 2025

Journal Articles

Overcoming midostaurin resistance via dual MYC and GSPT1 degradation by the protac GT19715 in FLT3-amplified AML cells

Xuan Zhang, Kazuhiro Katayama, Namiko Nomura, Eiji Sugihara, Kaori Saito, Fumiaki Sato, Hideaki Mizuno, Mizuki Fuakase, Pei Gao, Jing Bai, Kotoko Yamatani, Liandong Ma, Michael Andreeff, Yuki Nishida, Yoko Tabe

Blood (2025) 146 (Supplement 1): 3271.

https://doi.org/10.1182/blood-2025-3271

Published: 2025

Journal Articles

Spatial Analysis of Human p53 Mutated AML Bone Marrow Reveals Novel MRD Clusters and Spatial Microenvironmental Features of p53 Mutated AML

Hideaki Mizuno, Yuki Nishida, Edward Ayoub, Akshay Basi, Andrea Bedoy, Javier A. Gomez, Jared K. Burks, Rashmi Kanagal-Shamanna, Michael Andreeff

Blood (2024) 144 (Supplement 1): 1301.

https://doi.org/10.1182/blood-2024-209852

Published: 2024

Journal Articles

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Yuki Nishida, Hideaki Mizuno, Edward Ayoub, Eiji Sugihara, Lauren B. Ostermann, Shayaun Khazaei, Darah Scruggs, Po Yee Mak, Baozhen Ke, Bing Z. Carter, Abhishek Maiti, Liandong Ma, Michael Andreeff

Blood (2024) 144 (Supplement 1): 2755.

https://doi.org/10.1182/blood-2024-207812

Published: 2024

Journal Articles

Targeted Protein Degradation for c-MYC Overcomes Therapy Resistance in T-Cell Acute Lymphoblastic Leukemias

Faryal Munir, Shayaun Khazaei, Phoebe H. Calkins, Darah Scruggs, Hideaki Mizuno, Lauren B. Ostermann, Branko Cuglievan, Miriam B. Garcia, Dong Chen, Youzhi Tong, Zhihua Ren, Michael Andreeff, Yuki Nishida

Blood (2023) 142 (Supplement 1): 1447.

https://doi.org/10.1182/blood-2023-187496

Published: 2023

Journal Articles

EVI1 Promotes Immune-Evasive Microenvironment Via Cyclin D1 in Acute Myeloid Leukemia

Yosuke Masamoto, Akira Chiba, Toshiya Hino, Hiroki Hayashida, Hideaki Mizuno, Tomohiko Sato, Mineo Kurokawa

Blood (2022) 140 (Supplement 1): 85–86.

https://doi.org/10.1182/blood-2022-158107

Published: 2022

Journal Articles

Novel Recurrent Mutations in Eldheim-Chester Disease Patients Identified By Whole Exome Sequencing and Whole Genome Sequencing

Yu Oyama, Akira Honda, Kensuke Matsuda, Hideaki Mizuno, Kazuki Taoka, Mineo Kurokawa

Blood (2021) 138 (Supplement 1): 3123.

https://doi.org/10.1182/blood-2021-149864

Published: 2021

Journal Articles

EVI1-Positive AML Cells Show Distinct Features and High Dependency on ETS Transcription Factor ERG

Yosuke Masamoto, Akira Chiba, Toshiaki Takezaki, Toshiya Hino, Hiroki Hayashida, Hideaki Mizuno, Tomohiko Sato, Mineo Kurokawa

Blood (2021) 138 (Supplement 1): 784.

https://doi.org/10.1182/blood-2021-149015

Published: 2021

Journal Articles

Intrapatient Complex Transcriptional Responses to Conventional Chemotherapy in Relapsed Acute Myeloid Leukemia Revealed By Single Cell RNA-Seq Analysis

Hideaki Mizuno, Akira Honda, Mineo Kurokawa

Blood (2021) 138 (Supplement 1): 1179.

https://doi.org/10.1182/blood-2021-153848

Published: 2021

Journal Articles

eIF4B Is a Novel Target of CAMK2G and Promotes Proliferation of Malignant Cells in Myelofibrosis

Ken Sasaki, Hideaki Mizuno, Tadayuki Ogawa, Yosuke Masamoto, Mineo Kurokawa

Blood (2021) 138 (Supplement 1): 3586.

https://doi.org/10.1182/blood-2021-150349

Published: 2021

Journal Articles

Prognostic Factors of Idiopathic Hypereosinophilic Syndrome: A Nationwide Survey in Japan

Akira Honda, Kazuhiro Toyama, Yu Oyama, Kensuke Matsuda, Hideaki Mizuno, Akiko M Saito, Yoshio Katayama, Norio Komatsu, Mineo Kurokawa

Blood (2021) 138 (Supplement 1): 4192.

https://doi.org/10.1182/blood-2021-147609

Published: 2021

Journal Articles

GFI1 Is a Downstream Target of EVI1 in Normal Hematopoiesis

Akira Chiba, MDPhD, Yosuke Masamoto, MD PhD, Hideaki Mizuno, MD PhD, Mineo Kurokawa, MD PhD

Blood (2020) 136 (Supplement 1): 33.

https://doi.org/10.1182/blood-2020-134071

Published: 2020

Journal Articles

Activated Pentose Phosphate Pathway Mediated By Fbp-1 Upregulation Supports Progression of Acute Myeloid Leukemia with High EVI-1 Expression

Hideaki Mizuno, MD, Yuki Kagoya, MD PhD, Junji Koya, MD PhD, Yosuke Masamoto, MD PhD, Mineo Kurokawa, MD PhD

Blood (2018) 132 (Supplement 1): 757.

https://doi.org/10.1182/blood-2018-99-118922

Published: 2018

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Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia

Dichotomy of TP53 mutant AML MRD microenvironment: Spatially segregated immunosuppressive mechanisms and niche-specific structural support

Protein degradation of MYC/GSPT1 is a novel treatment modality for aggressive T-cell acute lymphoblastic leukemias

Overcoming midostaurin resistance via dual MYC and GSPT1 degradation by the protac GT19715 in FLT3-amplified AML cells

Spatial Analysis of Human p53 Mutated AML Bone Marrow Reveals Novel MRD Clusters and Spatial Microenvironmental Features of p53 Mutated AML

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Targeted Protein Degradation for c-MYC Overcomes Therapy Resistance in T-Cell Acute Lymphoblastic Leukemias

EVI1 Promotes Immune-Evasive Microenvironment Via Cyclin D1 in Acute Myeloid Leukemia

Novel Recurrent Mutations in Eldheim-Chester Disease Patients Identified By Whole Exome Sequencing and Whole Genome Sequencing

EVI1-Positive AML Cells Show Distinct Features and High Dependency on ETS Transcription Factor ERG

Intrapatient Complex Transcriptional Responses to Conventional Chemotherapy in Relapsed Acute Myeloid Leukemia Revealed By Single Cell RNA-Seq Analysis

eIF4B Is a Novel Target of CAMK2G and Promotes Proliferation of Malignant Cells in Myelofibrosis

Prognostic Factors of Idiopathic Hypereosinophilic Syndrome: A Nationwide Survey in Japan

GFI1 Is a Downstream Target of EVI1 in Normal Hematopoiesis

Activated Pentose Phosphate Pathway Mediated By Fbp-1 Upregulation Supports Progression of Acute Myeloid Leukemia with High EVI-1 Expression

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