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Journal Articles

FLAG-IDA plus venetoclax for children, adolescents, and young adults with newly diagnosed AML

Blood (2025) 146 (21): 2608–2611.

https://doi.org/10.1182/blood.2025029391

Published: 2025

Includes: Supplemental data

Journal Articles

Restoring p53 wild-type conformation in TP53 -Y220C–mutant acute myeloid leukemia

Bing Z. Carter, Po Yee Mak, Edward Ayoub, Xiaogang Wu, Baozhen Ke, Yuki Nishida, Andrew Futreal, Lauren B. Ostermann, Andrea D. Bedoy, Steffen Boettcher, Courtney D. DiNardo, Anna Puzio-Kuter, Masha V. Poyurovsky, Arnold Levine, Michael Andreeff

Blood (2025) 146 (21): 2574–2588.

https://doi.org/10.1182/blood.2025028935

Published: 2025

Includes: Supplemental data

Journal Articles

Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia

Shayaun Khazaei, Shreya Nair, Lauren Ostermann, Hideaki Mizuno, Po Yee Mak, Bing Carter, Steffen Boettcher, Liandong Ma, Miriam Garcia, Branko Cuglievan, Alexandra McLean Stevens, Michael Andreeff, Yuki Nishida

Blood (2025) 146 (Supplement 1): 1510.

https://doi.org/10.1182/blood-2025-1510

Published: 2025

Journal Articles

Dichotomy of TP53 mutant AML MRD microenvironment: Spatially segregated immunosuppressive mechanisms and niche-specific structural support

Hideaki Mizuno, Yuki Nishida, Edward Ayoub, Andrea Bedoy, Akshay Basi, Danielle L Stolley, Xuehong Gui, Jared Burks, Rashmi Kanagal-Shamanna, Michael Andreeff

Blood (2025) 146 (Supplement 1): 6714.

https://doi.org/10.1182/blood-2025-6714

Published: 2025

Journal Articles

MYC/GSPT1 protein degradation in refractory/relapsed T-cell prolymphocytic leukemias

Yuki Nishida, Claudia Kettlun, Lauren Ostermann, Tapan Kadia, Michael Andreeff, Francisco Vega

Blood (2025) 146 (Supplement 1): 3314.

https://doi.org/10.1182/blood-2025-3314

Published: 2025

Journal Articles

Protein degradation of MYC/GSPT1 is a novel treatment modality for aggressive T-cell acute lymphoblastic leukemias

Mikaela Garza, Shayaun Khazaei, Faryal Munir, Phoebe Calkins, Darah Threat, Hideaki Mizuno, Lauren Ostermann, Branko Cuglievan, Miriam Garcia, Liandong Ma, Michael Andreeff, Yuki Nishida

Blood (2025) 146 (Supplement 1): 1539.

https://doi.org/10.1182/blood-2025-1539

Published: 2025

Journal Articles

Overcoming midostaurin resistance via dual MYC and GSPT1 degradation by the protac GT19715 in FLT3-amplified AML cells

Xuan Zhang, Kazuhiro Katayama, Namiko Nomura, Eiji Sugihara, Kaori Saito, Fumiaki Sato, Hideaki Mizuno, Mizuki Fuakase, Pei Gao, Jing Bai, Kotoko Yamatani, Liandong Ma, Michael Andreeff, Yuki Nishida, Yoko Tabe

Blood (2025) 146 (Supplement 1): 3271.

https://doi.org/10.1182/blood-2025-3271

Published: 2025

Journal Articles

Spatial Analysis of Human p53 Mutated AML Bone Marrow Reveals Novel MRD Clusters and Spatial Microenvironmental Features of p53 Mutated AML

Hideaki Mizuno, Yuki Nishida, Edward Ayoub, Akshay Basi, Andrea Bedoy, Javier A. Gomez, Jared K. Burks, Rashmi Kanagal-Shamanna, Michael Andreeff

Blood (2024) 144 (Supplement 1): 1301.

https://doi.org/10.1182/blood-2024-209852

Published: 2024

Journal Articles

Single-Cell Multiomics Unveils Venetoclax-Resistant Monocytic Differentiation and Immune Evasion in TP53 Mutant AML Clones

Edward Ayoub, David Lehotzky, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Gad Getz, Michael Andreeff

Blood (2024) 144 (Supplement 1): 61.

https://doi.org/10.1182/blood-2024-211845

Published: 2024

Journal Articles

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Yuki Nishida, Hideaki Mizuno, Edward Ayoub, Eiji Sugihara, Lauren B. Ostermann, Shayaun Khazaei, Darah Scruggs, Po Yee Mak, Baozhen Ke, Bing Z. Carter, Abhishek Maiti, Liandong Ma, Michael Andreeff

Blood (2024) 144 (Supplement 1): 2755.

https://doi.org/10.1182/blood-2024-207812

Published: 2024

Journal Articles

Selective Targeting of TP53-Y220C Mutant AML By PC14586 Results in TP53 Wild-Type Conformation and Synergistical Apoptosis Induction By Concomitant Inhibition of Xpo-1, MDM2, or Bcl-2

Bing Z. Carter, Po Yee Mak, Baozhen Ke, Yuki Nishida, Steffen Boettcher, Andrea Bedoy, Lauren B. Ostermann, Courtney D. DiNardo, Anna Puzio-Kuter, Arnold Levine, Michael Andreeff

Blood (2023) 142 (Supplement 1): 2261.

https://doi.org/10.1182/blood-2023-181186

Published: 2023

Journal Articles

Targeted Protein Degradation for c-MYC Overcomes Therapy Resistance in T-Cell Acute Lymphoblastic Leukemias

Faryal Munir, Shayaun Khazaei, Phoebe H. Calkins, Darah Scruggs, Hideaki Mizuno, Lauren B. Ostermann, Branko Cuglievan, Miriam B. Garcia, Dong Chen, Youzhi Tong, Zhihua Ren, Michael Andreeff, Yuki Nishida

Blood (2023) 142 (Supplement 1): 1447.

https://doi.org/10.1182/blood-2023-187496

Published: 2023

Journal Articles

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Blood (2023) 142 (Supplement 1): 583.

https://doi.org/10.1182/blood-2023-174938

Published: 2023

Journal Articles

Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML

Edward Ayoub, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Michael Andreeff

Blood (2023) 142 (Supplement 1): 5014.

https://doi.org/10.1182/blood-2023-187121

Published: 2023

Journal Articles

Epichaperome inhibition targets TP53- mutant AML and AML stem/progenitor cells

Blood (2023) 142 (12): 1056–1070.

https://doi.org/10.1182/blood.2022019047

Published: 2023

Includes: Supplemental data

Journal Articles

Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia

Hiroki Akiyama, Ran Zhao, Yuki Nishida, Natalia Baran, Ziyi Li, Lauren B Ostermann, Po Yee Mak, Edward Ayoub, Sujan Piya, Bing Z Carter, Michael Andreeff, Jo Ishizawa

Blood (2022) 140 (Supplement 1): 8785–8786.

https://doi.org/10.1182/blood-2022-162354

Published: 2022

Journal Articles

Polyploidy Is Necessary for Apoptotic Cell Death in TP53 -Mut AML in Response to Polo-like-Kinase 4 (PLK4) Inhibition and Results in Caspase 3 Cleavage

Edward Ayoub, Akhil Marupudi, Yuki Nishida, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Mark R Bray, Tallie Patsilevas, Steffen Boettcher, Ghayas C. Issa, Ken Chen, Torsten Haferlach, Gautam Borthakur, Michael Andreeff

Blood (2022) 140 (Supplement 1): 5941–5943.

https://doi.org/10.1182/blood-2022-170152

Published: 2022

Journal Articles

Epichaperome Inhibition Targets Kinase and TP53 Mutant Therapy Resistant AML

Bing Z Carter, Po Yee Mak, Wenjing Tao, Lauren B Ostermann, Yuki Nishida, Naveen Pemmaraju, Steffen Boettcher, Elizabeth J Shpall, Gabriela Chiosis, Georgios Karras, Barbara Wallner, Robert A Morgan, Michael Andreeff

Blood (2022) 140 (Supplement 1): 5930–5931.

https://doi.org/10.1182/blood-2022-158547

Published: 2022

Journal Articles

C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53 -Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Yuki Nishida, Darah A Scruggs, Edward Ayoub, Tallie Patsilevas, Vivian Ruvolo, Po Yee Mak, Bing Z Carter, Steffen Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff

Blood (2022) 140 (Supplement 1): 483–484.

https://doi.org/10.1182/blood-2022-164968

Published: 2022

Journal Articles

Combined Inhibition of Bcl-2 and Mcl-1 Circumvents Resistance of TP53 Deficient/Mutant AML to BH3 Mimetics

Bing Z Carter, Po Yee Mak, Wenjing Tao, Lauren B Ostermann, Steffen Boettcher, Yuki Nishida, Edward Ayoub, Vivian Ruvolo, Elias J. Jabbour, Paul Hughes, PK Morrow, Michael Andreeff

Blood (2021) 138 (Supplement 1): 2239.

https://doi.org/10.1182/blood-2021-148014

Published: 2021

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FLAG-IDA plus venetoclax for children, adolescents, and young adults with newly diagnosed AML

Restoring p53 wild-type conformation in TP53 -Y220C–mutant acute myeloid leukemia

Protein degradation of MYC/GSPT1 combined with menin inhibition overcomes resistance to menin inhibition in KMT2A-rearranged Acute Myeloid Leukemia

Dichotomy of TP53 mutant AML MRD microenvironment: Spatially segregated immunosuppressive mechanisms and niche-specific structural support

MYC/GSPT1 protein degradation in refractory/relapsed T-cell prolymphocytic leukemias

Protein degradation of MYC/GSPT1 is a novel treatment modality for aggressive T-cell acute lymphoblastic leukemias

Overcoming midostaurin resistance via dual MYC and GSPT1 degradation by the protac GT19715 in FLT3-amplified AML cells

Spatial Analysis of Human p53 Mutated AML Bone Marrow Reveals Novel MRD Clusters and Spatial Microenvironmental Features of p53 Mutated AML

Single-Cell Multiomics Unveils Venetoclax-Resistant Monocytic Differentiation and Immune Evasion in TP53 Mutant AML Clones

Targeting Co-Regulatory Feedback Loop of MYC and GSPT1 By MYC/GSPT1 Dual Degradation Is Synthetic Lethal in Combination with Ven/Aza in TP53 Mutant Acute Myeloid Leukemia Stem and Progenitor Cells

Selective Targeting of TP53-Y220C Mutant AML By PC14586 Results in TP53 Wild-Type Conformation and Synergistical Apoptosis Induction By Concomitant Inhibition of Xpo-1, MDM2, or Bcl-2

Targeted Protein Degradation for c-MYC Overcomes Therapy Resistance in T-Cell Acute Lymphoblastic Leukemias

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML

Epichaperome inhibition targets TP53- mutant AML and AML stem/progenitor cells

Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia

Polyploidy Is Necessary for Apoptotic Cell Death in TP53 -Mut AML in Response to Polo-like-Kinase 4 (PLK4) Inhibition and Results in Caspase 3 Cleavage

Epichaperome Inhibition Targets Kinase and TP53 Mutant Therapy Resistant AML

C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53 -Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Combined Inhibition of Bcl-2 and Mcl-1 Circumvents Resistance of TP53 Deficient/Mutant AML to BH3 Mimetics

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