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Journal Articles

Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022

Francis Baumgartner, Constance Baer, Stefanos Bamopoulos, Edward Ayoub, Marietta Truger, Manja Meggendorfer, Miriam Lenk, Gregor Hoermann, Stephan Hutter, Heiko Müller, Wencke Walter, Martha-Lena Müller, Niroshan Nadarajah, Piers Blombery, Ulrich Keller, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach

Blood (2024) 143 (12): 1139–1156.

https://doi.org/10.1182/blood.2023021199

Published: 2024

Includes: Supplemental data

Journal Articles

Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML

Edward Ayoub, Li Li, Muharrem Muftuoglu, Yuki Nishida, Vakul Mohanty, Jake S Leighton, Tallie Patsilevas, Mahesh Basyal, Andrea Bedoy, Torsten Haferlach, Koichi Takahashi, Ken Chen, Nicholas Navin, Ghayas C. Issa, Michael Andreeff

Blood (2023) 142 (Supplement 1): 5014.

https://doi.org/10.1182/blood-2023-187121

Published: 2023

Journal Articles

Single-Cell Proteomic Analysis Reveals Menin Inhibition-Induced Proteomic Alterations in AML Patients Treated with Revumenib

Muharrem Muftuoglu, Li Li, Mahesh Basyal, Edward Ayoub, Jiangxing Lv, Andrea Bedoy, Tallie Patsilevas, Aram Bidikian, Ghayas C. Issa, Michael Andreeff

Blood (2023) 142 (Supplement 1): 2933.

https://doi.org/10.1182/blood-2023-191216

Published: 2023

Journal Articles

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Blood (2023) 142 (Supplement 1): 583.

https://doi.org/10.1182/blood-2023-174938

Published: 2023

Journal Articles

Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia

Hiroki Akiyama, Ran Zhao, Yuki Nishida, Natalia Baran, Ziyi Li, Lauren B Ostermann, Po Yee Mak, Edward Ayoub, Sujan Piya, Bing Z Carter, Michael Andreeff, Jo Ishizawa

Blood (2022) 140 (Supplement 1): 8785–8786.

https://doi.org/10.1182/blood-2022-162354

Published: 2022

Journal Articles

Somatic Mutations in TP53 Identified in T-Cells of Patients with TP53- mutated AML

Ghayas C. Issa, Aram Bidikian, Edward Ayoub, Feng Wang, Vakul Mohanty, Jake Leighton, Xiaogang Wu, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Naval Daver, Andy Futreal, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff

Blood (2022) 140 (Supplement 1): 6267–6269.

https://doi.org/10.1182/blood-2022-165439

Published: 2022

Journal Articles

Polyploidy Is Necessary for Apoptotic Cell Death in TP53 -Mut AML in Response to Polo-like-Kinase 4 (PLK4) Inhibition and Results in Caspase 3 Cleavage

Edward Ayoub, Akhil Marupudi, Yuki Nishida, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Mark R Bray, Tallie Patsilevas, Steffen Boettcher, Ghayas C. Issa, Ken Chen, Torsten Haferlach, Gautam Borthakur, Michael Andreeff

Blood (2022) 140 (Supplement 1): 5941–5943.

https://doi.org/10.1182/blood-2022-170152

Published: 2022

Journal Articles

Clinical and Molecular Profiling of AML Patients with Chromosome 7 or 7q Deletions Incontext of TP53 Alterations and Venetoclax Treatment

Blood (2022) 140 (Supplement 1): 6064–6066.

https://doi.org/10.1182/blood-2022-170458

Published: 2022

Journal Articles

C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53 -Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Yuki Nishida, Darah A Scruggs, Edward Ayoub, Tallie Patsilevas, Vivian Ruvolo, Po Yee Mak, Bing Z Carter, Steffen Boettcher, Abhishek Maiti, Qianxiang Zhou, Zhaohui Yang, Honghua Yan, Liandong Ma, Michael Andreeff

Blood (2022) 140 (Supplement 1): 483–484.

https://doi.org/10.1182/blood-2022-164968

Published: 2022

Journal Articles

Characterization of Dysregulated Transcription in TP53 -Mutated AML Subpopulations

Ghayas C. Issa, Vakul Mohanty, Edward Ayoub, Feng Wang, Jake Leighton, Xiaogang Wu, Aram Bidikian, Tallie Patsilevas, Zoe Alaniz, Jabra Zarka, Rashmi Kanagal-Shamanna, Andy Futreal, Naval Daver, Marina Konopleva, Nicholas Navin, Jianhua Zhang, Ken Chen, Michael Andreeff

Blood (2022) 140 (Supplement 1): 6323–6325.

https://doi.org/10.1182/blood-2022-168136

Published: 2022

Journal Articles

Mdm2 Loss of Heterozygosity Cooperates with Mutant p53 in the Development of Acute Myeloid Leukemia

Rasoul Pourebrahim, Rafael Heinz Montoya, Edward Ayoub, Hiroki Akiyama, Natalia Baran, Tom Lesluyes, Lauren B Ostermann, Bin Liu, Jo Ishizawa, Joseph D. Khoury, Marina Konopleva, Peter Van Loo, Michael Andreeff

Blood (2022) 140 (Supplement 1): 5876–5878.

https://doi.org/10.1182/blood-2022-167859

Published: 2022

Journal Articles

Targeting Polo-like Kinase 4 Triggers Polyploidy and Apoptotic Cell Death in TP53-Mutant Acute Myeloid Leukemia

Edward Ayoub, Rafael Heinz Montoya, Vakul Mohanty, Wencke Walter, Tallie Patsilevas, Ghayas C. Issa, Gautam Borthakur, Ken Chen, Marina Konopleva, Nicholas Navin, Torsten Haferlach, Michael Andreeff

Blood (2021) 138 (Supplement 1): 1167.

https://doi.org/10.1182/blood-2021-153436

Published: 2021

Journal Articles

Therapeutic Targeting of Ferroptosis Pathway in Combination with Mitochondrial Oxidative Stress Induction in Acute Myeloid Leukemia

Hiroki Akiyama, Ran Zhao, Adam Rahhal, Yuki Nishida, Edward Ayoub, Lauren B Ostermann, Michael Andreeff, Jo Ishizawa

Blood (2021) 138 (Supplement 1): 1162.

https://doi.org/10.1182/blood-2021-148248

Published: 2021

Journal Articles

Mdm2 Maintains Cholesterol Biosynthesis in Hematopoietic Stem/Progenitor Cells Independent of p53

Rasoul Pourebrahim, Rafael Heinz Montoya, Edward Ayoub, Joseph D. Khoury, Michael Andreeff

Blood (2021) 138 (Supplement 1): 1152.

https://doi.org/10.1182/blood-2021-152899

Published: 2021

Journal Articles

Enhanced p53 Activation By Dual Inhibition of MDM2 and XPO1 Disrupts MYC Transcriptional Program and Restores Sensitivity to BCL-2 Inhibition in Ven/HMA Resistant AML

Yuki Nishida, Jo Ishizawa, Edward Ayoub, Tallie Patsilevas, Lauren Ostermann, Rafael Heinz Montoya, Muharrem Muftuoglu, Vivian Ruvolo, Po Yee Mak, Wenjing Tao, Bing Z Carter, Kensuke Kojima, Naval Daver, Arnaud Lesegretain, Takahiko Seki, Sharon Shacham, Marina Konopleva, Michael Andreeff

Blood (2021) 138 (Supplement 1): 505.

https://doi.org/10.1182/blood-2021-149260

Published: 2021

Journal Articles

Combined Inhibition of Bcl-2 and Mcl-1 Circumvents Resistance of TP53 Deficient/Mutant AML to BH3 Mimetics

Bing Z Carter, Po Yee Mak, Wenjing Tao, Lauren B Ostermann, Steffen Boettcher, Yuki Nishida, Edward Ayoub, Vivian Ruvolo, Elias J. Jabbour, Paul Hughes, PK Morrow, Michael Andreeff

Blood (2021) 138 (Supplement 1): 2239.

https://doi.org/10.1182/blood-2021-148014

Published: 2021

Journal Articles

Mds1 CreERT2 -Based Lineage-Tracing Reveals Increasing Contributions of HSCs to Fetal Hematopoiesis and to Adult Tissue-Resident Macrophages in the Marrow

Kathleen E. McGrath, Yi Zhang, Edward Ayoub, Paul D. Kingsley, Hongbo Yu, Katherine H Fegan, Kelly A McGlynn, Sarah Rudzinskas, Archibald S. Perkins, James Palis

Blood (2021) 138 (Supplement 1): 2153.

https://doi.org/10.1182/blood-2021-154041

Published: 2021

Journal Articles

Exportin-1 (XPO1) Inhibition Sequesters p53 from MDM2 and MDM4 and Is Highly Synergistic with MDM2 Inhibition in Inducing Apoptosis in Wild-Type p53 Acute Myeloid Leukemias

Yuki Nishida, MDPhD, Jo Ishizawa, MDPhD, Edward Ayoub, PhD MS, BSc, Rafael Heinz Montoya, BS, Vivian Ruvolo, MS, Kensuke Kojima, MD PhD, Naval Daver, MD, Arnaud Lesegretain, Sharon Shacham, PhD MBA, Michael Andreeff, MD PhD

Blood (2020) 136 (Supplement 1): 23–24.

https://doi.org/10.1182/blood-2020-140768

Published: 2020

Journal Articles

MDS1-EVI1 Complex (MECOM) Activation Promotes Leukemic Stem Cell Quiescence By Upregulating CDKN1C/P57 Kip2

Edward Ayoub, PhD MS, BSc, Yi Zhang, PhD, Michael Andreeff, MD PhD, Archibald S. Perkins, MD PhD

Blood (2020) 136 (Supplement 1): 6–7.

https://doi.org/10.1182/blood-2020-143313

Published: 2020

Journal Articles

Mdm2 Haplo-Insufficiency in Hematopoietic and Mesenchymal Progenitor Cells Results in Cell Death

Rasoul Pourebrahim, MDPhD, Rafael Heinz Montoya, BS, Zoe Alaniz, BS, Lauren B Ostermann, BS, Edward Ayoub, PhD MS, BSc, Patrick P Lin, MD, Jared K. Burks, PhD, Michael Andreeff, MD PhD

Blood (2020) 136 (Supplement 1): 10.

https://doi.org/10.1182/blood-2020-142662

Published: 2020

NARROW

Comparing malignant monocytosis across the updated WHO and ICC classifications of 2022

Single-Cell Genomics and Proteomics Reveals Venetoclax-Resistant Monocytic Differentiation of TP53 LOH Clones in TP53 Mutant AML

Single-Cell Proteomic Analysis Reveals Menin Inhibition-Induced Proteomic Alterations in AML Patients Treated with Revumenib

Stem-Cell Enriched Cellular Hierarchy of TP53 Mutant Acute Myeloid Leukemia Is Vulnerable to Targeted Protein Degradation of c-MYC

Mitochondrial Regulation of Ferroptosis in Acute Myeloid Leukemia

Somatic Mutations in TP53 Identified in T-Cells of Patients with TP53- mutated AML

Polyploidy Is Necessary for Apoptotic Cell Death in TP53 -Mut AML in Response to Polo-like-Kinase 4 (PLK4) Inhibition and Results in Caspase 3 Cleavage

Clinical and Molecular Profiling of AML Patients with Chromosome 7 or 7q Deletions Incontext of TP53 Alterations and Venetoclax Treatment

C-MYC Targeting By Degradation: Novel Dual c-Myc/GSPT1 Degrader GT19715 Induces TP53 -Independent Cell Death in Acute Myeloid Leukemia and Lymphomas

Characterization of Dysregulated Transcription in TP53 -Mutated AML Subpopulations

Mdm2 Loss of Heterozygosity Cooperates with Mutant p53 in the Development of Acute Myeloid Leukemia

Targeting Polo-like Kinase 4 Triggers Polyploidy and Apoptotic Cell Death in TP53-Mutant Acute Myeloid Leukemia

Therapeutic Targeting of Ferroptosis Pathway in Combination with Mitochondrial Oxidative Stress Induction in Acute Myeloid Leukemia

Mdm2 Maintains Cholesterol Biosynthesis in Hematopoietic Stem/Progenitor Cells Independent of p53

Enhanced p53 Activation By Dual Inhibition of MDM2 and XPO1 Disrupts MYC Transcriptional Program and Restores Sensitivity to BCL-2 Inhibition in Ven/HMA Resistant AML

Combined Inhibition of Bcl-2 and Mcl-1 Circumvents Resistance of TP53 Deficient/Mutant AML to BH3 Mimetics

Mds1 CreERT2 -Based Lineage-Tracing Reveals Increasing Contributions of HSCs to Fetal Hematopoiesis and to Adult Tissue-Resident Macrophages in the Marrow

Exportin-1 (XPO1) Inhibition Sequesters p53 from MDM2 and MDM4 and Is Highly Synergistic with MDM2 Inhibition in Inducing Apoptosis in Wild-Type p53 Acute Myeloid Leukemias

MDS1-EVI1 Complex (MECOM) Activation Promotes Leukemic Stem Cell Quiescence By Upregulating CDKN1C/P57 Kip2

Mdm2 Haplo-Insufficiency in Hematopoietic and Mesenchymal Progenitor Cells Results in Cell Death

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American Society of Hematology

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ASH Publications

American Society of Hematology

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