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Andrew Futreal
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Journal Articles

Restoring p53 wild-type conformation in TP53 -Y220C–mutant acute myeloid leukemia

Available to Purchase
Bing Z. Carter, Po Yee Mak, Edward Ayoub, Xiaogang Wu, Baozhen Ke, Yuki Nishida, Andrew Futreal, Lauren B. Ostermann, Andrea D. Bedoy, Steffen Boettcher, Courtney D. DiNardo, Anna Puzio-Kuter, Masha V. Poyurovsky, Arnold Levine, Michael Andreeff
Journal: Blood
Blood (2025) 146 (21): 2574–2588.
https://doi.org/10.1182/blood.2025028935
Published: 2025
Includes: Supplemental data
Journal Articles

Phenotypic heterogeneity and remodeling drive resistance to venetoclax treatment in acute myeloid leukemia

Free
Yi June Kim, Ken Furudate, Courtney DiNardo, Abhishek Maiti, Mahesh Swaminathan, Zongrui Li, Eva Ordoñez, Okechukwu Nwogbo, Minggao Liang, Yoriko Saito, Akiko Kaneko, Kiyomi Morita, Jairo Matthews, Hongli Tang, Erika Thompson, Tomoyuki Tanaka, Hidetaka Uryu, Naval Daver, Naveen Pemmaraju, Tapan Kadia, Farhad Ravandi, Nicholas Short, Maro Ohanian, Gautam Borthakur, Nitin Jain, Ghayas Issa, Lucia Masarova, Steven Kornblau, William Wierda, Sanam Loghavi, Sa Wang, Guillermo Garcia-Manero, Hagop Kantarjian, Elias Jabbour, Carlos Bueso-Ramos, Shanshan Pei, Craig Jordan, Andrew Futreal, Fumihiko Ishikawa, Marina Konopleva, Koichi Takahashi
Journal: Blood
Blood (2025) 146 (Supplement 1): 222.
https://doi.org/10.1182/blood-2025-222
Published: 2025
Journal Articles

Dynamic biomarker trajectories predict outcomes in AML-associated hemophagocytic lymphohistiocytosis

Free
Vaishali Gautam, Benjamin Mescher, Rishab Prakash, Indraneel Deshmukh, Abhishek Maiti, Ranjit Nair, Luis Malpica, Dai Chihara, Fareed Khawaja, Nitin Jain, Naveen Pemmaraju, Mahesh Swaminathan, Kelly Chien, Sanu Abraham, Scott Woodman, Andrew Futreal, Christopher Flowers, Rashmi Kanagal-Shamanna, Naval Daver, James Long, Swami Iyer
Journal: Blood
Blood (2025) 146 (Supplement 1): 604.
https://doi.org/10.1182/blood-2025-604
Published: 2025
Journal Articles

Distinct Impact of Platinum Chemotherapies on the Fitness and Genome of Hematopoietic Stem Cells and the Risk of Therapy-Related Myeloid Neoplasms

Free
Jeremy Connors, Linda Zhang, Hidetaka Uryu, Koji Sasaki, Jennifer Padilla, Zongrui Li, Ken Furudate, Tomoyuki Tanaka, Courtney D. DiNardo, Nicholas J. Short, Naval Daver, Gautham Borthakur, Farhad Ravandi, Tapan M. Kadia, Hagop M. Kantarjian, Elias Jabbour, Simona Colla, Branko Cuglievan, Andrew Futreal, Adam S. Sperling, Guillermo Garcia-Manero, Margaret Goodell, Koichi Takahashi
Journal: Blood
Blood (2024) 144 (Supplement 1): 1816.
https://doi.org/10.1182/blood-2024-212052
Published: 2024
Journal Articles

Clonal Origin of Therapy-Related Myeloid Neoplasms after Autologous Stem Cell Transplant

Free
Hidetaka Uryu, Koichi Saeki, Hiroshi Haeno, Chiraag Kapadia, Ken Furudate, Jyoti Nangalia, Michael Spencer Chapman, Li Zhao, Joanne Hsu, Chong Zhao, Shujuan Chen, Tomoyuki Tanaka, Zongrui Li, Hui Yang, Courtney D. DiNardo, Naval Daver, Naveen Pemmaraju, Nitin Jain, Farhad Ravandi, Jianhua Zhang, Xingzhi Song, Erika Thompson, Hongli Tang, Latasha Little, Curtis Gumbs, Robert Z. Orlowski, Muzaffar H. Qazilbash, Kapil N. Bhalla, Simona Colla, Hagop M. Kantarjian, Rashmi Kanagal-Shamanna, Carlos E. Bueso-Ramos, Daisuke Nakada, Jeffrey J. Molldrem, Gheath Alatrash, Andrew Futreal, Elizabeth J. Shpall, Margaret Goodell, Guillermo Garcia-Manero, Koichi Takahashi
Journal: Blood
Blood (2024) 144 (Supplement 1): 346.
https://doi.org/10.1182/blood-2024-208106
Published: 2024
Journal Articles

Differing Inflammatory Profiles and Survival Outcomes of Cytokine Storm Arising from CAR T-Cell Therapy, COVID and Malignancy-Associated HLH in Patients with Hematological Malignancies

Free
Anath Lionel, James Long, Rishab Prakash, Paul Edelkamp, Jr., Mark Knafl, Sairah Ahmed, Paolo Strati, Ranjit Nair, Kelly S. Chien, Dai Chihara, Jason Westin, Fareed Khawaja, Loretta J. Nastoupil, Joanna-Grace Manzano, Victor Mulanovich, DCODE Team, Naval Daver, Andrew Futreal, Scott E. Woodman, Christopher R. Flowers, Sattva S. Neelapu, Swami P. Iyer
Journal: Blood
Blood (2023) 142 (Supplement 1): 3507.
https://doi.org/10.1182/blood-2023-187946
Published: 2023
Journal Articles

Cancer Chemotherapy Accelerates the Loss of Clonal Diversity in Hematopoietic Stem Cells and Promotes the Convergent Evolution of Therapy-Related Clonal Hematopoiesis

Free
Hidetaka Uryu, Koichi Saeki, Jyoti Nangalia, Michael Spencer Chapman, Li Zhao, Joanne I. Hsu, Carlos E. Bueso-Ramos, Shujuan Chen, Hui Yang, Hagop Kantarjian, Courtney D. DiNardo, Naval Daver, Simona Colla, Irene Ganan-Gomez, Jianhua Zhang, Xingzhi Song, Erika Thompson, Hongli Tang, Robert Z. Orlowski, Richard E Champlin, Muzaffar H Qazilbash, Elizabeth J Shpall, Guillermo Garcia-Manero, Hiroshi Haeno, Koichi Takahashi, Andrew Futreal
Journal: Blood
Blood (2022) 140 (Supplement 1): 2232–2233.
https://doi.org/10.1182/blood-2022-160294
Published: 2022
Journal Articles

Prediction of Mortality Following Cytokine Storm in Patients with Hematological Malignancies and COVID-19 Infections

Free
Rishab Prakash, James Long, Paul Edelkamp, Jr., Mark Knafl, Sairah Ahmed, Fareed Khawaja, Loretta J. Nastoupil, Joanna-Grace Manzano, Victor Mulanovich, Sabitha Prabhakaran, Andrew Futreal, Scott E Woodman, Swaminathan Padmanabhan Iyer
Journal: Blood
Blood (2022) 140 (Supplement 1): 10907–10908.
https://doi.org/10.1182/blood-2022-169853
Published: 2022
Journal Articles

Lenalidomide promotes the development of TP53 -mutated therapy-related myeloid neoplasms

Free
Clinical Trials & Observations
Adam S. Sperling, Veronica A. Guerra, James A. Kennedy, Yuanqing Yan, Joanne I. Hsu, Feng Wang, Andrew T. Nguyen, Peter G. Miller, Marie E. McConkey, Vanessa A. Quevedo Barrios, Ken Furudate, Linda Zhang, Rashmi Kanagal-Shamanna, Jianhua Zhang, Latasha Little, Curtis Gumbs, Naval Daver, Courtney D. DiNardo, Tapan Kadia, Farhad Ravandi, Hagop Kantarjian, Guillermo Garcia-Manero, P. Andrew Futreal, Benjamin L. Ebert, Koichi Takahashi
Journal: Blood
Blood (2022) 140 (16): 1753–1763.
https://doi.org/10.1182/blood.2021014956
Published: 2022
Includes: Supplemental data
Journal Articles

Clonal dynamics and clinical implications of postremission clonal hematopoiesis in acute myeloid leukemia

Free
Clinical Trials & Observations Brief Report
Tomoyuki Tanaka, Kiyomi Morita, Sanam Loghavi, Feng Wang, Ken Furudate, Yuya Sasaki, Latasha Little, Curtis Gumbs, Jairo Matthews, Naval Daver, Naveen Pemmaraju, Courtney D. DiNardo, Koji Sasaki, Musa Yilmaz, Tapan M. Kadia, Farhad Ravandi, Marina Y. Konopleva, Hagop M. Kantarjian, Richard E. Champlin, Gheath Al-Atrash, Guillermo Garcia-Manero, Sa A. Wang, P. Andrew Futreal, Koichi Takahashi
Journal: Blood
Blood (2021) 138 (18): 1733–1739.
https://doi.org/10.1182/blood.2020010483
Published: 2021
Includes: Supplemental data
Journal Articles

Extensive Changes of the Immune Microenvironment Are Associated with Progression from Precursor Stages to Multiple Myeloma

Free
Elisabet E. Manasanch, MD, Guangchun Han, Zheng Zhang, Minghao Dang, Manisha Singh, Maliha Khan, MD, Shubhra Singh, Hans C. Lee, MD, Krina K. Patel, MD, Gregory P. Kaufman, MD, Behrang Amini, MD PhD, Qaiser Bashir, MD, Samer A. Srour, MD MS, Yago Nieto, MD, Muzaffar H. Qazilbash, MD, Zuzana Berkova, PhD, Pei Lin, MDDM,MDC, Donald Berry, MD PhD, Sheeba K. Thomas, MD, Donna M. Weber, MD, P. Andrew Futreal, Linghua Wang, PhD, Robert Z. Orlowski, MDPhD, Sattva S. Neelapu, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 37–38.
https://doi.org/10.1182/blood-2020-137555
Published: 2020
Journal Articles

Single-Cell Characterization of Acute Myeloid Leukemia (AML) and Its Microenvironment Identifies Signatures of Resistance to PD-1 Blockade Based Therapy

Free
Hussein A Abbas, MDPhD, Dapeng Hao, Katarzyna Tomczak, PhD, Praveen Barrodia, Jin S. Im, Patrick K Reville, MD, Zoe Alaniz, Wei Wang, MD PhD, Ruiping Wang, PhD, Feng Wang, PhD, Koichi Takahashi, MD PhD, Jing Ning, PhD, Maomao Ding, Jairo A. Matthews, Latasha Little, BS, Jianhua Zhang, PhD, Sreyashi Basu, PhD, Courtney D. DiNardo, MD MSCE, Tapan M. Kadia, MD, Farhad Ravandi, MBBS, Gautam Borthakur, MD, Marina Konopleva, MD PhD, Guillermo Garcia-Manero, MD, Michael R Green, PhD, Gheath Alatrash, Padmanee Sharma, James P Allison, PhD, Steven M. Kornblau, MD, Kunal Rai, Linghua Wang, PhD, P Andrew Futreal, PhD, Naval Daver, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–31.
https://doi.org/10.1182/blood-2020-137335
Published: 2020
Journal Articles

Prognostic Significance of Genetic Alterations in Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated with Hyper-CVAD Plus Dasatinib or Hyper-CVAD Plus Ponatinib

Free
Yuya Sasaki, MDPhD, Hagop M. Kantarjian, MD, Nicholas J. Short, MD, Nitin Jain, MD, Koji Sasaki, MD, Farhad Ravandi, MBBS, Marina Konopleva, MD PhD, Guillermo Garcia-Manero, MD, Latasha Little, BS, Curtis Gumbs, Li Zhao, PhD, P Andrew Futreal, PhD, Feng Wang, PhD, Ken Furudate, DDM, PhD, Rebecca Garris, MSc, Koichi Takahashi, MD PhD, Elias Jabbour, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 40–41.
https://doi.org/10.1182/blood-2020-136676
Published: 2020
Journal Articles

Immunologic Predictors for Clinical Responses in Patients with Myelodysplastic Syndromes Treated with Immune Checkpoint Blockade

Free
Sung-Eun Lee, MD PhD, Feng Wang, PhD, Abel Trujillo-Ocampo, PhDMS, Wilfredo Ruiz Vazquez, Hyun-Woo Cho, Koichi Takahashi, MD PhD, Gheath Alatrash, Jeffrey J. Molldrem, Richard E. Champlin, MD, Naval Daver, MD, Hagop M. Kantarjian, MD, P. Andrew Futreal, Guillermo Garcia-Manero, MD, Jin S. Im
Journal: Blood
Blood (2020) 136 (Supplement 1): 4.
https://doi.org/10.1182/blood-2020-136963
Published: 2020
Journal Articles

Prognostic Significance of IKZF1 , PAX5 , and CDKN2A Deletions in Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Treated with Hyper-CVAD/MA with Dasatinib or Ponatinib

Free
Yuya Sasaki, MD PhD, Nicholas J. Short, MD, Hagop M. Kantarjian, MD, Rebecca Garris, MSc, Nitin Jain, MD, Koji Sasaki, MD, Farhad Ravandi, MD, Marina Y Konopleva, MD PhD, Michael E. Rytting, MD, Guillermo Garcia-Manero, MD, Latasha Little, BS, Curtis Gumbs, Li Zhao, PhD, P. Andrew Futreal, PhD, Feng Wang, PhD, Koichi Takahashi, MD, Elias Jabbour, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2753.
https://doi.org/10.1182/blood-2019-122017
Published: 2019
Journal Articles

Identification of Gene Expression Signatures in Leukemia Stem Cells and Minimal Residual Disease Following Treatment of Adverse Risk Acute Myeloid Leukemia

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Ghayas C. Issa, MD, Christopher B. Benton, MD, Vakul Mohanty, PhD, Yifei Shen, PhD, Zoe Alaniz, Feng Wang, PhD, P. Andrew Futreal, PhD, Wei Wang, MD PhD, Jeffrey L. Jorgensen, MD PhD, Nicholas Navin, PhD, Marina Y Konopleva, MD PhD, Ken Chen, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2717.
https://doi.org/10.1182/blood-2019-130540
Published: 2019
Journal Articles

Characterization of Changes in the T-Cell Receptor Repertoire in Patients with Acute Myeloid Leukemia with Durable Remission Following Allogeneic Stem Cell Transplant

Free
Ronald M. Paranal, MD, Hagop M. Kantarjian, MD, Alexandre Reuben, PhD, Celine Kerros, PhD, Priya Koppikar, PhD, Latasha Little, BS, Curtis Gumbs, Nicholas J. Short, MD, Jorge E. Cortes, MD, Elias Jabbour, MD, Jeffrey J. Molldrem, P. Andrew Futreal, PhD, Ghayas C. Issa, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5186.
https://doi.org/10.1182/blood-2019-129911
Published: 2019
Journal Articles

Comprehensive Analysis of Genotype and Prior Exposures in Therapy-Related Myeloid Neoplasms (t-MNs)

Free
Veronica A Guerra, MD, Yan Yuanqing, PhD, Joanne Hsu, BS, Feng Wang, PhD, Mansour Alfayez, MD, Kiyomi Morita, MD, Xingzhi Song, PhD, Courtney D. DiNardo, MD MSc, Marina Y Konopleva, MD PhD, Gautam M. Borthakur, MD, Guillermo Montalban Bravo, MD, Jianhua Zhang, PhD, Latasha Little, BS, Curtis Gumbs, Hagop M. Kantarjian, MD, Guillermo Garcia-Manero, MD, Andrew Futreal, PhD, Koichi Takahashi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 458.
https://doi.org/10.1182/blood-2019-127498
Published: 2019
Journal Articles

Clonal Dynamics and Clinical Implications of Post-Remission Clonal Hematopoiesis in Acute Myeloid Leukemia (AML)

Free
Tomoyuki Tanaka, Kiyomi Morita, MD, Feng Wang, PhD, Latasha Little, Curtis Gumbs, Jairo Matthews, Courtney D. DiNardo, MDMSc, Tapan M. Kadia, MD, Farhad Ravandi, MD, Marina Y Konopleva, MD PhD, Hagop M. Kantarjian, MD, Richard E. Champlin, MD, Guillermo Garcia-Manero, MD, P Andrew Futreal, PhD, Koichi Takahashi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 17.
https://doi.org/10.1182/blood-2019-122274
Published: 2019
Journal Articles

PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia–initiating cells

Free
Tianyuan Hu, Kiyomi Morita, Matthew C. Hill, Yajian Jiang, Ayumi Kitano, Yusuke Saito, Feng Wang, Xizeng Mao, Kevin A. Hoegenauer, Kazuhiro Morishita, James F. Martin, P. Andrew Futreal, Koichi Takahashi, Daisuke Nakada
Journal: Blood
Blood (2019) 134 (7): 614–625.
https://doi.org/10.1182/blood.2018888255
Published: 2019
Includes: Supplemental data