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Journal Articles

Inhibition of Menin, BCL-2, and FLT3 Combined with a Hypomethylating Agent Cures NPM1/FLT3 -ITD/-TKD Mutant AML in a PDX Model

Bing Z Carter, Po Yee Mak, Wenjing Tao, Lauren B Ostermann, Duncan Mak, Boazhen Ke, Peter Ordentlich, Gerard M. McGeehan, Michael Andreeff

Blood (2022) 140 (Supplement 1): 3063–3064.

https://doi.org/10.1182/blood-2022-158570

Published: 2022

Journal Articles

Menin inhibition decreases Bcl-2 and synergizes with venetoclax in NPM1/FLT3-mutated AML

Bing Z. Carter, Wenjing Tao, Po Yee Mak, Lauren B. Ostermann, Duncan Mak, Gerard McGeehan, Peter Ordentlich, Michael Andreeff

Blood (2021) 138 (17): 1637–1641.

https://doi.org/10.1182/blood.2021011917

Published: 2021

Includes: Supplemental data

Journal Articles

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

May Daher, Rafet Basar, Elif Gokdemir, Natalia Baran, Nadima Uprety, Ana Karen Nunez Cortes, Mayela Mendt, Lucila Nassif Kerbauy, Pinaki P. Banerjee, Mayra Shanley, Nobuhiko Imahashi, Li Li, Francesca Lorraine Wei Inng Lim, Mohsen Fathi, Ali Rezvan, Vakul Mohanty, Yifei Shen, Hila Shaim, Junjun Lu, Gonca Ozcan, Emily Ensley, Mecit Kaplan, Vandana Nandivada, Mustafa Bdiwi, Sunil Acharya, Yuanxin Xi, Xinhai Wan, Duncan Mak, Enli Liu, Xin Ru Jiang, Sonny Ang, Luis Muniz-Feliciano, Ye Li, Jing Wang, Shahram Kordasti, Nedyalko Petrov, Navin Varadarajan, David Marin, Lorenzo Brunetti, Richard J. Skinner, Shangrong Lyu, Leiser Silva, Rolf Turk, Mollie S. Schubert, Garrett R. Rettig, Matthew S. McNeill, Gavin Kurgan, Mark A. Behlke, Heng Li, Natalie W. Fowlkes, Ken Chen, Marina Konopleva, Richard E. Champlin, Elizabeth J. Shpall, Katayoun Rezvani

Blood (2021) 137 (5): 624–636.

https://doi.org/10.1182/blood.2020007748

Published: 2021

Includes: Supplemental data

Journal Articles

High-Dimensional Single-Cell Proteomic Analysis Reveals Therapeutic Vulnerabilities in Relapsed/Refractory AML By Concomitant Analysis of Cell Surface Antigens, Signaling Pathways and Anti-Apoptotic Proteins

Muharrem Muftuoglu, MD, Zoe Alaniz, BS, Duncan Mak, BSc, MPhil, Angelique J. Lin, MS, Jared K. Burks, PhD, Bing Z Carter, PhD, Michael Andreeff, MD PhD

Blood (2020) 136 (Supplement 1): 26.

https://doi.org/10.1182/blood-2020-143432

Published: 2020

Journal Articles

Single-Cell Mass Cytometry Characterizes Phenotypic and Functional Heterogeneity in Acute Myeloid Leukemia at Diagnosis, in Remission and Relapse

Lina Han, PhD, Peng Qiu, PhD, Jeffrey L. Jorgensen, MD PhD, Duncan Mak, BSc, MPhil, Jared K Burks, PhD, Teresa McQueen, MS, Zhihong Zeng, MD, Farhad Ravandi, MD, Gail J. Roboz, MD, Hagop M. Kantarjian, MD, Steven M. Kornblau, MD, Michael Andreeff, MD PhD, Monica L. Guzman, PhD, Marina Y. Konopleva, MD PhD

Blood (2018) 132 (Supplement 1): 912.

https://doi.org/10.1182/blood-2018-99-111970

Published: 2018

Journal Articles

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Bing Z Carter, PhD, Po Yee Mak, Wenjing Tao, Mark Warmoes, Philip L Lorenzi, PhD, Duncan Mak, BSc, MPhil, Vivian Ruvolo, MS, Xiangmeng Wang, Huaxian Ma, MS, Hong Mu, MD PhD, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 768.

https://doi.org/10.1182/blood-2018-99-113491

Published: 2018

Journal Articles

NK Cell Diversity Influences Outcomes after Cord Blood Transplantation

Blood (2017) 130 (Supplement 1): 1979.

https://doi.org/10.1182/blood.V130.Suppl_1.1979.1979

Published: 2017

Journal Articles

CS1-Specific Chimeric Antigen Receptor Drives Cord Blood NK Cell Maturation and Expansion In Vivo

Blood (2017) 130 (Supplement 1): 4454.

https://doi.org/10.1182/blood.V130.Suppl_1.4454.4454

Published: 2017

Journal Articles

Exploring the Cord Blood T Cell Compartment with Mass Cytometry Reveals the Existence of Memory CD4, CD8 and Regulatory T Cell Pools in the Fetal Period

Muharrem Muftuoglu, MD, Li Li, MD, Juan Jimenez, BS, Duncan Mak, BSc, MPhil, Jared K Burks, PhD, Bingqian Hu, MS, Hila Shaim, MD, Nobuhiko Imahashi, MD PhD, Francesca Lorraine Wei Inng Lim, MD, Pinaki P Banerjee, PhD, Mustafa H Bdiwi, MD, Lucila Nassif Kerbauy, MD, Mecit Kaplan, BS, Darius Armstrong James, MD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Katayoun Rezvani, MD PhD

Blood (2017) 130 (Supplement 1): 4467.

https://doi.org/10.1182/blood.V130.Suppl_1.4467.4467

Published: 2017

Journal Articles

Evaluation of T Cell Compartment By Mass Cytometry Reveals Distinct Patterns of Expression of Exhaustion Markers in Chronic Lymphocytic Leukemia

Blood (2017) 130 (Supplement 1): 4283.

https://doi.org/10.1182/blood.V130.Suppl_1.4283.4283

Published: 2017

Journal Articles

Activation of p53 Enhances Antileukemia Activity of Bcr-Abl Tyrosine Kinase Inhibitors in a Murine Model of CML

Bing Z Carter, PhD, Po Yee Mak, Hong Mu, MD PhD, Duncan Mak, Ej Dettman, Michael Cardone, Xiangmeng Wang, PhD, Wendy Schober, Wenjing Tao, PhD, Takahiko Seki, Michael Andreeff, MD PhD

Blood (2017) 130 (Supplement 1): 4170.

https://doi.org/10.1182/blood.V130.Suppl_1.4170.4170

Published: 2017

Journal Articles

Disruption of Wnt/β-Catenin Signaling Exerts Antileukemia Activity and Sensitizes with Tyrosine Kinase Inhibitors in FLT3 Mutated AML In Vivo

Xuejie Jiang, Po Yee Mak, MPhil, Hong Mu, MD PhD, Duncan Mak, BSc, MPhil, Qi Zhang, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD, Bing Z Carter, PhD

Blood (2016) 128 (22): 2828.

https://doi.org/10.1182/blood.V128.22.2828.2828

Published: 2016

Journal Articles

Inhibition of FAK Exerts Anti-Leukemic Activity and Potentiates ABT-199-Induced Apoptosis in AML

Xiangmeng Wang, Po Yee Mak, MPhil, Hong Mu, MD PhD, Xuejie Jiang, Duncan Mak, BSc, MPhil, Jonathan A. Pachter, PhD, David T. Weaver, PhD, Bing Xu, PhD, Michael Andreeff, MD PhD, Bing Z Carter, PhD

Blood (2016) 128 (22): 1574.

https://doi.org/10.1182/blood.V128.22.1574.1574

Published: 2016

Journal Articles

Mass Cytometry Reveals Heterogeneity in the Exhaustion Profile of T-Cells in Chronic Lymphocytic Leukemia and the CD4:CD8 Ratio May be a Reliable Predictor of CD8 + T Cell Compartment "Fitness"

Muharrem Muftuoglu, MD, Li Li, MD, Han Chen, PhD, Duncan Mak, BSc, MPhil, Elif Gokdemir, BS, Hila Shaim, MD, Jared Burks, PhD, Rafet Basar, MD, Nobuhiko Imahashi, MD PhD, Mayela Carolina Mendt, May Daher, MD, David Marin, MD, William G. Wierda, MD PhD, Nitin Jain, MD, Michael J. Keating, MD, Richard E. Champlin, MD, Elizabeth J. Shpall, MD, Katayoun Rezvani, MD, PhD

Blood (2016) 128 (22): 353.

https://doi.org/10.1182/blood.V128.22.353.353

Published: 2016

Journal Articles

Cytomegalovirus Reactivation Shapes NK Cells Diversity Following Allogeneic Hematopoietic Stem Cell Transplantation

Li Li, MD, Muharrem Muftuoglu, MD, Han Chen, PhD, Duncan Mak, BSc, MPhil, Elif Gokdemir, BS, Hila Shaim, MD, Jared Burks, PhD, May Daher, MD, Nobuhiko Imahashi, MD PhD, Mayela Carolina Mendt Vilchez, PhD, Rafet Basar, MD, David Marin, MD, Richard E. Champlin, MD, Elizabeth J. Shpall, MD, Katayoun Rezvani, MD, PhD

Blood (2016) 128 (22): 4588.

https://doi.org/10.1182/blood.V128.22.4588.4588

Published: 2016

Journal Articles

AMG925, a Dual FLT3-CDK4/6 Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML Progenitor/Stem Cells

Zhihong Zeng, MD, Charlie Ly, Duncan Mak, BSc, MPhil, Neil P. Shah, MD PhD, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 3938.

https://doi.org/10.1182/blood.V128.22.3938.3938

Published: 2016

Journal Articles

Concurrent Inhibition of Beta-Catenin/CBP and FLT3 Strongly Suppresses c-Myc and Synergistically Induces Apoptosis in FLT3 Mutant AML Cells

Xuejie Jiang, Po Yee Mak, MPhil, Hong Mu, MD PhD, Weiguo Zhang, MD, PhD, Duncan Mak, BSc, MPhil, Peter Ruvolo, PhD, Teresa McQueen, Hongsheng Zhou, Jorge E. Cortes, Michael Andreeff, MD, PhD, Bing Z Carter

Blood (2015) 126 (23): 3685.

https://doi.org/10.1182/blood.V126.23.3685.3685

Published: 2015

Journal Articles

Synergistic Effects of Combined Targeting of Beta-Catenin/CBP and Bcr-Abl in CML Blast Crisis Stem/Progenitor Cells in Vitro and in Vivo as Analyzed By Single Cell Mass Cytometry (CyTOF)

Hongsheng Zhou, MD, Po Yee Mak, MPhil, Hong Mu, MD PhD, Duncan Mak, BSc, MPhil, Zhihong Zeng, MD, Jorge Cortes, MD, Michael Andreeff, MD PhD, Bing Z Carter

Blood (2015) 126 (23): 1566.

https://doi.org/10.1182/blood.V126.23.1566.1566

Published: 2015

Journal Articles

BRD4 Proteolysis Targeting Chimera (PROTAC) Leads to Sustained Degradation of BRD4 with Broad Activity Against Acute Leukemias and Overcomes Stroma Mediated Resistance By Modulating Surface Expression of CXCR4

Sujan Piya, Teresa McQueen, Duncan Mak, BSc, MPhil, Marina Konopleva, MD PhD, Patrick Zweidler-McKay, MD PhD, Jing Lu, PhD, Yimin Qian, PhD, Michael Andreeff, MD PhD, Gautam Borthakur, MD

Blood (2015) 126 (23): 675.

https://doi.org/10.1182/blood.V126.23.675.675

Published: 2015

NARROW

Inhibition of Menin, BCL-2, and FLT3 Combined with a Hypomethylating Agent Cures NPM1/FLT3 -ITD/-TKD Mutant AML in a PDX Model

Menin inhibition decreases Bcl-2 and synergizes with venetoclax in NPM1/FLT3-mutated AML

Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells

High-Dimensional Single-Cell Proteomic Analysis Reveals Therapeutic Vulnerabilities in Relapsed/Refractory AML By Concomitant Analysis of Cell Surface Antigens, Signaling Pathways and Anti-Apoptotic Proteins

Single-Cell Mass Cytometry Characterizes Phenotypic and Functional Heterogeneity in Acute Myeloid Leukemia at Diagnosis, in Remission and Relapse

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

NK Cell Diversity Influences Outcomes after Cord Blood Transplantation

CS1-Specific Chimeric Antigen Receptor Drives Cord Blood NK Cell Maturation and Expansion In Vivo

Exploring the Cord Blood T Cell Compartment with Mass Cytometry Reveals the Existence of Memory CD4, CD8 and Regulatory T Cell Pools in the Fetal Period

Evaluation of T Cell Compartment By Mass Cytometry Reveals Distinct Patterns of Expression of Exhaustion Markers in Chronic Lymphocytic Leukemia

Activation of p53 Enhances Antileukemia Activity of Bcr-Abl Tyrosine Kinase Inhibitors in a Murine Model of CML

Disruption of Wnt/β-Catenin Signaling Exerts Antileukemia Activity and Sensitizes with Tyrosine Kinase Inhibitors in FLT3 Mutated AML In Vivo

Inhibition of FAK Exerts Anti-Leukemic Activity and Potentiates ABT-199-Induced Apoptosis in AML

Mass Cytometry Reveals Heterogeneity in the Exhaustion Profile of T-Cells in Chronic Lymphocytic Leukemia and the CD4:CD8 Ratio May be a Reliable Predictor of CD8 + T Cell Compartment "Fitness"

Cytomegalovirus Reactivation Shapes NK Cells Diversity Following Allogeneic Hematopoietic Stem Cell Transplantation

AMG925, a Dual FLT3-CDK4/6 Inhibitor, Disrupts Survival Signaling and Triggers Apoptosis in AML Progenitor/Stem Cells

Effects of CCL2/CCR2 Blockade in Acute Myeloid Leukemia

Concurrent Inhibition of Beta-Catenin/CBP and FLT3 Strongly Suppresses c-Myc and Synergistically Induces Apoptosis in FLT3 Mutant AML Cells

Synergistic Effects of Combined Targeting of Beta-Catenin/CBP and Bcr-Abl in CML Blast Crisis Stem/Progenitor Cells in Vitro and in Vivo as Analyzed By Single Cell Mass Cytometry (CyTOF)

BRD4 Proteolysis Targeting Chimera (PROTAC) Leads to Sustained Degradation of BRD4 with Broad Activity Against Acute Leukemias and Overcomes Stroma Mediated Resistance By Modulating Surface Expression of CXCR4

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American Society of Hematology

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American Society of Hematology

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