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Journal Articles

AXL Inhibitor ONO-9330547 Suppresses PLK1 Gene and Protein Expression and Effectively Induces Growth Arrest and Apoptosis in FLT3 ITD Acute Myeloid Leukemia Cells

Peter Ruvolo, PhD, Huaxian Ma, BS, Vivian Ruvolo, MS, Hong Mu, MD PhD, Wendy Schober, Tomoko Yasuhiro, Toshio Yoshizawa, PhD, Miguel Gallardo, PhD, Xiaorui Zhang, BS, Joseph D Khoury, MD, Jorge Cortes, MD, Michael Andreeff, MD PhD, Sean M. Post, PhD

Blood (2016) 128 (22): 3939.

https://doi.org/10.1182/blood.V128.22.3939.3939

Published: 2016

Journal Articles

Targeting Aggregation of Wilde-Type p53 and Mutant p53 with ReACp53 As a Novel Therapeutic Concept for AML

Jianfang Zeng, MD PhD, Alice Soragni, PhD, Jo Ishizawa, MDPhD, Vivian Ruvolo, MS, Christopher B. Benton, MD, Teresa McQueen, MS, Peter Ruvolo, PhD, Yuan Qi, PhD, Xiaoping Su, PhD, Jared Burks, PhD, David S. Eisenberg, PhD, Michael Andreeff, MD PhD

Blood (2016) 128 (22): 3944.

https://doi.org/10.1182/blood.V128.22.3944.3944

Published: 2016

Journal Articles

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

Mohammed Dany, Salih Gencer, Rose Nganga, Raquela J. Thomas, Natalia Oleinik, Kyla D. Baron, Zdzislaw M. Szulc, Peter Ruvolo, Steven Kornblau, Michael Andreeff, Besim Ogretmen

Blood (2016) 128 (15): 1944–1958.

https://doi.org/10.1182/blood-2016-04-708750

Published: 2016

Includes: Supplemental data

Journal Articles

Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach

Jo Ishizawa, MD PhD, Rodrigo Omar Jacamo, PhD, Kensuke Kojima, MD PhD, Dhruv Chachad, MS, Vivian Ruvolo, MS, Peter Ruvolo, PhD, Weiguo Zang, PhD, Yoko Tabe, MD PhD, Marina Konopleva, MD PhD, William Devine, PhD, Susan Lindquist, PhD, John A Porco, Jr., Luke Whitesell, MD PhD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 2548.

https://doi.org/10.1182/blood.V126.23.2548.2548

Published: 2015

Journal Articles

Role of Mesenchymal Stem Cell Galectin 3 in the AML Tumor Microenvironment

Peter Ruvolo, PhD, Yihua Qiu, MD, Vivian Ruvolo, MS, Rui-Yu Wang, MD PhD, Zhihong Zeng, MD, Jared Burks, PhD, Rongqing Pan, MS, Numsen Hail, Jr., PhD, Teresa McQueen, Suk-Young Yoo, Steven M. Kornblau, MD, Michael Andreeff, MD PhD

Blood (2015) 126 (23): 1198.

https://doi.org/10.1182/blood.V126.23.1198.1198

Published: 2015

Journal Articles

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Blood (2015) 126 (23): 2051.

https://doi.org/10.1182/blood.V126.23.2051.2051

Published: 2015

Journal Articles

Concurrent Inhibition of Beta-Catenin/CBP and FLT3 Strongly Suppresses c-Myc and Synergistically Induces Apoptosis in FLT3 Mutant AML Cells

Xuejie Jiang, Po Yee Mak, MPhil, Hong Mu, MD PhD, Weiguo Zhang, MD, PhD, Duncan Mak, BSc, MPhil, Peter Ruvolo, PhD, Teresa McQueen, Hongsheng Zhou, Jorge E. Cortes, Michael Andreeff, MD, PhD, Bing Z Carter

Blood (2015) 126 (23): 3685.

https://doi.org/10.1182/blood.V126.23.3685.3685

Published: 2015

Journal Articles

Acute Myelogenous Leukemia (AML) Mesenchymal Stromal Cell (MSC) Have Distinct Protein Expression Patterns Compared to Normal MSC

Steven M. Kornblau, MD, Peter Ruvolo, PhD, Rui-Yu Wang, MD PhD, Vivian Ruvolo, MS, Yihua Qiu, MD, Venkata Lokesh Battula, PhD, Zhihong Zeng, MD, Teresa McQueen, Suk-Young Yoo, Marina Konopleva, MD PhD, Michael Andreeff, MD, PhD

Blood (2015) 126 (23): 3813.

https://doi.org/10.1182/blood.V126.23.3813.3813

Published: 2015

Journal Articles

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance

Blood (2014) 123 (17): 2691–2702.

https://doi.org/10.1182/blood-2013-06-511527

Published: 2014

Includes: Supplemental data

Journal Articles

Triterpenoid Methyl-CDDO Is a Potent Inducer of Apoptosis in CD34 + AML Progenitor Cells Via Activation of SAPK Pathways and Inhibition of MAPK Cascades.

Marina Konopleva, M.D., Ph.D., Peter Ruvolo, Ph.D., Rooha Contractor, Svitlana Kurinna, Yue-Xi Shi, Teresa McQueen, Michele Milella, M.D., Michael Andreeff, M.D., Ph.D.

Blood (2004) 104 (11): 2533.

https://doi.org/10.1182/blood.V104.11.2533.2533

Published: 2004

Journal Articles

Inhibition of Bcl-2 Signaling at Nanomolar Concentrations by Small Molecule BH3 Inhibitor, ABT-737 as a Novel Therapeutic Strategy in Acute Myeloid Leukemia (AML).

Rooha Contractor, Marina Konopleva, M.D., Ph.D., Xingming Deng, M.D., Ph.D., David Harris, Peter Ruvolo, Ph.D., Zeev Estrov, M.D., W. Stratford May, M.D., Ph.D., Saul H. Rosenberg, Ph.D., Michael Andreeff, M.D., Ph.D.

Blood (2004) 104 (11): 760.

https://doi.org/10.1182/blood.V104.11.760.760

Published: 2004

Journal Articles

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

Marina Konopleva, Twee Tsao, Peter Ruvolo, Irina Stiouf, Zeev Estrov, Clinton E. Leysath, Shourong Zhao, David Harris, Shirong Chang, C. Ellen Jackson, Mark Munsell, Nanjoo Suh, Gordon Gribble, Tadashi Honda, W. Stratford May, Michael B. Sporn, Michael Andreeff

Blood (2002) 99 (1): 326–335.

https://doi.org/10.1182/blood.V99.1.326

Published: 2002

NARROW

AXL Inhibitor ONO-9330547 Suppresses PLK1 Gene and Protein Expression and Effectively Induces Growth Arrest and Apoptosis in FLT3 ITD Acute Myeloid Leukemia Cells

Targeting Aggregation of Wilde-Type p53 and Mutant p53 with ReACp53 As a Novel Therapeutic Concept for AML

Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

Inactivating Heat Shock Factor 1 (HSF1) in Acute Myeloid Leukemia By Pharmacological Inhibition of eIF4a: A Promising Therapeutic Approach

Effects of CCL2/CCR2 Blockade in Acute Myeloid Leukemia

Role of Mesenchymal Stem Cell Galectin 3 in the AML Tumor Microenvironment

ONC201 Induces p53-Independent Apoptosis and Abrogates Stem Cell Function in Hematological Malignancies By Induction of ATF4 through Integrated Stress Response

Concurrent Inhibition of Beta-Catenin/CBP and FLT3 Strongly Suppresses c-Myc and Synergistically Induces Apoptosis in FLT3 Mutant AML Cells

Acute Myelogenous Leukemia (AML) Mesenchymal Stromal Cell (MSC) Have Distinct Protein Expression Patterns Compared to Normal MSC

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance

Triterpenoid Methyl-CDDO Is a Potent Inducer of Apoptosis in CD34 + AML Progenitor Cells Via Activation of SAPK Pathways and Inhibition of MAPK Cascades.

Inhibition of Bcl-2 Signaling at Nanomolar Concentrations by Small Molecule BH3 Inhibitor, ABT-737 as a Novel Therapeutic Strategy in Acute Myeloid Leukemia (AML).

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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