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Journal Articles

STAT3 Activates Anti-Apoptotic Genes But When In Access Induces Apoptosis Of CLL Cells

Rozovski Uri, MD, David Harris, Ping Li, PhD, Zhiming Liu, Ji Yuan, Srdana Grugurevic, Susan Lerner, MS, William G. Wierda, MD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2013) 122 (21): 5294.

https://doi.org/10.1182/blood.V122.21.5294.5294

Published: 2013

Journal Articles

STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis

Ping Li, PhD, Uri Rozovski, MD, David Harris, Lui Zhiming, Alessandra Ferrajoli, MD, Carlos E. Bueso-Ramos, MD, PhD, Inbal Hazan-Halevy, Srdana Grugurevic, William G. Wierda, MD, PhD, Jan A. Burger, MD, PhD, Susan O'Brien, MD, Stefan H. Faderl, MD, Michael J. Keating, MD, Zeev Estrov, MD

Blood (2013) 122 (21): 4118.

https://doi.org/10.1182/blood.V122.21.4118.4118

Published: 2013

Journal Articles

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a

Alfonso Quintás-Cardama, Omar Abdel-Wahab, Taghi Manshouri, Outi Kilpivaara, Jorge Cortes, Anne-Laure Roupie, Su-Jiang Zhang, David Harris, Zeev Estrov, Hagop Kantarjian, Ross L. Levine, Srdan Verstovsek

Blood (2013) 122 (6): 893–901.

https://doi.org/10.1182/blood-2012-07-442012

Published: 2013

Includes: Supplemental data

Journal Articles

Signal Transducer and Activator of Transcription (STAT)-3 Induces the Expression of Microrna-155 in Chronic Lymphocytic Leukemia (CLL) Cells.

Ping Li, PhD, Srdana Grgurevic, MS, Zhiming Liu, MS, David Harris, BS, Uri Rozovski, MD, Michael J. Keating, MD, George Calin, MD PhD, Zeev Estrov, MD

Blood (2012) 120 (21): 2885.

https://doi.org/10.1182/blood.V120.21.2885.2885

Published: 2012

Journal Articles

Signal Transducer and Activator of Transcription (STAT)-3-Dependent Regulation of Non-Coding RNA Genes in Chronic Lymphocytic Leukemia (CLL).

Uri Rozovski, MD, George Calin, MD PhD, Setoyama Tetsirp, Lucilla D'Abundo, David Harris, Ping Li, Zhiming Liu, Srdana Grgurevic, MS, Alessandra Ferrajoli, Stefan Faderl, MD, Jan A. Burger, MD, PhD, Susan M. O'Brien, MD, William G. Wierda, MD, Ph.D., Michael J. Keating, MD, Zeev Estrov, MD

Blood (2012) 120 (21): 2886.

https://doi.org/10.1182/blood.V120.21.2886.2886

Published: 2012

Journal Articles

Spontaneous Apoptosis of Chronic Lymphocytic Leukemia (CLL) Cells Correlates with Disease Burden and Inversely Correlates with Intracellular Levels of Signal Transducer and Activator of Transcription-3 (STAT3)

Rozovski Uri, MD, David Harris, Ping Li, PhD, Zhiming Liu, Srdana Grgurevic, Susan Lerner, MS, Matthew Martinez, William G. Wierda, MD, Ph.D., Michael Keating, MD, Zeev Estrov, MD, PhD

Blood (2012) 120 (21): 3910.

https://doi.org/10.1182/blood.V120.21.3910.3910

Published: 2012

Journal Articles

Signal Transducer and Activator of Transcription (STAT)-3 Induces Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Receptor-α Expression in Chronic Lymphocytic Leukemia (CLL) Cells,

Ping Li, PhD, Zhiming Liu, MS, David Harris, BS, Alessandra Ferrajoli, MD, Yongtao Wang, MD, Inbal Hazan-Halevy, PhD, Srdana Grgurevic, MS, William G. Wierda, MD, PhD, Jan A. Burger, MD, PhD, Susan O'Brien, MD, Stefan Faderl, MD, Michael J Keating, MD, Zeev Estrov

Blood (2011) 118 (21): 3879.

https://doi.org/10.1182/blood.V118.21.3879.3879

Published: 2011

Journal Articles

Signal Transducer and Activator of Transcription (STAT)-3 Activates Nuclear Factor (NF)-κB in Primary Myelofibrosis (PMF) Bone Marrow Cells

Srdana Grgurevic, MS, Srdan Verstovsek, MD, PhD, Zhiming Liu, MS, Taghi Manshouri, PhD, David Harris, BS, Ping Li, PhD, Hagop M. Kantarjian, Zeev Estrov

Blood (2011) 118 (21): 1742.

https://doi.org/10.1182/blood.V118.21.1742.1742

Published: 2011

Journal Articles

Signal Transducer and Activator of Transcription (STAT)-3 Activates Nuclear Factor (NF)-κB In Chronic Lymphocytic Leukemia (CLL) Cells

Zhiming Liu, Inbal Hazan-Halevy, David Harris, Ping Li, Alessandra Ferrajoli, MD, Stefan Faderl, MD, Michael Keating, MD, Zeev Estrov, MD

Blood (2010) 116 (21): 376.

https://doi.org/10.1182/blood.V116.21.376.376

Published: 2010

Journal Articles

Phase I Trial Results for SL-401, a Novel Cancer Stem Cell (CSC) Targeting Agent, Demonstrate Clinical Efficacy at Tolerable Doses In Patients with Heavily Pre-Treated AML, Poor Risk Elderly AML, and High Risk MDS

Blood (2010) 116 (21): 3298.

https://doi.org/10.1182/blood.V116.21.3298.3298

Published: 2010

Journal Articles

Response: Lentiviral vectors and transduction of human cancer B cells

Inbal Hazan-Halevy, David Harris, Zhiming Liu, Ping Li, Zeev Estrov

Blood (2010) 116 (3): 500.

https://doi.org/10.1182/blood-2010-04-278903

Published: 2010

Journal Articles

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

Inbal Hazan-Halevy, David Harris, Zhiming Liu, Jie Liu, Ping Li, Xiaomin Chen, Sreejesh Shanker, Alessandra Ferrajoli, Michael J. Keating, Zeev Estrov

Blood (2010) 115 (14): 2852–2863.

https://doi.org/10.1182/blood-2009-10-230060

Published: 2010

Journal Articles

APcK 110, a novel Inhibitor of Kit, Extends Survival of NOD-SCID Mice in An AML Xenograft Model.

Stefan Faderl, MD, Carlos Bueso-Ramos, MD, PhD, Zhiming Liu, Ashutosh Pal, William Bornmann, PhD, David Harris, Inbal Hazan-Halevy, PhD, Hagop M. Kantarjian, MD, Zeev Estrov, MD

Blood (2009) 114 (22): 1045.

https://doi.org/10.1182/blood.V114.22.1045.1045

Published: 2009

Journal Articles

Cross-Talk Between CLL Cells and Endothelial Cells in the Bone Marrow Microenvironment: Role of Signal Transducer and Activator of Transcription (Stat)-3.

Xavier C. Badoux, MBBS, Carlos Bueso Ramos, MD, PhD, David Harris, B.S., Ping Li, Ph.D., Zhiming Liu, B.S., Jan Burger, M.D., Susan O'Brien, MD, Alessandra Ferrajoli, MD., Michael Keating, MD, Zeev Estrov, MD

Blood (2009) 114 (22): 1242.

https://doi.org/10.1182/blood.V114.22.1242.1242

Published: 2009

Journal Articles

Signal Transducer and Activator of Transcription (Stat)-3 Activates the Receptor Tyrosine Kinase-Like Orphan (ROR)-1 Gene in Chronic Lymphocytic Leukemia (CLL).

Li Ping, David Harris, Zhiming Liu, Michael Keating, MD, Zeev Estrov, MD

Blood (2009) 114 (22): 57.

https://doi.org/10.1182/blood.V114.22.57.57

Published: 2009

Journal Articles

STAT3 Is Constitutively Phosphorylated on Serine 727 Residues, Activates Transcription, and Plays a Major Role in the Pathogenesis of B-Cell Chronic Lymphocytic Leukemia.

Inbal Hazan-Halevy, PhD., David Harris, Zhiming Liu, Alessandra Ferrajoli, M.D., Michael J Keating, M.D., Zeev Estrov, M.D.

Blood (2008) 112 (11): 1058.

https://doi.org/10.1182/blood.V112.11.1058.1058

Published: 2008

Journal Articles

Importin-β1 and Nucleus Transporter Chromosome Region Maintenance 1 (CRM1) Constitute the Nucleocytoplasmic Transport System of STAT3 in Blood-Derived CLL Cells.

Inbal Hazan-Halevy, PhD., David Harris, Zhiming Liu, Alessandra Ferrajoli, MD., Michael J Keating, M.D., Zeev Estrov, MD

Blood (2008) 112 (11): 1059.

https://doi.org/10.1182/blood.V112.11.1059.1059

Published: 2008

Journal Articles

Bone Marrow Stromal Cells Reverse Proapoptotic Effects of JAK2 Inhibitor Atiprimod in Cells Carrying the JAK2 V617F mutation

Taghi Manshouri, Zeev Estrov, Jan Burger, Ana Livun, Ying Zhang, Shuhuang Ma, Amos Gaikwad, David Harris, Hagop M Kantarjian, Srdan Verstovsek

Blood (2008) 112 (11): 3738.

https://doi.org/10.1182/blood.V112.11.3738.3738

Published: 2008

Journal Articles

Constitutively Serine Phosphorylated STAT3 Provides Chronic Lymphocytic Leukemia (CLL) Cells with Survival Advantage and Promotes Their Proliferation.

Inbal Hazan-Halevy, PhD, Alessandra Ferrajoli, MD, David Harris, Pijus K. Mandal, Ph.D, John S. McMurray, Ph.D, Michael Keating, MD, Zeev Estrov, MD

Blood (2007) 110 (11): 1132.

https://doi.org/10.1182/blood.V110.11.1132.1132

Published: 2007

Journal Articles

Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death Via the Mitochondrial Pathway in AML Cells.

Bing Z. Carter, PhD, Duncan H. Mak, MS, Wendy D. Schober, BS, Richard Woessner, PhD, Stefan Gross, PhD, David Harris, BS, Zeev Estrov, MD, Michael Andreeff, MD, PhD

Blood (2007) 110 (11): 2782.

https://doi.org/10.1182/blood.V110.11.2782.2782

Published: 2007

NARROW

STAT3 Activates Anti-Apoptotic Genes But When In Access Induces Apoptosis Of CLL Cells

STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a

Signal Transducer and Activator of Transcription (STAT)-3 Induces the Expression of Microrna-155 in Chronic Lymphocytic Leukemia (CLL) Cells.

Signal Transducer and Activator of Transcription (STAT)-3-Dependent Regulation of Non-Coding RNA Genes in Chronic Lymphocytic Leukemia (CLL).

Spontaneous Apoptosis of Chronic Lymphocytic Leukemia (CLL) Cells Correlates with Disease Burden and Inversely Correlates with Intracellular Levels of Signal Transducer and Activator of Transcription-3 (STAT3)

Signal Transducer and Activator of Transcription (STAT)-3 Induces Granulocyte/Macrophage Colony-Stimulating Factor (GM-CSF) Receptor-α Expression in Chronic Lymphocytic Leukemia (CLL) Cells,

Signal Transducer and Activator of Transcription (STAT)-3 Activates Nuclear Factor (NF)-κB in Primary Myelofibrosis (PMF) Bone Marrow Cells

Signal Transducer and Activator of Transcription (STAT)-3 Activates Nuclear Factor (NF)-κB In Chronic Lymphocytic Leukemia (CLL) Cells

Phase I Trial Results for SL-401, a Novel Cancer Stem Cell (CSC) Targeting Agent, Demonstrate Clinical Efficacy at Tolerable Doses In Patients with Heavily Pre-Treated AML, Poor Risk Elderly AML, and High Risk MDS

Response: Lentiviral vectors and transduction of human cancer B cells

STAT3 is constitutively phosphorylated on serine 727 residues, binds DNA, and activates transcription in CLL cells

APcK 110, a novel Inhibitor of Kit, Extends Survival of NOD-SCID Mice in An AML Xenograft Model.

Cross-Talk Between CLL Cells and Endothelial Cells in the Bone Marrow Microenvironment: Role of Signal Transducer and Activator of Transcription (Stat)-3.

Signal Transducer and Activator of Transcription (Stat)-3 Activates the Receptor Tyrosine Kinase-Like Orphan (ROR)-1 Gene in Chronic Lymphocytic Leukemia (CLL).

STAT3 Is Constitutively Phosphorylated on Serine 727 Residues, Activates Transcription, and Plays a Major Role in the Pathogenesis of B-Cell Chronic Lymphocytic Leukemia.

Importin-β1 and Nucleus Transporter Chromosome Region Maintenance 1 (CRM1) Constitute the Nucleocytoplasmic Transport System of STAT3 in Blood-Derived CLL Cells.

Bone Marrow Stromal Cells Reverse Proapoptotic Effects of JAK2 Inhibitor Atiprimod in Cells Carrying the JAK2 V617F mutation

Constitutively Serine Phosphorylated STAT3 Provides Chronic Lymphocytic Leukemia (CLL) Cells with Survival Advantage and Promotes Their Proliferation.

Inhibition of KSP by ARRY-520 Induces Cell Cycle Block and Cell Death Via the Mitochondrial Pathway in AML Cells.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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