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Leandro Cerchietti
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Journal Articles

Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma

Leandro Cerchietti
Journal: Blood
Blood (2024) 143 (12): 1101–1111.
https://doi.org/10.1182/blood.2023021002
Published: 2024
Journal Articles

Remodeling of the Immune Microenvironment By Oncogenic MYD88 Dictates Immunotherapy Responses across Indolent and Aggressive B-Cell Lymphomas

Jon Celay, Miriam Recalde, María Victoria Revuelta, Marta Larrayoz, Sara Rodriguez, Maria J Garcia-Barchino, Jennifer R. Chapman-Fredricks, Teresa Lozano, Juan J Lasarte, Ming Q. Du, Izidore S. Lossos, Sergio Roa, Aldo Roccaro, Miguel Canales, Felipe Prosper, Bruno Paiva, Leandro Cerchietti, Jose A. Martinez-Climent
Journal: Blood
Blood (2023) 142 (Supplement 1): 431.
https://doi.org/10.1182/blood-2023-173394
Published: 2023
Journal Articles

Qpctl Inhibition, By Targeting the Inflammatory Tumor Microenvironment, Constitutes a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma

Nicolas Di Siervi, Jasper Mullender, María Victoria Revuelta, Nahuel Zamponi, Eloisi Caldas-Lopes, Yusuke Isshiki, Wendy Béguelin, Marcel Scheepstra, Bastiaan Evers, Jens Wuerthner, Leandro Cerchietti
Journal: Blood
Blood (2023) 142 (Supplement 1): 49.
https://doi.org/10.1182/blood-2023-181264
Published: 2023
Journal Articles

Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL

Clinical Trials & Observations
Jia Ruan, Alison Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Nikita Kotlov, Grigorii Nos, Maria Sorokina, Vladislav Maksimov, Andrea Sboner, Michael Sigouros, Koen van Besien, Steven Horwitz, Sarah C. Rutherford, Erin Mulvey, Maria V. Revuelta, Jenny Xiang, Alicia Alonso, Ari Melnick, Olivier Elemento, Giorgio Inghirami, John P. Leonard, Leandro Cerchietti, Peter Martin
Journal: Blood
Blood (2023) 141 (18): 2194–2205.
https://doi.org/10.1182/blood.2022018254
Published: 2023
Includes: Supplemental data
Journal Articles

Endothelial cell–leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities

Luca Vincenzo Cappelli, Danilo Fiore, Jude M. Phillip, Liron Yoffe, Filomena Di Giacomo, William Chiu, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, Jose Gabriel Barcia Duran, Nahuel Zamponi, Ari M. Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foà, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2023) 141 (5): 503–518.
https://doi.org/10.1182/blood.2022015414
Published: 2023
Includes: Supplemental data
Journal Articles

FGFR1 Is a Novel Therapeutic Target in Relapsed/Refractory Diffuse Large B Cell Lymphoma (RR-DLBCL)

Nicolas Di Siervi, Maria Victoria Revuelta, Maria Teresa Cacciapuoti, Nahuel Zamponi, Rossella Marullo, Ari Melnick, Giorgio Inghirami, Leandro Cerchietti
Journal: Blood
Blood (2022) 140 (Supplement 1): 1322.
https://doi.org/10.1182/blood-2022-169529
Published: 2022
Journal Articles

Phase 1 study of oral azacitidine (CC-486) plus R-CHOP in previously untreated intermediate- to high-risk DLBCL

Clinical Trials & Observations
Peter Martin, Nancy L. Bartlett, Julio C. Chavez, John L. Reagan, Sonali M. Smith, Ann S. LaCasce, Jeffrey Jones, James Drew, Chengqing Wu, Erin Mulvey, Maria V. Revuelta, Leandro Cerchietti, John P. Leonard
Journal: Blood
Blood (2022) 139 (8): 1147–1159.
https://doi.org/10.1182/blood.2021011679
Published: 2022
Includes: Supplemental data
Journal Articles

High Rates of Remission with the Initial Treatment of Oral Azacitidine Plus CHOP for Peripheral T-Cell Lymphoma (PTCL): Clinical Outcomes and Biomarker Analysis of a Multi-Center Phase II Study

Jia Ruan, Alison J. Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Riyaad Rahim, Wei Song, Nikita Kotlov, Grigorii Nos, Vladislav Maksimov, Maria Victoria Revuelta, Andrea Sboner, Michael Sigouros, Koen van Besien, Steven M. Horwitz, Sarah C. Rutherford, Erin C. Mulvey, Morton Coleman, Ari Melnick, Olivier Elemento, Giorgio Inghirami, John P. Leonard, Peter Martin, Leandro Cerchietti
Journal: Blood
Blood (2021) 138 (Supplement 1): 138.
https://doi.org/10.1182/blood-2021-145495
Published: 2021
Journal Articles

A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments

Luca Vincenzo Cappelli, Danilo Fiore, Jude M Phillip, Liron Yoffe, Filomena Di Giacomo, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, José Gabriel Barcia Durán, Nahuel Zamponi, Ari Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foa, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 704.
https://doi.org/10.1182/blood-2021-153300
Published: 2021
Journal Articles

Aging-Associated Epigenetic Reprogramming Alters the Germinal Center Reaction and Targets Pathways Related to Lymphomagenesis

Rossella Marullo, Maria Victoria Revuelta, Wendy Béguelin, Juan Lara-Garcia, Leandro Cerchietti
Journal: Blood
Blood (2021) 138 (Supplement 1): 676.
https://doi.org/10.1182/blood-2021-152684
Published: 2021
Journal Articles

Phase I Study of Oral Azacitidine (CC-486) Plus Salvage Chemotherapy in Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Brian T. Hess, Leandro Cerchietti, Lindsey Hendrickson, Elizabeth Hill, Anshu Giri, Shanta Salzer, Sarah Hogan, Lacey Finch, Robin Klingenberg, Fang Hu, Nina D. Wagner-Johnston
Journal: Blood
Blood (2021) 138 (Supplement 1): 3567.
https://doi.org/10.1182/blood-2021-145493
Published: 2021
Journal Articles

S1918: A Phase II/III Randomized Study of R-Minichop with or without Oral Azacitidine (CC-486) in Participants Age 75 Years or Older with Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIb Follicular Lymphoma, Transformed Lymphoma, and High-Grade B-Cell Lymphomas with MYC and BCL2 and/or BCL6 Rearrangements

Elizabeth A Brem, Hongli Li, Anne W. Beaven, Paolo F. Caimi, Leandro Cerchietti, Ash A. Alizadeh, Rebecca L. Olin, Norah Lynn Henry, Hildy Dilon, Richard F. Little, Cara Laubach, Michael L. Leblanc, Jonathan W. Friedberg, Sonali M. Smith
Journal: Blood
Blood (2021) 138 (Supplement 1): 3565.
https://doi.org/10.1182/blood-2021-148193
Published: 2021
Journal Articles

Multi-Center Phase II Study of Oral Azacitidine (CC-486) Plus CHOP As Initial Treatment for Peripheral T-Cell Lymphoma (PTCL)

Jia Ruan, MD PhD, Alison J. Moskowitz, MD, Neha Mehta-Shah, MD, Lubomir Sokol, MD PhD, Zhengming Chen, PhD MPH, MS, Riyaad Rahim, Wei Song, Koen Van Besien, MD PhD, Steven M. Horwitz, MD, Sarah C. Rutherford, MD, Morton Coleman, MD FACP, Ari Melnick, MD, Giorgio Inghirami, MD, Leandro Cerchietti, MD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-136023
Published: 2020
Journal Articles

A Phase I Study of Selinexor and R-ICE in Patients with Relapsed/Refractory Aggressive B-Cell Lymphomas

Sarah C. Rutherford, MD, John N. Allan, MD, Jia Ruan, MD PhD, Richard R. Furman, MD, Kristy Richards, MD PhD, Amelyn Rodriguez, BSN, RN, OCN, Kseniya Gololobova, Arcania Garcia, Leandro Cerchietti, MD, Rossella Marullo, MDPhD, Zhengming Chen, PhD MPH, MS, Jennifer Santamala, PharmD, Tsiporah B. Shore, MD, Adrienne A. Phillips, MD MPH, Sebastian Mayer, MD, Jingmei Hsu, MD, Usama Gergis, MD, Silvia Senese, Trisha Ali-Shaw, Riyaad Rahim, Koen van Besien, MD PhD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-134699
Published: 2020
Journal Articles

XPO1 Relieves MYC-Induced Replication Stress Limiting the Immunogenicity of DLBCL Cells

Rossella Marullo, MDPhD, Maria Victoria Revuelta, PhD, Nahuel Zamponi, PhD, Sarah C. Rutherford, MD, Peter Martin, FRCPC, MD MS, Giorgio Inghirami, MD, John P. Leonard, MD, Leandro Cerchietti, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18.
https://doi.org/10.1182/blood-2020-141464
Published: 2020
Journal Articles

Microenvironmental Signatures Reveal Biological Subtypes of Diffuse Large B-Cell Lymphoma (DLBCL) Distinct from Tumor Cell Molecular Profiling

Leandro Cerchietti, MD, Giorgio Inghirami, MD, Nikita Kotlov, PhD, Viktor Svekolkin, PhD, Alexander Bagaev, PhD, Felix Frenkel, PhD, Maria Victoria Revuelta, PhD, Jude M Phillip, PhD, Maria Teresa Cacciapuoti, MS, Sarah C. Rutherford, MD, Peter Martin, FRCPC, MD MS, John P. Leonard, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 656.
https://doi.org/10.1182/blood-2019-128889
Published: 2019
Journal Articles

Heat Shock Factor 1 Reprograms the DLBCL Microenvironment to Evade Immune Surveillance and Support Tumor Growth

Jude M Phillip, DPhil, Maria Nieves Calvo Vidal, PhD, Maria Victoria Revuelta, PhD, Nahuel Zamponi, PhD, Stephen Sloan, Benet Pera Gresely, PhD, Tharu Fernando, PhD, Wayne Tam, MD PhD, Giorgio Inghirami, MD, Lawrence Bonassar, PhD, Ari M. Melnick, MD, Leandro Cerchietti, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2854.
https://doi.org/10.1182/blood-2018-99-117774
Published: 2018
Journal Articles

Oral Azacitidine (CC-486) Plus R-CHOP in Patients with High-Risk or Previously Untreated Diffuse Large B-Cell Lymphoma, Grade 3B Follicular Lymphoma, or Transformed Lymphoma (AFT-08)

Peter Martin, FRCPC, MD MS, Nancy L. Bartlett, MD, Julio C. Chavez, MD, John L. Reagan, MD, Sonali M. Smith, MD, Ann S. LaCasce, MD MSc, Jeffrey A. Jones, MD MPH, James Drew, MA, Chengqing Wu, PhD, Leandro Cerchietti, MD, John P. Leonard, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2964.
https://doi.org/10.1182/blood-2018-99-114438
Published: 2018
Journal Articles

Five-year follow-up of lenalidomide plus rituximab as initial treatment of mantle cell lymphoma

Clinical Trials & Observations
Jia Ruan, Peter Martin, Paul Christos, Leandro Cerchietti, Wayne Tam, Bijal Shah, Stephen J. Schuster, Amelyn Rodriguez, David Hyman, Maria Nieves Calvo-Vidal, Sonali M. Smith, Jakub Svoboda, Richard R. Furman, Morton Coleman, John P. Leonard
Journal: Blood
Blood (2018) 132 (19): 2016–2025.
https://doi.org/10.1182/blood-2018-07-859769
Published: 2018
Journal Articles

Generation and Application of T-Cell Lymphoma Patient Derived Tumor Xenograft Models

Danilo Fiore, PhD, Xujun Wang, Inna Khodos, Filomena Di Giacomo, PhD, Marcello Gaudiano, BS, Jude M Phillip, DPhil, Rui Wang, Zhiwei Yang, Michael Ginsberg, Andrew M Intlekofer, MD PhD, Craig B. Thompson, MD, Jon C. Aster, MD PhD, Jia Ruan, MD PhD, Samuel Y. Ng, MDPhD, Eric Jacobsen, MD, Ahmet Dogan, MD PhD, Elisa de Stanchina, Marissa Mattar, Leandro Cerchietti, MD, Rohan Bareja, Olivier Elemento, PhD, Wayne Tam, MD PhD, David M. Weinstock, MD, Shahin Rafii, MD, Steven M. Horwitz, MD, Giorgio Inghirami, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 109.
https://doi.org/10.1182/blood.V130.Suppl_1.109.109
Published: 2017