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Leandro Cerchietti
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Journal Articles

Sasp-driven immune evasion defines a novel African ancestry-associated DLBCL subtype with distinctive molecular and immune vulnerabilities

Free
Sanket Shah, Meng Li, Michelle Lee, Matthew Teater, Kumudha Balakrishnan, Vishal Sahu, Vignesh Shanmugam, Sunjae Lee, Isabella Kong, Ioannis Karagiannidis, Tania Sainz, Wilfred Leung, Andrea Orlando, Jongkuen Lee, Benedikt Pelzer, Dejauwne Young, Sravya Tumuluru, David Jaye, Mohamed Moustafa, Deniz Peker, Yusuke Isshiki, Daniela Magliulo, Hao Shen, Piali Mukherjee, Anthony Santella, Maneeza Bilal, Pengyan Fa, Lisa Roth, Giorgio Inghirami, Victoria Alagiozian-Angelova, Leandro Cerchietti, Simone Sidoli, Paul Rubinstein, Roberta Zappasodi, Wendy Béguelin, Yuri Fedoriw, Francisco Vega, Jean Koff, Christopher Flowers, Ari Melnick
Journal: Blood
Blood (2025) 146 (Supplement 1): 3.
https://doi.org/10.1182/blood-2025-3
Published: 2025
Journal Articles

Epigenetically driven upregulation of immunoproteasome component PSMB8 characterizes diffuse large B-cell lymphoma (DLBCL) with inflammatory microenvironment in African ancestry patients

Free
María Revuelta, Ines Mota, Vishal Sahu, Tania Sainz, Kumudha Balakrishnan, Federico Ruiz Moreno, Nahuel Zamponi, Francisco Vega, Christopher Flowers, Leandro Cerchietti
Journal: Blood
Blood (2025) 146 (Supplement 1): 3674.
https://doi.org/10.1182/blood-2025-3674
Published: 2025
Journal Articles

CDK7 enables adaptive gene transcription required by stromal cells to support distinct T-cell lymphoma phenotypes and represents a novel microenvironment-directed therapeutic target

Free
Khouloud Kouidri, Danilo Fiore, María Revuelta, Nicolás Di Siervi, Federico Ruiz Moreno, Subhashini Joshi, Clarisse Kayembe, Abigail Taylor, Giorgio Inghirami, Leandro Cerchietti, Nahuel Zamponi
Journal: Blood
Blood (2025) 146 (Supplement 1): 554.
https://doi.org/10.1182/blood-2025-554
Published: 2025
Journal Articles

Primary central nervous system lymphoma reveals a pro-tumoral brain-specific myeloid landscape.

Free
Subhashini Joshi, María Revuelta, Nahuel Zamponi, Khouloud Kouidri, Federico Ruiz Moreno, Giorgio Inghirami, Ari Melnick, Leandro Cerchietti
Journal: Blood
Blood (2025) 146 (Supplement 1): 145.
https://doi.org/10.1182/blood-2025-145
Published: 2025
Journal Articles

Humanized PDX models reveal Lymphoma–Host interactions and enhanced T-cell therapies via epigenetic modulation

Free
Giovanni Medico, Giorgia Zanetti, Giorgio Bertolazzi, Francesco Vallania, Paul Zumbo, Maider Amiama, Doron Betel, Maria Cacciapuoti, Abigail Taylor, Clarisse Kayembe, Sanjay Patel, Jennifer Ziello, Arvin Ruiz, Jason Weirather, Gulpreet Kaur, Luca Cappelli, Luca Paruzzo, Marco Ruella, Zhenyuan Dong, Larry Kwak, Nicolás Di Siervi, María Revuelta, Claudio Tripodo, Leandro Cerchietti, Giorgio Inghirami
Journal: Blood
Blood (2025) 146 (Supplement 1): 350.
https://doi.org/10.1182/blood-2025-350
Published: 2025
Journal Articles

Subsequent Treatment and Clinical Outcome Following Induction Therapy on a Phase II Study of Oral Azacitidine Plus CHOP for Peripheral T-Cell Lymphoma (PTCL)

Free
Jia Ruan, Evelyn H. Orlando, Alison Moskowitz, Zhengming Chen, Neha Mehta-Shah, Lubomir Sokol, Steven Horwitz, Sarah C. Rutherford, Tejasvi Sahni, Ari M Melnick, Giorgio Inghirami, Leandro Cerchietti, John P. Leonard, Peter Martin
Journal: Blood
Blood (2024) 144 (Supplement 1): 1693.
https://doi.org/10.1182/blood-2024-206606
Published: 2024
Journal Articles

Genetic mechanisms underlying tumor microenvironment composition and function in diffuse large B-cell lymphoma

Free
Leandro Cerchietti
Journal: Blood
Blood (2024) 143 (12): 1101–1111.
https://doi.org/10.1182/blood.2023021002
Published: 2024
Journal Articles

Qpctl Inhibition, By Targeting the Inflammatory Tumor Microenvironment, Constitutes a Novel Therapeutic Approach for Diffuse Large B-Cell Lymphoma

Free
Nicolas Di Siervi, Jasper Mullender, María Victoria Revuelta, Nahuel Zamponi, Eloisi Caldas-Lopes, Yusuke Isshiki, Wendy Béguelin, Marcel Scheepstra, Bastiaan Evers, Jens Wuerthner, Leandro Cerchietti
Journal: Blood
Blood (2023) 142 (Supplement 1): 49.
https://doi.org/10.1182/blood-2023-181264
Published: 2023
Journal Articles

Remodeling of the Immune Microenvironment By Oncogenic MYD88 Dictates Immunotherapy Responses across Indolent and Aggressive B-Cell Lymphomas

Free
Jon Celay, Miriam Recalde, María Victoria Revuelta, Marta Larrayoz, Sara Rodriguez, Maria J Garcia-Barchino, Jennifer R. Chapman-Fredricks, Teresa Lozano, Juan J Lasarte, Ming Q. Du, Izidore S. Lossos, Sergio Roa, Aldo Roccaro, Miguel Canales, Felipe Prosper, Bruno Paiva, Leandro Cerchietti, Jose A. Martinez-Climent
Journal: Blood
Blood (2023) 142 (Supplement 1): 431.
https://doi.org/10.1182/blood-2023-173394
Published: 2023
Journal Articles

Multicenter phase 2 study of oral azacitidine (CC-486) plus CHOP as initial treatment for PTCL

Free
Clinical Trials & Observations
Jia Ruan, Alison Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Nikita Kotlov, Grigorii Nos, Maria Sorokina, Vladislav Maksimov, Andrea Sboner, Michael Sigouros, Koen van Besien, Steven Horwitz, Sarah C. Rutherford, Erin Mulvey, Maria V. Revuelta, Jenny Xiang, Alicia Alonso, Ari Melnick, Olivier Elemento, Giorgio Inghirami, John P. Leonard, Leandro Cerchietti, Peter Martin
Journal: Blood
Blood (2023) 141 (18): 2194–2205.
https://doi.org/10.1182/blood.2022018254
Published: 2023
Includes: Supplemental data
Journal Articles

Endothelial cell–leukemia interactions remodel drug responses, uncovering T-ALL vulnerabilities

Free
Luca Vincenzo Cappelli, Danilo Fiore, Jude M. Phillip, Liron Yoffe, Filomena Di Giacomo, William Chiu, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, Jose Gabriel Barcia Duran, Nahuel Zamponi, Ari M. Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foà, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2023) 141 (5): 503–518.
https://doi.org/10.1182/blood.2022015414
Published: 2023
Includes: Supplemental data
Journal Articles

FGFR1 Is a Novel Therapeutic Target in Relapsed/Refractory Diffuse Large B Cell Lymphoma (RR-DLBCL)

Free
Nicolas Di Siervi, Maria Victoria Revuelta, Maria Teresa Cacciapuoti, Nahuel Zamponi, Rossella Marullo, Ari Melnick, Giorgio Inghirami, Leandro Cerchietti
Journal: Blood
Blood (2022) 140 (Supplement 1): 1322.
https://doi.org/10.1182/blood-2022-169529
Published: 2022
Journal Articles

Phase 1 study of oral azacitidine (CC-486) plus R-CHOP in previously untreated intermediate- to high-risk DLBCL

Open Access
Clinical Trials & Observations
Peter Martin, Nancy L. Bartlett, Julio C. Chavez, John L. Reagan, Sonali M. Smith, Ann S. LaCasce, Jeffrey Jones, James Drew, Chengqing Wu, Erin Mulvey, Maria V. Revuelta, Leandro Cerchietti, John P. Leonard
Journal: Blood
Blood (2022) 139 (8): 1147–1159.
https://doi.org/10.1182/blood.2021011679
Published: 2022
Includes: Supplemental data
Journal Articles

High Rates of Remission with the Initial Treatment of Oral Azacitidine Plus CHOP for Peripheral T-Cell Lymphoma (PTCL): Clinical Outcomes and Biomarker Analysis of a Multi-Center Phase II Study

Free
Jia Ruan, Alison J. Moskowitz, Neha Mehta-Shah, Lubomir Sokol, Zhengming Chen, Riyaad Rahim, Wei Song, Nikita Kotlov, Grigorii Nos, Vladislav Maksimov, Maria Victoria Revuelta, Andrea Sboner, Michael Sigouros, Koen van Besien, Steven M. Horwitz, Sarah C. Rutherford, Erin C. Mulvey, Morton Coleman, Ari Melnick, Olivier Elemento, Giorgio Inghirami, John P. Leonard, Peter Martin, Leandro Cerchietti
Journal: Blood
Blood (2021) 138 (Supplement 1): 138.
https://doi.org/10.1182/blood-2021-145495
Published: 2021
Journal Articles

A Predictive Endothelial-Leukemia Pre-Clinical Platform to Uncover Drug Vulnerabilities for Personalized Treatments

Free
Luca Vincenzo Cappelli, Danilo Fiore, Jude M Phillip, Liron Yoffe, Filomena Di Giacomo, Yang Hu, Clarisse Kayembe, Michael Ginsberg, Lorena Consolino, José Gabriel Barcia Durán, Nahuel Zamponi, Ari Melnick, Francesco Boccalatte, Wayne Tam, Olivier Elemento, Sabina Chiaretti, Anna Guarini, Robin Foa, Leandro Cerchietti, Shahin Rafii, Giorgio Inghirami
Journal: Blood
Blood (2021) 138 (Supplement 1): 704.
https://doi.org/10.1182/blood-2021-153300
Published: 2021
Journal Articles

Aging-Associated Epigenetic Reprogramming Alters the Germinal Center Reaction and Targets Pathways Related to Lymphomagenesis

Free
Rossella Marullo, Maria Victoria Revuelta, Wendy Béguelin, Juan Lara-Garcia, Leandro Cerchietti
Journal: Blood
Blood (2021) 138 (Supplement 1): 676.
https://doi.org/10.1182/blood-2021-152684
Published: 2021
Journal Articles

Phase I Study of Oral Azacitidine (CC-486) Plus Salvage Chemotherapy in Relapsed/Refractory Diffuse Large B-Cell Lymphoma

Free
Brian T. Hess, Leandro Cerchietti, Lindsey Hendrickson, Elizabeth Hill, Anshu Giri, Shanta Salzer, Sarah Hogan, Lacey Finch, Robin Klingenberg, Fang Hu, Nina D. Wagner-Johnston
Journal: Blood
Blood (2021) 138 (Supplement 1): 3567.
https://doi.org/10.1182/blood-2021-145493
Published: 2021
Journal Articles

S1918: A Phase II/III Randomized Study of R-Minichop with or without Oral Azacitidine (CC-486) in Participants Age 75 Years or Older with Newly Diagnosed Diffuse Large B Cell Lymphoma, Grade IIIb Follicular Lymphoma, Transformed Lymphoma, and High-Grade B-Cell Lymphomas with MYC and BCL2 and/or BCL6 Rearrangements

Free
Elizabeth A Brem, Hongli Li, Anne W. Beaven, Paolo F. Caimi, Leandro Cerchietti, Ash A. Alizadeh, Rebecca L. Olin, Norah Lynn Henry, Hildy Dilon, Richard F. Little, Cara Laubach, Michael L. Leblanc, Jonathan W. Friedberg, Sonali M. Smith
Journal: Blood
Blood (2021) 138 (Supplement 1): 3565.
https://doi.org/10.1182/blood-2021-148193
Published: 2021
Journal Articles

XPO1 Relieves MYC-Induced Replication Stress Limiting the Immunogenicity of DLBCL Cells

Free
Rossella Marullo, MDPhD, Maria Victoria Revuelta, PhD, Nahuel Zamponi, PhD, Sarah C. Rutherford, MD, Peter Martin, FRCPC, MD MS, Giorgio Inghirami, MD, John P. Leonard, MD, Leandro Cerchietti, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18.
https://doi.org/10.1182/blood-2020-141464
Published: 2020
Journal Articles

A Phase I Study of Selinexor and R-ICE in Patients with Relapsed/Refractory Aggressive B-Cell Lymphomas

Free
Sarah C. Rutherford, MD, John N. Allan, MD, Jia Ruan, MD PhD, Richard R. Furman, MD, Kristy Richards, MD PhD, Amelyn Rodriguez, BSN, RN, OCN, Kseniya Gololobova, Arcania Garcia, Leandro Cerchietti, MD, Rossella Marullo, MDPhD, Zhengming Chen, PhD MPH, MS, Jennifer Santamala, PharmD, Tsiporah B. Shore, MD, Adrienne A. Phillips, MD MPH, Sebastian Mayer, MD, Jingmei Hsu, MD, Usama Gergis, MD, Silvia Senese, Trisha Ali-Shaw, Riyaad Rahim, Koen van Besien, MD PhD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-134699
Published: 2020