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Journal Articles

Glutaminase Upregulation As a Mechanism of Chemotherapy Resistance in High-Risk Leukemia

Gregory Harrison Nalesnik, Sinisa Dovat, Daniel Bogush, Joseph Schramm
Journal: Blood
Blood (2023) 142 (Supplement 1): 5801.
https://doi.org/10.1182/blood-2023-172631
Published: 2023
Journal Articles

Dual Targeting Novel WDR5/ATAD2 Oncogenic Signaling through CK2/Ikaros Axis Demonstrates Synergistic Efficacy in T-ALL

Qi Han, Yan Gu, Chan Yang, Jun Li, Sinisa Dovat, Chunhua Song, Zheng Ge
Journal: Blood
Blood (2023) 142 (Supplement 1): 4188.
https://doi.org/10.1182/blood-2023-182745
Published: 2023
Journal Articles

Suppressing IKZF1 Deletion-Mediated Activation of Ras Oncogenic Signaling By the Combination of Azacitidine and Flumatinib in High-Risk B-ALL

Linyao Zhang, Sinisa Dovat, Chunhua Song, Zheng Ge
Journal: Blood
Blood (2023) 142 (Supplement 1): 5720.
https://doi.org/10.1182/blood-2023-185311
Published: 2023
Journal Articles

Regulation of Heterochromatin Landscape in T-Cell Acute Lymphoblastic Leukemia

Yali Ding, Bing He, Jonathon Payne, Dhimant Desai, Arati Sharma, Daniel Bogush, Elanora Dovat, Joseph Schramm, Melanie Ehudin, Diwakar Bastihalli Tukaramrao, Chandrika Gowda, Sinisa Dovat
Journal: Blood
Blood (2021) 138 (Supplement 1): 2217.
https://doi.org/10.1182/blood-2021-154388
Published: 2021
Journal Articles

DJ4 Targets Rho-associated Protein Kinase Pathway and Attenuates Disease Progression in Pre-clinical Murine Models of Acute Myeloid Leukemia

Melanie Ehudin, Upendarrao Golla, Charyguly Annageldiyev, Zheng Zeng, Diwakar Bastihalli Tukaramrao, Anna Tarren, Dhimant Desai, David F. Claxton, Sinisa Dovat, Arati Sharma
Journal: Blood
Blood (2021) 138 (Supplement 1): 3350.
https://doi.org/10.1182/blood-2021-154542
Published: 2021
Journal Articles

IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia

Chunhua Song, Zheng Ge, Yali Ding, Bi-Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M. Cury, José Andrés Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat
Journal: Blood
Blood (2020) 136 (13): 1520–1534.
https://doi.org/10.1182/blood.2019002655
Published: 2020
Includes: Supplemental data
Journal Articles

Oncogenesis of CRLF2 Overexpression and Effect of JAK2 Inhibitor in CRLF2 Overexpressed B-Cell Acute Lymphoblastic Leukemia

Yan Gu, MD, Chunhua Song, MD, Sinisa Dovat, MD PhD, Qinglong Guo, PhD, Qinyu Ge, PhD, Zheng Ge, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2757.
https://doi.org/10.1182/blood-2019-125259
Published: 2019
Journal Articles

CK2 Inhibitor CX4945 Shows Strong In Vivo Synergistic Anti-Leukemia Activity with Rapamycin in B-ALL Due to Enhanced Ikaros Mediated Repression of mTOR Pathway

Chandrika Gowda, MBBS, Chunhua Song, MD, Yali Ding, PhD, Pavan kumar Dhanyamraju, PhD, Soumya Iyer, PhD, Jonathon Payne, Yevgeniya Bamme, MD, Arati Sharma, PhD, Kimberly J. Payne, PhD, Sinisa Dovat, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2634.
https://doi.org/10.1182/blood-2019-131790
Published: 2019
Journal Articles

CK2 Inhibitor CX4945 Shows Strong In Vivo Anti Leukemia Effect in AML Via Augmented Ikaros-Mediated Regulation of Global Epigenetic Landscape

Chandrika Gowda, MBBS, Chunhua Song, MD, Sadie Steffens, PhD, Yali Ding, PhD, Bo Zhang, Feng Yue, PhD, Soumya Iyer, PhD, Pavan kumar Dhanyamraju, PhD, Jonathon Payne, Morgann Reed, BS, Kimberly J. Payne, PhD, Sinisa Dovat, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2522.
https://doi.org/10.1182/blood-2019-131200
Published: 2019
Journal Articles

High-Dose TSLP Induces Co-Receptor Internalization and Signal Shutdown in Ph-like B-ALL with Overexpression of CRLF2

WayAnne B. Watson, Hossam Alkashgari, MD, Cornelia Stoian, PhD, Jacqueline S. Coats, Ineavely Baez, Hannah Choi, Benjamin Becerra, DrPH, Rishikesh Chavan, MD, Muhammad Omair Kamal, MD, Shadi Farzin Gohar, MD, Xianmei Meng, PhD, Sinisa Dovat, MD PhD, Kimberly J. Payne, PhD, Hoda Erjaee, DVM, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4024.
https://doi.org/10.1182/blood-2018-99-114336
Published: 2018
Journal Articles

The Novel Small Molecule Inhibitor KS99 Targets AML and Inhibits Stemness Markers STAT3 and ALDH

Charyguly Annageldiyev, Krishne Gowda, Dhimant Desai, Viola Devine, Daniel Brosius, Chandrika Gowda, MBBS, Sinisa Dovat, MD PhD, Shantu Amin, David F. Claxton, MD, Arati Sharma, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1440.
https://doi.org/10.1182/blood-2018-99-117376
Published: 2018
Journal Articles

Biologic for the Treatment of Ph-like B-Cell Acute Lymphoblastic Leukemia with Overexpression of CRLF2

Cornelia Stoian, Jacqueline S. Coats, Veriah Vidales, Ineavely Baez, Juliette Personius, Hannah Choi, Lawrence Liu, Evgeny Chirshev, Hossam Alkashgari, Brandon Ng, Garcia Esmeralda, Benjamin Becerra, Rishikesh Chavan, Muhammad Omair Kamal, Shadi Farzin Gohar, Sinisa Dovat, Kimberly Payne
Journal: Blood
Blood (2017) 130 (Supplement 1): 2600.
https://doi.org/10.1182/blood.V130.Suppl_1.2600.2600
Published: 2017
Journal Articles

Aberrant ARID5B Expression and Its Association with Ikaros Dysfunction in Acute Lymphoblastic Leukemia

Qi Han, MD, Jinlong Ma, MD, Yan Gu, MD, Bao-An Chen, MD PhD, Sinisa Dovat, Chunhua Song, MD, Zheng Ge, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3974.
https://doi.org/10.1182/blood.V130.Suppl_1.3974.3974
Published: 2017
Journal Articles

Epigenetic Regulation of c-Kit Expression in Acute Myeloid Leukemia By Oncogenic Casein Kinase II (CK2)

Chandrika Gowda, MD, Mexian Xiang, PhD, Chunhua Song, MD, Kimberly Payne, Sinisa Dovat
Journal: Blood
Blood (2017) 130 (Supplement 1): 3787.
https://doi.org/10.1182/blood.V130.Suppl_1.3787.3787
Published: 2017
Journal Articles

Transcriptional Regulation of the CDC42 Signaling Pathway By Ikaros in T-Cell Acute Lymphoblastic Leukemia

Sinisa Dovat, Zheng Ge, MD PhD, Kimberly Payne, Chandrika Gowda, MD, Chunhua Song, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1213.
https://doi.org/10.1182/blood.V130.Suppl_1.1213.1213
Published: 2017
Journal Articles

Clinical Significance of Phd Finger Protein 2 As a Novel Ikaros Target in Acute Lymphoblastic Leukemia

Yan Gu, MD, Huihui Song, MD, Qi Han, MD, Bao-An Chen, MD PhD, Sinisa Dovat, Zheng Ge, MD PhD, Chunhua Song, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1224.
https://doi.org/10.1182/blood.V130.Suppl_1.1224.1224
Published: 2017
Journal Articles

Targeting High Dynamin2 Expression By Restoring Ikaros Function in Acute Lymphoblastic Leukemia

Zheng Ge, MD PhD, Jianyong Li, Baoan Chen, PhD Professor, Sinisa Dovat, MD PhD, Chunhua Song, PhD
Journal: Blood
Blood (2016) 128 (22): 2713.
https://doi.org/10.1182/blood.V128.22.2713.2713
Published: 2016
Journal Articles

Transcriptional Repression of the LMO2 Oncogene By Ikaros in T-Cell Acute Lymphoblastic Leukemia

Yali Ding, PhD, Chunhua Song, PhD, Chandrika S. Gowda, MD, Malika Kapadia, Kimberly Payne, PhD, Sinisa Dovat, MDPhD
Journal: Blood
Blood (2016) 128 (22): 439.
https://doi.org/10.1182/blood.V128.22.439.439
Published: 2016
Journal Articles

A Patient-Derived Xenograft Model for Identifying Therapies and Defining Mechanisms of TSLP-Induced CRLF2 Signals in Ph-like B-ALL

Olivia L Francis, BS,PhD, Terry-Ann MIlford, BS, Ineavely Baez, BS, Jacqueline Coats, BS, Christopher L. Morris, MD PhD, Ross Fisher, MD, Benjamin Joseph Van Handel, BS, PhD, Ruijun Su, MD PhD, Batul T. Suterwala, MD, Shadi Farzingohar, MD, Sinisa Dovat, MD,PhD, Kimberly Payne, PhD
Journal: Blood
Blood (2015) 126 (23): 2633.
https://doi.org/10.1182/blood.V126.23.2633.2633
Published: 2015
Journal Articles

Clinical Significance of High C -MYC and Low MYCBP2 Expression and Their Association with Ikaros Dysfunction in Adult Acute Lymphoblastic Leukemia

Zheng Ge, MD PhD, Xing Guo, MD, Jianyong Li, MD PhD, Melanie Hartman, Yuka Imamura Kawasawa, Sinisa Dovat, MDPhD, Chunhua Song, PhD
Journal: Blood
Blood (2015) 126 (23): 3713.
https://doi.org/10.1182/blood.V126.23.3713.3713
Published: 2015