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Arati Sharma
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Journal Articles

A defined culture model for ex vivo expansion of primary AML cells preserves leukemic stem cells and clonal architecture for functional and therapeutic studies

Free
Charyguly Annageldiyev, Upendar Golla, Satyam Patel, Rebecca Gelfer, Joseph Cioccio, Kentaro Minagawa, Hong Zheng, Su-Fern Tan, David Feith, Thomas Loughran, Ross Levine, Arati Sharma, David Claxton
Journal: Blood
Blood (2025) 146 (Supplement 1): 3488.
https://doi.org/10.1182/blood-2025-3488
Published: 2025
Journal Articles

Oncofetal RNA-binding proteins IGF2BP suppress innate immunity signaling pathways in leukemia stem cells

Free
Garrett Knox, Ruba Agili-Shaban, Alexis Morrissey, Karamveer Karamveer, Ahsan Polash, Stefanija Kinzy, Maria Wohlbowne, Cheryl Keller, George-Lucian Moldovan, Arati Sharma, Hong Zheng, Edward Harhaj, Markus Hafner, Zhenqiu Liu, Yasin Uzun, Shaun Mahony, Irina Elcheva
Journal: Blood
Blood (2025) 146 (Supplement 1): 3236.
https://doi.org/10.1182/blood-2025-3236
Published: 2025
Journal Articles

HoxBlinc LncRNA Reprograms CTCF Independent TADs to Drive Leukemic Transcription and HSC Dysregulation in NUP98 Fusion Transformed Leukemia

Free
Karina Hamamoto, Ganqian Zhu, Julia Lesperance, Huacheng Luo, Ying D Li, Nupur Nigam, Arati Sharma, Feng-Chun Yang, David F. Claxton, Yi Qiu, Peter D. Aplan, Mingjiang Xu, Suming Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4108.
https://doi.org/10.1182/blood-2024-199171
Published: 2024
Journal Articles

Regulation of Heterochromatin Landscape in T-Cell Acute Lymphoblastic Leukemia

Free
Yali Ding, Bing He, Jonathon Payne, Dhimant Desai, Arati Sharma, Daniel Bogush, Elanora Dovat, Joseph Schramm, Melanie Ehudin, Diwakar Bastihalli Tukaramrao, Chandrika Gowda, Sinisa Dovat
Journal: Blood
Blood (2021) 138 (Supplement 1): 2217.
https://doi.org/10.1182/blood-2021-154388
Published: 2021
Journal Articles

DJ4 Targets Rho-associated Protein Kinase Pathway and Attenuates Disease Progression in Pre-clinical Murine Models of Acute Myeloid Leukemia

Free
Melanie Ehudin, Upendarrao Golla, Charyguly Annageldiyev, Zheng Zeng, Diwakar Bastihalli Tukaramrao, Anna Tarren, Dhimant Desai, David F. Claxton, Sinisa Dovat, Arati Sharma
Journal: Blood
Blood (2021) 138 (Supplement 1): 3350.
https://doi.org/10.1182/blood-2021-154542
Published: 2021
Journal Articles

Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia

Free
Melat T. Gebru, Jennifer M. Atkinson, Megan M. Young, Lijun Zhang, Zhenyuan Tang, Zhenqiu Liu, Pinyi Lu, Christopher M. Dower, Longgui Chen, Charyguly Annageldiyev, Arati Sharma, Yuka Imamura Kawasawa, Zhongming Zhao, Barbara A. Miller, David F. Claxton, Hong-Gang Wang
Journal: Blood
Blood (2020) 136 (9): 1067–1079.
https://doi.org/10.1182/blood.2019003124
Published: 2020
Includes: Supplemental data
Journal Articles

CK2 Inhibitor CX4945 Shows Strong In Vivo Synergistic Anti-Leukemia Activity with Rapamycin in B-ALL Due to Enhanced Ikaros Mediated Repression of mTOR Pathway

Free
Chandrika Gowda, MBBS, Chunhua Song, MD, Yali Ding, PhD, Pavan kumar Dhanyamraju, PhD, Soumya Iyer, PhD, Jonathon Payne, Yevgeniya Bamme, MD, Arati Sharma, PhD, Kimberly J. Payne, PhD, Sinisa Dovat, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2634.
https://doi.org/10.1182/blood-2019-131790
Published: 2019
Journal Articles

The Novel Small Molecule Inhibitor KS99 Targets AML and Inhibits Stemness Markers STAT3 and ALDH

Free
Charyguly Annageldiyev, Krishne Gowda, Dhimant Desai, Viola Devine, Daniel Brosius, Chandrika Gowda, MBBS, Sinisa Dovat, MD PhD, Shantu Amin, David F. Claxton, MD, Arati Sharma, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1440.
https://doi.org/10.1182/blood-2018-99-117376
Published: 2018