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Hardik Modi
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Journal Articles

Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells

Elisabeth Bolton-Gillespie, Mirle Schemionek, Hans-Ulrich Klein, Sylwia Flis, Grazyna Hoser, Thoralf Lange, Margaret Nieborowska-Skorska, Jacqueline Maier, Linda Kerstiens, Mateusz Koptyra, Martin C. Müller, Hardik Modi, Tomasz Stoklosa, Ilona Seferynska, Ravi Bhatia, Tessa L. Holyoake, Steffen Koschmieder, Tomasz Skorski
Journal: Blood
Blood (2013) 121 (20): 4175–4183.
https://doi.org/10.1182/blood-2012-11-466938
Published: 2013
Includes: Supplemental data
Journal Articles

Genomic Instability in CML-CP originates From the Most Primitive Imatinib-Refractory Leukemia Stem Cells

Elisabeth Bolton, Mirle Schemionek, PhD, Hans-Urlich Klein, Grazyna Hoser, PhD, Sylwia Flis, Thoralf Lange, Linda Kerstiens, Margaret Nieborowska-Skorska, MD, PhD, Martin C. Müller, MD, Hardik Modi, Ravi Bhatia, MD, Steffen Koschmieder, MD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 909.
https://doi.org/10.1182/blood.V120.21.909.909
Published: 2012
Journal Articles

Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining

Sujata Chakraborty, Jeremy M. Stark, Can-Lan Sun, Hardik Modi, WenYong Chen, Timothy R. O'Connor, Stephen J. Forman, Smita Bhatia, Ravi Bhatia
Journal: Blood
Blood (2012) 119 (26): 6187–6197.
https://doi.org/10.1182/blood-2011-05-352252
Published: 2012
Includes: Supplemental data
Journal Articles

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

Hongfeng Yuan, Zhiqiang Wang, Ling Li, Hao Zhang, Hardik Modi, David Horne, Ravi Bhatia, WenYong Chen
Journal: Blood
Blood (2012) 119 (8): 1904–1914.
https://doi.org/10.1182/blood-2011-06-361691
Published: 2012
Includes: Supplemental data
Journal Articles

A critical role for SHP2 in STAT5 activation and growth factor–mediated proliferation, survival, and differentiation of human CD34 + cells

Liang Li, Hardik Modi, Tinisha McDonald, John Rossi, Jiing-Kuan Yee, Ravi Bhatia
Journal: Blood
Blood (2011) 118 (6): 1504–1515.
https://doi.org/10.1182/blood-2010-06-288910
Published: 2011
Includes: Supplemental data
Journal Articles

CML-CP Mouse Model of Genomic Instability.

Elisabeth Bolton, Linda Kamp, Hardik Modi, Ravi Bhatia, MD, Steffen Koschmieder, MD, Tomasz Skorski, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1210.
https://doi.org/10.1182/blood.V116.21.1210.1210
Published: 2010
Journal Articles

Jak2 Regulates Bcr-Abl In CD34+ Cells From Imatinib Mesylate-Resistant CML Patients.

Ajoy K. Samanta, Ph.D., Bastianella Perazzona, Ph.D., Sandip N. Chakraborty, Xiaoping Sun, MD, PhD, Hardik Modi, Ravi Bhatia, MD, Ralph B. Arlinghaus, PhD
Journal: Blood
Blood (2010) 116 (21): 1220.
https://doi.org/10.1182/blood.V116.21.1220.1220
Published: 2010
Journal Articles

SHP-2 Knockdown Results in Profound Inhibition of Human CD34+ Hematopoietic Stem/Progenitor Cell Survival, Proliferation and Differentiation in Response to Growth Factor Stimulation

Li ang Li, MD, PhD, Tinisha McDonald, Hardik Modi, Arjun Sehgal, Ravi Bhatia
Journal: Blood
Blood (2008) 112 (11): 3859.
https://doi.org/10.1182/blood.V112.11.3859.3859
Published: 2008
Journal Articles

Effect of Inhibition of Grb2 Expression on BCR-ABL Mediated Transformation of Primary Human Hematopoietic Cells.

Hardik Modi, MS, Liang Li, PhD, Su Chu, MD, Ravi Bhatia, MD
Journal: Blood
Blood (2007) 110 (11): 1020.
https://doi.org/10.1182/blood.V110.11.1020.1020
Published: 2007
Journal Articles

Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells

Hardik Modi, Tinisha McDonald, Su Chu, Jiing-Kuan Yee, Stephen J. Forman, Ravi Bhatia
Journal: Blood
Blood (2007) 109 (12): 5411–5421.
https://doi.org/10.1182/blood-2006-06-032490
Published: 2007
Journal Articles

Nilotinib Inhibits Bcr-Abl Kinase Activity in CML Progenitor Cells More Effectively Than Imatinib but Is Equipotent in Inducing Growth Inhibition.

Heiko Konig, Melissa Holtz, Hardik Modi, Paul Manley, Tessa L. Holyoake, Stephen J. Forman, Ravi Bhatia
Journal: Blood
Blood (2006) 108 (11): 744.
https://doi.org/10.1182/blood.V108.11.744.744
Published: 2006
Journal Articles

Effects of Elevated BCR/ABL Expression Level on Cellular Transformation and Sensitivity to Imatinib in Primitive Human Hematopoietic Cells.

Hardik Modi, MS, Su Chu, M.D, Tinisha McDonald, BS, Stephen Forman, M.D, Ravi Bhatia, M.D
Journal: Blood
Blood (2005) 106 (11): 1998.
https://doi.org/10.1182/blood.V106.11.1998.1998
Published: 2005