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Roberto D. Polakiewicz
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Journal Articles

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor

Christian Pecquet, Judith Staerk, Ronan Chaligné, Valerie Goss, Kimberly A. Lee, Xiaowu Zhang, John Rush, Joanne Van Hees, Hélène A. Poirel, Jean-Marie Scheiff, William Vainchenker, Stéphane Giraudier, Roberto D. Polakiewicz, Stefan N. Constantinescu
Journal: Blood
Blood (2010) 115 (5): 1037–1048.
https://doi.org/10.1182/blood-2008-10-183558
Published: 2010
Journal Articles

The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL

Francesco E. Boccalatte, Claudia Voena, Chiara Riganti, Amalia Bosia, Lucia D'Amico, Ludovica Riera, Mangeng Cheng, Bruce Ruggeri, Ole N. Jensen, Valerie L. Goss, Kimberly Lee, Julie Nardone, John Rush, Roberto D. Polakiewicz, Michael J. Comb, Roberto Chiarle, Giorgio Inghirami
Journal: Blood
Blood (2009) 113 (12): 2776–2790.
https://doi.org/10.1182/blood-2008-06-161018
Published: 2009
Includes: Supplemental data
Journal Articles

p90RSK2 as a Therapeutic Target in Treatment of FGFR3-Expressing t(4;14) Multiple Myeloma.

Sumin Kang, PhD, Shaozhong Dong, PhD, Tinglei Gu, PhD, Ailan Guo, PhD, Michael S. Cohen, PhD, Sagar Lonial, MD, PhD, Petet Leif Bergsagel, MD, PhD, Jack Taunton, PhD, Roberto D. Polakiewicz, PhD, Jing Chen, PhD
Journal: Blood
Blood (2007) 110 (11): 253.
https://doi.org/10.1182/blood.V110.11.253.253
Published: 2007
Journal Articles

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

Ting-lei Gu, Thomas Mercher, Jeffrey W. Tyner, Valerie L. Goss, Denise K. Walters, Melanie G. Cornejo, Cynthia Reeves, Lana Popova, Kimberly Lee, Michael C. Heinrich, John Rush, Masanori Daibata, Isao Miyoshi, D. Gary Gilliland, Brian J. Druker, Roberto D. Polakiewicz
Journal: Blood
Blood (2007) 110 (1): 323–333.
https://doi.org/10.1182/blood-2006-10-052282
Published: 2007
Includes: Supplemental data
Journal Articles

Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia

Ting-Lei Gu, Valerie L. Goss, Cynthia Reeves, Lana Popova, Julie Nardone, Joan MacNeill, Denise K. Walters, Yi Wang, John Rush, Michael J. Comb, Brian J. Druker, Roberto D. Polakiewicz
Journal: Blood
Blood (2006) 108 (13): 4202–4204.
https://doi.org/10.1182/blood-2006-06-026666
Published: 2006
Includes: Supplemental data
Journal Articles

FGFR3 Activates RSK2 To Mediate Hematopoietic Transformation through Both Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway.

Sumin Kang, PhD, Shaozhong Dong, PhD, Ting-lei Gu, PhD, Michael S. Cohen, Sagar Lonial, MD, H. Jean Khoury, PhD, D. Gary Gilliland, MD, PhD, Jack Taunton, PhD, Roberto D. Polakiewicz, PhD, Jing Chen, PhD
Journal: Blood
Blood (2006) 108 (11): 514.
https://doi.org/10.1182/blood.V108.11.514.514
Published: 2006
Journal Articles

JAK2 T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

Thomas Mercher, Gerlinde Wernig, Sandra A. Moore, Ross L. Levine, Ting-Lei Gu, Stefan Fröhling, Dana Cullen, Roberto D. Polakiewicz, Olivier A. Bernard, Titus J. Boggon, Benjamin H. Lee, D. Gary Gilliland
Journal: Blood
Blood (2006) 108 (8): 2770–2779.
https://doi.org/10.1182/blood-2006-04-014712
Published: 2006
Includes: Supplemental data
Journal Articles

A common phosphotyrosine signature for the Bcr-Abl kinase

Valerie L. Goss, Kimberly A. Lee, Albrecht Moritz, Julie Nardone, Erik J. Spek, Joan MacNeill, John Rush, Michael J. Comb, Roberto D. Polakiewicz
Journal: Blood
Blood (2006) 107 (12): 4888–4897.
https://doi.org/10.1182/blood-2005-08-3399
Published: 2006
Includes: Supplemental data