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Judith Staerk
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Journal Articles

Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation

Nicolas Papadopoulos, Ajda Pristavec, Audrey Nédélec, Gabriel Levy, Judith Staerk, Stefan N. Constantinescu
Journal: Blood
Blood (2023) 142 (21): 1818–1830.
https://doi.org/10.1182/blood.2022019580
Published: 2023
Includes: Supplemental data
Journal Articles

Modulation of the Human Thrombopoietin Receptor Conformation Uncouples JAK2 V617F-Driven from Cytokine-Induced Activation

Nicolas Papadopoulos, Ajda Pristavec, Gabriel Levy, Audrey Nédélec, Judith Staerk, Stefan N. Constantinescu
Journal: Blood
Blood (2022) 140 (Supplement 1): 3878–3879.
https://doi.org/10.1182/blood-2022-166405
Published: 2022
Journal Articles

Thrombopoietin Activates STAT2 Inducing Type I Interferon Effects and Gene Expression: Implications for in Vivo Tpo Treatment and for Myeloproliferative Neoplasms

Stefan N Constantinescu, MD PhD Prof., Jean-Philippe Defour, BPharm,, Celine Mouton, Isabelle Plo, William Vainchenker, MD PhD, Jean-Luc Villeval, PhD, Thomas Michiels, MD PhD, Judith Staerk, Christian Pecquet, PhD
Journal: Blood
Blood (2014) 124 (21): 820.
https://doi.org/10.1182/blood.V124.21.820.820
Published: 2014
Journal Articles

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes

Christian Pecquet, Carmen C. Diaconu, Judith Staerk, Michael Girardot, Caroline Marty, Yohan Royer, Jean-Philippe Defour, Alexandra Dusa, Rodolphe Besancenot, Stephane Giraudier, Jean-Luc Villeval, Laurent Knoops, Pierre J. Courtoy, William Vainchenker, Stefan N. Constantinescu
Journal: Blood
Blood (2012) 119 (20): 4625–4635.
https://doi.org/10.1182/blood-2011-08-372524
Published: 2012
Includes: Supplemental data
Journal Articles

Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor

Christian Pecquet, Judith Staerk, Ronan Chaligné, Valerie Goss, Kimberly A. Lee, Xiaowu Zhang, John Rush, Joanne Van Hees, Hélène A. Poirel, Jean-Marie Scheiff, William Vainchenker, Stéphane Giraudier, Roberto D. Polakiewicz, Stefan N. Constantinescu
Journal: Blood
Blood (2010) 115 (5): 1037–1048.
https://doi.org/10.1182/blood-2008-10-183558
Published: 2010
Journal Articles

ALL-Associated JAK1 Mutants Activate the JAK/STAT Pathway Via IL-9Rα Homodimers

Tekla Hornakova, Judith Staerk, Yohan Royer, Elisabetta Flex, Marco Tartaglia, Stefan N. Constantinescu, MD, PhD, Jean-Christophe Renauld, Laurent Knoops
Journal: Blood
Blood (2008) 112 (11): 2848.
https://doi.org/10.1182/blood.V112.11.2848.2848
Published: 2008
Journal Articles

The ubiquitin-mediated degradation of Jak1 modulates osteoclastogenesis by limiting interferon-β–induced inhibitory signaling

Youngkyun Lee, Seok-Won Hyung, Hee Jung Jung, Hyung-Joon Kim, Judith Staerk, Stefan N. Constantinescu, Eun-Ju Chang, Zang Hee Lee, Sang-Won Lee, Hong-Hee Kim
Journal: Blood
Blood (2008) 111 (2): 885–893.
https://doi.org/10.1182/blood-2007-03-082941
Published: 2008
Includes: Supplemental data
Journal Articles

The myeloproliferative disorder–associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3

Michelle B. Hookham, Joanne Elliott, Yvonne Suessmuth, Judith Staerk, Alister C. Ward, William Vainchenker, Melanie J. Percy, Mary Frances McMullin, Stefan N. Constantinescu, James A. Johnston
Journal: Blood
Blood (2007) 109 (11): 4924–4929.
https://doi.org/10.1182/blood-2006-08-039735
Published: 2007
Includes: Supplemental data
Journal Articles

An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor

Judith Staerk, Catherine Lacout, Takeshi Sato, Steven O. Smith, William Vainchenker, Stefan N. Constantinescu
Journal: Blood
Blood (2006) 107 (5): 1864–1871.
https://doi.org/10.1182/blood-2005-06-2600
Published: 2006