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Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Blood (2023) 141 (8): 917–929.

https://doi.org/10.1182/blood.2022016846

Published: 2023

Includes: Supplemental data

Journal Articles

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

Sara Lecomte, Julien Devreux, Grégoire de Streel, Nicolas van Baren, Violaine Havelange, David Schröder, Noora Vaherto, Christophe Vanhaver, Christophe Vanderaa, Noémie Dupuis, Christian Pecquet, Pierre G. Coulie, Stefan N. Constantinescu, Sophie Lucas

Blood (2023) 141 (5): 490–502.

https://doi.org/10.1182/blood.2022017097

Published: 2023

Includes: Supplemental data

Journal Articles

Canonical Thrombopoietin Receptor Mutants in Myeloproliferative Neoplasms Rely Differently on the Extracellular Domain of the Receptor but Share Similar Mechanisms of Inactivation: An Open Field for the Development of New Therapies

Gabriel Levy, Nicolas Papadopoulos, Christian Pecquet, Jean-Philippe Defour, Emilie Leroy, Nabih Maslah, Bruno Cassinat, Steven Smith, Stefan N Constantinescu

Blood (2022) 140 (Supplement 1): 8736–8737.

https://doi.org/10.1182/blood-2022-168663

Published: 2022

Journal Articles

Degrading JAK2 in ALL by ruxolitinib-based PROTACs

Stefan N. Constantinescu, Christian Pecquet

Blood (2021) 138 (23): 2301–2302.

https://doi.org/10.1182/blood.2021012004

Published: 2021

Journal Articles

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Blood (2019) 133 (25): 2669–2681.

https://doi.org/10.1182/blood-2018-09-874578

Published: 2019

Includes: Supplemental data

Journal Articles

Cooccurring JAK2 V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms

Cristina Mambet, Olga Babosova, Jean-Philippe Defour, Emilie Leroy, Laura Necula, Oana Stanca, Aurelia Tatic, Nicoleta Berbec, Daniel Coriu, Monika Belickova, Barbora Kralova, Lucie Lanikova, Jitka Vesela, Christian Pecquet, Pascale Saussoy, Violaine Havelange, Carmen C. Diaconu, Vladimir Divoky, Stefan N. Constantinescu

Blood (2018) 132 (25): 2695–2699.

https://doi.org/10.1182/blood-2018-04-843060

Published: 2018

Includes: Supplemental data

Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Blood (2018) 132 (Supplement 1): 4.

https://doi.org/10.1182/blood-2018-99-118348

Published: 2018

Journal Articles

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

Fabrizia Favale, Kahia Messaoudi, Leila N. Varghese, Siham Boukour, Christian Pecquet, Vitalina Gryshkova, Jean Philippe Defour, Roxana-Irina Albu, Olivier Bluteau, Paola Ballerini, Guy Leverger, Isabelle Plo, Najet Debili, Hana Raslova, Remi Favier, Stefan N. Constantinescu, William Vainchenker

Blood (2016) 128 (26): 3146–3158.

https://doi.org/10.1182/blood-2016-06-722058

Published: 2016

Includes: Supplemental data

Journal Articles

Crispr/Cas9 Engineered 61bp Deletion in the Calr Gene of Mice Leads to Development of Thrombocytosis

Thomas Balligand, MD, Younes Achouri, PhD, Ilyas Chachoua, MSc, Christian Pecquet, PhD, Jean-Philippe Defour, BPharm,, Stefan N. Constantinescu

Blood (2016) 128 (22): 4274.

https://doi.org/10.1182/blood.V128.22.4274.4274

Published: 2016

Journal Articles

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

Mira EL Khoury, Gaelle Vertenoeil, Caroline Marty, Christophe Marzac, Matthieu Mosca, Christian Pecquet, PhD, Fabrizia Favale, Robert Kralovics, Najet Debili, Nicole Casadevall, MD, Hana Raslova, PhD, Stefan N. Constantinescu, MD PhD, Isabelle Plo, William Vainchenker, MD PhD

Blood (2016) 128 (22): 1959.

https://doi.org/10.1182/blood.V128.22.1959.1959

Published: 2016

Journal Articles

Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia

Katarina Kapralova, Monika Horvathova, Christian Pecquet, Jana Fialova Kucerova, Dagmar Pospisilova, Emilie Leroy, Barbora Kralova, Jelena D. Milosevic Feenstra, Fiorella Schischlik, Robert Kralovics, Stefan N. Constantinescu, Vladimir Divoky

Blood (2016) 128 (10): 1418–1423.

https://doi.org/10.1182/blood-2016-02-698951

Published: 2016

Includes: Supplemental data

Journal Articles

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

Ilyas Chachoua, Christian Pecquet, Mira El-Khoury, Harini Nivarthi, Roxana-Irina Albu, Caroline Marty, Vitalina Gryshkova, Jean-Philippe Defour, Gaëlle Vertenoeil, Anna Ngo, Ann Koay, Hana Raslova, Pierre J. Courtoy, Meng Ling Choong, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu

Blood (2016) 127 (10): 1325–1335.

https://doi.org/10.1182/blood-2015-11-681932

Published: 2016

Includes: Supplemental data

Journal Articles

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Caroline Marty, Christian Pecquet, Harini Nivarthi, Mira El-Khoury, Ilyas Chachoua, Micheline Tulliez, Jean-Luc Villeval, Hana Raslova, Robert Kralovics, Stefan N. Constantinescu, Isabelle Plo, William Vainchenker

Blood (2016) 127 (10): 1317–1324.

https://doi.org/10.1182/blood-2015-11-679571

Published: 2016

Includes: Supplemental data

Journal Articles

Thrombopoietin Activates STAT2 Inducing Type I Interferon Effects and Gene Expression: Implications for in Vivo Tpo Treatment and for Myeloproliferative Neoplasms

Stefan N Constantinescu, MD PhD Prof., Jean-Philippe Defour, BPharm,, Celine Mouton, Isabelle Plo, William Vainchenker, MD PhD, Jean-Luc Villeval, PhD, Thomas Michiels, MD PhD, Judith Staerk, Christian Pecquet, PhD

Blood (2014) 124 (21): 820.

https://doi.org/10.1182/blood.V124.21.820.820

Published: 2014

Journal Articles

Calr Mutants Retroviral Mouse Models Lead to a Myeloproliferative Neoplasm Mimicking an Essential Thrombocythemia Progressing to a Myelofibrosis

Caroline Marty, PhD, Nivarthi Harini, Christian Pecquet, PhD, Ilyas Chachoua, Vitalina Gryshkova, PhD, Jean-Luc Villeval, PhD, Stefan N. Constantinescu, MD PhD, Robert Kralovics, PhD, William Vainchenker, MD, PhD, Isabelle Plo

Blood (2014) 124 (21): 157.

https://doi.org/10.1182/blood.V124.21.157.157

Published: 2014

Journal Articles

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

Caroline Marty, Cécile Saint-Martin, Christian Pecquet, Sarah Grosjean, Joseph Saliba, Céline Mouton, Emilie Leroy, Ashot S. Harutyunyan, Jean-François Abgrall, Rémi Favier, Aurélie Toussaint, Eric Solary, Robert Kralovics, Stefan N. Constantinescu, Albert Najman, William Vainchenker, Isabelle Plo, Christine Bellanné-Chantelot

Blood (2014) 123 (9): 1372–1383.

https://doi.org/10.1182/blood-2013-05-504555

Published: 2014

Includes: Supplemental data

Journal Articles

Germline JAK2 Mutations In The Kinase Domain Are Responsible For Hereditary Thrombocytosis and Are Resistant To JAK2 and HSP90 Inhibitors

Caroline Marty, Ph.D, Cecile Saint-martin, Christian Pecquet, PhD, Sarah Grosjean, Joseph Saliba, PhD Student, Celine Mouton, Leroy Emilie, Ashot S. Harutyunyan, Jean-François Abgrall, Remy Favier, Eric Solary, Robert Kralovics, PhD, Stefan N. Constantinescu, MD, PhD, Albert Najman, MD, William Vainchenker, MD, PhD, Isabelle Plo, Ph.D, Christine Bellanné-Chantelot

Blood (2013) 122 (21): 1603.

https://doi.org/10.1182/blood.V122.21.1603.1603

Published: 2013

Journal Articles

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

Adam J. Mead, Onima Chowdhury, Christian Pecquet, Alexandra Dusa, Petter Woll, Deborah Atkinson, Adam Burns, Joannah Score, Michelle Rugless, Ruth Clifford, Simon Moule, Nicola Bienz, Paresh Vyas, Nick Cross, Rosemary E. Gale, Shirley Henderson, Stefan N. Constantinescu, Anna Schuh, Sten Eirik W. Jacobsen

Blood (2013) 121 (20): 4156–4165.

https://doi.org/10.1182/blood-2012-05-430926

Published: 2013

Includes: Supplemental data

Journal Articles

Controlling Thrombopoietin Receptor Dimerization, Orientation and Activation Via Tryptophan 515

Jean-Philippe Defour, BPharm, Miki Itaya, MSc., Vitalina Gryshkova, PhD, Ian Brett, MSc., Christian Pecquet, PhD, Takeshi Sato, PhD, Steven O. Smith, PhD, Stefan N. Constantinescu, MD, PhD

Blood (2012) 120 (21): 3449.

https://doi.org/10.1182/blood.V120.21.3449.3449

Published: 2012

Journal Articles

Combination Treatment with JAK2 and PI3K Inhibitors in Myeloproliferative Neoplasms

Meng Ling Choong, PhD, Christian Pecquet, PhD, Shi Jing Tai, Jacklyn WY Yong, PhD, Vishal Pendharkar, SiFang Wang, Jean-Philippe Defour, BPharm, Carmen C. Diaconu, PhD, Kanda Sangthongpitag, PhD, Jean-Luc Villeval, PhD, William Vainchenker, MD, PhD, Stefan N. Constantinescu, MD, PhD, May Ann Lee, PhD

Blood (2012) 120 (21): 180.

https://doi.org/10.1182/blood.V120.21.180.180

Published: 2012

NARROW

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

Canonical Thrombopoietin Receptor Mutants in Myeloproliferative Neoplasms Rely Differently on the Extracellular Domain of the Receptor but Share Similar Mechanisms of Inactivation: An Open Field for the Development of New Therapies

Degrading JAK2 in ALL by ruxolitinib-based PROTACs

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Cooccurring JAK2 V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

Crispr/Cas9 Engineered 61bp Deletion in the Calr Gene of Mice Leads to Development of Thrombocytosis

Calreticulin Mutants Induce an Early Clonal Dominance and a Megakaryocytic Phenotype through the Activation of MPL/JAK2 Pathway in Human Primary Cells

Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Thrombopoietin Activates STAT2 Inducing Type I Interferon Effects and Gene Expression: Implications for in Vivo Tpo Treatment and for Myeloproliferative Neoplasms

Calr Mutants Retroviral Mouse Models Lead to a Myeloproliferative Neoplasm Mimicking an Essential Thrombocythemia Progressing to a Myelofibrosis

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

Germline JAK2 Mutations In The Kinase Domain Are Responsible For Hereditary Thrombocytosis and Are Resistant To JAK2 and HSP90 Inhibitors

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

Controlling Thrombopoietin Receptor Dimerization, Orientation and Activation Via Tryptophan 515

Combination Treatment with JAK2 and PI3K Inhibitors in Myeloproliferative Neoplasms

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American Society of Hematology

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American Society of Hematology

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