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Journal Articles

Fixed-duration versus continuous targeted treatment for previously untreated chronic lymphocytic leukemia: Results from the randomized CLL17 trial

Free
Othman Al-Sawaf, Janina Stumpf, Can Zhang, Florian Simon, Francesc Bosch Albareda, Emadoldin Feyzi, Paolo Ghia, Michael Gregor, Arnon Kater, Vesa Lindström, Mattias Mattsson, Carsten Niemann, Philipp Staber, Tamar Tadmor, Patrick Thornton, Clemens-Martin Wendtner, Ann Janssens, Thomas Noesslinger, Jan-Paul Bohn, Caspar da Cunha-Bang, Christian Poulsen, Juha Ranti, Thomas Illmer, Bjoern Schoettker, Sebastian Böttcher, Tobias Gaska, Elisabeth Vandenberghe, Ruth Clifford, Ohad Benjamini, Annamaria Frustaci, Lydia Scarfo, Paolo Sportoletti, John Schreurs, Mark-David Levin, Hanneke van der Straaten, Marjolein van der Klift, Hoa Tran, Javier de la Serna, Javier Loscertales, Oscar Lindblad, Anna Bergendahl Sandstedt, Jeroen Goede, Michael Baumann, Anna Maria Fink, Kirsten Fischer, Matthias Ritgen, Karl-Anton Kreuzer, Christof Schneider, Eugen Tausch, Stephan Stilgenbauer, Sandra Robrecht, Barbara Eichhorst, Michael Hallek
Journal: Blood
Blood (2025) 146 (Supplement 1): 1.
https://doi.org/10.1182/blood-2025-1
Published: 2025
Journal Articles

A phase 3, randomized, open-label, multicenter study of sonrotoclax (BGB-11417) plus anti-CD20 antibody therapies vs venetoclax plus rituximab in patients with relapsed/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL-RR1/CELESTIAL-RRCLL)

Free
Othman Al-Sawaf, Sandra Robrecht, Matthew S Davids, Mary Ann Anderson, Romain Guieze, Valeria Buccheri, Celso Arrais-Rodrigues, Francesc Bosch Albareda, Ruth Clifford, Michael Doubek, Krzysztof Jamroziak, Arnon Kater, Mattias Mattsson, Carsten Niemann, Miguel Pavlovsky, Lydia Scarfo, Renata Walewska, Peng Liu, Ki-Seong Eom, Karl Kreuzer, Eugen Tausch, Christof Schneider, Stephan Stilgenbauer, Kirsten Fischer, Michael Hallek, Kenneth Wu, Marcus Lefebure, Wei Ding, Remus Vezan, Barbara Eichhorst
Journal: Blood
Blood (2025) 146 (Supplement 1): 2137.
https://doi.org/10.1182/blood-2025-2137
Published: 2025
Journal Articles

Isatuximab (Isa) plus lenalidomide (R), Bortezomib (V), and dexamethasone (d) (Isa-RVd) as induction therapy in transplant-eligible patients (pts) with newly diagnosed multiple myeloma (NDMM): Primary analysis of parallel phase 2 studies by the Dana-Farber Cancer Institute (DFCI) and Cancer Trials Ireland (CTI)

Free
Peter O'Gorman, Jacob Laubach, Ruth Clifford, Clifton Mo, Senthil Kumar, Omar Nadeem, Monique Hartley-Brown, Siobhan Glavey, Shonali Midha, Yuxin Liu, Maja Vase, Keith Pratz, Patrick Hayden, Jessica Liegel, Paul Dowling, Emily Benjamin, Vicky Donachie, Zahra Beers, Olivia McLoughlin, Layla Horwitz, Jacinta Marron, Emma Sueiro, Marc Nolan, David Poretsky, Anna Shevlin, Sarah Beaton, Charlotte Prior, Catherine Piper, Bindu Krishnanivas, Emily Simpson, Elizabeth Karimi, Marissa Davis, Lourdes McAlester, Alanna Allen, Paul Richardson
Journal: Blood
Blood (2025) 146 (Supplement 1): 4030.
https://doi.org/10.1182/blood-2025-4030
Published: 2025
Journal Articles

Examining the Usefulness of the Charlson Comorbidity Index to Predict Early Mortality in Patients with Acute Myeloid Leukaemia

Free
Mohamed Bakri Mohamed, Seán R Millar, Vitaliy Mykytiv, Rose McMorrow, Conan Donnelly, Paul M Walsh, Eamonn O'Leary, Nina Orfali, Philip Murphy, Paul V. Browne, John Quinn, Peter O'Gorman, Ruth Clifford, Ezzat El Hassadi, Oonagh Gilligan, Janusz Krawczyk, Michael E. O'Dwyer, Eva Szegezdi, Mary R Cahill
Journal: Blood
Blood (2021) 138 (Supplement 1): 1218.
https://doi.org/10.1182/blood-2021-149832
Published: 2021
Journal Articles

Highly Comprehensive Genomic Testing for CLL: WGS, One Key to CLL Patient Stratification

Free
Kate E Ridout, PhD, Pauline Robbe, MSc, PhD, Doriane Cavalieri, MSc, Jennifer Becq, PhD, Miao He, PhD, Ruth Clifford, FRCPath, PhD, Niamh Appleby, FRCPath, MD, Reem Alsolami, PhD, Adam Burns, BSc, PhD, Melanie Oates, PhD, Basile Stamatopoulos, PhD, Samantha Knight, PhD, Alona Sosinsky, PhD, Pavlos Antoniou, PhD, Mark Ross, PhD, David Bentley, PhD, Andrew Pettitt, FRCPath, PhD, Peter Hillmen, MB ChB, PhD FRCP, FRCPath, Mark Caulfield, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3115.
https://doi.org/10.1182/blood-2018-99-115935
Published: 2018
Journal Articles

Detection of Clinically Relevant Molecular Alterations in Chronic Lymphocytic Leukemia (CLL) By Nanopore Sequencing

Free
Adam Burns, BSc, PhD, David Robert Bruce, MRCP, Pauline Robbe, MSc, PhD, Adele Timbs, Basile Stamatopoulos, PhD, Ruth Clifford, FRCPath, PhD, Maria Lopopolo, Duncan Parkes, Kate E Ridout, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2018-99-110948
Published: 2018
Journal Articles

The Contribution of Gene Mutations to Long-Term Clinical Outcomes: Data from the Randomised UK LRF CLL4 Trial

Free
Stuart Blakemore, PhD, Ruth Clifford, Pavlos Antoniou, Helen Parker, PhD, Pauline Robbe, MSc, Marta Larrayoz, PhD, Zadie Davis, Latha Kadalyayil, Andrew Collins, Jade Forster, PhD, Monica Else, Andrew J Steele, PhD, Jacqueline Chan, PhD, Graham Speight, PhD, Mark Cragg, PhD, Matthew John Jerome Rose-Zerilli, PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Anna Schuh, MD PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 259.
https://doi.org/10.1182/blood.V130.Suppl_1.259.259
Published: 2017
Journal Articles

Clinical Importance of DNA Methylation Signatures in Chronic Lymphocytic Leukaemia Patients Treated with Chemo-Immunotherapy

Free
Harindra Amarasinghe, PhD, Tomasz K Wojdacz, PhD MSc, Matthew John Jerome Rose-Zerilli, PhD, Alice Beattie, Jade Forster, PhD, Latha Kadalayil, Stuart Blakemore, PhD, Helen Parker, PhD, Marta Larrayoz, PhD, Ruth Clifford, Zadie Davis, Monica Else, Dena Cohen, Andrew J Steele, PhD, Richard Rosenquist, MD PhD, Andrew Collins, Andrew Pettitt, FRCPath, PhD, Peter Hillmen, MBChB, PhD, Pauline Robbe, MSc, Christopher Plass, Anna Schuh, MD PhD, Daniel Catovsky, MD FRCP, David Oscier, MD PhD, Christopher C. Oakes, PhD, Jonathan C Strefford, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 56.
https://doi.org/10.1182/blood.V130.Suppl_1.56.56
Published: 2017
Journal Articles

Characterization of Recurrent Mutations in Patient with a Richter Syndrome By Targeted Next Generation Sequencing

Free
Basile Stamatopoulos, PhD, Pavlos Antoniou, Dimitris Vavoulis, Toby A. Eyre, MD, Ruth Clifford, MD, Maité Cabes, Msc, Hélène Dreau, MSc, Anna Schuh, MD PhD
Journal: Blood
Blood (2016) 128 (22): 3200.
https://doi.org/10.1182/blood.V128.22.3200.3200
Published: 2016
Journal Articles

Identifying High-Risk CLL to Predict Early Relapse after FCR Based Treatment Using Whole Genome Sequencing: First Results from the Genomics England CLL Pilot

Free
Pauline Robbe, Kate Ridout, Jennifer Becq, Miao He, Ruth Clifford, MD, Reem Alsolami, Adam Burns, Samantha JL Knight, Melanie Oates, Dena Howard, Andrew R. Pettitt, Augusto Rendon, Niko Popitsch, Peter Hillmen, Jenny C Taylor, Mark Caulfield, David Bentley, Clare Turnbull, Anna Schuh, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2022.
https://doi.org/10.1182/blood.V128.22.2022.2022
Published: 2016
Journal Articles

Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations

Free
Viktor Ljungström, Diego Cortese, Emma Young, Tatjana Pandzic, Larry Mansouri, Karla Plevova, Stavroula Ntoufa, Panagiotis Baliakas, Ruth Clifford, Lesley-Ann Sutton, Stuart J. Blakemore, Niki Stavroyianni, Andreas Agathangelidis, Davide Rossi, Martin Höglund, Jana Kotaskova, Gunnar Juliusson, Chrysoula Belessi, Nicholas Chiorazzi, Panagiotis Panagiotidis, Anton W. Langerak, Karin E. Smedby, David Oscier, Gianluca Gaidano, Anna Schuh, Frederic Davi, Christiane Pott, Jonathan C. Strefford, Livio Trentin, Sarka Pospisilova, Paolo Ghia, Kostas Stamatopoulos, Tobias Sjöblom, Richard Rosenquist
Journal: Blood
Blood (2016) 127 (8): 1007–1016.
https://doi.org/10.1182/blood-2015-10-674572
Published: 2016
Includes: Supplemental data
Journal Articles

Genomic Disruption of the Histone Methyltransferase SETD2 in Chronic Lymphocytic Leukemia

Free
Matthew John Jerome Rose-Zerilli, PhD, Helen Parker, Marta Larrayoz, PhD, Ruth Clifford, Stuart Blakemore, Jennifer Edelmann, MD, Jane Gibson, Jun Wang, Viktor Ljungstrom, Tracy Chaplin, Ali Roghanian, Zadie Davis, Anton Parker, BSc, Eugen Tausch, MD, Stavroula Ntoufa, Sara Ramos, Pauline Robbe, MSc, Andrew J Steele, PhD, Graham Packham, PhD, Ana E. Rodriguez, Lee Brown, Feargal McNicholl, Francesco Forconi, MD DM, PhD FRCPath, Andrew R Pettitt, MRCP PhD, Peter Hillmen, Martin J.S. Dyer, Prof., Mark S Cragg, PhD, Bryan D Young, BSc, PhD, Claude Chelala, Richard Rosenquist, Kostas Stamatopoulos, MD, Stephan Stilgenbauer, Samantha Knight, Anna Schuh, MD PhD, David Oscier, Jonathan C Strefford, PhD
Journal: Blood
Blood (2015) 126 (23): 365.
https://doi.org/10.1182/blood.V126.23.365.365
Published: 2015
Journal Articles

EGR2 Mutations in Chronic Lymphocytic Leukemia: A New Bad Player

Free
Daniel Noerenberg*, Emma Young*, Viktor Ljungström, Larry Mansouri, Karla Plevova, Panagiotis Baliakas, Stuart Blakemore, Davide Rossi, MD PhD, Ruth Clifford, Veronika Navrkalova, PhD, Lesley-Ann Sutton, Karin E Smedby, MD PhD, Gunnar Juliusson, Chrysoula Belessi, Panagiotis Panagiotidis, Nicholas Chiorazzi, MD, Frederic Davi, Anton W. Langerak, Anna Schuh, MD PhD, Gianluca Gaidano, MD PhD, Jonathan C Strefford, PhD, Paolo Ghia, Kostas Stamatopoulos, Sarka Pospisilova, Thorsten Zenz, Richard Rosenquist**, Frederik Damm**
Journal: Blood
Blood (2015) 126 (23): 4126.
https://doi.org/10.1182/blood.V126.23.4126.4126
Published: 2015
Journal Articles

Next-Generation Deep Sequencing Reveals Multiple Ighv Clones in One Third of CLL Patients Defining New Prognostic Subgroups and Improving Previous Classification

Free
Basile Stamatopoulos, PhD, Adele Timbs, Msc, Hélène Dreau, MSc, Ruth Clifford, Pauline Robbe, MSc, Adam Burns, BSc, Joanne Mason, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4127.
https://doi.org/10.1182/blood.V126.23.4127.4127
Published: 2015
Journal Articles

Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL

Free
Clinical Trials & Observations
Romain Guièze, Pauline Robbe, Ruth Clifford, Sophie de Guibert, Bruno Pereira, Adele Timbs, Marie-Sarah Dilhuydy, Maite Cabes, Loïc Ysebaert, Adam Burns, Florence Nguyen-Khac, Frédéric Davi, Lauren Véronèse, Patricia Combes, Magali Le Garff-Tavernier, Véronique Leblond, Hélène Merle-Béral, Reem Alsolami, Angela Hamblin, Joanne Mason, Andrew Pettitt, Peter Hillmen, Jenny Taylor, Samantha J. L. Knight, Olivier Tournilhac, Anna Schuh
Journal: Blood
Blood (2015) 126 (18): 2110–2117.
https://doi.org/10.1182/blood-2015-05-647578
Published: 2015
Includes: Supplemental data
Journal Articles

The Identification of Further Minimal Regions of Overlap in Chronic Lymphocytic Leukemia Using High-Resolution SNP Arrays

Free
Samantha JL Knight, PhD CBiol, MSB, FRCPath, Ruth Clifford, MD, Pauline Robbe, MSc, Sara DC Ramos, MSc, Adam Burns, BSc, Adele T Timbs, MSc, Reem Alsolami, BSc, Susanne Weller, PhD, Angela Hamblin, MDPhD, Joanne Mason, PhD, Melanie Oates, PhD, Michalis Titsias, PhD, Christopher Yau, DPhil, Chris C Holmes, PhD, Andrew R Pettitt, FRCP, PhD, Peter Hillmen, MB, ChB, PhD, Jenny Taylor, DPhil, Anna Shuh, MD PhD FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 3315.
https://doi.org/10.1182/blood.V124.21.3315.3315
Published: 2014
Journal Articles

Development and Evaluation of the Clinical Utility of a Next Generation Sequencing (NGS) Tool for Myeloid Disorders

Free
Angela Hamblin, MDPhD, Adam Burns, BSc, Christopher Tham, BA, Ruth Clifford, MD, Pauline Robbe, MSc, Adele Timbs, MSc, Joanne Mason, PhD, Helene Dreau, MSc, Andreas Weller, PhD, Puthen Jithesh, PhD, Olivia Fox, BSc, Melody Tabiner, MA, Adam Mead, MDPhD, Andrew Peniket, MD, Paresh Vyas, MDPhD, Shirley Henderson, PhD, Anna Schuh, MDPhD
Journal: Blood
Blood (2014) 124 (21): 2373.
https://doi.org/10.1182/blood.V124.21.2373.2373
Published: 2014
Journal Articles

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage

Free
Ruth Clifford, Tania Louis, Pauline Robbe, Sam Ackroyd, Adam Burns, Adele T. Timbs, Glen Wright Colopy, Helene Dreau, Francois Sigaux, Jean Gabriel Judde, Margalida Rotger, Amalio Telenti, Yea-Lih Lin, Philippe Pasero, Jonathan Maelfait, Michalis Titsias, Dena R. Cohen, Shirley J. Henderson, Mark T. Ross, David Bentley, Peter Hillmen, Andrew Pettitt, Jan Rehwinkel, Samantha J. L. Knight, Jenny C. Taylor, Yanick J. Crow, Monsef Benkirane, Anna Schuh
Journal: Blood
Blood (2014) 123 (7): 1021–1031.
https://doi.org/10.1182/blood-2013-04-490847
Published: 2014
Includes: Supplemental data
Journal Articles

Impact of isolated germline JAK2V617I mutation on human hematopoiesis

Free
Adam J. Mead, Onima Chowdhury, Christian Pecquet, Alexandra Dusa, Petter Woll, Deborah Atkinson, Adam Burns, Joannah Score, Michelle Rugless, Ruth Clifford, Simon Moule, Nicola Bienz, Paresh Vyas, Nick Cross, Rosemary E. Gale, Shirley Henderson, Stefan N. Constantinescu, Anna Schuh, Sten Eirik W. Jacobsen
Journal: Blood
Blood (2013) 121 (20): 4156–4165.
https://doi.org/10.1182/blood-2012-05-430926
Published: 2013
Includes: Supplemental data
Journal Articles

SAMHD1, A Putative Tumour Suppressor, Is Recurrently Mutated in Chronic Lymphocytic Leukaemia, and Is Associated with Poor Risk Features

Free
Ruth Clifford, Sam Ackroyd, Adam Burns, Adele Timbs, Jonathan Maelfait, Helene Dreau, Shirley Henderson, Mark Ross, David Bentley, Peter Hillmen, MBChB, PhD, Samantha Knight, Jenny Taylor, Chris S.R Hatton, Jan Rehwinkel, Yanick Crow, Anna Schuh
Journal: Blood
Blood (2012) 120 (21): 713.
https://doi.org/10.1182/blood.V120.21.713.713
Published: 2012