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Adele Timbs
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Journal Articles

Detection of Clinically Relevant Molecular Alterations in Chronic Lymphocytic Leukemia (CLL) By Nanopore Sequencing

Adam Burns, BSc, PhD, David Robert Bruce, MRCP, Pauline Robbe, MSc, PhD, Adele Timbs, Basile Stamatopoulos, PhD, Ruth Clifford, FRCPath, PhD, Maria Lopopolo, Duncan Parkes, Kate E Ridout, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1847.
https://doi.org/10.1182/blood-2018-99-110948
Published: 2018
Journal Articles

Next-Generation Deep Sequencing Reveals Multiple Ighv Clones in One Third of CLL Patients Defining New Prognostic Subgroups and Improving Previous Classification

Basile Stamatopoulos, PhD, Adele Timbs, Msc, Hélène Dreau, MSc, Ruth Clifford, Pauline Robbe, MSc, Adam Burns, BSc, Joanne Mason, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4127.
https://doi.org/10.1182/blood.V126.23.4127.4127
Published: 2015
Journal Articles

Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL

Clinical Trials & Observations
Romain Guièze, Pauline Robbe, Ruth Clifford, Sophie de Guibert, Bruno Pereira, Adele Timbs, Marie-Sarah Dilhuydy, Maite Cabes, Loïc Ysebaert, Adam Burns, Florence Nguyen-Khac, Frédéric Davi, Lauren Véronèse, Patricia Combes, Magali Le Garff-Tavernier, Véronique Leblond, Hélène Merle-Béral, Reem Alsolami, Angela Hamblin, Joanne Mason, Andrew Pettitt, Peter Hillmen, Jenny Taylor, Samantha J. L. Knight, Olivier Tournilhac, Anna Schuh
Journal: Blood
Blood (2015) 126 (18): 2110–2117.
https://doi.org/10.1182/blood-2015-05-647578
Published: 2015
Includes: Supplemental data
Journal Articles

Development and Evaluation of the Clinical Utility of a Next Generation Sequencing (NGS) Tool for Myeloid Disorders

Angela Hamblin, MDPhD, Adam Burns, BSc, Christopher Tham, BA, Ruth Clifford, MD, Pauline Robbe, MSc, Adele Timbs, MSc, Joanne Mason, PhD, Helene Dreau, MSc, Andreas Weller, PhD, Puthen Jithesh, PhD, Olivia Fox, BSc, Melody Tabiner, MA, Adam Mead, MDPhD, Andrew Peniket, MD, Paresh Vyas, MDPhD, Shirley Henderson, PhD, Anna Schuh, MDPhD
Journal: Blood
Blood (2014) 124 (21): 2373.
https://doi.org/10.1182/blood.V124.21.2373.2373
Published: 2014
Journal Articles

Mutational Landscape of 118 Relapsed Chronic Lymphocytic Leukemia Clinical Trial Samples; Evidence for a Multiple-Hit Profile Using Targeted Next Generation Sequencing

Pauline Robbe, MSc, Romain Guièze, MD, Ruth M Clifford, MD, Sophie de Guibert, Adele Timbs, MSc, Marie-Sarah Dilhuydy, MD, Maite Cabes, BSc, Loic Ysebaert, MDPhD, Adam Burns, BSc, Florence Nguyen-Khac, MDPhD, Frederic Davi, MD PhD, Lauren Veronese, MD PhD, Patricia Combes, Magali Le Garff-Tavernier, MD PhD, Veronique Leblond, MD PhD, Hélène Merle-Béral, MD PhD, Reem Alsolami, MSc, Susanne Weller, PhD, Angela Hamblin, MDPhD, Joanne Mason, PhD, Andrew R Pettitt, MRCP, PhD, Peter Hillmen, MB, ChB, PhD, Jenny Taylor, DPhil, Samantha JL Knight, PhD CBiol, MSB, FRCPath, Anna Schuh, MDPhD, Olivier Tournilhac, MD
Journal: Blood
Blood (2014) 124 (21): 1974.
https://doi.org/10.1182/blood.V124.21.1974.1974
Published: 2014
Journal Articles

SAMHD1, A Putative Tumour Suppressor, Is Recurrently Mutated in Chronic Lymphocytic Leukaemia, and Is Associated with Poor Risk Features

Ruth Clifford, Sam Ackroyd, Adam Burns, Adele Timbs, Jonathan Maelfait, Helene Dreau, Shirley Henderson, Mark Ross, David Bentley, Peter Hillmen, MBChB, PhD, Samantha Knight, Jenny Taylor, Chris S.R Hatton, Jan Rehwinkel, Yanick Crow, Anna Schuh
Journal: Blood
Blood (2012) 120 (21): 713.
https://doi.org/10.1182/blood.V120.21.713.713
Published: 2012
Journal Articles

Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

Anna Schuh, Jennifer Becq, Sean Humphray, Adrian Alexa, Adam Burns, Ruth Clifford, Stephan M. Feller, Russell Grocock, Shirley Henderson, Irina Khrebtukova, Zoya Kingsbury, Shujun Luo, David McBride, Lisa Murray, Toshi Menju, Adele Timbs, Mark Ross, Jenny Taylor, David Bentley
Journal: Blood
Blood (2012) 120 (20): 4191–4196.
https://doi.org/10.1182/blood-2012-05-433540
Published: 2012
Includes: Supplemental data
Journal Articles

Quantitative Whole Genome Analysis of Sequential Samples From Patients with B-CLL Identifies Novel Recurrent Copy Number Alterations Involving Critical B-Cell Transcription Factors

Adele Timbs, Sam Knight, Elham SadighiAkha, Adam Burns, Helene Dreau, Anne-Marie Hewitt, Chris Hatton, Chris Yau, Chris Holmes, Jenny Taylor, Anna Schuh
Journal: Blood
Blood (2010) 116 (21): 3590.
https://doi.org/10.1182/blood.V116.21.3590.3590
Published: 2010
Journal Articles

Identification of Novel Recurrent Copy Number Variations and Regions of Copy-Neutral Loss of Heterozygosity by High Resolution Genomic Array in Pre-Treatment and Relapsed B-CLL.

Samantha JL Knight, Elham Sadighi Akha, Adele Timbs, Tariq Enver, Andrew R Pettitt, Jenny Taylor, Chris S Hatton, Anna Schuh
Journal: Blood
Blood (2009) 114 (22): 1098.
https://doi.org/10.1182/blood.V114.22.1098.1098
Published: 2009