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Journal Articles

Presence of multiple recurrent mutations confers poor trial outcome of relapsed/refractory CLL

Clinical Trials & Observations
Romain Guièze, Pauline Robbe, Ruth Clifford, Sophie de Guibert, Bruno Pereira, Adele Timbs, Marie-Sarah Dilhuydy, Maite Cabes, Loïc Ysebaert, Adam Burns, Florence Nguyen-Khac, Frédéric Davi, Lauren Véronèse, Patricia Combes, Magali Le Garff-Tavernier, Véronique Leblond, Hélène Merle-Béral, Reem Alsolami, Angela Hamblin, Joanne Mason, Andrew Pettitt, Peter Hillmen, Jenny Taylor, Samantha J. L. Knight, Olivier Tournilhac, Anna Schuh
Journal: Blood
Blood (2015) 126 (18): 2110–2117.
https://doi.org/10.1182/blood-2015-05-647578
Published: 2015
Includes: Supplemental data
Journal Articles

Mutational Landscape of 118 Relapsed Chronic Lymphocytic Leukemia Clinical Trial Samples; Evidence for a Multiple-Hit Profile Using Targeted Next Generation Sequencing

Pauline Robbe, MSc, Romain Guièze, MD, Ruth M Clifford, MD, Sophie de Guibert, Adele Timbs, MSc, Marie-Sarah Dilhuydy, MD, Maite Cabes, BSc, Loic Ysebaert, MDPhD, Adam Burns, BSc, Florence Nguyen-Khac, MDPhD, Frederic Davi, MD PhD, Lauren Veronese, MD PhD, Patricia Combes, Magali Le Garff-Tavernier, MD PhD, Veronique Leblond, MD PhD, Hélène Merle-Béral, MD PhD, Reem Alsolami, MSc, Susanne Weller, PhD, Angela Hamblin, MDPhD, Joanne Mason, PhD, Andrew R Pettitt, MRCP, PhD, Peter Hillmen, MB, ChB, PhD, Jenny Taylor, DPhil, Samantha JL Knight, PhD CBiol, MSB, FRCPath, Anna Schuh, MDPhD, Olivier Tournilhac, MD
Journal: Blood
Blood (2014) 124 (21): 1974.
https://doi.org/10.1182/blood.V124.21.1974.1974
Published: 2014
Journal Articles

Whole Genome Sequencing, Targeted Deep Sequencing and Copy-Number Analysis Provide a Comprehensive Picture of the Mutational Landscape of 41 Clinically Annotated CLL Cases

Adam Burns, BSc, Susanne Weller, PhD, Sean Humphray, PhD, Jennifer Becq, PhD, Reem Alsolami, MSc, Angela Hamblin, MDPhD, Ruth M Clifford, MD, Samantha JL Knight, PhD CBiol, MSB, FRCPath, Pauline Robbe, MSc, Maite Cabes, BSc, Joanne Mason, PhD, Chris S.R Hatton, MD, Jenny Taylor, DPhil, David Bentley, DPhil, Anna Schuh, MDPhD
Journal: Blood
Blood (2014) 124 (21): 1958.
https://doi.org/10.1182/blood.V124.21.1958.1958
Published: 2014
Journal Articles

The Identification of Further Minimal Regions of Overlap in Chronic Lymphocytic Leukemia Using High-Resolution SNP Arrays

Samantha JL Knight, PhD CBiol, MSB, FRCPath, Ruth Clifford, MD, Pauline Robbe, MSc, Sara DC Ramos, MSc, Adam Burns, BSc, Adele T Timbs, MSc, Reem Alsolami, BSc, Susanne Weller, PhD, Angela Hamblin, MDPhD, Joanne Mason, PhD, Melanie Oates, PhD, Michalis Titsias, PhD, Christopher Yau, DPhil, Chris C Holmes, PhD, Andrew R Pettitt, FRCP, PhD, Peter Hillmen, MB, ChB, PhD, Jenny Taylor, DPhil, Anna Shuh, MD PhD FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 3315.
https://doi.org/10.1182/blood.V124.21.3315.3315
Published: 2014
Journal Articles

Towards Response Prediction Using Integrated Genomics in Chronic Lymphocytic Leukaemia: Results on 250 First-Line FCR Treated Patients from UK Clinical Trials

Ruth M Clifford, MD, Pauline Robbe, MSc, Susanne Weller, PhD, Adele T Timbs, MSc, Michalis Titsias, PhD, Adam Burns, BSc, Maite Cabes, BSc, Reem Alsolami, MSc, Christopher Yau, DPhil, Angela Hamblin, MDPhD, Joanne Mason, PhD, Melanie Oates, PhD, Andrew Pettitt, MD PhD, Chris Holmes, PhD, Peter Hillmen, MB, ChB, PhD, Jenny Taylor, DPhil, Samantha JL Knight, PhD CBiol, MSB, FRCPath, Anna Schuh, MDPhD
Journal: Blood
Blood (2014) 124 (21): 1942.
https://doi.org/10.1182/blood.V124.21.1942.1942
Published: 2014
Journal Articles

SAMHD1, A Putative Tumour Suppressor, Is Recurrently Mutated in Chronic Lymphocytic Leukaemia, and Is Associated with Poor Risk Features

Ruth Clifford, Sam Ackroyd, Adam Burns, Adele Timbs, Jonathan Maelfait, Helene Dreau, Shirley Henderson, Mark Ross, David Bentley, Peter Hillmen, MBChB, PhD, Samantha Knight, Jenny Taylor, Chris S.R Hatton, Jan Rehwinkel, Yanick Crow, Anna Schuh
Journal: Blood
Blood (2012) 120 (21): 713.
https://doi.org/10.1182/blood.V120.21.713.713
Published: 2012
Journal Articles

Targeted Gene Profiling Identifies Differential Genetic Make-up Depending On Chronic Lymphocytic Leukaemia Subtype

Adam Burns, Ruth Clifford, MB, MRCP, Helene Dreau, MSc, Chris S.R Hatton, Shirley Henderson, PhD, Jenny Taylor, Anna Schuh, PhD
Journal: Blood
Blood (2012) 120 (21): 1383.
https://doi.org/10.1182/blood.V120.21.1383.1383
Published: 2012
Journal Articles

Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns

Anna Schuh, Jennifer Becq, Sean Humphray, Adrian Alexa, Adam Burns, Ruth Clifford, Stephan M. Feller, Russell Grocock, Shirley Henderson, Irina Khrebtukova, Zoya Kingsbury, Shujun Luo, David McBride, Lisa Murray, Toshi Menju, Adele Timbs, Mark Ross, Jenny Taylor, David Bentley
Journal: Blood
Blood (2012) 120 (20): 4191–4196.
https://doi.org/10.1182/blood-2012-05-433540
Published: 2012
Includes: Supplemental data
Journal Articles

Quantitative Whole Genome Analysis of Sequential Samples From Patients with B-CLL Identifies Novel Recurrent Copy Number Alterations Involving Critical B-Cell Transcription Factors

Adele Timbs, Sam Knight, Elham SadighiAkha, Adam Burns, Helene Dreau, Anne-Marie Hewitt, Chris Hatton, Chris Yau, Chris Holmes, Jenny Taylor, Anna Schuh
Journal: Blood
Blood (2010) 116 (21): 3590.
https://doi.org/10.1182/blood.V116.21.3590.3590
Published: 2010
Journal Articles

Identification of Novel Recurrent Copy Number Variations and Regions of Copy-Neutral Loss of Heterozygosity by High Resolution Genomic Array in Pre-Treatment and Relapsed B-CLL.

Samantha JL Knight, Elham Sadighi Akha, Adele Timbs, Tariq Enver, Andrew R Pettitt, Jenny Taylor, Chris S Hatton, Anna Schuh
Journal: Blood
Blood (2009) 114 (22): 1098.
https://doi.org/10.1182/blood.V114.22.1098.1098
Published: 2009