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Journal Articles

Prediction of outcomes for high-count monoclonal B lymphocytosis using an epigenetic and immunogenetic signature

Brief Report
Salma B. Abdelbaky, Brian Giacopelli, Kari G. Rabe, Kyoko Yamaguchi, Yue-Zhong Wu, Huihuang Yan, Tait D. Shanafelt, Sameer A. Parikh, Wei Ding, Paul J. Hampel, Sochilt Brown, James R. Cerhan, Celine M. Vachon, Neil E. Kay, Curtis A. Hanson, Alexander S. Parker, Esteban Braggio, Susan L. Slager, Christopher C. Oakes
Journal: Blood
Blood (2024) 143 (17): 1752–1757.
https://doi.org/10.1182/blood.2023022180
Published: 2024
Includes: Supplemental data
Journal Articles

Follow-up from the A041202 study shows continued efficacy of ibrutinib regimens for older adults with CLL

CME Clinical Trials & Observations
Jennifer A. Woyach, Gabriela Perez Burbano, Amy S. Ruppert, Cecelia Miller, Nyla A. Heerema, Weiqiang Zhao, Anna Wall, Wei Ding, Nancy L. Bartlett, Danielle M. Brander, Paul M. Barr, Kerry A. Rogers, Sameer A. Parikh, Deborah M. Stephens, Jennifer R. Brown, Gerard Lozanski, James Blachly, Sreenivasa Nattam, Richard A. Larson, Harry Erba, Mark Litzow, Selina Luger, Carolyn Owen, Charles Kuzma, Jeremy S. Abramson, Richard F. Little, Shira Dinner, Richard M. Stone, Geoffrey Uy, Wendy Stock, Sumithra J. Mandrekar, John C. Byrd
Journal: Blood
Blood (2024) 143 (16): 1616–1627.
https://doi.org/10.1182/blood.2023021959
Published: 2024
Includes: Supplemental data
Journal Articles

CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS

R. Leo Sakemura, Claudia Manriquez Roman, Paulina Horvei, Elizabeth L. Siegler, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Brooke L. Kimball, Long K. Mai, Truc N. Huynh, Wendy K. Nevala, Kristina Ilieva, Christian Augsberger, Maria Patra-Kneuer, Jürgen Schanzer, Jan Endell, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Saad S. Kenderian
Journal: Blood
Blood (2024) 143 (3): 258–271.
https://doi.org/10.1182/blood.2022018905
Published: 2024
Includes: Supplemental data
Journal Articles

Incidence of Richter Transformation in Patients with Chronic Lymphocytic Leukemia (CLL) /Small Lymphocytic Lymphoma (SLL): A Cohort Study Evaluating Different Therapeutic Eras

Paul J. Hampel, Kari G. Rabe, Yucai Wang, Steven R Hwang, Saad S. Kenderian, Eli Muchtar, Jose F. Leis, Amber Koehler, Mazie Tsang, Ricardo Parrondo, Rachel Bubik, Susan Marie Schwager, Curtis A. Hanson, Esteban Braggio, Susan L. Slager, Min Shi, Daniel L. Van Dyke, Timothy G. Call, Neil E. Kay, Wei Ding, Sameer A. Parikh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3271.
https://doi.org/10.1182/blood-2023-185076
Published: 2023
Journal Articles

Clinical Outcomes with Venetoclax-Based Treatment Regimens in Patients with Chronic Lymphocytic Leukemia (CLL)

Paul J. Hampel, Kari G. Rabe, Yucai Wang, Saad S. Kenderian, Wei Ding, Eli Muchtar, Jose F. Leis, Amber Koehler, Mazie Tsang, Ricardo Parrondo, Rachel Bubik, Susan Marie Schwager, Curtis A. Hanson, Esteban Braggio, Susan L. Slager, Min Shi, Daniel L. Van Dyke, Timothy G. Call, Neil E. Kay, Sameer A. Parikh
Journal: Blood
Blood (2023) 142 (Supplement 1): 3276.
https://doi.org/10.1182/blood-2023-183007
Published: 2023
Journal Articles

Outcomes of Patients with Small Lymphocytic Lymphoma (SLL) Receiving First Line Treatment

Samuel Kosydar, Kari G. Rabe, Yucai Wang, Saad S. Kenderian, Wei Ding, Eli Muchtar, Jose F. Leis, Amber Koehler, Mazie Tsang, Ricardo Parrondo, Talal Hilal, Rachel Bubik, Susan Marie Schwager, Curtis A. Hanson, Esteban Braggio, Susan L. Slager, Min Shi, Daniel L. Van Dyke, Timothy G. Call, Neil E. Kay, Sameer A. Parikh, Paul J Hampel
Journal: Blood
Blood (2023) 142 (Supplement 1): 3284.
https://doi.org/10.1182/blood-2023-181866
Published: 2023
Journal Articles

PD-1 Expression in Lymphoma Cells Mediates Cellular Proliferation By Engaging Phosphatase SHP-1/SHP-2

Sutapa Sinha, Tammy Price-Troska, Shulan Tian, R. Leo Sakemura, Huihuang Yan, Justin Boysen, Zhiquan Wang, Xiaosheng Wu, Rong He, Min Shi, Yucai Wang, Eric W Klee, Sameer A. Parikh, Paul J Hampel, Timothy G. Call, Jose F. Leis, Tait D. Shanafelt, Stephen M Ansell, Saad S. Kenderian, Neil E. Kay, Wei Ding
Journal: Blood
Blood (2023) 142 (Supplement 1): 3261.
https://doi.org/10.1182/blood-2023-177755
Published: 2023
Journal Articles

Outcomes of Patients with Richter Transformation without Prior Chemoimmunotherapy for CLL/SLL: An International Multicenter Retrospective Study

Adam S Kittai, Ying Huang, Sarah Miller, John N. Allan, Seema A Bhat, David A. Bond, Danielle M Brander, John C. Byrd, Julio C Chavez, Elise A. Chong, Matthew S Davids, Alexey Danilov, Wei Ding, Mark R Dowling, Kaitlyn M. Dvorak-Kornaus, Hannah Freedman, Paul J Hampel, Carrie I Ho, Steven R Hwang, Prioty Islam, Nitin Jain, Matthew Matasar, Cecelia Miller, Erin M Parry, Kari G. Rabe, Manoj Rai, Phil Raess, Lindsey E. Roeker, Joanna M. Rhodes, Kerry A Rogers, Aditi Saha, Jake Schade, Hamish S Scott, Mazyar Shadman, Geoffrey P. Shouse, Alan Skarbnik, Stephen E Spurgeon, Deborah M. Stephens, Meghan C. Thompson, Philip A. Thompson, Yucai Wang, William G. Wierda, Max Yano, Omer Zulfa, Jennifer A. Woyach
Journal: Blood
Blood (2023) 142 (Supplement 1): 497.
https://doi.org/10.1182/blood-2023-182114
Published: 2023
Journal Articles

First Results from a Phase 1, First-in-Human Study of the Bruton's Tyrosine Kinase (BTK) Degrader Bgb-16673 in Patients (Pts) with Relapsed or Refractory (R/R) B-Cell Malignancies (BGB-16673-101)

John F. Seymour, Chan Yoon Cheah, Ricardo Parrondo, Meghan C. Thompson, Don A. Stevens, Masa Lasica, Michael L. Wang, Abhijeet Kumar, Judith Trotman, Maan Alwan, Wei Ding, Kunthel By, Bilal Tariq, Xiangmei Chen, Shannon Fabre, Jason Paik, Amit Agarwal, Constantine S. Tam
Journal: Blood
Blood (2023) 142 (Supplement 1): 4401.
https://doi.org/10.1182/blood-2023-180109
Published: 2023
Journal Articles

Chronic Lymphoproliferative Disorder of Natural Killer Cells: Patient Characteristics, Laboratory Features, and Clinical Outcomes

Richard C. Godby, Kari G. Rabe, Steven R. Hwang, Hadiyah Audil, Susan L. Slager, Saad S. Kenderian, Neil E. Kay, Yucai Wang, Paul J Hampel, Sameer A. Parikh, Wei Ding, Min Shi
Journal: Blood
Blood (2023) 142 (Supplement 1): 4446.
https://doi.org/10.1182/blood-2023-182545
Published: 2023
Journal Articles

Beyond CLL Progression: Unveiling Th17 and Th2 T Cell Subsets As Predictors of Pembrolizumab Response in Richter's Transformation

Prajish Iyer, Lu Yang, Sutapa Sinha, Miles Del Busso, Zhi-Zhang Yang, Hyojin Kim, Charla Secreto, Yucai Wang, Neil E. Kay, Stephen M Ansell, Wei Ding, Lili Wang
Journal: Blood
Blood (2023) 142 (Supplement 1): 1888.
https://doi.org/10.1182/blood-2023-181004
Published: 2023
Journal Articles

Treatment Patterns and Outcomes of Patients with Chronic Lymphocytic Leukemia with TP53 Mutations

Steven R Hwang, Yucai Wang, Kari G Rabe, Rong He, Saad S. Kenderian, Eli Muchtar, Paul J. Hampel, Neil E. Kay, Timothy G. Call, Amber Koehler, Amy L Behnken, Jose F. Leis, Esteban Braggio, Min Shi, David S. Viswanatha, Daniel L. Van Dyke, Susan L. Slager, Sameer A. Parikh, Wei Ding
Journal: Blood
Blood (2022) 140 (Supplement 1): 12390–12392.
https://doi.org/10.1182/blood-2022-165508
Published: 2022
Journal Articles

Comparison of Treatment-Emergent Adverse Events of Covalent BTK Inhibitors in Clinical Trials in B-Cell Malignancies: A Systematic Review and Meta-Analysis

Jacqueline F Wang, Steven R Hwang, Yi Jiang, Xinyue Qi, Shijia Zhang, Sameer A. Parikh, Wei Ding, Saad S. Kenderian, Eli Muchtar, Paul J. Hampel, Jose F. Leis, Javier L Munoz, Gita Thanarajasingam, Jonas Paludo, David J. Inwards, Grzegorz S. Nowakowski, Stephen M. Ansell, Thomas M. Habermann, Thomas E. Witzig, Neil E. Kay, Shouhao Zhou, Yucai Wang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9882–9884.
https://doi.org/10.1182/blood-2022-168152
Published: 2022
Journal Articles

CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy

Reona Leo Sakemura, Claudia Manriquez-Roman, Paulina Horvei, Michelle J. Cox, Truc Huynh, James H. Girsch, Olivia Sirpilla, Kun Yun, Carli M. Stewart, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Kristina Ilieva-Babinsky, Christian Augsberger, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 2362–2364.
https://doi.org/10.1182/blood-2022-158273
Published: 2022
Journal Articles

Favorable Modulation of Chimeric Antigen Receptor T Cells Safety and Efficacy By the Non-Covalent BTK Inhibitor Vecabrutinib

Mohamad M. Adada, Reona Sakemura, Michelle J. Cox, Caludia Manriquez-Roman, Elizabeth L. Siegler, Erin E. Tapper, Carli M. Stewart, Kendall J. Schick, Ismail Can, Ekene J. Ogbodo, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Pietro Taverna, Judith A. Fox, Gloria Olivier, Susan L. Slager, Wei Ding, Sameer A. Parikh, Neil E. Kay, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 906.
https://doi.org/10.1182/blood-2021-151073
Published: 2021
Journal Articles

TNFR2 As a Target to Improve CD19-Directed CART Cell Fitness and Antitumor Activity in Large B Cell Lymphoma

Claudia Manriquez Roman, Michelle J. Cox, Reona Sakemura, Kun Yun, Mohamad M. Adada, Elizabeth L. Siegler, Olivia Sirpilla, Erin E. Tapper, Carli M. Stewart, Ekene J. Ogbodo, Ismail Can, Kendall J. Schick, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Wei Ding, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Gloria Olivier, Nathalie Scholler, Adrian Bot, Mike Mattie, Jenny J. Kim, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 901.
https://doi.org/10.1182/blood-2021-148591
Published: 2021
Journal Articles

The Impact of Prior Treatment with a CD19 Targeting Monoclonal Antibody on Subsequent Treatment with CD19 Targeting CART Cell Therapy in Preclinical Models

Reona Sakemura, Paulina Horvei, Claudia Manriquez-Roman, Ekene J. Ogbodo, Erin E. Tapper, Elizabeth L. Siegler, Carli M. Stewart, Kendall J. Schick, Ismail Can, Mohamad M. Adada, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Christian Augsberger, Juergen Schanzer, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Jan Endell, Wei Ding, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Grzegorz S. Nowakowski, Michelle J. Cox, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 2412.
https://doi.org/10.1182/blood-2021-145649
Published: 2021
Journal Articles

A041702: A Randomized Phase III Study of Ibrutinib Plus Obinutuzumab Versus Ibrutinib Plus Venetoclax and Obinutuzumab in Untreated Older Patients (≥ 70 Years of Age) with Chronic Lymphocytic Leukemia (CLL)

Jennifer A. Woyach, Amy S. Ruppert, Gabriela Perez, Allison M Booth, Diane Feldman, Elie G Dib, Aminah Jatoi, Jennifer Le-Rademacher, Nyla A. Heerema, Cecelia Miller, Gerard Lozanski, Richard F. Little, Brian T. Hill, Wei Ding, Richard M. Stone, Sumithra J Mandrekar, John C. Byrd
Journal: Blood
Blood (2021) 138 (Supplement 1): 3728.
https://doi.org/10.1182/blood-2021-151471
Published: 2021
Journal Articles

Long-Term Results of Alliance A041202 Show Continued Advantage of Ibrutinib-Based Regimens Compared with Bendamustine Plus Rituximab (BR) Chemoimmunotherapy

Jennifer A. Woyach, Amy S. Ruppert, Nyla A. Heerema, Weiqiang Zhao, Allison M Booth, Wei Ding, Nancy L. Bartlett, Danielle M. Brander, Paul M. Barr, Kerry Rogers, Sameer A. Parikh, Steven Coutre, Gerard Lozanski, Sreenivasa Nattam, Richard A. Larson, Harry P. Erba, Mark R. Litzow, James S. Blachly, Carolyn Owen, Charles Kuzma, Jeremy S. Abramson, Jennifer R Brown, Richard F. Little, Scott E. Smith, Richard M. Stone, Sumithra J Mandrekar, John C. Byrd
Journal: Blood
Blood (2021) 138 (Supplement 1): 639.
https://doi.org/10.1182/blood-2021-153146
Published: 2021
Journal Articles

Outcomes of Patients with Chronic Lymphocytic Leukemia (CLL) Treated with the Combination of Ibrutinib (I) and Venetoclax (V; I+V) after Progression on I Alone (V-naïve) or after Progression on Sequential I and V (Double-Refractory)

Paul J. Hampel, Kari G. Rabe, Timothy G. Call, Wei Ding, Jose F. Leis, Asher Chanan-Khan, Saad S. Kenderian, Eli Muchtar, Yucai Wang, Sikander Ailawadhi, Amber Koehler, Susan M. Schwager, Taimur Sher, Curtis A. Hanson, Min Shi, Daniel L. Van Dyke, Esteban Braggio, Susan L. Slager, Neil E. Kay, Sameer A. Parikh
Journal: Blood
Blood (2021) 138 (Supplement 1): 1560.
https://doi.org/10.1182/blood-2021-151668
Published: 2021