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Mohamad M. Adada
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Journal Articles

CD19 occupancy with tafasitamab increases therapeutic index of CART19 cell therapy and diminishes severity of CRS

R. Leo Sakemura, Claudia Manriquez Roman, Paulina Horvei, Elizabeth L. Siegler, James H. Girsch, Olivia L. Sirpilla, Carli M. Stewart, Kun Yun, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Brooke L. Kimball, Long K. Mai, Truc N. Huynh, Wendy K. Nevala, Kristina Ilieva, Christian Augsberger, Maria Patra-Kneuer, Jürgen Schanzer, Jan Endell, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Saad S. Kenderian
Journal: Blood
Blood (2024) 143 (3): 258–271.
https://doi.org/10.1182/blood.2022018905
Published: 2024
Includes: Supplemental data
Journal Articles

CD19 Antigen Occupancy on Cancer Cells with the CD19 Monoclonal Antibody Tafasitamab Improves the Activation, Antitumor Efficacy, and Safety Profile of CART19 Cell Therapy

Reona Leo Sakemura, Claudia Manriquez-Roman, Paulina Horvei, Michelle J. Cox, Truc Huynh, James H. Girsch, Olivia Sirpilla, Kun Yun, Carli M. Stewart, Ismail Can, Ekene J. Ogbodo, Mohamad M. Adada, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Kristina Ilieva-Babinsky, Christian Augsberger, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Sameer A. Parikh, Wei Ding, Neil E. Kay, Grzegorz S. Nowakowski, Elizabeth L. Siegler, Saad S. Kenderian
Journal: Blood
Blood (2022) 140 (Supplement 1): 2362–2364.
https://doi.org/10.1182/blood-2022-158273
Published: 2022
Journal Articles

Targeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma

Reona Sakemura, Mehrdad Hefazi, Elizabeth L. Siegler, Michelle J. Cox, Daniel P. Larson, Michael J. Hansen, Claudia Manriquez Roman, Kendall J. Schick, Ismail Can, Erin E. Tapper, Paulina Horvei, Mohamad M. Adada, Evandro D. Bezerra, Lionel Aurelien Kankeu Fonkoua, Michael W. Ruff, Wendy K. Nevala, Denise K. Walters, Sameer A. Parikh, Yi Lin, Diane F. Jelinek, Neil E. Kay, P. Leif Bergsagel, Saad S. Kenderian
Journal: Blood
Blood (2022) 139 (26): 3708–3721.
https://doi.org/10.1182/blood.2021012811
Published: 2022
Includes: Supplemental data
Journal Articles

Favorable Modulation of Chimeric Antigen Receptor T Cells Safety and Efficacy By the Non-Covalent BTK Inhibitor Vecabrutinib

Mohamad M. Adada, Reona Sakemura, Michelle J. Cox, Caludia Manriquez-Roman, Elizabeth L. Siegler, Erin E. Tapper, Carli M. Stewart, Kendall J. Schick, Ismail Can, Ekene J. Ogbodo, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Pietro Taverna, Judith A. Fox, Gloria Olivier, Susan L. Slager, Wei Ding, Sameer A. Parikh, Neil E. Kay, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 906.
https://doi.org/10.1182/blood-2021-151073
Published: 2021
Journal Articles

TNFR2 As a Target to Improve CD19-Directed CART Cell Fitness and Antitumor Activity in Large B Cell Lymphoma

Claudia Manriquez Roman, Michelle J. Cox, Reona Sakemura, Kun Yun, Mohamad M. Adada, Elizabeth L. Siegler, Olivia Sirpilla, Erin E. Tapper, Carli M. Stewart, Ekene J. Ogbodo, Ismail Can, Kendall J. Schick, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Wei Ding, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Gloria Olivier, Nathalie Scholler, Adrian Bot, Mike Mattie, Jenny J. Kim, Simone Filosto, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 901.
https://doi.org/10.1182/blood-2021-148591
Published: 2021
Journal Articles

Optimized Inhibition of GM-CSF in Preclinical Models of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy

Evandro D. Bezerra, Reona Sakemura, James Girsch, Carli M. Stewart, Gunjan A Awatramani, Claudia Manriquez-Roman, Kendall J. Schick, Ismail Can, Ekene J. Ogbodo, Erin E. Tapper, Elizabeth L. Siegler, Mohamad M. Adada, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Susan L. Slager, Sameer A. Parikh, Neil E. Kay, Cameron Durrant, Omar Ahmed, Dale Chappell, Michelle J. Cox, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 2777.
https://doi.org/10.1182/blood-2021-149859
Published: 2021
Journal Articles

The Impact of Prior Treatment with a CD19 Targeting Monoclonal Antibody on Subsequent Treatment with CD19 Targeting CART Cell Therapy in Preclinical Models

Reona Sakemura, Paulina Horvei, Claudia Manriquez-Roman, Ekene J. Ogbodo, Erin E. Tapper, Elizabeth L. Siegler, Carli M. Stewart, Kendall J. Schick, Ismail Can, Mohamad M. Adada, Evandro D. Bezerra, Lionel A. Kankeu Fonkoua, Mehrdad Hefazi, Michael W. Ruff, Christian Augsberger, Juergen Schanzer, Maria Patra-Kneuer, Christina Heitmüller, Stefan Steidl, Jan Endell, Wei Ding, Sameer A. Parikh, Susan L. Slager, Neil E. Kay, Grzegorz S. Nowakowski, Michelle J. Cox, Saad S. Kenderian
Journal: Blood
Blood (2021) 138 (Supplement 1): 2412.
https://doi.org/10.1182/blood-2021-145649
Published: 2021