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Andreas Agathangelidis
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Journal Articles

Evidence of Defective Cell-Autonomous Signalling By B Cell Receptors in CLL Stereotyped Subset #1

Claudia Minici, Paolo G. Cocomazzi, Can Akpınaroğlu, Anastasia Iatrou, Maria Gounari, Michela Frenquelli, Lydia Scarfo, Christian Buske, Andreas Agathangelidis, Hassan Jumaa, Palash Maity, Paolo Ghia, Kostas Stamatopoulos, Massimo Degano
Journal: Blood
Blood (2023) 142 (Supplement 1): 3255.
https://doi.org/10.1182/blood-2023-181702
Published: 2023
Journal Articles

Broad Superiority of Zanubrutinib (Zanu) Over Bendamustine + Rituximab (BR) Across Multiple High-Risk Factors: Biomarker Subgroup Analysis in the Phase 3 SEQUOIA Study in Patients With Treatment-Naive (TN) Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) without del(17p)

Vanitha Ramakrishnan, Linlin Xu, Jason C. Paik, Carol Marimpietri, Eric Shen, Xiaoxi Dong, Jessica Li, Andreas Agathangelidis, Tian Tian, Aileen Cleary Cohen, Tadeusz Robak, Constantine S. Tam, Paolo Ghia, Andrew Rawstron, Jennifer R. Brown
Journal: Blood
Blood (2023) 142 (Supplement 1): 1902.
https://doi.org/10.1182/blood-2023-174543
Published: 2023
Journal Articles

DeepSurf2.0: A Deep Learning Approach for Predicting Interactions of B Cell Receptors with Antigens

Angelos-Michael Papadopoulos, Anastasia Iatrou, Apostolos Axenopoulos, Andreas Agathangelidis, Kostas Stamatopoulos, Petros Daras
Journal: Blood
Blood (2023) 142 (Supplement 1): 3930.
https://doi.org/10.1182/blood-2023-188537
Published: 2023
Journal Articles

A Comprehensive DNA Methylome Analysis of Stereotyped and Non-Stereotyped CLL Reveals an Epigenetic Signature with Strong Clinical Impact Encompassing IGHV Status, Stereotypes and IGLV3-21 R110

Martí Duran-Ferrer, Larry Mansouri, Ferran Nadeu, Guillem Clot, Sujata Bhoi, Lesley Ann Sutton, Panagiotis Baliakas, Sara Ek, Venera Kuci Emruli, Karla Plevova, Zadie Davis, Hanna Goransson-Kultima, Anders Isaksson, Karin E. Smedby, Gianluca Gaidano, Anton W. Langerak, Frederic Davi, Davide Rossi, David Oscier, Sarka Pospisilova, Maria Karypidou, Andreas Agathangelidis, Wolfgang Huber, Junyan Lu, Thorsten Zenz, Julio Delgado, Armando Lopez-Guillermo, Paolo Ghia, Elías Campo, Kostas Stamatopoulos, Richard Rosenquist, José I. Martín-Subero
Journal: Blood
Blood (2022) 140 (Supplement 1): 1800–1802.
https://doi.org/10.1182/blood-2022-165181
Published: 2022
Journal Articles

Autonomous BCR Signaling and Genetic Aberrations in CLL-Phenotype Monoclonal B Lymphocytosis in Siblings of CLL Patients

Julieta H. Sepulveda Yanez, Edwin Quinten, Marvyn T. Koning, Janneke A. Eken, Dietmar Pfeifer, Ruben A.L. De Groen, Diego Alvarez Saravia, Andreas Agathangelidis, Cornelis A.M. van Bergen, Kostas Stamatopoulos, Joost S.P. Vermaat, Katja Zirlik, Marcelo Navarrete, Hassan Jumaa, Hendrik Veelken
Journal: Blood
Blood (2022) 140 (Supplement 1): 1526–1527.
https://doi.org/10.1182/blood-2022-169429
Published: 2022
Journal Articles

Secondary resistance to idelalisib is characterized by upregulation of IGF1R rather than by MAPK/ERK pathway mutations

Eugen Tausch, Viktor Ljungström, Andreas Agathangelidis, Marc Zapatka, Lydia Scarfò, Billy Michael Chelliah Jebaraj, Deyan Y. Yosifov, Annika Müller, Veerendra Munugalavadla, Jeremiah D. Degenhardt, Paolo Ghia, Richard Rosenquist, Stephan Stilgenbauer
Journal: Blood
Blood (2022) 139 (22): 3340–3344.
https://doi.org/10.1182/blood.2021014550
Published: 2022
Includes: Supplemental data
Journal Articles

High-risk subtypes of chronic lymphocytic leukemia are detectable as early as 16 years prior to diagnosis

Brief Report
P. Martijn Kolijn, Fatemeh Saberi Hosnijeh, Florentin Späth, Paul J. Hengeveld, Andreas Agathangelidis, Manal Saleh, Delphine Casabonne, Yolanda Benavente, Mats Jerkeman, Antonio Agudo, Aurelio Barricarte, Caroline Besson, Maria-Jose Sánchez, María-Dolores Chirlaque, Giovanna Masala, Carlotta Sacerdote, Sara Grioni, Matthias B. Schulze, Alexandra Nieters, Peter Engelfriet, Magnus Hultdin, James D. McKay, Roel C.H. Vermeulen, Anton W. Langerak
Journal: Blood
Blood (2022) 139 (10): 1557–1563.
https://doi.org/10.1182/blood.2021012890
Published: 2022
Includes: Supplemental data
Journal Articles

Distinct Modes of Ongoing Antigen Interactions Shape Intraclonal Dynamics in Splenic Marginal Zone Lymphoma

Laura Zaragoza-Infante, Andreas Agathangelidis, Valentin Junet, Nikos Pechlivanis, Triantafylia Koletsa, Alessio Bruscaggin, Zadie Davis, Sotiria Markantonatou, Valeria Spina, Aurelie Verney, Anastasia Iatrou, Fotis Psomopoulos, David Oscier, Alexandra Traverse-Glehen, Maria Papaioannou, Davide Rossi, Anastasia Chatzidimitriou, Kostas Stamatopoulos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1330.
https://doi.org/10.1182/blood-2021-148722
Published: 2021
Journal Articles

The Clonotypic BCR IG of CLL Patients Contain Predicted T-Cell Class I Epitopes with Shared Structural Properties

Anna Vardi, Andreas Agathangelidis, Sofia Gkagkaridou, Anna-Lisa Schaap-Johansen, Maria Karipidou, Anna Boukla, Asimina Fylaktou, Niki Stavroyianni, Michail Iskas, Achilles Anagnostopoulos, Sine Reker Hadrup, Anastasia Chatzidimitriou, Paolo Marcatili, Kostas Stamatopoulos
Journal: Blood
Blood (2021) 138 (Supplement 1): 1540.
https://doi.org/10.1182/blood-2021-152422
Published: 2021
Journal Articles

Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL

Andreas Agathangelidis, Anastasia Chatzidimitriou, Katerina Gemenetzi, Veronique Giudicelli, Maria Karypidou, Karla Plevova, Zadie Davis, Xiao-Jie Yan, Sabine Jeromin, Christof Schneider, Lone Bredo Pedersen, Renee C. Tschumper, Lesley-Ann Sutton, Panagiotis Baliakas, Lydia Scarfò, Ellen J. van Gastel, Marine Armand, Eugen Tausch, Bella Biderman, Constance Baer, Davide Bagnara, Alba Navarro, Anne Langlois de Septenville, Valentina Guido, Gerlinde Mitterbauer-Hohendanner, Aleksandar Dimovski, Christian Brieghel, Sarah Lawless, Manja Meggendorfer, Kamila Brazdilova, Matthias Ritgen, Monica Facco, Cristina Tresoldi, Andrea Visentin, Andrea Patriarca, Mark Catherwood, Lisa Bonello, Andrey Sudarikov, Katrina Vanura, Maria Roumelioti, Hana Skuhrova Francova, Theodoros Moysiadis, Silvio Veronese, Krzysztof Giannopoulos, Larry Mansouri, Teodora Karan-Djurasevic, Raphael Sandaltzopoulos, Csaba Bödör, Franco Fais, Arnon Kater, Irina Panovska, Davide Rossi, Salem Alshemmari, Panagiotis Panagiotidis, Paul Costeas, Blanca Espinet, Darko Antic, Letizia Foroni, Marco Montillo, Livio Trentin, Niki Stavroyianni, Gianluca Gaidano, Paola Francia di Celle, Carsten Niemann, Elias Campo, Achilles Anagnostopoulos, Christiane Pott, Kirsten Fischer, Michael Hallek, David Oscier, Stephan Stilgenbauer, Claudia Haferlach, Diane Jelinek, Nicholas Chiorazzi, Sarka Pospisilova, Marie-Paule Lefranc, Sofia Kossida, Anton W. Langerak, Chrysoula Belessi, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood
Blood (2021) 137 (10): 1365–1376.
https://doi.org/10.1182/blood.2020007039
Published: 2021
Includes: Supplemental data
Journal Articles

Discordances between Immunofixation (IFx) and Minimal Residual Disease (MRD) Assessment with Next-Generation Flow (NGF) and Sequencing (NGS) in Patients (Pts) with Multiple Myeloma (MM): Clinical and Pathogenic Significance

Sara Rodríguez, PhD, Ibai Goicoechea, PhD, Katerina Gemenetzi, Cirino Botta, MDPhD, Andreas Agathangelidis, PhD, Noemi Puig, MD PhD, María Teresa Cedena, MD, Alejandro Medina, MD, Rafael Valdés-Mas, Juan José Garcés, José J Pérez, Leire Burgos, María José Calasanz, PhD, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Sarvide Sarai, Felipe Prosper, MD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Ana Jiménez Ubieto, MDPhD, Joaquin Martinez Lopez, Juan Jose Lahuerta, MD PhD, Laura Rosinol, MD PhD, Joan Bladé, MD PhD, María-Victoria Mateos, MD PhD, Anastasia Chatzidimitriou, Jesus F. San-Miguel, MD PhD, Bruno Paiva, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 5–6.
https://doi.org/10.1182/blood-2020-136258
Published: 2020
Journal Articles

The Pathogenesis of Multiple Myeloma (MM) Is Preceded By Mutated Lymphopoiesis and B Cell Oligoclonality That Persist in Patients with Negative Minimal Residual Disease (MRD)

Sara Rodríguez, PhD, Noemi Puig, MD PhD, Katerina Gemenetzi, Ibai Goicoechea, PhD, Cirino Botta, MD, Andreas Agathangelidis, PhD, Rafael Valdés-Mas, Juan José Garcés, María Teresa Cedena, José J Pérez, Leire Burgos, Maria Jose Calasanz, PhD BSc, Diego Alignani, PhD, Amaia Vilas-Zornoza, PhD, Erika Lorenzo-Vivas, PhD, Irene Aires, Idoia Rodriguez, Sarvide Sarai, Felipe Prosper, MD PhD, Jose Angel Martinez-Climent, MD PhD, Alberto Orfao, MD PhD, Ramón García-Sanz, MD PhD, Joaquin Martinez-Lopez, MD PhD, Juan-José Lahuerta, MD PhD, Laura Rosinol Dachs, Joan Bladé, MD, Maria-Victoria Mateos, Anastasia Hadzidimitriou, PhD, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 509.
https://doi.org/10.1182/blood-2019-128049
Published: 2019
Journal Articles

Higher Order Restrictions of the Immunoglobulin Repertoire in CLL: The Illustrative Case of Stereotyped Subsets #2 and #169

Katerina Gemenetzi, Andreas Agathangelidis, PhD, Fotis Psomopoulos, Karla Plevova, PhD, Lesley-Ann Sutton, Kostas Pasentsis, Achilles Anagnostopoulos, Raphael Sandaltzopoulos, Richard Rosenquist, MD PhD, Frederic Davi, MD PhD, Sarka Pospisilova, Prof PhD, Kostas Stamatopoulos, Anastasia Chatzidimitriou
Journal: Blood
Blood (2019) 134 (Supplement_1): 5453.
https://doi.org/10.1182/blood-2019-128017
Published: 2019
Journal Articles

VH CDR3-Focused Somatic Hypermutation in CLL IGHV-IGHD-IGHJ Gene Rearrangements with 100% IGHV Germline Identity

Katerina Gemenetzi, Andreas Agathangelidis, PhD, Fotis Psomopoulos, Kostas Pasentsis, Evdoxia Koravou, Michail Iskas, MD MSc, Niki Stavroyianni, Achilles Anagnostopoulos, Raphael Sandaltzopoulos, Kostas Stamatopoulos, Anastasia Chatzidimitriou
Journal: Blood
Blood (2019) 134 (Supplement_1): 4277.
https://doi.org/10.1182/blood-2019-127979
Published: 2019
Journal Articles

Evidence for Epitope-Specific T Cell Responses in HIV-Associated Non Neoplastic Lymphadenopathy: High-Throughput Immunogenetic Evidence

Katerina Gemenetzi, Evangelia Stalika, Andreas Agathangelidis, PhD, Fotis Psomopoulos, Elisavet Vlachonikola, Chrysi Galigalidou, Symeon Metallidis, Triantafylia Koletsa, Kostas Stamatopoulos, MD PhD, Maria Papaioannou, Anastasia Hadzidimitriou, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1117.
https://doi.org/10.1182/blood-2018-99-118975
Published: 2018
Journal Articles

High-Throughput T Cell Receptor (TR) Repertoire Analysis of Virus-Specific T Cells: Implications for T Cell Immunotherapy and Viral Infection Risk Stratification

Chrysi Galigalidou, Anastasia Papadopoulou, PhD, Evangelia Stalika, Andreas Agathangelidis, PhD, Elisavet Vlachonikola, Katerina Gemenetzi, Kiriakos Koukoulias, Kostas Pasentsis, Achilles Anagnostopoulos, Kostas Stamatopoulos, MD PhD, Evangelia Yannaki, MD, Anastasia Hadzidimitriou, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2057.
https://doi.org/10.1182/blood-2018-99-118851
Published: 2018
Journal Articles

Remarkable Functional Constraints on the Antigen Receptors of CLL Stereotyped Subset #2: High-Throughput Immunogenetic Evidence

Katerina Gemenetzi, Andreas Agathangelidis, PhD, Lesley-Ann Sutton, Elisavet Vlachonikola, Chrysi Galigalidou, Fotis Psomopoulos, Maria Gounari, Achilles Anagnostopoulos, Raphael Sandaltzopoulos, Richard Rosenquist, MD PhD, Kostas Stamatopoulos, MD PhD, Anastasia Hadzidimitriou, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1839.
https://doi.org/10.1182/blood-2018-99-119125
Published: 2018
Journal Articles

IGHV Gene Replacement: A Potential Mechanism for Establishing Stereotypy in Certain Cases of Chronic Lymphocytic Leukemia

Sophia Yancopoulos, PhD, Wentian Li, PhD, Xiao J. Yan, MD PhD, Andreas Agathangelidis, PhD, Anastasia Hadzidimitriou, PhD, Frederic Davi, MD PhD, Richard Rosenquist, MD PhD, Paolo Ghia, MD PhD, Kostas Stamatopoulos, MD PhD, Nicholas Chiorazzi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1841.
https://doi.org/10.1182/blood-2018-99-119803
Published: 2018
Journal Articles

High Throughput Immunoprofiling of Low Count B Lymphocytosis Reveals a Distinct T Cell Receptor Repertoire from Chronic Lymphocytic Leukemia

Andreas Agathangelidis, Chrysi Galigalidou, Lydia Scarfo, Alessandra Rovida, Theodoros Moysiadis, PhD BSc, MSc, Elisavet Vlachonikola, Fotis Psomopoulos, Pamela Ranghetti, Anna Vardi, MD PhD, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Paolo Ghia
Journal: Blood
Blood (2017) 130 (Supplement 1): 4296.
https://doi.org/10.1182/blood.V130.Suppl_1.4296.4296
Published: 2017
Journal Articles

Differential Impact of Signaling Inhibitor Treatment Versus Standard Chemoimmunotherapy on Chronic Lymphocytic Leukemia T Cells: Clinical Implications

Anna Vardi, MD PhD, Elisavet Vlachonikola, Evangelia Koravou, Chrysi Galigalidou, Katerina Gemenetzi, Evangelia Stalika, Andreas Agathangelidis, Michalis Iskas, Niki Stavroyianni, Achilles Anagnostopoulos, Kostas Stamatopoulos, Anastasia Hadzidimitriou
Journal: Blood
Blood (2017) 130 (Supplement 1): 2999.
https://doi.org/10.1182/blood.V130.Suppl_1.2999.2999
Published: 2017