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Journal Articles

Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

Christian Pecquet, Nicolas Papadopoulos, Thomas Balligand, Ilyas Chachoua, Amandine Tisserand, Gaëlle Vertenoeil, Audrey Nédélec, Didier Vertommen, Anita Roy, Caroline Marty, Harini Nivarthi, Jean-Philippe Defour, Mira El-Khoury, Eva Hug, Andrea Majoros, Erica Xu, Oleh Zagrijtschuk, Tudor E. Fertig, Daciana S. Marta, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, Ilaria Casetti, Elisa Rumi, Daniela Pietra, Chiara Cavalloni, Luca Arcaini, Mario Cazzola, Norio Komatsu, Yoshihiko Kihara, Yoshitaka Sunami, Yoko Edahiro, Marito Araki, Roman Lesyk, Veronika Buxhofer-Ausch, Sonja Heibl, Florence Pasquier, Violaine Havelange, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2023) 141 (8): 917–929.
https://doi.org/10.1182/blood.2022016846
Published: 2023
Includes: Supplemental data
Journal Articles

Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor

Ruochen Jia, Thomas Balligand, Vasyl Atamanyuk, Harini Nivarthi, Erica Xu, Leon Kutzner, Jakob Weinzierl, Audrey Nedelec, Stefan Kubicek, Roman Lesyk, Oleh Zagrijtschuk, Stefan N. Constantinescu, Robert Kralovics
Journal: Blood
Blood (2021) 137 (14): 1920–1931.
https://doi.org/10.1182/blood.2020006264
Published: 2021
Includes: Supplemental data
Journal Articles

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Christian Pecquet, Ilyas Chachoua, Anita Roy, Thomas Balligand, Gaëlle Vertenoeil, Emilie Leroy, Roxana-Irina Albu, Jean-Philippe Defour, Harini Nivarthi, Eva Hug, Erica Xu, Yasmine Ould-Amer, Céline Mouton, Didier Colau, Didier Vertommen, Myat Marlar Shwe, Caroline Marty, Isabelle Plo, William Vainchenker, Robert Kralovics, Stefan N. Constantinescu
Journal: Blood
Blood (2019) 133 (25): 2669–2681.
https://doi.org/10.1182/blood-2018-09-874578
Published: 2019
Includes: Supplemental data
Journal Articles

Secreted Mutant Calreticulins As Rogue Cytokines Trigger Thrombopoietin Receptor Activation Specifically in CALR Mutated Cells: Perspectives for MPN Therapy

Christian Pecquet, PhD, Thomas Balligand, MD, Ilyas Chachoua, PhD, Anita Roy, PhD, Gaelle Vertenoeil, MD, Didier Colau, PhD, Emanuel Fertig, MD, Caroline Marty, PhD, Harini Nivarthi, PhD, Jean-Philippe Defour, BPharm, PhD, Erica Xu, Eva Hug, PhD, Heinz Gisslinger, Bettina Gisslinger, Martin Schalling, MSc, Ilaria Carola Casetti, MD, Elisa Rumi, MD, Daniela Pietra, PhD, Chiara Cavalloni, MD, Luca Arcaini, MD, Mario Cazzola, Norio Komatsu, MD PhD, Yoshihiko Kihara, PhD, Yoshitaka Sunami, MD PhD, Yoko Edahiro, MD PhD, Marito Araki, PhD, Isabelle Plo, PhD, William Vainchenker, MD PhD, Robert Kralovics, PhD, Stefan N Constantinescu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4.
https://doi.org/10.1182/blood-2018-99-118348
Published: 2018