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Journal Articles

Somatic Mutational Landscape of Hereditary Hematopoietic Malignancies Associated with Germline Variants in RUNX1 , GATA2 and DDX41

Anna L. Brown, Claire Homan, Michael W. Drazer, Kai Yu, David Lawrence, Jinghua Feng, Luis Arriola-Martinez, Matthew Pozsgai, Kelsey McNeely, Thuong Ha, Parvathy Venugopal, Peer Arts, Sarah King-Smith, Jesse JC Cheah, Mark Armstrong, Csaba Bödör, Paul Wang, Alan B. Cantor, Mario Cazzola, Erin Degelman, Courtney D. DiNardo, Nicolas Duployez, Remi Favier, Stefan Fröhling, Ana Rio-Machin, Jeffery M. Klco, Alwin Krämer, Mineo Kurokawa, Joanne Lee, Luca Malcovati, Neil V Morgan, Georges Natsoulis, Carolyn Owen, Keyur P. Patel, Claude Preudhomme, Hana Raslova, Hugh Young Rienhoff, Jr., Tim Ripperger, Rachael Schulte, Kiran Tawana, Elvira Deolinda Rodrigues Pereira Velloso, Benedict Yan, Raman Sood, Amy Hsu, Steven M. Holland, Kerry Phillips, Nicola Poplawski, Milena Babic, Erika M Kwon Kim, Andrew H. Wei, Cecily Forsyth, Helen Mar Fan, Ian D Lewis, Julian Cooney, Rachel Susman, Lucy C Fox, Piers Blombery, Deepak Singhal, Devendra Hiwase, Andreas W Schreiber, Christopher N Hahn, Hamish S Scott, Paul P. Liu, Lucy A. Godley
Journal: Blood
Blood (2022) 140 (Supplement 1): 4030–4033.
https://doi.org/10.1182/blood-2022-167600
Published: 2022
Journal Articles

Inferring the dynamics of mutated hematopoietic stem and progenitor cells induced by IFNα in myeloproliferative neoplasms

Matthieu Mosca, Gurvan Hermange, Amandine Tisserand, Robert Noble, Christophe Marzac, Caroline Marty, Cécile Le Sueur, Hugo Campario, Gaëlle Vertenoeil, Mira El-Khoury, Cyril Catelain, Philippe Rameau, Cyril Gella, Julien Lenglet, Nicole Casadevall, Rémi Favier, Eric Solary, Bruno Cassinat, Jean-Jacques Kiladjian, Stefan N. Constantinescu, Florence Pasquier, Michael E. Hochberg, Hana Raslova, Jean-Luc Villeval, François Girodon, William Vainchenker, Paul-Henry Cournède, Isabelle Plo
Journal: Blood
Blood (2021) 138 (22): 2231–2243.
https://doi.org/10.1182/blood.2021010986
Published: 2021
Includes: Supplemental data
Journal Articles

Dual role of EZH2 in megakaryocyte differentiation

Stefania Mazzi, Philippe Dessen, Mathieu Vieira, Virginie Dufour, Marie Cambot, Mira El Khoury, Iléana Antony-Debré, Brahim Arkoun, Francesca Basso-Valentina, Salwa BenAbdoulahab, Valerie Edmond, Philippe Rameau, Rachel Petermann, Monika Wittner, Bruno Cassinat, Isabelle Plo, Najet Debili, Hana Raslova, William Vainchenker
Journal: Blood
Blood (2021) 138 (17): 1603–1614.
https://doi.org/10.1182/blood.2019004638
Published: 2021
Includes: Supplemental data
Journal Articles

The megakaryocyte: a cell with 3 faces as a mythic god?

William Vainchenker, Hana Raslova
Journal: Blood
Blood (2021) 138 (14): 1199–1200.
https://doi.org/10.1182/blood.2021012760
Published: 2021
Journal Articles

CALR mutant protein rescues the response of MPL p.R464G variant associated with CAMT to eltrombopag

Francesca Basso-Valentina, Gabriel Levy, Leila N. Varghese, Myriam Oufadem, Benedicte Neven, Charlotte Boussard, Nathalie Balayn, Caroline Marty, William Vainchenker, Isabelle Plo, Paola Ballerini, Stefan N. Constantinescu, Remi Favier, Hana Raslova
Journal: Blood
Blood (2021) 138 (6): 480–485.
https://doi.org/10.1182/blood.2020010567
Published: 2021
Includes: Supplemental data
Journal Articles

Palbociclib Prevents CDK4/6 Dependent-Myeloproliferation and Myelofibrosis

Helene Duparc, Delphine Muller, Ileana Antony-Debre, PhD PharmD, Caroline Marty, PhD, Najet Debili, Jean-Luc Villeval, PhD, Isabelle Plo, William Vainchenker, Laure Gilles, PhD, Hana Raslova
Journal: Blood
Blood (2020) 136 (Supplement 1): 25.
https://doi.org/10.1182/blood-2020-141092
Published: 2020
Journal Articles

Modeling Acute Megakaryoblastic Leukemia of Down Syndrome Using Induced Pluripotent Stem Cells

Brahim Arkoun, Virginie Dufour, Aurélie Siret, Stefania Mazzi, Yasmine Mammasse, Mathieu Vieira, Fabien Boudia, Elie Robert, Zakia Aid, Marie Cambot, Rachel Petermann, Sylvie Souquere, Philippe Rameau, Cyril Catelain, Romain Diot, Gérard Tachdjian, Najet Debili, Isabelle Plo, Hana Raslova, Sebastien Malinge, Eric Soler, Thomas Mercher, William Vainchenker
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-140986
Published: 2020
Journal Articles

Disease Phenotype and Clonal Amplification in Calreticulin del52 and ins5 Knock-in Mice Are Dependent on the Type of Mutations and Gene Dosage

Camélia Benlabiod, Maira da Costa Cacemiro, PhD, Thomas Balligand, MD, Barbara Panneau-Schmaltz, PhD, Delphine Muller, Laure Touchard, Patrick Gonin, DVM, Jean-Luc Villeval, PhD, Stefan N Constantinescu, MD PhD, Hana Raslova, PhD, William Vainchenker, MD PhD, Isabelle Plo, Caroline Marty, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 311.
https://doi.org/10.1182/blood-2019-127918
Published: 2019
Journal Articles

Clonal Hematopoiesis in the Molecular Landscape of Therapy-Related Myeloid Neoplasms in Patients Previously Treated for Gynecologic and Breast Cancers

Sabine Khalife-Hachem, Khalil Saleh, MD, Florence Pasquier, MD PhD, Anthony Tarabay, Cyril Quivoron, Sophie Cotteret, Christophe Willekens, MD, Veronique Saada, Ines-Maria Vaz-Luis, Suzette Delaloge, Alexandra Leary, Hana Raslova, PhD, Filippo Rosselli, Olivier Caron, Iléana Antony-Debre, PhD, Eric Solary, MD PhD, Stephane de Botton, MD PhD, Christophe Marzac, MD, Jean-Baptiste Micol, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3722.
https://doi.org/10.1182/blood-2019-126872
Published: 2019
Journal Articles

Predicting the Long-Term Efficacy of Ifnα in JAK2 V617F and Calr -Mutated MPN Patients

Amandine Tisserand, Robert Noble, PhD, Matthieu Mosca, PhD, Christophe Marzac, MD, Gaelle Vertenoeil, MD, Hugo Campario, PharmD, Mira El-Khoury, PhD, Caroline Marty, PhD, Philippe Rameau, Nicole Casadevall, MD, Eric Solary, MD PhD, Florence Pasquier, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD PhD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Michael Hochberg, PhD, Villeval Jean-Luc, PhD, William Vainchenker, MD PhD, Isabelle Plo
Journal: Blood
Blood (2019) 134 (Supplement_1): 4196.
https://doi.org/10.1182/blood-2019-127903
Published: 2019
Journal Articles

Filamin A: key actor in platelet biology

Jean-Philippe Rosa, Hana Raslova, Marijke Bryckaert
Journal: Blood
Blood (2019) 134 (16): 1279–1288.
https://doi.org/10.1182/blood.2019000014
Published: 2019
Journal Articles

Disrupted filamin A/α IIb β 3 interaction induces macrothrombocytopenia by increasing RhoA activity

Alessandro Donada, Nathalie Balayn, Dominika Sliwa, Larissa Lordier, Valentina Ceglia, Francesco Baschieri, Cyril Goizet, Rémi Favier, Lucie Tosca, Gérard Tachdjian, Cecile V. Denis, Isabelle Plo, William Vainchenker, Najet Debili, Jean-Philippe Rosa, Marijke Bryckaert, Hana Raslova
Journal: Blood
Blood (2019) 133 (16): 1778–1788.
https://doi.org/10.1182/blood-2018-07-861427
Published: 2019
Includes: Supplemental data
Journal Articles

Differential Impact of Interferon Alpha on JAK2 V617F and Calr Mutated Hematopoietic Stem and Progenitor Cells in Classical MPN

Matthieu Mosca, PhDstudent, Lamia Lamrani, PhD, Christophe Marzac, MD, Amandine Tisserand, Valérie Edmond, PhD, Tracy Dagher, PhDstudent, Mira El-Khoury, PhD, Caroline Marty, PhD, Hugo Campario, PharmD, Nicole Casadevall, MD, Eric Solary, MD PhD, Hana Raslova, PhD, Bruno Cassinat, PharmD, PhD, Stefan N Constantinescu, MD, Jean-Jacques Kiladjian, MD PhD, Francois Girodon, MD PhD, Jean-Luc Villeval, PhD, William Vainchenker, MD PhD, Isabelle Plo, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4333.
https://doi.org/10.1182/blood-2018-99-114744
Published: 2018
Journal Articles

CK2: a key regulator of thrombopoiesis

William Vainchenker, Hana Raslova
Journal: Blood
Blood (2017) 130 (25): 2695–2697.
https://doi.org/10.1182/blood-2017-10-808568
Published: 2017
Journal Articles

The ETO2-GLIS2 Fusion Oncogene Alters Early Human Hematopoiesis in an Induced Pluripotent Stem Cells-Derived Model of Pediatric Acute Megakaryoblastic Leukemia

Salvatore Nicola Bertuccio, Marie Cambot, Cécile K Lopez, Larissa Lordier, Alessandro Donada, Zakia Aid, Franco Locatelli, MD PhD, Riccardo Masetti, MDPhD, William Vainchenker, MD PhD, Hana Raslova, PhD, Andrea Pession, MD, Thomas Mercher, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2512.
https://doi.org/10.1182/blood.V130.Suppl_1.2512.2512
Published: 2017
Journal Articles

Rare Type 1-like and Type 2-like Calrecticulin Mutants Induce Similar Myeloproliferative Neoplasms Than Type 1 and Type 2 Mutants in Mice

Katte Rao Toppaldoddi, Maira da Costa Cacemiro, Olivier Bluteau, PhD, Amélie Pioch, Barbara Panneau-Schmaltz, PhD, Delphine Muller, Nicole Casadevall, MD, Hana Raslova, PhD, Stefan N. Constantinescu, MD PhD, Isabelle Plo, William Vainchenker, MD PhD, Caroline Marty, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1665.
https://doi.org/10.1182/blood.V130.Suppl_1.1665.1665
Published: 2017
Journal Articles

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L

Fabrizia Favale, Kahia Messaoudi, Leila N. Varghese, Siham Boukour, Christian Pecquet, Vitalina Gryshkova, Jean Philippe Defour, Roxana-Irina Albu, Olivier Bluteau, Paola Ballerini, Guy Leverger, Isabelle Plo, Najet Debili, Hana Raslova, Remi Favier, Stefan N. Constantinescu, William Vainchenker
Journal: Blood
Blood (2016) 128 (26): 3146–3158.
https://doi.org/10.1182/blood-2016-06-722058
Published: 2016
Includes: Supplemental data
Journal Articles

Activity of nonmuscle myosin II isoforms determines localization at the cleavage furrow of megakaryocytes

Anita Roy, Larissa Lordier, Stefania Mazzi, Yunhua Chang, Valérie Lapierre, Jérome Larghero, Najet Debili, Hana Raslova, William Vainchenker
Journal: Blood
Blood (2016) 128 (26): 3137–3145.
https://doi.org/10.1182/blood-2016-04-711630
Published: 2016
Includes: Multimedia, Supplemental data
Journal Articles

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Cecile Thirant, PhD, Cecile K Lopez, Cathy Ignacimouttou, M'Boyba Diop, Lou Le Mouël, MD, Clarisse Thiollier, MD PhD, Aurelie Siret, Philippe Dessen, Zakia Aid, Julie Riviere, PhD, Philippe Rameau, Celine Lefebvre, Mehdi Khaled, PhD, Guy Leverger, MD, Paola Fabiola Ballerini, MDPhD, Arnaud Petit, MD PhD, Hana Raslova, PhD, Catherine Carmichael, Benjamin T. Kile, PhD, Eric Soler, PhD, John Crispino, PhD, Christian Wichmann, MD, Camille Lobry, PhD, Francoise Pfumio, PhD, Juerg Schwaller, MD, Nathalie M. Droin, PhD, William Vainchenker, MD PhD, Olivier A. Bernard, PhD, Sebastien Malinge, PhD, Thomas Mercher, PhD
Journal: Blood
Blood (2016) 128 (22): 572.
https://doi.org/10.1182/blood.V128.22.572.572
Published: 2016
Journal Articles

New Insights into Mechanisms of Erythropoietin Receptor Mutations in Primary Familial and Congenital Polycythemia

Florence Pasquier, MD PhD, Caroline Marty, PhD, Frédérique Verdier, PhD, Sarah Grosjean, MBiol, Claude Préhu, MD, Stefan N. Constantinescu, MD PhD, Hana Raslova, PhD, Nicole Casadevall, MD, William Vainchenker, MD PhD, Christine Bellanné-Chantelot, PharmD, PhD, Isabelle Plo, PhD
Journal: Blood
Blood (2016) 128 (22): 631.
https://doi.org/10.1182/blood.V128.22.631.631
Published: 2016