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Journal Articles

The NFIA-ETO2 fusion blocks erythroid maturation and induces pure erythroid leukemia in cooperation with mutant TP53

Maria-Riera Piqué-Borràs, Zivojin Jevtic, Frederik Otzen Bagger, Jonathan Seguin, Rathick Sivalingam, Matheus Filgueira Bezerra, Amber Louwagie, Sabine Juge, Ioannis Nellas, Robert Ivanek, Alexandar Tzankov, Ute M. Moll, Oriano Cantillo, Ramona Schulz-Heddergott, Alexandre Fagnan, Thomas Mercher, Juerg Schwaller
Journal: Blood
Blood (2023) 141 (18): 2245–2260.
https://doi.org/10.1182/blood.2022017273
Published: 2023
Includes: Supplemental data
Journal Articles

ERGonomics for EVI1 acute myeloid leukemia

Cécile K. Lopez, Thomas Mercher
Journal: Blood
Blood (2023) 141 (5): 441–443.
https://doi.org/10.1182/blood.2022018318
Published: 2023
Journal Articles

Dissecting GATA1 Protein Interactions in Normal and Malignant Human Erythroblasts

Samantha Tauchmann, Frederik Otzen Bagger, Thomas Bock, Roos Krimpenfort, Francesca Aglialoro, Peter Valent, Alexandre Fagnan, Marieke von Lindern, Thomas Mercher, Juerg Schwaller
Journal: Blood
Blood (2021) 138 (Supplement 1): 3293.
https://doi.org/10.1182/blood-2021-148351
Published: 2021
Journal Articles

Modeling Acute Megakaryoblastic Leukemia of Down Syndrome Using Induced Pluripotent Stem Cells

Brahim Arkoun, Virginie Dufour, Aurélie Siret, Stefania Mazzi, Yasmine Mammasse, Mathieu Vieira, Fabien Boudia, Elie Robert, Zakia Aid, Marie Cambot, Rachel Petermann, Sylvie Souquere, Philippe Rameau, Cyril Catelain, Romain Diot, Gérard Tachdjian, Najet Debili, Isabelle Plo, Hana Raslova, Sebastien Malinge, Eric Soler, Thomas Mercher, William Vainchenker
Journal: Blood
Blood (2020) 136 (Supplement 1): 1.
https://doi.org/10.1182/blood-2020-140986
Published: 2020
Journal Articles

Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers

Alexandre Fagnan, Frederik Otzen Bagger, Maria-Riera Piqué-Borràs, Cathy Ignacimouttou, Alexis Caulier, Cécile K. Lopez, Elie Robert, Benjamin Uzan, Véronique Gelsi-Boyer, Zakia Aid, Cécile Thirant, Ute Moll, Samantha Tauchmann, Amina Kurtovic-Kozaric, Jaroslaw Maciejewski, Christine Dierks, Orietta Spinelli, Silvia Salmoiraghi, Thomas Pabst, Kazuya Shimoda, Virginie Deleuze, Hélène Lapillonne, Connor Sweeney, Véronique De Mas, Betty Leite, Zahra Kadri, Sébastien Malinge, Stéphane de Botton, Jean-Baptiste Micol, Benjamin Kile, Catherine L. Carmichael, Ilaria Iacobucci, Charles G. Mullighan, Martin Carroll, Peter Valent, Olivier A. Bernard, Eric Delabesse, Paresh Vyas, Daniel Birnbaum, Eduardo Anguita, Loïc Garçon, Eric Soler, Juerg Schwaller, Thomas Mercher
Journal: Blood
Blood (2020) 136 (6): 698–714.
https://doi.org/10.1182/blood.2019003062
Published: 2020
Includes: Supplemental data
Journal Articles

Transformation Mechanisms of the Nfia -ETO2 Fusion Gene Associated with Pediatric Pure Acute Erythroleukemia

Maria-Riera Piqué-Borràs, Msc, Frederik Otzen Bagger, PhD, Matheus Filgueira Bezerra, MSc, Amber Louwaige, Msc, Sabine Juge, Ioannis Nellas, Msc, Robert Ivanek, PhD, Alexandar Tzankov, MD, Ute M Moll, MD, Ramona Schulz-Heddergott, PhD, Thomas Mercher, PhD, Juerg Schwaller, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 532.
https://doi.org/10.1182/blood-2019-126416
Published: 2019
Journal Articles

Crispri-Based Screening of Clustered Regulatory Elements Reveals Novel Leukemia Dependencies

Salima Benbarche, PhD, Cécile K Lopez, Thomas Mercher, PhD, Camille Lobry, PhD MSc
Journal: Blood
Blood (2018) 132 (Supplement 1): 654.
https://doi.org/10.1182/blood-2018-99-111865
Published: 2018
Journal Articles

The ETO2-GLIS2 Fusion Oncogene Alters Early Human Hematopoiesis in an Induced Pluripotent Stem Cells-Derived Model of Pediatric Acute Megakaryoblastic Leukemia

Salvatore Nicola Bertuccio, Marie Cambot, Cécile K Lopez, Larissa Lordier, Alessandro Donada, Zakia Aid, Franco Locatelli, MD PhD, Riccardo Masetti, MDPhD, William Vainchenker, MD PhD, Hana Raslova, PhD, Andrea Pession, MD, Thomas Mercher, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2512.
https://doi.org/10.1182/blood.V130.Suppl_1.2512.2512
Published: 2017
Journal Articles

ETO2-GLIS2 Controls Differentiation Arrest and Self-Renewal through Aberrant Enhancers Regulation in Pediatric Leukemia

Cecile Thirant, PhD, Cecile K Lopez, Cathy Ignacimouttou, M'Boyba Diop, Lou Le Mouël, MD, Clarisse Thiollier, MD PhD, Aurelie Siret, Philippe Dessen, Zakia Aid, Julie Riviere, PhD, Philippe Rameau, Celine Lefebvre, Mehdi Khaled, PhD, Guy Leverger, MD, Paola Fabiola Ballerini, MDPhD, Arnaud Petit, MD PhD, Hana Raslova, PhD, Catherine Carmichael, Benjamin T. Kile, PhD, Eric Soler, PhD, John Crispino, PhD, Christian Wichmann, MD, Camille Lobry, PhD, Francoise Pfumio, PhD, Juerg Schwaller, MD, Nathalie M. Droin, PhD, William Vainchenker, MD PhD, Olivier A. Bernard, PhD, Sebastien Malinge, PhD, Thomas Mercher, PhD
Journal: Blood
Blood (2016) 128 (22): 572.
https://doi.org/10.1182/blood.V128.22.572.572
Published: 2016
Journal Articles

Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling

Sébastien Malinge, Clarisse Thiollier, Timothy M. Chlon, Louis C. Doré, Lauren Diebold, Olivier Bluteau, Vinciane Mabialah, William Vainchenker, Philippe Dessen, Susan Winandy, Thomas Mercher, John D. Crispino
Journal: Blood
Blood (2013) 121 (13): 2440–2451.
https://doi.org/10.1182/blood-2012-08-450627
Published: 2013
Includes: Supplemental data
Journal Articles

In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells

Brief Report
Erinn Soucie, Katia Hanssens, Thomas Mercher, Sophie Georgin-Lavialle, Gandhi Damaj, Cristina Livideanu, Maria Olivia Chandesris, Yolène Acin, Sebastien Létard, Paulo de Sepulveda, Olivier Hermine, Olivier A. Bernard, Patrice Dubreuil
Journal: Blood
Blood (2012) 120 (24): 4846–4849.
https://doi.org/10.1182/blood-2011-12-397588
Published: 2012
Includes: Supplemental data
Journal Articles

TET2 Favors Mesoderm and Hematopoietic Differentiation in Human Embryonic Stem Cells

Barbara da Costa Reis Monte Mor, Ph.D, Thierry Langlois, Nathalie Droin, Ph.D, Elodie Pronier, Jean-Pierre Le Couédic, Nathalie Auger, M.D., Carole Almire, M.D., Thomas Mercher, PhD, Francois Delhommeau, PharmD, PhD, Debili Najet, Ph.D, Olivier Bernard, Eric Solary, Isabelle Plo, Ph.D, William Vainchenker, MD., Ph.D
Journal: Blood
Blood (2011) 118 (21): 2418.
https://doi.org/10.1182/blood.V118.21.2418.2418
Published: 2011
Journal Articles

RUNX1-Induced Silencing of Non-Muscle Myosin Iib (MYH10) Is Required for Megakaryocyte Polyploidization

Dominique Bluteau, PhD, Larissa Lordier, PhD, Iléana Antony-Debré, Abdelali Jalil, Céline Legrand, Philippe Rameau, Olivier Bluteau, PhD, Dima Jouni, Thomas Mercher, PhD, Catherine Leon, Christian Gachet, MD, PhD, Najet Debili, PhD, William Vainchenker, MD., Ph.D, Yunhua Chang, PhD, Hana Raslova, PhD
Journal: Blood
Blood (2011) 118 (21): 1308.
https://doi.org/10.1182/blood.V118.21.1308.1308
Published: 2011
Journal Articles

Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification

Melanie G. Cornejo, Vinciane Mabialah, Stephen M. Sykes, Tulasi Khandan, Cristina Lo Celso, Cécile K. Lopez, Paola Rivera-Muñoz, Philippe Rameau, Zuzana Tothova, Jon C. Aster, Ronald A. DePinho, David T. Scadden, D. Gary Gilliland, Thomas Mercher
Journal: Blood
Blood (2011) 118 (5): 1264–1273.
https://doi.org/10.1182/blood-2011-01-328567
Published: 2011
Includes: Supplemental data
Journal Articles

Ikaros Is a GATA Switch Target Gene That Restrains Megakaryopoiesis In Part by Blocking Notch Signaling.

Sebastien Malinge, PhD, Clarisse Thiollier, Timothy M Chlon, Louis C Dore, Lauren Diebold, Susan Winandy, PhD, Thomas Mercher, PhD, John Crispino, PhD
Journal: Blood
Blood (2010) 116 (21): 1602.
https://doi.org/10.1182/blood.V116.21.1602.1602
Published: 2010
Journal Articles

Inhibition of AKT Signaling Potently Inhibits Growth of MPL-Mutant Cells in the Myeloproliferative Neoplasms.

Zan Huang, PhD, Priya Koppikar, PhD, Thomas Mercher, Ph.D, Ross L. Levine, MD, John Crispino, PhD
Journal: Blood
Blood (2009) 114 (22): 1896.
https://doi.org/10.1182/blood.V114.22.1896.1896
Published: 2009
Journal Articles

A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells.

Melanie G Cornejo, Stephen M Sykes, Cristina Lo Celso, Zuzana Tothova, Jon Aster, MD, PhD, Ronald A DePinho, MD, David T Scadden, MD, D. Gary Gilliland, MD, PhD, Thomas Mercher, Ph.D
Journal: Blood
Blood (2009) 114 (22): 384.
https://doi.org/10.1182/blood.V114.22.384.384
Published: 2009
Journal Articles

Identification of Inducers of Megakaryocyte Polyploidization and Their Use as Targeted Differentiation Therapy for Acute Megakaryocytic Leukemia.

Qiang Wen, PhD, MD, Zan Huang, PhD, Sara Small, Niket Bubna, Frank An, PhD, Meghan Bliss-Moreau, Lynn Verplank, PhD, Tim Lewis, PhD, Monica Schenone, PhD, Nicola Tolliday, PhD, Chris Moore, Ann Carpenter, PhD, Thomas Mercher, Ph.D, Ross L. Levine, MD, Shai Izraeli, MD, Andrew Stern, PhD, Robert Gould, PhD, James E. Bradner, MD, John Crispino, PhD
Journal: Blood
Blood (2009) 114 (22): 792.
https://doi.org/10.1182/blood.V114.22.792.792
Published: 2009
Journal Articles

Constitutive JAK3 activation induces lymphoproliferative syndromes in murine bone marrow transplantation models

Melanie G. Cornejo, Michael G. Kharas, Miriam B. Werneck, Séverine Le Bras, Sandra A. Moore, Brian Ball, Marie Beylot-Barry, Scott J. Rodig, Jon C. Aster, Benjamin H. Lee, Harvey Cantor, Jean-Philippe Merlio, D. Gary Gilliland, Thomas Mercher
Journal: Blood
Blood (2009) 113 (12): 2746–2754.
https://doi.org/10.1182/blood-2008-06-164368
Published: 2009
Includes: Supplemental data
Journal Articles

Cdx4 Is Dispensable for Murine Hematopoiesis and MLL-AF9 Mediated Leukemogenesis.

Sumin Koo, Thomas Mercher, Ph.D, Shannon Mckinney- Freeman, Ph.D, Yuan Wang, Ph.D, Brian Ball, Brian JP Huntly, MD, PhD, Dimple Bansal, Ph.D, George Q. Daley, MD, PhD, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (11): 1404.
https://doi.org/10.1182/blood.V112.11.1404.1404
Published: 2008