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Kazuya Shimoda
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Journal Articles

A mouse model of aggressive ATL associated with oncogenic mutations and an HBZ-expressing hematopoietic environment

Free
Takuro Kameda, Kotaro Shide, Yuki Tahira, Taisuke Uchida, Ayako Kamiunten, Keiichi Akizuki, Masayoshi Karasawa, Kengo Matsumoto, Ryoma Ikeda, Koshiro Nagamine, Ayuka Kuroki, Yoko Kubuki, Kazuya Shimoda
Journal: Blood
Blood (2025) 146 (Supplement 1): 1482.
https://doi.org/10.1182/blood-2025-1482
Published: 2025
Journal Articles

Preliminary data from the Phase I/II study of nuvisertib, an oral investigational selective PIM1 inhibitor, in combination with momelotinib showed clinical responses in patients with relapsed/refractory myelofibrosis

Free
John Mascarenhas, Joseph Scandura, Vikas Gupta, Kazuya Shimoda, James McCloskey, Firas El Chaer, Prithviraj Bose, Raajit Rampal, Andrew Srisuwananukorn, Timothy Devos, Ruben Mesa, Professor Francesco Passamonti, Srinivas Tantravahi, David Ross, Lindsay Rein, Jean-Jacques Kiladjian, Takanori Teshima, Takuji Yamauchi, Noboru Asada, Anna Halpern, Tamanna Haque, Etienne Paubelle, Noriko Fukuhara, Pankit Vachhani, Michiko Ichii, Ronald Hoffman, Marcello Rotta, Michael Keng, Stefan Wickenhauser, Karen Ansaldo, Masataka Seki, Jinny Lee, Vincent Loksa, Zhonggai Li, Jason Foulks, Sujan Kabir, Jatin Shah, Claire Harrison
Journal: Blood
Blood (2025) 146 (Supplement 1): 482.
https://doi.org/10.1182/blood-2025-482
Published: 2025
Journal Articles

Nuvisertib, an oral investigational selective PIM1 kinase inhibitor, showed clinical responses strongly correlating with cytokine modulation in patients with relapsed/refractory myelofibrosis in the ongoing global phase I/II study

Free
Lindsay Rein, Firas El Chaer, Junichiro Yuda, Joseph Scandura, Shuichi Shirane, Kazuya Shimoda, Prithviraj Bose, Akiyoshi Takami, Alessandra Iurlo, Michiko Ichii, James McCloskey, Michael Keng, Samah Alimam, Noriko Fukuhara, Nikki Granacher, Giulia Benevolo, Alessandro Lucchesi, Tamanna Haque, Jean-Jacques Kiladjian, Srinivas Tantravahi, Pankit Vachhani, Anand Patel, Stanley Cheung, Paul Yeh, Francesca Palandri, Ashwin Kishtagari, Ciro Rinaldi, Marcello Rotta, Vincent Ribrag, Michael Loschi, Idoroenyi Amanam, Terrence Bradley, Karen Ansaldo, Masataka Seki, Guia Guffanti, Jinny Lee, Prasanthi Pellakuru, Zhonggai Li, Jason Foulks, Sujan Kabir, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2025) 146 (Supplement 1): 2018.
https://doi.org/10.1182/blood-2025-2018
Published: 2025
Journal Articles

Association between momelotinib exposure and hemoglobin improvement in patients with myelofibrosis and anemia: An exposure-response and time-to-event analysis

Free
Vikas Gupta, Jose Torregrosa, Georgios Vlasakakis, Meenakshi Srinivasan, Fernando Carreño, Jasmine Sahni, Dwaipayan Patnaik, Kazuya Shimoda
Journal: Blood
Blood (2025) 146 (Supplement 1): 5580.
https://doi.org/10.1182/blood-2025-5580
Published: 2025
Journal Articles

Impact of Cooperating Myeloid Gene Mutations on Disease Progression and Survival in Japanese MPN Patients: A Multicenter Study

Free
Saki Ogawa, Kotaro Shide, Masami Takeuchi, Kosei Matsue, Takuro Kameda, Masato Yasumi, Takahiro Karasuno, Taizo Shimomura, Hitoshi Suzushima, Kiyoshi Yamashita, Noriaki Kawano, Osamu Imataki, Norimitsu Kadowaki, Akihito Yonezawa, Eiichi Otsuka, Yoshio Saburi, Yuki Tahira, Ayako Kamiunten, Keiichi Akizuki, Masayoshi Karasawa, Ryoma Ikeda, Kengo Matsumoto, Ayuka Kuroki, Koshiro Nagamine, Yoko Kubuki, Kazuya Shimoda
Journal: Blood
Blood (2024) 144 (Supplement 1): 1805.
https://doi.org/10.1182/blood-2024-208908
Published: 2024
Journal Articles

HOPE-PMF: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study to Assess Efficacy and Safety of Ropeginterferon Alfa-2b in Patients with Early/Lower-Risk Primary Myelofibrosis

Free
Ghaith Abu-Zeinah, Albert Qin, Harinder Gill, Norio Komatsu, John O. Mascarenhas, Weichung Joe Shih, Oleh Zagrijtschuk, Toshiaki Sato, Kazuya Shimoda, Richard T. Silver, Ruben A. Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3191.1.
https://doi.org/10.1182/blood-2024-200319
Published: 2024
Journal Articles

Phase I Safety Study of Anti-Transferrin Receptor 1 Antibody (PPMX-T003) in Patients with Polycythemia Vera and Erythrocythemia

Free
Tomoki Ito, Teruhito Takakuwa, Masayuki Hino, Hirohisa Nakamae, Kazunori Murai, Yoko Kubuki, Kazuya Shimoda, Yuji Kumagai, Yukiya Yamamoto, Tadashi Matsuura
Journal: Blood
Blood (2024) 144 (Supplement 1): 4542.
https://doi.org/10.1182/blood-2024-206911
Published: 2024
Journal Articles

A Phase 1/2 Study of Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, in Combination with JAK Inhibitors Ruxolitinib or Momelotinib in Patients with Myelofibrosis

Free
John O. Mascarenhas, Raajit Rampal, Firas El Chaer, Vikas Gupta, Kazuya Shimoda, Jean-Jacques Kiladjian, Francesco Passamonti, Prithviraj Bose, Joseph M. Scandura, Ruben Mesa, Lindsay A.M. Rein, Junichiro Yuda, David M Ross, Timothy Devos, Moshe Talpaz, Ronald Hoffman, Sujan Kabir, Zhonggai Li, Jason M. Foulks, Karen Ansaldo, Masataka Seki, Vishnu Peddagali, Jatin Shah, Claire Harrison
Journal: Blood
Blood (2024) 144 (Supplement 1): 6629.
https://doi.org/10.1182/blood-2024-200268
Published: 2024
Journal Articles

Cytokine Modulation Correlates Strongly with Symptom Improvement in Patients with Myelofibrosis Treated with Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor

Free
Lindsay A.M. Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, Raajit Rampal, Joseph M. Scandura, Akiyoshi Takami, James McCloskey, Michiko Ichii, Shuichi Shirane, Alessandra Iurlo, Prithviraj Bose, Alessandro Lucchesi, Giulia Benevolo, Idoroenyi Amanam, Pankit Vachhani, Srinivas K Tantravahi, Marcello Rotta, Yasushi Onishi, Jean-Jacques Kiladjian, Ciro Rinaldi, Nikki Granacher, Terrence Bradley, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Masataka Seki, Karen Ansaldo, Guia Guffanti, Jinny Lee, Steven L. Warner, Jason M. Foulks, Ruben Mesa
Journal: Blood
Blood (2024) 144 (Supplement 1): 3179.
https://doi.org/10.1182/blood-2024-200999
Published: 2024
Journal Articles

Nuvisertib (TP-3654), an Investigational Selective PIM1 Kinase Inhibitor, Showed Durable Clinical Response and Sustained Hematological Improvement in Relapsed/Refractory Myelofibrosis Patients

Free
Firas El Chaer, Lindsay A.M. Rein, Junichiro Yuda, Kazuya Shimoda, Akiyoshi Takami, Michiko Ichii, James McCloskey, Joseph M. Scandura, Alessandra Iurlo, Prithviraj Bose, Tamanna Haque, Alessandro Lucchesi, Shuichi Shirane, Giulia Benevolo, Idoroenyi Amanam, Jean-Jacques Kiladjian, Pankit Vachhani, Srinivas K Tantravahi, Yasushi Onishi, Ciro Rinaldi, Marcello Rotta, Nikki Granacher, Anand Ashwin Patel, Michael Loschi, Samah Alimam, Terrence Bradley, Stanley Cheung, Vincent Ribrag, Sujan Kabir, Karen Ansaldo, Masataka Seki, Vincent Loksa, Zhonggai Li, Jason M. Foulks, Jatin Shah, Raajit Rampal
Journal: Blood
Blood (2024) 144 (Supplement 1): 655.
https://doi.org/10.1182/blood-2024-200312
Published: 2024
Journal Articles

Phase 1/2 Study of TP-3654, a Selective PIM1 Kinase Inhibitor: Preliminary Data Showed Clinical Activity and Cytokine Reductions in Relapsed/Refractory Myelofibrosis Patients

Free
Lindsay A.M Rein, Firas El Chaer, Junichiro Yuda, Kazuya Shimoda, James McCloskey, Akiyoshi Takami, Tamanna Haque, Michiko Ichii, Shuichi Shirane, Masafumi Fukaya, Joseph M. Scandura, Terrence Bradley, Pankit Vachhani, Takayuki Tabayashi, Steven Green, Stanley Cheung, Prithviraj Bose, Sharad Khurana, Casey L. O'Connell, Idoroenyi Amanam, David M. Ross, Sujan Kabir, Masataka Seki, Mark Wade, Vishnu Peddagali, Zhonggai Li, Jatin Shah, Raajit K. Rampal
Journal: Blood
Blood (2023) 142 (Supplement 1): 626.
https://doi.org/10.1182/blood-2023-180164
Published: 2023
Journal Articles

TYK2 Is Essential for IFNα-Induced Resolution of MPN Features in a Murine Jak2 V617F PMF Model

Free
Yuki Tahira, Kotaro Shide, Takuro Kameda, Ayako Kamiunten, Keiichi Akizuki, Masayoshi Karasawa, Ryoma Ikeda, Kengo Matsumoto, Yoko Kubuki, Kazuya Shimoda
Journal: Blood
Blood (2023) 142 (Supplement 1): 864.
https://doi.org/10.1182/blood-2023-181335
Published: 2023
Journal Articles

The Association between Blood Cell Counts and Thrombotic Events in Japanese Patients with Polycythemia Vera: A Retrospective Database Study

Free
Kazuya Shimoda, Hideo Yasunaga, Yuka Sugimoto, Hidetoshi Uenaka, Takeo Dochi, Gyungjin Jun
Journal: Blood
Blood (2023) 142 (Supplement 1): 3191.
https://doi.org/10.1182/blood-2023-182706
Published: 2023
Journal Articles

Thrombotic and Bleeding Events in Japanese Adolescent and Young Adult PV and ET: Results from Japanese Multicenter Retrospective Study

Free
Yuka Sugimoto, Keiki Nagaharu, Eiko Oya, Kohshi Ohishi, Isao Tawara, Tomoki Ito, Akihiko Gotoh, Mika Nakamae, Fumihiko Kimura, Michiaki Koike, Keita Kirito, Hideho Wada, Kensuke Usuki, Takayuki Tanaka, Takehiko Mori, Satoshi Wakita, Toshiki I Saito, Akiko Kada, Akiko M Saito, Kazuya Shimoda, Toshio Kurokawa, Akihiro Tomita, Yoko Edahiro, Yoshinori Hashimoto, Hitoshi Kiyoi, Koichi Akashi, Itaru Matsumura, Katsuto Takenaka, Norio Komatsu
Journal: Blood
Blood (2023) 142 (Supplement 1): 1831.
https://doi.org/10.1182/blood-2023-180561
Published: 2023
Journal Articles

Preclinical Translational Research Suggests a Clinical Trial Strategy for a Novel MALT1 Inhibitor ONO-7018/CTX-177 Against Malignant Lymphomas

Free
Daisuke Morishita, Akio Mizutani, Hiroko Yamakawa, Yasuyoshi Arikawa, Hirokazu Tozaki, Takuro Kameda, Ayako Kamiunten, Keisuke Kataoka, Akinori Yoda, Yotaro Ochi, Kotaro Shide, Koji Izutsu, Yosuke Minami, Kazuya Shimoda, Seishi Ogawa
Journal: Blood
Blood (2022) 140 (Supplement 1): 8874–8875.
https://doi.org/10.1182/blood-2022-171019
Published: 2022
Journal Articles

Preliminary Data from the Phase I/II Study of TP-3654, a Selective Oral PIM1 Kinase Inhibitor, in Patients with Myelofibrosis Previously Treated with or Ineligible for JAK Inhibitor Therapy

Free
Firas El Chaer, James McCloskey, Lindsay A.M. Rein, Randy A. Brown, Steven D. Green, Jeffrey J. Pu, Shuichi Shirane, Kazuya Shimoda, Michiko Ichii, Junichiro Yuda, Joseph Scandura, Sujan Kabir, Jason M Foulks, Jian Mei, Huyuan Yang, Mark Wade, Carl Stapinski, Claudia Lebedinsky, Raajit K Rampal
Journal: Blood
Blood (2022) 140 (Supplement 1): 594–595.
https://doi.org/10.1182/blood-2022-159086
Published: 2022
Journal Articles

Whole-genome landscape of adult T-cell leukemia/lymphoma

Free
Yasunori Kogure, Takuro Kameda, Junji Koya, Makoto Yoshimitsu, Kisato Nosaka, Jun-ichirou Yasunaga, Yoshitaka Imaizumi, Mizuki Watanabe, Yuki Saito, Yuta Ito, Marni B. McClure, Mariko Tabata, Sumito Shingaki, Kota Yoshifuji, Kenichi Chiba, Ai Okada, Nobuyuki Kakiuchi, Yasuhito Nannya, Ayako Kamiunten, Yuki Tahira, Keiichi Akizuki, Masaaki Sekine, Kotaro Shide, Tomonori Hidaka, Yoko Kubuki, Akira Kitanaka, Michihiro Hidaka, Nobuaki Nakano, Atae Utsunomiya, R. Alejandro Sica, Ana Acuna-Villaorduna, Murali Janakiram, Urvi Shah, Juan Carlos Ramos, Tatsuhiro Shibata, Kengo Takeuchi, Akifumi Takaori-Kondo, Yasushi Miyazaki, Masao Matsuoka, Kenji Ishitsuka, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, B. Hilda Ye, Kazuya Shimoda, Keisuke Kataoka
Journal: Blood
Blood (2022) 139 (7): 967–982.
https://doi.org/10.1182/blood.2021013568
Published: 2022
Includes: Supplemental data
Journal Articles

CARD11 Mutation Induces Oligoclonal Expansion of T-Cells, and Accelerates ATL Development in Combination with HBZ

Free
Takuro Kameda, MD PhD, Kotaro Shide, MD PhD, Ayako Kamiunten, MD, Tahira Yuki, Masaaki Sekine, MD, Keiichi Akizuki, MD, Tomonori Hidaka, MD, Yoko Kubuki, MD PhD, Midori Sugiyama, Daisuke Morishita, PhD, Kazuya Shimoda, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 17–18.
https://doi.org/10.1182/blood-2020-142242
Published: 2020
Journal Articles

Preclinical Evaluation of a Novel MALT1 Inhibitor CTX-177 for Relapse/Refractory Lymphomas

Free
Daisuke Morishita, PhD, Akio Mizutani, PhD, Hirokazu Tozaki, PhD, Yasuyoshi Arikawa, PhD, Takuro Kameda, MD PhD, Ayako Kamiunten, MD, Keisuke Kataoka, MD PhD, Akinori Yoda, PhD, Yotaro Ochi, MD, Kotaro Shide, MD PhD, Koji Izutsu, MD PhD, Yosuke Minami, MDPhD, Kazuya Shimoda, MD PhD, Hiroshi Miyake, PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 3–4.
https://doi.org/10.1182/blood-2020-141824
Published: 2020
Journal Articles

Whole-Genome Analysis of Adult T-Cell Leukemia/Lymphoma

Free
Yasunori Kogure, MD PhD, Takuro Kameda, MD PhD, Junji Koya, PhD MD, Ayako Kamiunten, MD, Kotaro Shide, MD PhD, Tomonori Hidaka, MD, Yoko Kubuki, MD PhD, Makoto Yoshimitsu, MD PhD, Kisato Nosaka, MD PhD, Yoshitaka Imaizumi, MD PhD, Mizuki Watanabe, MD, Yuki Saito, MD, Marni B McClure, MD PhD, Mariko Tabata, MD, Sumito Shingaki, PhD MD, Kota Yoshifuji, MD, Yuichi Shiraishi, PhD, Michihiro Hidaka, MD PhD, Atae Utsunomiya, MD, Urvi A. Shah, MD, Ana Acuna-Villaorduna, MD, Aditi Shastri, MD, R. Alejandro Sica, MD, Murali Janakiram, MD, Juan Carlos Ramos, MD BS, Tatsuhiro Shibata, MD PhD, Akifumi Takaori-Kondo, MD PhD, Yasushi Miyazaki, MD PhD, Masao Matsuoka, MDPhD, Kenji Ishitsuka, MD PhD, Seishi Ogawa, MD PhD, B. Hilda Ye, PhD, Kazuya Shimoda, MD PhD, Keisuke Kataoka, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 29–30.
https://doi.org/10.1182/blood-2020-134360
Published: 2020