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Ting-lei Gu
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Journal Articles

Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth

Taro Hitosugi, PhD, Sumin Kang, PhD, Matthew Vander Heiden, MD/PhD, Tea-wook Chung, PhD, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, PhD, Sagar Lonial, MD, Xu Wang, PhD, Georgia Chen, PhD, Jianxin Xie, PhD, Ting-Lei Gu, PhD, Roberto Polakiewicz, PhD, Johannes L. Roesel, PhD, Titus Boggon, PhD, Fadlo Khuri, MD, D. Gary Gilliland, MD, PhD, Lewis Cantley, PhD, Jonathan L. Kaufman, MD, Jing Chen, PhD
Journal: Blood
Blood (2010) 116 (21): 3142.
https://doi.org/10.1182/blood.V116.21.3142.3142
Published: 2010
Journal Articles

Phosphoproteomic Analysis of Primary Acute Myeloid Leukemia Cells Reveals Redundant Roles for Src Family Kinases in AML Survival

Jamil K. Dierov, MD, PhD, DSc, Tae Kon Kim, Xiaowei Yang, Ph.D., Alexander Perl, MD, Beth A Burke, BS, Zhu Wang, Ting-Lei Gu, Alan M. Gewirtz, MD, Seth J. Corey, Roberto Polakiewicz, Ph.D., Martin Carroll, MD
Journal: Blood
Blood (2008) 112 (11): 2650.
https://doi.org/10.1182/blood.V112.11.2650.2650
Published: 2008
Journal Articles

FGFR3 Associates with and Tyrosine-Phosphorylates p90RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation

Sumin Kang, Shannon Elf, Shaozhong Dong, Taro Hitosugi, Ailan Guo, Hong Ruan, Sagar Lonial, Hanna Khoury, Ifor Williams, Gerard Karsenty, André Hanauer, Ting-Lei Gu, Jing Chen
Journal: Blood
Blood (2008) 112 (11): 3722.
https://doi.org/10.1182/blood.V112.11.3722.3722
Published: 2008
Journal Articles

Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells

Winnie F. Tam, Ting-Lei Gu, Jing Chen, Benjamin H. Lee, Lars Bullinger, Stefan Fröhling, Andrew Wang, Stefano Monti, Todd R. Golub, D. Gary Gilliland
Journal: Blood
Blood (2008) 112 (5): 1981–1992.
https://doi.org/10.1182/blood-2007-07-103010
Published: 2008
Includes: Supplemental data
Journal Articles

14–3-3 integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1–transformed hematopoietic cells

Shaozhong Dong, Sumin Kang, Ting-Lei Gu, Sean Kardar, Haian Fu, Sagar Lonial, Hanna Jean Khoury, Fadlo Khuri, Jing Chen
Journal: Blood
Blood (2007) 110 (1): 360–369.
https://doi.org/10.1182/blood-2006-12-065615
Published: 2007
Journal Articles

A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia

Ting-lei Gu, Thomas Mercher, Jeffrey W. Tyner, Valerie L. Goss, Denise K. Walters, Melanie G. Cornejo, Cynthia Reeves, Lana Popova, Kimberly Lee, Michael C. Heinrich, John Rush, Masanori Daibata, Isao Miyoshi, D. Gary Gilliland, Brian J. Druker, Roberto D. Polakiewicz
Journal: Blood
Blood (2007) 110 (1): 323–333.
https://doi.org/10.1182/blood-2006-10-052282
Published: 2007
Includes: Supplemental data
Journal Articles

Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia

Ting-Lei Gu, Valerie L. Goss, Cynthia Reeves, Lana Popova, Julie Nardone, Joan MacNeill, Denise K. Walters, Yi Wang, John Rush, Michael J. Comb, Brian J. Druker, Roberto D. Polakiewicz
Journal: Blood
Blood (2006) 108 (13): 4202–4204.
https://doi.org/10.1182/blood-2006-06-026666
Published: 2006
Includes: Supplemental data
Journal Articles

14-3-3 Integrates Pro-Survival Signals in Hematopoietic Cells Transformed by Diverse Leukemogenic Tyrosine Kinases, and Represents a Common Target.

Shaozhong Dong, PhD, Sumin Kang, PhD, Ting-lei Gu, PhD, Sean Kardar, Sagar Lonial, MD, H. Jean Khoury, MD, Fadlo Khuri, MD, Haian Fu, PhD, Jing Chen, PhD
Journal: Blood
Blood (2006) 108 (11): 1138.
https://doi.org/10.1182/blood.V108.11.1138.1138
Published: 2006
Journal Articles

FGFR3 Activates RSK2 To Mediate Hematopoietic Transformation through Both Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway.

Sumin Kang, PhD, Shaozhong Dong, PhD, Ting-lei Gu, PhD, Michael S. Cohen, Sagar Lonial, MD, H. Jean Khoury, PhD, D. Gary Gilliland, MD, PhD, Jack Taunton, PhD, Roberto D. Polakiewicz, PhD, Jing Chen, PhD
Journal: Blood
Blood (2006) 108 (11): 514.
https://doi.org/10.1182/blood.V108.11.514.514
Published: 2006
Journal Articles

JAK2 T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model

Thomas Mercher, Gerlinde Wernig, Sandra A. Moore, Ross L. Levine, Ting-Lei Gu, Stefan Fröhling, Dana Cullen, Roberto D. Polakiewicz, Olivier A. Bernard, Titus J. Boggon, Benjamin H. Lee, D. Gary Gilliland
Journal: Blood
Blood (2006) 108 (8): 2770–2779.
https://doi.org/10.1182/blood-2006-04-014712
Published: 2006
Includes: Supplemental data
Journal Articles

Oncogenic Tyrosine Kinases Regulate Proliferative and Survival Signals through Activation of Id1.

Ting-Lei Gu, M.D./Ph.D., Winnie F. Tam, Ph.D., Jing Chen, Ph.D., Benjamin H. Lee, M.D./Ph.D, Andrew Z. Wang, M.D., Michael R. Cooper, M.D., Stefano Monti, Ph.D., Todd Golub, M.D., Gary D. Gilliland, Ph.D./M.D.
Journal: Blood
Blood (2004) 104 (11): 417.
https://doi.org/10.1182/blood.V104.11.417.417
Published: 2004
Journal Articles

Biochemical and In Vivo Characterization of Amino Acid Substitutions in the Runx1 (AML1) Runt Domain Found in FPD/AML, AML M0, and Cleidocranial Dysplasia (CCD) Patients.

Christina J. Matheny, B.S., Takeshi Corpora, B.S., Maren E. Speck, B.A., Ting-Lei Gu, Ph.D., John H. Bushweller, Ph.D., Nancy A. Speck, Ph.D.
Journal: Blood
Blood (2004) 104 (11): 464.
https://doi.org/10.1182/blood.V104.11.464.464
Published: 2004
Journal Articles

NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a

Ting-Lei Gu, Zuzana Tothova, Blanca Scheijen, James D. Griffin, D. Gary Gilliland, David W. Sternberg
Journal: Blood
Blood (2004) 103 (12): 4622–4629.
https://doi.org/10.1182/blood-2003-03-0820
Published: 2004