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Jerald Noble
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Journal Articles

Nfkb signaling in idecabtagene vicleucel infusion product drives response in relapsed/refractory multiple myeloma

Free
Jerald Noble, Barbara Peixoto, Meghan Menges, Julieta Abraham Miranda, Constanza Savid-Frontera, Salvatore Corallo, Emily Merritt, Gabriel De Avila, Omar Alexis Castaneda Puglianini, Hien Liu, Melissa Alsina, Taiga Nishihori, Kenneth Shain, Ariosto Siqueira Silva, Rachid Baz, Brandon Blue, Ariel Grajales-Cruz, Doris Hansen, John Cleveland, Fabiana Perna, Conor Lynch, Jennifer Binning, Reginald Atkins, Frederick Locke, Ciara Louise Freeman
Journal: Blood
Blood (2025) 146 (Supplement 1): 504.
https://doi.org/10.1182/blood-2025-504
Published: 2025
Journal Articles

Real-time multimodal AI outperforms conventional scores for early risk prediction in BCMA CAR-T–Treated myeloma

Free
Ciara Louise Freeman, K. Ruwani M. Fernando, Yoganand Balagurunathan, Nicholas Figura, Gabriel De Avila, Daniel Deavila, Praneeth Reddy Sudalagunta, Ariosto Siqueira Silva, Omar Alexis Castaneda Puglianini, Hien Liu, Brandon Blue, Rachid Baz, Melissa Alsina, Taiga Nishihori, Rolf Tonseth, Meghan Menges, Luis Cuadrado Delgado, Salvatore Corallo, Jerald Noble, Rachel Howard, Ariel Grajales-Cruz, Frederick Locke, Doris Hansen, Issam El Naqa
Journal: Blood
Blood (2025) 146 (Supplement 1): 6140.
https://doi.org/10.1182/blood-2025-6140
Published: 2025
Journal Articles

Humanin-like 8 regulates metabolic fitness and anti-apoptotic programming in CD19 CAR-T cells

Free
Samira Naderinezhad, Jerald Noble, Constanza Savid-Frontera, Bin Fang, Meghan Menges, John Koomen, Reginald Atkins, Frederick Locke
Journal: Blood
Blood (2025) 146 (Supplement 1): 5906.
https://doi.org/10.1182/blood-2025-5906
Published: 2025
Journal Articles

Tumor burden quantified by soluble B-cell maturation antigen and metabolic tumor volume determines myeloma CAR-T outcomes

Available to Purchase
Ciara L. Freeman, Jerald Noble, Meghan Menges, Ricardo Villanueva, Justyn Y. Nakashima, Nicholas B. Figura, Rolf Petter Tonseth, Dietrich Werner Idiaquez, Lawrence Skelson, Eric Smith, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar A. Castaneda Puglianini, Hien Liu, Melissa Alsina, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Brandon Blue, Ariel Grajales-Cruz, John M. Koomen, Reginald M. Atkins, Doris K. Hansen, Ariosto S. Silva, Jongphil Kim, Yoganand Balagurunathan, Frederick L. Locke
Journal: Blood
Blood (2025) 145 (15): 1645–1657.
https://doi.org/10.1182/blood.2024024965
Published: 2025
Includes: Supplemental data
Journal Articles

Single-Cell Analysis of CAR-T Cell Products Idecabtagene Vicleucel and Ciltacabtagene Autoleucel Reveals Factors That Influence Clinical Outcomes

Free
Jerald Noble, Xiaofei Song, Meghan Menges, Julieta Abraham-Miranda, Salvatore Corallo, Gabriel De Avila, Omar Puglianini, Hien Liu, Melissa Alsina, Taiga Nishihori, Kenneth H. Shain, Rachid Baz, Brandon Blue, Ariel Grajales-Cruz, Doris K. Hansen, Reginald Atkins, Frederick L. Locke, Ciara Louise Freeman
Journal: Blood
Blood (2024) 144 (Supplement 1): 7173.
https://doi.org/10.1182/blood-2024-208709
Published: 2024
Journal Articles

Intrinsic Tumor Drivers and Immune Escape Mechanisms in CD19 CAR T-Cell Therapy Resistance for Aggressive Large B Cell Lymphoma

Free
Bachisio Ziccheddu, Michael D. Jain, Monika Chojnacka, Michael Durante, Venu Venkatarame Gowda Saralamma, Austin Daniel Newsam, Jerald Noble, Nicholas B Figura, Meghan Menges, Ola Landgren, Marco Davila, Jonathan H. Schatz, Francesco Maura, Frederick L. Locke
Journal: Blood
Blood (2024) 144 (Supplement 1): 232.
https://doi.org/10.1182/blood-2024-208372
Published: 2024
Journal Articles

Single Cell RNA Sequencing of Sequential Samples before and after BCMA-Directed CAR-T Reveal Features Associated with Non-Durable Response, Exhausted T-Cells and Decreased Expression of Genes Encoding Key Surface Targets in Particular in Patients with Extramedullary Disease

Free
Ciara Louise L. Freeman, Xiaohong Zhao, Mark B Meads, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Ariosto Siqueira Silva, Rachid Baz, Melissa Alsina, Doris K. Hansen, Xiaofei Song, Kenneth H. Shain
Journal: Blood
Blood (2023) 142 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2023-191013
Published: 2023
Journal Articles

Expression of Cell Surface Immunotherapy Targets across the Multiple Myeloma Disease Spectrum: Implications for Sequencing and Multi-Target Strategies

Free
Ciara Louise L. Freeman, Meghan Menges, Jerald Noble, Raghunandan Reddy Alugubelli, Rafael Renatino-Canevarolo, Oliver Hampton, Praneeth Reddy Sudalagunta, Salvatore Corallo, Ariosto Siqueira Silva, Mark B Meads, Rachid Baz, Melissa Alsina, Doris K. Hansen, Taiga Nishihori, Omar Castaneda, Brandon Blue, Ariel F. Grajales-Cruz, Yunfei Wang, Patrick Hwu, John Koomen, Kenneth H. Shain, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 4678.
https://doi.org/10.1182/blood-2023-185930
Published: 2023
Journal Articles

CD19 Intron Retention Is Mechanism of CAR-T Treatment Resistance in Non-Hodgkin Lymphoma

Free
Jerald Noble, Frederick L. Locke, Constanza Savid-Frontera, Michael D. Jain, Joel G. Turner, Julieta Abraham Miranda, Thushara W Madanayake, Samira Naderinezhad, Salvatore Corallo, Meghan Menges, Kayla Reid, Timothy J Robinson
Journal: Blood
Blood (2023) 142 (Supplement 1): 3506.
https://doi.org/10.1182/blood-2023-185074
Published: 2023
Journal Articles

Impact of Sarcopenia and Subsequent Muscle Loss on Post-CAR T-Cell Outcomes in Relapsed/Refractory Large B-Cell Lymphoma

Free
Khushali Jhaveri, Ram Thapa, Jerald Noble, Dalia Ercan, Pranit Singh, Johannes Fahrmann, Neeraj Y. Saini, Ranran Wu, Jennifer Dennison, Samir Hanash, Robert R. Jenq, Karnav Modi, Nicholas Figura, Julio C Chavez, Bijal D. Shah, Taiga Nishihori, Aleksandr Lazaryan, Farhad Khimani, Christina A Bachmeier, Kenneth Gage, Asmita Mishra, Fabiana Perna, Marco Davila, Kai Rejeski, Marion Subklewe, Frederick L. Locke, Ciara Louise L. Freeman, Nathan Parker, Michael D. Jain
Journal: Blood
Blood (2023) 142 (Supplement 1): 2130.
https://doi.org/10.1182/blood-2023-187294
Published: 2023
Journal Articles

Paired Analysis from Patients with Myeloma Elucidates Favorable CAR-T Manufacture and Phenotype, Starting from Mobilized Pre-Transplant Apheresis Vs. Non-Mobilized Apheresis after Four Prior Lines

Free
Ciara Louise L. Freeman, Julieta Abraham Miranda, Meghan Menges, Jerald Noble, Hien Liu, Salvatore Corallo, Albert J Ribickas, Constanza Savid-Frontera, Gabriel De Avila, Omar Castaneda, Jose L. Ochoa-Bayona, Rachid Baz, Doris K. Hansen, Melissa Alsina, Kenneth H. Shain, Taiga Nishihori, Reginald Atkins, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 1931.
https://doi.org/10.1182/blood-2023-187539
Published: 2023
Journal Articles

CAR-T Phenotype and Efficacy Is Impaired By Lymphoma-Associated CD39 + T Cells

Free
Michael D. Jain, Xiaoqing Yu, Reginald Atkins, Joel G. Turner, Jerald Noble, Meghan Menges, Kayla Reid, Salvatore Corallo, Ling Cen, Sean J. Yoder, Julieta Abraham Miranda, Samira Naderinezhad, Hien Liu, Bijal D. Shah, Julio C Chavez, Erin Dean, Johannes Fahrmann, Neeraj Y. Saini, Samir Hanash, Rebecca S. Hesterberg, Paulo C. Rodriguez, John L. Cleveland, Marco Davila, Xuefeng Wang, Frederick L. Locke
Journal: Blood
Blood (2023) 142 (Supplement 1): 3500.
https://doi.org/10.1182/blood-2023-178113
Published: 2023