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Soraya Kharboutli
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Journal Articles

Impact of bridging therapy on efficacy of CD19 CAR T cell therapy in diffuse-large B cell lymphoma: Histology and the choice of drug matter

Free
Julia Katharina Scholz, Evgenii Shumilov, Valeria Carobin, Viktoria Blumenberg, Jonas Wisskirchen, Sabine Seiffert, Philipp Nakov, Guranda Chitadze, Andreas Riedel, Nico Gagelmann, Tobias A.W. Holderried, Christian Schultze-Florey, Monika Fischer, Dennis Harrer, Kerstin Schaefer-Eckart, Soraya Kharboutli, Dimitrios Mougiakakos, Stefan Knop, Leo Hansmann, Peter Dreger, Christian Koenecke, Francis Ayuk, Wolfgang Bethge, Christiane Pott, Vladan Vucinic, Eva-Maria Wagner Drouet, Marion Subklewe, Georg Lenz, Simon Voelkl, Andreas Mackensen, Fabian Müller
Journal: Blood
Blood (2025) 146 (Supplement 1): 1949.
https://doi.org/10.1182/blood-2025-1949
Published: 2025
Journal Articles

Distinct inflammatory and immune recovery patterns after CD19-directed CAR T-cell therapy in SLE and B-cell lymphoma

Free
Nora Rebecca Schwingen, Fabian Müller, Melanie Hagen, Andreas Wirsching, Michael Aigner, Sascha Kretschmann, Soraya Kharboutli, Julia Scholz, Giulia Benintende, Jule Taubmann, Tobias Krickau, Nora Naumann-Bartsch, Heiko Bruns, Ricardo Grieshaber-Bouyer, Frederik Graw, Markus Metzler, Georg Schett, Andreas Mackensen, Simon Voelkl
Journal: Blood
Blood (2025) 146 (Supplement 1): 1947.
https://doi.org/10.1182/blood-2025-1947
Published: 2025
Journal Articles

Late re-expansion and high-level persistence of CAR T-cells can be driven by single CAR+ T-cell clones without clinically evident CAR+ T-cell lymphoma

Free
Fabian Müller, Nora Rebecca Schwingen, Anne Hartebrodt, Nicolai Meyerhoefer, Guranda Chitadze, Soraya Kharboutli, Heiko Bruns, Arif Ekici, Kerstin Schäfer-Eckart, Stefan Knop, Frederik Graw, David Blumenthal, Michael Rehli, Monika Brüggemann, Andreas Mackensen, Simon Voelkl
Journal: Blood
Blood (2025) 146 (Supplement 1): 4171.
https://doi.org/10.1182/blood-2025-4171
Published: 2025
Journal Articles

Safety and preliminary efficacy of anti-CD19 CAR T cells zorpocabtagene-autoleucel in systemic autoimmune diseases: Final analysis of the castle trial

Free
Fabian Müller, Melanie Hagen, Silvia Spoerl, Andreas Wirsching, Soraya Kharboutli, Sascha Kretschmann, Koray Tascilar, Jule Taubmann, Laura Bucci, Maria Raimondo, Christina Bergmann, Carlo Tur, Luis Muñoz, Ingrid Vasova, Armin Gerbitz, Bernd Spriewald, Diana Ginnarelli, Franco Locatelli, Maria-Antonietta D'Agostino, Linda Hanssen, Aline Bozec, Ricardo Grieshaber-Boyer, Stefan Miltenyi, Michael Aigner, Simon Voelkl, Georg Schett, Andreas Mackensen
Journal: Blood
Blood (2025) 146 (Supplement 1): 2380.
https://doi.org/10.1182/blood-2025-2380
Published: 2025
Journal Articles

Comparison of the safety profiles of CD19-targeting CAR T-cell therapy in patients with SLE and B-cell lymphoma

Available to Purchase
Brief Report
Fabian Müller, Nora Rebecca Schwingen, Melanie Hagen, Julia Katharina Scholz, Michael Aigner, Andreas Wirsching, Jule Taubmann, Sascha Kretschmann, Soraya Kharboutli, Tobias Krickau, Nora Naumann-Bartsch, Giulia Benintende, Silvia Spoerl, Tobias Rothe, Heiko Bruns, Ricardo Grieshaber-Bouyer, Markus Metzler, David B. Blumenthal, Frederik Graw, Georg Schett, Andreas Mackensen, Simon Völkl
Journal: Blood
Blood (2025) 146 (9): 1088–1095.
https://doi.org/10.1182/blood.2025028375
Published: 2025
Includes: Supplemental data
Journal Articles

Cilta-Cel Is Associated with Improved Outcomes and Distinct Cellular Dynamics Compared with Ide-Cel for Relapsed or Refractory Multiple Myeloma

Free
Nico Gagelmann, Friedrich Stölzel, Roland Fenk, Tobias A.W. Holderried, Fabian Mueller, Natalia Tovar, Aina Oliver-Caldés, Kristin Rathje, Vladan Vucinic, Soraya Kharboutli, Ben-Niklas Bärmann, Francis A. Ayuk, Uwe Platzbecker, Anca Maria Albici, Natalie Schub, Friederike Schmitz, Cyrus Khandanpour, Marcel Teichert, Barbara Jeker, Nicolaus Kroeger, Bastian von Tresckow, Carlos Fernandez de Larrea, Thomas Pabst, Maximilian Merz
Journal: Blood
Blood (2024) 144 (Supplement 1): 2003.
https://doi.org/10.1182/blood-2024-211410
Published: 2024
Journal Articles

Distinct Safety and Toxicity Profile of CD19-Directed CAR T-Cell Therapy in Systemic Lupus Erythematosus Versus B-Cell Lymphoma - a Single-Center Experience

Free
Nora Rebecca Schwingen, Fabian Mueller, Julia Katharina Scholz, Michael Aigner, Melanie Hagen, Andreas Wirsching, Jule Taubmann, Sascha Kretschmann, Soraya Kharboutli, Tobias Krickau, Nora Naumann-Bartsch, Giulia Benintende, Silvia Spoerl, Ingrid Vasova, Tobias Rothe, Heiko Bruns, Ricardo Grieshaber-Bouyer, Frederik Graw, Markus Metzler, Georg Schett, Andreas Mackensen, Simon Voelkl
Journal: Blood
Blood (2024) 144 (Supplement 1): 4835.
https://doi.org/10.1182/blood-2024-207051
Published: 2024
Journal Articles

Update on Monocentric CD19-CAR T-Cell Therapy in 30 Patients with Autoimmune Disease

Free
Fabian Mueller, Melanie Hagen, Andreas Wirsching, Soraya Kharboutli, Silvia Spoerl, Carlo Tur, Tobias Krickau, Laura Bucci, Christina Bergmann, Janina Auth, Panayiotis Garantziotis, Sebastian Boeltz, Sascha Kretschmann, Ingrid Vasova, Dimitrios Mougiakakos, Michael Aigner, Ricardo Grieshaber-Bouyer, Markus Metzler, Simon Voelkl, Georg Schett, Andreas Mackensen
Journal: Blood
Blood (2024) 144 (Supplement 1): 684.
https://doi.org/10.1182/blood-2024-206163
Published: 2024
Journal Articles

Impact of Sex on Clinical Outcomes after CD19 CAR T-Cell Therapy for Large B-Cell Lymphoma: Response and Survival Are Significantly Superior in Female Compared to Male Patients

Free
Veit L. Buecklein, Kai Rejeski, Ariel Perez, Gloria Iacoboni, Vindi Jurinovic, Soraya Kharboutli, Viktoria Blumenberg, Josephine Ackermann, Lisa Frölich, Grace Johnson, Kedar Patel, Brian Arciola, Rahul Mhaskar, Christian Schmidt, Anthony Wood, Eva Hoster, Andreas Mackensen, Frederick L. Locke, Michael von Bergwelt-Baildon, Fabian Mueller, Pere Barba, Michael D. Jain, Marion Subklewe
Journal: Blood
Blood (2023) 142 (Supplement 1): 3787.
https://doi.org/10.1182/blood-2023-186510
Published: 2023
Journal Articles

CD19-Targeted CAR-T Cells in Refractory Systemic Autoimmune Diseases: A Monocentric Experience from the First Fifteen Patients

Free
Fabian Mueller, Jule Taubmann, Simon Voelkl, Laura Bucci, Christina Bergmann, Michael Aigner, Artur Wilhelm, Tobias Rothe, Ioanna Minopoulou, Johannes Knitza, Soraya Kharboutli, Silvia Spoerl, Ingrid Vasova, Dagmar Werner, Hannah Reimann, Sascha Kretschmann, Dimitrios Mougiakakos, Gerhard Krönke, Georg Schett, Andreas Mackensen
Journal: Blood
Blood (2023) 142 (Supplement 1): 220.
https://doi.org/10.1182/blood-2023-180547
Published: 2023
Journal Articles

CAR-T Cell Therapy in Patients with Refractory Systemic Autoimmune Diseases Exhibits Less Inflammation, Toxicities and Different Cellular Dynamics Compared to Patients with B Cell Lymphoma

Free
Fabian Mueller, Nora Rebecca Schwingen, Lena Stabel, Michael Aigner, Jule Taubmann, Sascha Kretschmann, Hannah Reimann, Gloria Lutzny-Geier, Michael Schletter, Nina Eisenhauer, Soraya Kharboutli, Artur Wilhelm, Tobias Rothe, Dagmar Werner, Julio Vera Gonzalez, Ioanna Minopoulou, Christina Bergmann, Heiko Bruns, Gerhard Krönke, Frederik Graw, Georg Schett, Andreas Mackensen, Simon Voelkl
Journal: Blood
Blood (2023) 142 (Supplement 1): 6871.
https://doi.org/10.1182/blood-2023-188830
Published: 2023
Journal Articles

CD19-Targeted CAR-T Cells in Refractory Systemic Lupus Erythematosus: Safety, Efficacy, and Mechanistic Insights from the First Five Patients

Free
Fabian Mueller, Simon Voelkl, Dimitrios Mougiakakos, Sebastian Boeltz, Michael Aigner, Regina Gary, Sascha Kretschmann, Soraya Kharboutli, Arnd Kleyer, David Simon, Wolf Rösler, Katharina M. Habenicht, Thomas H. Winkler, Gerhard Krönke, Georg Schett, Andreas Mackensen
Journal: Blood
Blood (2022) 140 (Supplement 1): 4562–4563.
https://doi.org/10.1182/blood-2022-165077
Published: 2022
Journal Articles

Inferior Outcomes of EU Vs. US Patients with Relapsed/Refractory Large B-Cell Lymphoma after CD19 CAR T-Cell Therapy Are Associated with Differences in Tumor Burden, Systemic Inflammation, Bridging Therapy Utilization and CAR-T Product Selection

Free
Veit L Buecklein, Ariel Perez-Perez, Kai Rejeski, Gloria Iacoboni, Vindi Jurinovic, Udo Holtick, Olaf Penack, Soraya Kharboutli, Viktoria Blumenberg, Josephine Ackermann, Lisa Frölich, Grace Johnson, Kedar Patel, Brian Arciola, Christian Schmidt, Omar Albanyan, Philipp Gödel, Eva Hoster, Lars Bullinger, Andreas Mackensen, Frederick L. Locke, Michael von Bergwelt, Pere Barba, Michael D. Jain, Marion Subklewe
Journal: Blood
Blood (2022) 140 (Supplement 1): 2411–2413.
https://doi.org/10.1182/blood-2022-165452
Published: 2022