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Ana Alfonso Pierola
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Journal Articles

The Transcriptional Impact of 5q Deletion in MDS at Single Cell Resolution

Aintzane Diaz-Mazkiaran, Guillermo Serrano, Nerea Berastegui, Paula Garcia-Olloqui, Sofia Huerga, Ana Alfonso Pierola, Asier Ullate-Agote, Beñat Ariceta, Marina Ainciburu, Amaia Vilas-Zornoza, Patxi San-Martin, Paula Aguirre-Ruiz, Jose Maria Lamo De Espinosa, Pamela Acha, Oriol Calvete, Tamara Jimenez, Antonieta Molero, Julia Montoro, Maria Diez-Campelo, David Valcarcel, Francesc Sole, Idoia Ochoa, Teresa Ezponda, Felipe Prosper, Mikel Hernaez
Journal: Blood
Blood (2023) 142 (Supplement 1): 1850.
https://doi.org/10.1182/blood-2023-186173
Published: 2023
Journal Articles

Bone Marrow Cytokines Concentrations in Myelodysplastic Neoplasms: Its Correlation with the Immune Populations and Clonal Hematopoiesis

Antonieta Molero Yordi, Soraya Peralta Garzón, Laura Gallur, Barbara Tazon, Daniel Medina, Victor Navarro Garces, Maria Julia Montoro, Silvia Saumell, Tamara Jimenez, Félix López Cadenas, Teresa Ezponda, Ana Alfonso Pierola, Felipe Prosper, Maria Diez-Campelo, Olga Salamero, Ana Pérez González, Sara Garrido Paniagua, David Valcarcel
Journal: Blood
Blood (2023) 142 (Supplement 1): 6457.
https://doi.org/10.1182/blood-2023-185616
Published: 2023
Journal Articles

Prevalence, Dynamics and Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in Newly Diagnosed Cancer Patients

Ana Pérez González, Clàudia Pellín Jou, Laura Palomo, Victor Navarro Garces, Oriol Calvete, Esther Zamora, Nadia Saoudí Gonzalez, Lorena Fariñas-Madrid, Juan David Assaf, María Eugenia Rivero, Antonieta Molero Yordi, Olga Salamero, Andres Jerez, Sara Garrido Paniagua, Maria Sola, Sandra Novoa Jáuregui, Moraima Jiménez, Francisco Beas, Francesc Sole, Maria Diez-Campelo, Ana Alfonso Pierola, Francesc Bosch, Julia Montoro, David Valcarcel Ferreiras
Journal: Blood
Blood (2023) 142 (Supplement 1): 5593.
https://doi.org/10.1182/blood-2023-189503
Published: 2023
Journal Articles

Sequential Scmultiomics of In Vivo CAR-T Cells Allows Characterization of Transcriptional Differences between Patients, and Identifies IL10 As a Potential Mechanism of Resistance to CAR-T Cells in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 3433.
https://doi.org/10.1182/blood-2023-182887
Published: 2023
Journal Articles

A First-in-Human Phase 1 Study of the Menin-KMT2A (MLL1) Inhibitor JNJ-75276617 in Adult Patients with Relapsed/Refractory Acute Leukemia Harboring KMT2A or NPM1 Alterations

Elias Jabbour, Emma Searle, Maher Abdul-Hay, Sameem Abedin, Ibrahim Aldoss, Ana Alfonso Piérola, Juan Manuel Alonso-Dominguez, Patrice Chevallier, Carrye Cost, Nikki Daskalakis, Richard Dillon, Neil Dunavin, Jordi Esteve, Amir T. Fathi, Pasquale L. Fedele, Lucille Ferrante, Sylvain Garciaz, Christina Guttke, Emmanuel Gyan, Brett Hiebert, Min Chul Kwon, Jonathan Miller, Teng Fong Ng, Kathryn Packman, Ulrike Philippar, Arnaud Pigneux, Christian Recher, Olga Salamero, Madhu Sanga, Richard M Stone, Peter Tan, Jan Willem Thuring, Trevor Tucker, Paresh Vyas
Journal: Blood
Blood (2023) 142 (Supplement 1): 57.
https://doi.org/10.1182/blood-2023-172422
Published: 2023
Journal Articles

Longitudinal Transcriptomic Analysis of CAR-T Cells at Single-Cell Level Allows the Identification of Molecular Mechanisms Promoting Long-Term CAR-T Cell Persistence in MM

Juan Roberto Rodriguez-Madoz, Lorea Jordana-Urriza, Guillermo Serrano, Aina Oliver-Caldes, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabanas Perianes, Juan Luis Reguera, Almudena Navarro-Bailon, Marta Español-Rego, Mariona Pascal, Jose Maria Moraleda, Jose A. Perez-Simon, Maria Victoria Mateos, Fermin Sanchez-Guijo Martin, Alvaro Urbano-Ispizua, Manel Juan, Ana Alfonso Pierola, Jose J. Rifon, Paula Rodriguez Otero, Bruno Paiva, Susana Inogés, Ascensión López-Díaz De Cerio, Juan J Lasarte, Jesús San Miguel, Carlos Fernández de Larrea, Mikel Hernaez, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 2069.
https://doi.org/10.1182/blood-2023-182933
Published: 2023
Journal Articles

Trial in Progress: An Open Label Phase I/II, Multicenter Study Evaluating Safety, Pharmacokinetics and Efficacy of S65487, a BCL-2 Inhibitor Combined with Azacitidine in Adults with Previously Untreated Acute Myeloid Leukemia Ineligible for Intensive Treatment

Ana Alfonso Pierola, Stephane De Botton, Jun Ho Jang, Victoria Campbell, Jenny O'Nions, Maria Calbacho, Annette L. Ervin-Haynes, Kristen Keagle, Aline Maillard, Maud Beneton, Mathilde Romagnoli, Alberto Broniscer
Journal: Blood
Blood (2023) 142 (Supplement 1): 1555.
https://doi.org/10.1182/blood-2023-180795
Published: 2023
Journal Articles

Multiomics Characterization of Normal CD34+ Hematopoietic Progenitor Cells (HPC) and Blasts in the Bone Marrow (BM) and Peripheral Blood (PB) of Patients with Acute Myeloid Leukemia (AML)

Catia Simoes, Carmen Gonzalez, Leire Burgos, Sarai Sarvide, Diego Alignani, Aitziber Lopez, Ivan Quispe, Jose A. Pérez-Simón, María García-Fortes, Teresa Bernal Del Castillo, Mercedes Colorado, Teresa Olave, Ana Alfonso Pierola, Felipe Prosper, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2023) 142 (Supplement 1): 2951.
https://doi.org/10.1182/blood-2023-185760
Published: 2023
Journal Articles

Preliminary Results of Nathali-01: A First-in-Human Phase I/IIa Study of UCART20x22, a Dual Allogeneic CAR-T Cell Product Targeting CD20 and CD22, in Relapsed or Refractory (R/R) Non-Hodgkin Lymphoma (NHL)

Jeremy S. Abramson, Aravind Ramakrishnan, Ana Alfonso Pierola, Ira Braunschweig, Guillaume Cartron, Catherine Thieblemont, Jose A. Pérez-Simón, Pere Barba, Peter A. Riedell, Carlos Solano, Thomas Gastinne, Alexandra LaCroce, Denise Thomas, Camille Poirot, Sarah Meadows, Kathryn J. Newhall, Daniel J. Lee, Mark G. Frattini, Emmanuel Bachy
Journal: Blood
Blood (2023) 142 (Supplement 1): 2110.
https://doi.org/10.1182/blood-2023-186570
Published: 2023
Journal Articles

Optimization of a Universal Allogeneic CAR-T Cells Combining CRISPR and Transposon-Based Technologies for Treatment of Acute Myeloid Leukemia

Candela Ceballos Bolaños, Cristina Calviño, Ana Alfonso Pierola, Patricia Jauregui, Maria Erendira Calleja-Cervantes, Patxi San-Martin, Paula Rodríguez Márquez, Ángel Martin Mallo, Elena Iglesias, Gloria Abizanda, Saray Rodríguez Diaz, Rebeca Martínez Turrillas, Jorge Illarramendi Esteban, Ana Margarita Redondo, MC Viguria-Alegría, Carlos Panizo, Jose J. Rifon, Sara Villar, Juan J Lasarte, Susana Inogés, Ascensión López-Díaz De Cerio, Mikel Hernaez, Felipe Prosper, Juan Roberto Rodriguez-Madoz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3457.
https://doi.org/10.1182/blood-2023-189410
Published: 2023
Journal Articles

Minimal Residual Disease Detection By Single Cell DNA Sequencing Technology: A Feasible Approach for Clinical Application and Identification of the Landscape of MRD Clones

Ana Alfonso Pierola, Beñat Ariceta, Amaia Vilas-Zornoza, Paula Aguirre-Ruiz, Sarai Sarvide, Patxi San-Martin, Maria-Antonia Fortuño, Catia Simoes, Leire Burgos, Maria Jose Larrayoz, Carmen Chillon, Olga Arce, Teresa Bernal Del Castillo, Mercedes Colorado, Laida Cuevas Palomares, Inmaculada Marchante, Maria Carmen Mateos, Mayte Olave, Jose A. Pérez-Simón, Maria Jose Calasanz, Ramon Garcia-Sanz, Bruno Paiva, Pau Montesinos, Felipe Prosper
Journal: Blood
Blood (2023) 142 (Supplement 1): 2958.
https://doi.org/10.1182/blood-2023-188865
Published: 2023
Journal Articles

Intravenous and Subcutaneous Administration of RG6234, a Novel GPRC5DxCD3 T-Cell Engaging Bispecific Antibody, Is Highly Active in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Biomarker Results from a Phase I Study

Iryna Dekhtiarenko, Iva Lelios, Jan Attig, Nassim Sleiman, Domenico Lazzaro, Emilie Schindler, Jan Eckmann, Pablo Umana, Wolfgang Jacob, Meike Schneider, Carmelo Carlo-Stella, Rita Mazza, Salomon Manier, Thierry Facon, Sung-Soo Yoon, Youngil Koh, Simon J Harrison, Jeremy Er, Antonio Pinto, Francesco Volzone, Giulia Perrone, Paolo Corradini, Titouan Cazaubiel, Cyrille Hulin, Cyrille Touzeau, Philippe Moreau, Enrique M. Ocio, Carmen Maria Montes Gaisan, Rakesh Popat, Sarah Leong, Fritz Offner, Paula Rodriguez Otero, Ana Alfonso-Pierola, Martin Hutchings, Caroline Hasselbalch Riley, Ann-Marie E Bröske
Journal: Blood
Blood (2022) 140 (Supplement 1): 10137–10139.
https://doi.org/10.1182/blood-2022-158146
Published: 2022
Journal Articles

Identification of Molecular Mechanisms Governing CAR-T Cell Response in MM Patients Using Single Cell Transcriptomics

Lorea Jordana-Urriza, Guillermo Serrano, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Asier Ullate-Agote, Aintzane Zabaleta, Diego Alignani, Teresa Lozano, Valentin Cabañas, Almudena Navarro-Bailón, Aina Oliver-Caldes, Marta Español-Rego, Mariona Pascal, Manel Juan, Álvaro Urbano-Ispizua, Juan Luis Reguera, Jose Maria Moraleda, Maria-Victoria Mateos, Fermin Sanchez-Guijo, Ana Alfonso Pierola, José J. Rifón Roca, Paula Rodríguez-Otero, Carlos Fernandez de Larrea, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Juan Jose Lasarte, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Mikel Hernáez, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 7366–7368.
https://doi.org/10.1182/blood-2022-163082
Published: 2022
Journal Articles

CTX110 Allogeneic CRISPR-Cas9-Engineered CAR T Cells in Patients (Pts) with Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL): Results from the Phase 1 Dose Escalation Carbon Study

Joseph P. McGuirk, Constantine S. Tam, Nicolaus Kröger, Peter A. Riedell, Hemant S. Murthy, Phoebe Joy Ho, Joseph E. Maakaron, Edmund K. Waller, Farrukh T. Awan, Paul J. Shaughnessy, Armin Ghobadi, Michael R. Bishop, Ana Alfonso-Pierola, Michael Dickinson, Praveen Ramakrishnan Geethakumari, Ainsley Ross, William Stevens, Huansheng Xu, Anna Ma, Sarah Beaussant Cohen, Richard T. Maziarz, Carlos Bachier
Journal: Blood
Blood (2022) 140 (Supplement 1): 10303–10306.
https://doi.org/10.1182/blood-2022-166432
Published: 2022
Journal Articles

11 c-Methionine PET/CT in Assessment of Multiple Myeloma Patients: Comparison to 18 f-FDG PET/CT and Prognostic Value Evaluation

María Isabel Morales-Lozano, María Marcos Jubilar, Lidia Sancho Rodriguez, Ana Alfonso-Pierola, Jorge M Nuñez-Cordoba, Elena Prieto Azcárate, Luis Esteban Tamariz-Amador, Juan J Rosales Castillo, Maria Luisa Palacios-Berraquero, Fernando Guillen Valderrama, Andrea Manubens Guarch, Angela Bronte Viedma, Sofía Huerga Domínguez, Victoria Betech Antar, Maria Panizo Inogés, Felipe Prosper, Ramon Lecumberri, Jesús San-Miguel, Paula Rodríguez Otero, María José García Velloso
Journal: Blood
Blood (2022) 140 (Supplement 1): 7170–7171.
https://doi.org/10.1182/blood-2022-169473
Published: 2022
Journal Articles

Characterization of Transcriptional Alterations Leading to Aberrant Myeloid Differentiation in Myelodysplastic Syndromes

Aintzane Diaz-Mazkiaran, Jesús De la Fuente, Guillermo Serrano, Paula Garcia-Olloqui, Nerea Berastegui, Marina Ainciburu, Ana Alfonso Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Jose Maria Lamo De Espinosa, Mikel San Julián, Pamela Acha, Francesc Solé, Tamara Jimenez, Félix López Cadenas, Maria Diez-Campelo, Antonieta Molero, Maria Julia Montoro, David Valcarcel, Teresa Ezponda, Mikel Hernáez, Felipe Prosper
Journal: Blood
Blood (2022) 140 (Supplement 1): 5852–5854.
https://doi.org/10.1182/blood-2022-166921
Published: 2022
Journal Articles

RG6234, a GPRC5DxCD3 T-Cell Engaging Bispecific Antibody, Is Highly Active in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM): Updated Intravenous (IV) and First Subcutaneous (SC) Results from a Phase I Dose-Escalation Study

Carmelo Carlo-Stella, Rita Mazza, Salomon Manier, Thierry Facon, Sung-Soo Yoon, Youngil Koh, Simon J Harrison, Jeremy Er, Antonio Pinto, Francesco Volzone, Giulia Perrone, Paolo Corradini, Titouan Cazaubiel, Cyrille Hulin, Cyrille Touzeau, Philippe Moreau, Enrique M. Ocio, Carmen Maria Montes Gaisan, Rakesh Popat, Sarah Leong, Fritz Offner, Paula Rodriguez Otero, Ana Alfonso-Pierola, Ann-Marie E Bröske, Iryna Dekhtiarenko, Hans-Joachim Helms, Sara Belli, Eva Rossmann, Tanja Fauti, Jan Eckmann, Tom Moore, Meike Schneider, Wolfgang Jacob, Martin Weisser, Martin Hutchings, Caroline Hasselbalch Riley
Journal: Blood
Blood (2022) 140 (Supplement 1): 397–399.
https://doi.org/10.1182/blood-2022-157988
Published: 2022
Journal Articles

Transcriptional and Genomic Characterization of Measurable Residual Disease (MRD) Cells in Acute Myeloid Leukemia (AML)

Catia Patricia Simoes, Sara Villar, Beñat Ariceta, Juan-José Garcés, Leire Burgos, Diego Alignani, Sarvide Sarai, David Martinez-Cuadron, Juan Miguel Bergua Burgués, Susana Vives, Lorenzo Algarra, Mar Tormo, Pilar Martinez Sanchez, Josefina Serrano, Pilar Herrera, Fernando Ramos, Olga Salamero, Esperanza Lavilla, Cristina Gil, Jose Luiz Lopez Lorenzo, María Belén Vidriales, María Carmen Chillón Santos, Jorge Labrador, José F. Falantes, Maria Jose Sayas, Rosa Ayala, Joaquín Martínez-López, Ana Alfonso-Pierola, María José Calasanz, Felipe Prosper, Jesús San-Miguel, Miguel A. Sanz, Pau Montesinos, Bruno Paiva
Journal: Blood
Blood (2022) 140 (Supplement 1): 2270–2272.
https://doi.org/10.1182/blood-2022-163159
Published: 2022
Journal Articles

BCMA CAR-T Cell Phenotype and Functionality Is Affected By Disease Stage of Multiple Myeloma Patients

Angel Martin-Mallo, Maria Erendira Calleja-Cervantes, Patxi San Martin-Uriz, Amaia Vilas-Zornoza, Aintzane Zabaleta, Diego Alignani, Paula Rodríguez-Márquez, Saray Rodríguez-Diaz, Rebeca Martínez-Turrillas, Patricia Jauregui, Cristina Calviño, Maria Luisa Palacios-Berraquero, Candela Ceballos, Jorge Illarramendi Esteban, Diana Gisell Gabaldon Limas, Maria Cruz Viguria, Ana Margarita Redondo, Manel Juan, Álvaro Urbano-Ispizua, Carlos Fernandez de Larrea, Paula Rodríguez-Otero, Jose J. Rifon Roca, Ana Alfonso Pierola, Teresa Lozano, Juan Jose Lasarte, Bruno Paiva, Susana Inogés, Ascensión López-Diaz de Cerio, Jesús San-Miguel, Juan Roberto Rodriguez-Madoz, Felipe Prósper
Journal: Blood
Blood (2022) 140 (Supplement 1): 12708–12710.
https://doi.org/10.1182/blood-2022-163149
Published: 2022
Journal Articles

Bone Marrow Microenvironment Changes in Myelodysplastic Neoplasms and Its Relationship with Clonal Hematopoiesis and Disease Progression

Antonieta Molero Yordi, Soraya Peralta, Laura Gallur, Bárbara Tazón, Víctor Navarro Garcés, Silvia Saumell, Maria Julia Montoro, Olga Salamero, Ana Pérez González, Sara Garrido, Maria Sola, Tamara Jimenez, Félix López Cadenas, Teresa Ezponda, Ana Alfonso-Pierola, Lídia Altimiras, Maria Diez-Campelo, Felipe Prosper, David Valcárcel
Journal: Blood
Blood (2022) 140 (Supplement 1): 4024–4025.
https://doi.org/10.1182/blood-2022-163188
Published: 2022