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Robert Chiesa
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Journal Articles

CD19/CD22 targeting with cotransduced CAR T cells to prevent antigen-negative relapse after CAR T-cell therapy for B-cell ALL

Clinical Trials & Observations Brief Report
Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Aleks Guvenel, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-Yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Rebecca Thomas, Christopher Connor, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Allan Hackshaw, Evangelia Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Denise Bonney, Robert Wynn, Martin Pule, Rachael Hough, Persis J. Amrolia
Journal: Blood
Blood (2024) 143 (2): 118–123.
https://doi.org/10.1182/blood.2023020621
Published: 2024
Includes: Supplemental data
Journal Articles

A Single Centre Cohort Study of Monitoring B Cell Populations in the Bone Marrow and Peripheral Blood Post Tisagenlecleucel Therapy of Relapsed/Refractory Acute Lymphoblastic Leukaemia

Sneha Fernandes, Archana Rauthan, Macarena Oporto Epuelas, Katherine Berry, Saskia Burridge, Charlotte Twigdon-Williams, Christopher Connor, Mark Davis, Kimberly Gilmour, Rebecca Thomas, Phil Ancliff, Jack Bartram, Robert Chiesa, Giovanna Lucchini, Vesna Pavasovic, Anupama Rao, Kanchan Rao, Sujith Samarasinghe, Juliana Silva, Ajay Vora, Persis Amrolia, Sara Ghorashian
Journal: Blood
Blood (2023) 142 (Supplement 1): 3508.
https://doi.org/10.1182/blood-2023-182730
Published: 2023
Journal Articles

Tvt CAR7: Phase 1 Clinical Trial of Base-Edited "Universal” CAR7 T Cells for Paediatric Relapsed/Refractory T-ALL

Robert Chiesa, Christos Georgiadis, Giorgio Ottaviano, Farhatullah Syed, Toni Braybrook, Annie Etuk, Hong Zhan, Soragia Athina Gkazi, Roland Preece, Stuart Adams, Rebecca Thomas, Arnold Awuah, Kimberly Gilmour, Lana Mhaldien, Jan Chu, Danielle Pinner, Agnieszka Kubat, Paul Veys, Kanchan Rao, Giovanna Lucchini, David O'Connor, Ajay Vora, Waseem Qasim
Journal: Blood
Blood (2022) 140 (Supplement 1): 4579–4580.
https://doi.org/10.1182/blood-2022-169114
Published: 2022
Journal Articles

Dual Antigen Targeting with Co-Transduced CD19/22 CAR T Cells May Prevent Antigen-Negative Relapse after CAR T Cell Therapy for Relapsed/Refractory ALL

Sara Ghorashian, Giovanna Lucchini, Rachel Richardson, Kyvi Nguyen, Craig Terris, Macarena Oporto-Espuelas, Jenny Yeung, Danielle Pinner, Jan Chu, Lindsey Williams, Ka-yuk Ko, Chloe Walding, Kelly Watts, Sarah Inglott, Stuart Adams, Emma Gravett, Kimberly Gilmour, Alka Lal, Sangeetha Kunaseelan, Bilyana Popova, Andre Lopes, Yenting Ngai, Evangelia K Kokalaki, Milena Balasch Carulla, Khushnuma Mullanfiroze, Arina Lazareva, Vesna Pavasovic, Anupama Rao, Jack Bartram, Ajay Vora, Robert Chiesa, Juliana Silva, Kanchan Rao, Katherine Clesham, Denise Bonney, Robert F Wynn, Martin Pule, Rachael E Hough, Persis J Amrolia
Journal: Blood
Blood (2022) 140 (Supplement 1): 10352–10354.
https://doi.org/10.1182/blood-2022-164879
Published: 2022
Journal Articles

Hematopoietic stem cell transplantation for Wiskott-Aldrich syndrome: an EBMT Inborn Errors Working Party analysis

Clinical Trials & Observations
Michael H. Albert, Mary A. Slatter, Andrew R. Gennery, Tayfun Güngör, Katerina Bakunina, Benyamin Markovitch, Sheree Hazelaar, Tiarlan Sirait, Virginie Courteille, Alessandro Aiuti, Olga V. Aleinikova, Dmitry Balashov, Maria Ester Bernardo, Ivana Bodova, Benedicte Bruno, Marina Cavazzana, Robert Chiesa, Alain Fischer, Fabian Hauck, Marianne Ifversen, Krzysztof Kałwak, Christoph Klein, Alexander Kulagin, Alphan Kupesiz, Baris Kuskonmaz, Caroline A. Lindemans, Franco Locatelli, Su Han Lum, Alexey Maschan, Roland Meisel, Despina Moshous, Fulvio Porta, Martin G. Sauer, Petr Sedlacek, Ansgar Schulz, Felipe Suarez, Tanja C. Vallée, Jacek H. Winiarski, Marco Zecca, Bénédicte Neven, Paul Veys, Arjan C. Lankester
Journal: Blood
Blood (2022) 139 (13): 2066–2079.
https://doi.org/10.1182/blood.2021014687
Published: 2022
Includes: Supplemental data
Journal Articles

Outcomes of Children and Young Adults with Acute Lymphoblastic Leukaemia Administered Inotuzumab Pre CAR-T Therapy

Khushnuma Mullanfiroze, Giorgio Ottaviano, Avijeet K Mishra, Maria Gabelli, Arina Lazareva, Saskia Burridge, Susan Farish, Jan Chu, Kirsty Sharplin, David I. Marks, Maeve A O'Reilly, Emma Nicholson, Kelly Watts, Denise Bonney, Danny Cheng, Jack Bartram, Sujith Samarasinghe, Vesna Pavasovic, Anupama Rao, Philip Ancliffe, Ajay Vora, Giovanna Lucchini, Robert Chiesa, Paul Veys, Kanchan Rao, Persis J Amrolia, Sara Ghorashian
Journal: Blood
Blood (2021) 138 (Supplement 1): 1743.
https://doi.org/10.1182/blood-2021-148820
Published: 2021
Journal Articles

ALL Maintenance Treatment for Early Loss of B-Cell Aplasia after Tisagenlecleucel Therapy

Maria Gabelli, Macarena Oporto Espuelas, Denise Bonney, Saskia Burridge, Susan Farish, Khushnuma Mullanfiroze, Arina Lazareva, Sujith Samarasinghe, Philip Ancliffe, Ajay Vora, Jack Bartram, Emma Hedges, Kirsty Ware, Lindsey Young, Chiara Cugno, Lenka Chenchara, Juliana Silva, Oana Mirci-Danicar, Lynne Riley, Vesna Pavasovic, Anupama Rao, Paul Veys, Giovanna Lucchini, Robert Chiesa, Kanchan Rao, Persis J Amrolia, Sara Ghorashian
Journal: Blood
Blood (2021) 138 (Supplement 1): 3859.
https://doi.org/10.1182/blood-2021-152344
Published: 2021
Journal Articles

Hematopoietic cell transplantation in chronic granulomatous disease: a study of 712 children and adults

Robert Chiesa, Junfeng Wang, Henric-Jan Blok, Sheree Hazelaar, Benedicte Neven, Despina Moshous, Ansgar Schulz, Manfred Hoenig, Fabian Hauck, Amal Al Seraihy, Jolanta Gozdzik, Per Ljungman, Caroline A. Lindemans, Juliana F. Fernandes, Krzysztof Kalwak, Brigitte Strahm, Urs Schanz, Petr Sedlacek, Karl-Walter Sykora, Serap Aksoylar, Franco Locatelli, Polina Stepensky, Robert Wynn, Su Han Lum, Marco Zecca, Fulvio Porta, Mervi Taskinen, Brenda Gibson, Susanne Matthes, Musa Karakukcu, Mathias Hauri-Hohl, Paul Veys, Andrew R. Gennery, Giovanna Lucchini, Matthias Felber, Michael H. Albert, Dmitry Balashov, Arjan Lankester, Tayfun Güngör, Mary A. Slatter
Journal: Blood
Blood (2020) 136 (10): 1201–1211.
https://doi.org/10.1182/blood.2020005590
Published: 2020
Includes: Supplemental data
Journal Articles

Therapy of Paediatric B-ALL with a Fast Off Rate CD19 CAR Leads to Enhanced Expansion and Prolonged CAR T Cell Persistence in Patients with Low Bone Marrow Tumour Burden, and Is Associated with a Favourable Toxicity Profile

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Shimobi Onuoha, PhD, Gary Wright, Jack Luke Bartram, MD, Rachel Richardson, MSc, Sarah J Albon, MSc, Joan Casanovas Company, Fernanda Castro, Bilyana Popova, Krystal Villanueva, Jenny Yeung, Aleks Guvenel, PhD, Patrycja Wawrzyniecka, Danielle Pinner, Jan Chu, Giovanna Lucchini, Juliana Silva, MD, Oana Ciocarlie, Arina Lazareva, Sarah Inglott, Kimberly Gilmour, Gulrukh Ahsan, Kim Champion, Andre Lopes, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Denise Bonney, Sujith Samarasinghe, Nicholas John Goulden, MD PhD MRCPath, Ajay Vora, Paul Veys, MD PhD, Rachael E Hough, MD, Robert Wynn, Martin Pule, MD, Persis J Amrolia, FRCP, FRCPath, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 225.
https://doi.org/10.1182/blood-2019-125009
Published: 2019
Journal Articles

Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy Targeting CD19 and CD22, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael E Hough, MD, Ajay Vora, Denise Bonney, Paul Veys, MD PhD, Robert Chiesa, Kanchan Rao, Liz Clark, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, MD, Vijay G R Peddareddigari
Journal: Blood
Blood (2019) 134 (Supplement_1): 2620.
https://doi.org/10.1182/blood-2019-123424
Published: 2019
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adults with Chronic Granulomatous Disease (CGD): A Study of the Inborn Errors Working Party (IEWP) of the EBMT

Robert Chiesa, Junfeng Wang, Henric-Jan Blok, Benedicte Neven, MD, Despina Moshous, MD, Ansgar Schulz, MD, Manfred Hoenig, MD, Michael H. Albert, MD, Fabian Hauck, MD, Amal Al-Seraihy, MD, Jolanta Gozdzik, MD PhD, Per Ljungman, MD PhD, Caroline A. Lindemans, MD, Krzysztof Kalwak, MD, Brigitte Strahm, PD Dr., Urs Schanz, MD, Petr Sedlacek, MD, Karl-Walter Sykora, MD, Serap Aksoylar, MD, Franco Locatelli, Polina Stepensky, MD, Robert Wynn, MD, Su Han Lum, MD, Marco Zecca, MD, Paul Veys, MD PhD, Andrew Gennery, MD, Matthias Felber, MD, Arjan Lankester, MD PhD, Tayfun Guengoer, MD, Mary Slatter, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 970.
https://doi.org/10.1182/blood-2018-99-114841
Published: 2018
Journal Articles

Simultaneous Targeting of CD19 and CD22: Phase I Study of AUTO3, a Bicistronic Chimeric Antigen Receptor (CAR) T-Cell Therapy, in Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia (r/r B-ALL): Amelia Study

Persis J Amrolia, FRCP, FRCPath, PhD, Robert Wynn, MD, Rachael Hough, MD BMBS, FRCP, FRCPath, Ajay Vora, MD, Denise Bonney, Paul Veys, MD PhD, Kanchan Rao, Robert Chiesa, Muhammad Al-Hajj, Shaun P Cordoba, PhD, Shimobi Onuoha, PhD, Ekaterini Kotsopoulou, Nushmia Z Khokhar, Martin Pule, PhD, Vijay G R Peddareddigari
Journal: Blood
Blood (2018) 132 (Supplement 1): 279.
https://doi.org/10.1182/blood-2018-99-118616
Published: 2018
Journal Articles

Busulfan/Fludarabine- or Treosulfan/Fludarabine-Based Conditioning Regimen in Patients with Wiskott-Aldrich Syndrome Given Allogeneic Hematopoietic Cell Transplantation — an EBMT Inborn Errors Working Party and Scetide Retrospective Analysis

Michael H. Albert, MD, Mary Slatter, MD, Andrew Gennery, MD, Tayfun Guengoer, MD, Henric-Jan Blok, Junfeng Wang, Virginie Courteille, Maria Ester Bernardo, MD, Ivana Bodova, MD, Benedicte Bruno, MD, Tatjana A Bykova, MD PhD, Robert Chiesa, Alain Fischer, MD PhD, Renata Formankova, MD, Krzysztof Kalwak, MD, Christoph Klein, MD PhD, Svetlana Kozlovskaya, MD, O. Alphan Kupesiz, MD, Franco Locatelli, Nizar Mahlaoui, MD, Despina Moshous, MD, Benedicte Neven, MD, Fulvio Porta, MD, Ansgar Schulz, MD, Karl-Walter Sykora, MD, Ekrem Unal, MD, Jacek H. Winiarski, MD PhD, Marco Zecca, MD, Paul Veys, MD PhD, Arjan Lankester, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2175.
https://doi.org/10.1182/blood-2018-99-112394
Published: 2018
Journal Articles

Treatment dilemmas in asymptomatic children with primary hemophagocytic lymphohistiocytosis

Giovanna Lucchini, Rebecca Marsh, Kimberly Gilmour, Austen Worth, Zohreh Nademi, Anupama Rao, Claire Booth, Persis Amrolia, Juliana Silva, Robert Chiesa, Robert Wynn, Kai Lehmberg, Itziar Astigarraga, Tayfun Güngör, Jan Stary, Despina Moshous, Marianne Ifversen, Daniel Zinn, Michael Jordan, Ashish Kumar, Takahiro Yasumi, Paul Veys, Kanchan Rao
Journal: Blood
Blood (2018) 132 (19): 2088–2096.
https://doi.org/10.1182/blood-2018-01-827485
Published: 2018
Includes: Supplemental data
Journal Articles

Treatment Dilemmas in Asymptomatic Children with Primary Haemophagocytic Lymphohistiocytosis

Giovanna Lucchini, MD, Rebecca A Marsh, Kimberly Gilmour, Austen Worth, Anupama Rao, Claire Booth, Persis J Amrolia, Juliana Silva, MD, Robert Chiesa, Robert Wynn, MD, Kai Lehmberg, Itziar Astigarraga, Tayfun Guengoer, Jan Stary, Despina Moshous, Marianne Ifversen, Stephan Ehl, Daniel Zinn, MD, Paul Veys, MD PhD, Kanchan Rao
Journal: Blood
Blood (2017) 130 (Supplement 1): 3564.
https://doi.org/10.1182/blood.V130.Suppl_1.3564.3564
Published: 2017
Journal Articles

Preliminary Results of UCART19, an Allogeneic Anti-CD19 CAR T-Cell Product in a First-in-Human Trial (PALL) in Pediatric Patients with CD19+ Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia

Waseem Qasim, MD PhD, Oana Ciocarlie, Stuart Adams, PhD, Sarah Inglott, Claire Murphy, Christine Rivat, Gary Wright, Giovanna Lucchini, MD, Juliana Silva, MD, Kanchan Rao, Amina Zinaï, MD, Florence Binlich, MD, Sandra Dupouy, Pharm.D, PhD, Jeanne Pauly, PharmD, Svetlana Balandraud, MD, Frédéric Dubois, Cyril Konto, MD, Premal Patel, MD PhD BSPharm, Robert Chiesa, Sujith Samarasinghe, Havinder Hara, Alayna Boyle, Jan Chu, Danielle Pinner, Persis J Amrolia, Ajay Vora, MD, Anupama Rao, Philip Ancliffe, MD, Paul Veys, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1271.
https://doi.org/10.1182/blood.V130.Suppl_1.1271.1271
Published: 2017
Journal Articles

A Novel Low Affinity CD19CAR Results in Durable Disease Remissions and Prolonged CAR T Cell Persistence without Severe CRS or Neurotoxicity in Patients with Paediatric ALL

Sara Ghorashian, FRCPath, PhD, Anne Marijn Kramer, MD, Sarah Jayne Albon, BSc, MSc, Gary Wright, Fernanda Castro, Bilyana Popova, Joan Casanovas Company, Catherine Irving, Winston Vetharoy, Rachel Richardson, Danielle Pinner, Jan Chu, Giovanna Lucchini, MD, Juliana Silva, MD, Oana Ciocarlie, Sarah Inglott, Kim Champion, Allan Hackshaw, Farzin Farzaneh, PhD, Robert Chiesa, Kanchan Rao, Anupama Gopala Rao, MB, MRCP, MRCPath, Philip Ancliffe, MD, Sujith Samarasinghe, Ajay Vora, MD, Paul Veys, MD PhD, Rachael Hough, MD BMBS, FRCP, FRCPath, Robert Wynn, MD, Martin Pule, PhD, Persis J Amrolia
Journal: Blood
Blood (2017) 130 (Supplement 1): 806.
https://doi.org/10.1182/blood.V130.Suppl_1.806.806
Published: 2017
Journal Articles

Stem cell transplantation for tetratricopeptide repeat domain 7A deficiency: long-term follow-up

Clinical Trials & Observations
Jochen Kammermeier, Giovanna Lucchini, Sung-Yun Pai, Austen Worth, Dyanne Rampling, Persis Amrolia, Juliana Silva, Robert Chiesa, Kanchan Rao, Gabriele Noble-Jamieson, Marco Gasparetto, Drew Ellershaw, Holm Uhlig, Neil Sebire, Mamoun Elawad, Luigi Notarangelo, Neil Shah, Paul Veys
Journal: Blood
Blood (2016) 128 (9): 1306–1308.
https://doi.org/10.1182/blood-2016-01-696385
Published: 2016
Includes: Supplemental data
Journal Articles

First Clinical Application of Talen Engineered Universal CAR19 T Cells in B-ALL

Waseem Qasim, MBBS PhD, Persis Jal Amrolia, Sujith Samarasinghe, MD PhD, Sara Ghorashian, MD PhD FRCPath, Hong Zhan, PhD, Sian Stafford, PhD, Katie Butler, PhD, Gul Ahsan, Kimberly Gilmour, Stuart Adams, PhD, Danielle Pinner, Robert Chiesa, Steve Chatters, PhD, Sue Swift, PhD, Nicholas Goulden, MD PhD, Karl Peggs, MBBChir, MRCP, FRCPath, Adrian J Thrasher, MD PhD, Paul Veys, Martin Pule, PhD
Journal: Blood
Blood (2015) 126 (23): 2046.
https://doi.org/10.1182/blood.V126.23.2046.2046
Published: 2015
Journal Articles

The Best of Both? Megadose Stem Cells with CD34 Selection and T-Cell Addback Enables Engraftment from Mismatched Unrelated Donors Using Reduced Toxicity Conditioning in Primary Immunodeficiency

Juliana Montibeller Silva, MD, Kanchan Rao, MNAMS (Paed), MRCP (Paed), Robert Chiesa, Stuart Adams, PhD, Margaret Brocklesby, Gulrukh Ahsan, Giovanna Lucchini, Paul Veys, Persis Jal Amrolia, Nicholas Goulden, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4303.
https://doi.org/10.1182/blood.V126.23.4303.4303
Published: 2015