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Journal Articles

Differentiation Scoring (DS) Derived from Cellworks Computational Omics Biology Model (CBM) Predicts Response to Hypomethylating Agents (HMA) and Patient Survival in Myelodysplastic Syndrome (MDS)

Michael Castro, Shahabuddin Usmani, Ansu Kumar, Jyoti Chauhan, Shweta Kapoor, Swati Khandelwal, Vivek Patil, Subrat Mohapatra, Anuj Tyagi, Mohammed Sauban, Prashant Ramachandran Nair, Vijayashree P. Shyamasundar, Neha Dutta, Upasana Mitra, Neha Gupta, Nagendra Prasad, Ashish Kumar Agrawal, Ashokraja Balla, Rakhi Purushothaman Suseela, Veena Balakrishnan, Kishore Promod, Sanjana Patel, Michele Dundas Macpherson, James Wingrove, Scott C. Howard, Guido Marcucci
Journal: Blood
Blood (2022) 140 (Supplement 1): 4970–4971.
https://doi.org/10.1182/blood-2022-166284
Published: 2022
Journal Articles

Demographics and Outcomes of Multiple Myeloma Patients Undergoing Modern Modality Treatments Proceeding to ASCT: A Retrospective Study

Shubham Adroja, Arslan Babar, Muhammad Ali, Gauranga Mahalwar, Taeyeong Ko, Ashish Kumar, Tapas Ranjan Behera, Doaa Attia, Fatima Babar, Faiz Anwer
Journal: Blood
Blood (2021) 138 (Supplement 1): 4743.
https://doi.org/10.1182/blood-2021-154070
Published: 2021
Journal Articles

Therapy Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Is Predictive of Individual Acute Myeloid Leukemia (AML) Patient Probability of Clinical Response (CR) and Overall Survival (OS): Mycare-023

Scott C Howard, Drew Watson, Michael Castro, Shweta Kapoor, Prashant Ramachandran Nair, Samiksha Avinash Prasad, Swaminathan Rajagopalan, Aftab Alam, Kunal Ghosh Roy, Diwyanshu Sahu, Deepak Anil Lala, Kabya Basu, Yashaswini S Ullal, Yugandhara Narvekar, Adity Ghosh, Mohammed Sauban, Poornachandra G, Ashish Kumar Agrawal, Anuj Tyagi, Rakhi Purushothaman Suseela, Karthik Sundara Raju, Anusha Pampana, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 689.
https://doi.org/10.1182/blood-2021-154023
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Genomic and Molecular Markers for Decitabine (DAC) Plus Valproic-Acid (VPA) Treatment Response in Patients with Myelodysplastic Syndromes (MDS)

Michael Castro, Ansu Kumar, Himanshu Grover, Vivek Patil, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Samiksha Avinash Prasad, Kabya Basu, Rakhi Purushothaman Suseela, Chandan Kumar, Prashant Ramachandran Nair, Pallavi Kumari, Anusha Pampana, Yashaswini S Ullal, Humera Azam, Nagendra Prasad, Anish Raju R Amara, Diwyanshu Sahu, Nithya T Raveendaran, Archana Palillam Veedu, Nirjhar Mundkur, Sanjana Patel, James Christie, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 2615.
https://doi.org/10.1182/blood-2021-153220
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Predicted Novel Biomarkers for Hyper-CVAD (CVAD) Treatment Response and Combination of Rituximab and Cladribine (RC) in CVAD Resistant Cases of Mantle Cell Lymphoma (MCL)

Guido Marcucci, Ansu Kumar, Michael Castro, Swati Khandelwal, Subrat Mohapatra, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Kabya Basu, Vijayashree P Shyamasundar, Deepak Anil Lala, Karthik Sundara Raju, Naga Ganesh Palaniyeppa, Yashaswini S Ullal, Vishwas Joseph, Liptimayee Behura, Diwyanshu Sahu, Annapoorna Prakash, Upasana Mitra, Ashokraja Balla, Mamatha Patil, Jharana Mohanty, Sanjana Patel, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3550.
https://doi.org/10.1182/blood-2021-152423
Published: 2021
Journal Articles

Recommendations for the management of hemophagocytic lymphohistiocytosis in adults

Clinical Trials & Observations
Paul La Rosée, AnnaCarin Horne, Melissa Hines, Tatiana von Bahr Greenwood, Rafal Machowicz, Nancy Berliner, Sebastian Birndt, Juana Gil-Herrera, Michael Girschikofsky, Michael B. Jordan, Ashish Kumar, Jan A. M. van Laar, Gunnar Lachmann, Kim E. Nichols, Athimalaipet V. Ramanan, Yini Wang, Zhao Wang, Gritta Janka, Jan-Inge Henter
Journal: Blood
Blood (2019) 133 (23): 2465–2477.
https://doi.org/10.1182/blood.2018894618
Published: 2019
Journal Articles

Predicting Response to BET Inhibitor in Combination with Palbociclib / Sorafenib Using a Computational Model and Its Validation: A Beat AML Project Study

Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Stephen E Kurtz, PhD, Cristina E. Tognon, PhD, Leylah M. Drusbosky, PhD, Robinson Vidva, B.Tech, Yugandhara Narvekar, M.Sc., Ashish Kumar Agrawal, B.V.Sc, A.H., Saji Gera, M.Tech, Samiksha Avinash Prasad, M.Sc., Vijayashree P Shyamasundar, M.Sc., Gaurav Singh Tunwer, M.Sc., Taher Abbasi, MS, MBA, Shireen Vali, PhD, Christopher R. Cogle, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1540.
https://doi.org/10.1182/blood-2018-99-115284
Published: 2018
Journal Articles

Treatment dilemmas in asymptomatic children with primary hemophagocytic lymphohistiocytosis

Giovanna Lucchini, Rebecca Marsh, Kimberly Gilmour, Austen Worth, Zohreh Nademi, Anupama Rao, Claire Booth, Persis Amrolia, Juliana Silva, Robert Chiesa, Robert Wynn, Kai Lehmberg, Itziar Astigarraga, Tayfun Güngör, Jan Stary, Despina Moshous, Marianne Ifversen, Daniel Zinn, Michael Jordan, Ashish Kumar, Takahiro Yasumi, Paul Veys, Kanchan Rao
Journal: Blood
Blood (2018) 132 (19): 2088–2096.
https://doi.org/10.1182/blood-2018-01-827485
Published: 2018
Includes: Supplemental data
Journal Articles

Predicting Response to BET Inhibitors Using a Computational Model and Its Validation: A Beat AML Project Study

Leylah M. Drusbosky, PhD, Robinson Vidva, BT, Saji Gera, MT, Anjanasree V. Lakshminarayana, BE, Vijayashree P. Shyamasundar, MS, Ashish Kumar Agrawal, BS, Anay Talawdekar, MT, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Cristina E. Tognon, PhD, Stephen E Kurtz, PhD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD, Christopher R. Cogle, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3908.
https://doi.org/10.1182/blood.V130.Suppl_1.3908.3908
Published: 2017
Journal Articles

BRAF-V600E in Peripheral Mononuclear Cells and Microglia-like Brain Cells Suggest Hematopoietic Origin of Langerhans Cell Histiocytosis-Associated Neurodegeneration

Daniel Zinn, MD, Jennifer Picarsic, Rikhia Chakraborty, PhD BSc, MSc, Howard Lin, Harshal Abhyankar, MS, Brooks Scull, Albert Shih, Karen Phaik Har Lim, Olive S. Eckstein, MD, Tricia L. Peters, MD, Walter Olea, Thomas Burke, Nabil Ahmed, MD, John Hicks, Brandon Tran, Jeremy Jones, Robert Dauser, Michael R. Jeng, MD, Robert A Baiocchi, MD PhD, Deborah E. Schiff, MD, Stanton Goldman, MD, Kenneth Matthew Heym, MD, Harry Wilson, Benjamin Carcamo, Ashish Kumar, MBBS, Carlos Rodriguez-Galindo, MD, Nicholas Whipple, Patrick Campbell, MD PhD, Geoffrey Murdoch, Simon Heales, Marian Malone, Randy Woltjer, Joseph Quinn, Paul Orchard, MD, Michael Kruer, Ronald Jaffe, Markus G Manz, MD, Sergio Lira, Donald Will Parsons, MD PhD, Miriam Merad, MD, Tsz-kwong Man, Kenneth L. McClain, MD PhD, Carl E. Allen, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2930.
https://doi.org/10.1182/blood.V130.Suppl_1.2930.2930
Published: 2017
Journal Articles

Hypercalcaemia at Diagnosis Is an Independent Predictor of Poor Survival in Diffuse Large B-Cell Lymphoma

Michael P Gilbertson, MBBS,FRACP,FRCPA, Maciej Tatarczuch, BMBS, FRACP, FRCPA, Ashish Kumar Panigrahi, MBBS, Samuel Robinson, David Wong, PhD, Pasquale L. Fedele, FRACP, FRCPA, Gareth Gregory, MBBS,PhDFRACP,FRCPA, George Grigoriadis, MBBS PhDFRACP FRCPA, Michael S. Low, MBBS, Sushrut S. Patil, FRACP, FRCPA, Sumita Ratnasingham, FRACP, FRCPA, Jake Shortt, MBBS PhDFRACP FRCPA, Fathima Shahla Vilcassim, MBBS, FRACP, FRCPA, Jonathan Wong, MBBS, Sophie Lee, FRACP, FRCPA, PhD, Duncan P. Carradice, MBBS, FRCPA, FRACP, William E. P. Renwick, MBBS, FRACP, FRCPA, Stephen Opat, FRACP, FRCPA
Journal: Blood
Blood (2017) 130 (Supplement 1): 1568.
https://doi.org/10.1182/blood.V130.Suppl_1.1568.1568
Published: 2017
Journal Articles

Early Monoclonal Para Protein Reduction and Response in Multiple Myeloma (EMPEROR study)

Ashish Kumar Panigrahi, MBBS, William E. P. Renwick, MBBS, FRACP, FRCPA, Duncan P. Carradice, MBBS, FRCPA, FRACP, PhD, Andrew Lim, MBBS, FRACP, FRCPA, Eleni Hatzis, MBBS
Journal: Blood
Blood (2016) 128 (22): 5707.
https://doi.org/10.1182/blood.V128.22.5707.5707
Published: 2016
Journal Articles

Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche.

Bijender Kumar, PhD, Mayra Garcia, PhD, Lihong Weng, Xiaoman Lewis, Jodi Murakami, Xingbin Hu, Tinisha McDonald, B.S., David DiGiusto, PhD, Ashish Kumar, MBBS, PhD, Ravi Bhatia, MD, Ching-Cheng Chen, PhD
Journal: Blood
Blood (2014) 124 (21): 352.
https://doi.org/10.1182/blood.V124.21.352.352
Published: 2014
Journal Articles

Leukemia-Derived Exosomes Reorganize Bone Marrow Microenvironment In AML

Bijender Kumar, Ph.D., Lihong Weng, Xiaoman Lewis, Jodi Murakami, Xingbin Hu, Tinisha McDonald, Ashish Kumar, MBBS, PhD, David DiGiusto, Ph.D., Ravi Bhatia, MD, Ching-Cheng Cheng Chen, Ph.D.
Journal: Blood
Blood (2013) 122 (21): 2455.
https://doi.org/10.1182/blood.V122.21.2455.2455
Published: 2013
Journal Articles

PU.1 Is Essential For MLL Leukemia Via Activation Of The Meis/HOX Pathway and A Monocytic Cytokine Mediated Anti-Apoptotic Inflammatory Program

Jing Zhou, Jun Wu, Bo Li, Dan Liu, Jian Yu, Xiaomei Yan, Si Zheng, Jiguang Wang, Lixia Zhang, Lin Zhang, Fuhong He, Qiang Li, Aili Chen, Yue Zhang, MD,, Xinghui Zhao, Yinghui Guan, Xiaohong Zhao, Jin Yan, Jun Ni, Marcelo Nobrega, Bob Löwenberg, MD, PhD, Ruud Delwel, Peter J. Valk, PhD, Ashish Kumar, MBBS, PhD, Xie Lu, Daniel G. Tenen, MD, Gang Huang, PhD, Qian-fei Wang, Ph.D
Journal: Blood
Blood (2013) 122 (21): 1276.
https://doi.org/10.1182/blood.V122.21.1276.1276
Published: 2013
Journal Articles

Genetic Models Demonstrate a Requirement of MEIS1 in Survival of MLL-AF9 Leukemia

Jayeeta Roychoudhury, PhD, Jason P Clark, M.S, Kevin A. Link, PhD, Gang Huang, James C. Mulloy, PhD, Ashish Kumar, MBBS, PhD
Journal: Blood
Blood (2012) 120 (21): 120.
https://doi.org/10.1182/blood.V120.21.120.120
Published: 2012
Journal Articles

MEIS1 Is Required for the Maintenance of Long Term Hematopoietic Stem Cells Wherein It Regulates Quiescence

Zeenath Unnisa, PhD, Jason P Clark, Elizabeth Wojtowicz, Lino Tessarollo, Ph.D., Neal G. Copeland, Nancy A Jenkins, Ashish Kumar, MBBS, PhD
Journal: Blood
Blood (2011) 118 (21): 551.
https://doi.org/10.1182/blood.V118.21.551.551
Published: 2011
Journal Articles

Rac GTPase Survival Signaling Through Anti-Apoptotic Bcl-2 Proteins Reveals a Target for Combination Therapy in MLL-AF9 Acute Myeloid Leukemia

Benjamin Mizukawa, MD, Mahesh Shrestha, MS, Mark Wunderlich, MS, Fu-Sheng Chou, MD, PhD, Andrea Griesinger, BS, Ashish Kumar, MBBS, PhD, Yi Zheng, PhD, David A. Williams, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2011) 118 (21): 1536.
https://doi.org/10.1182/blood.V118.21.1536.1536
Published: 2011
Journal Articles

Allogeneic Hematopoietic Cell Transplantation (Allo-HCT) for Treatment of Pediatric Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (ALL).

Michael Burke, MD, Barb Trotz, BA, BSN, MSN, Qing Cao, MS, Brenda Weigel, MSc, MD, Ashish Kumar, MBBS, PhD, Angela Smith, MD, MS, Michael Verneris, MD
Journal: Blood
Blood (2009) 114 (22): 3377.
https://doi.org/10.1182/blood.V114.22.3377.3377
Published: 2009
Journal Articles

Toll-Like Receptor-7 Agonist Directly Inhibits the Growth and Induces Apoptosis of MLL-AF9 Leukemia Cells in Vitro and in Vivo

Xueqing Liang, MD, PhD, Ashish Kumar, MBBS, PhD, Zhimei Wang, MD, Brenda Weigel, MSc, MD, Bruce R Blazar, M.D., Wei Chen, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 2989.
https://doi.org/10.1182/blood.V112.11.2989.2989
Published: 2008