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Journal Articles

Preclinical Study of DZD8586, a Non-Covalent LYN/BTK Dual Inhibitor with Excellent BBB Penetration, for the Treatment of B-Cell Non-Hodgkin Lymphoma (B-NHL)

Yu Bai, Ting Wu, Minghui Hu, Sufang Han, Yu Liu, Jie Zheng, Junjun Qin, Lin Zhang, Zhenfan Yang

Blood (2023) 142 (Supplement 1): 2822.

https://doi.org/10.1182/blood-2023-185156

Published: 2023

Journal Articles

Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis

Qidi Chen, Min Xin, Lingjun Wang, Lin Li, Yingzhi Shen, Yan Geng, Haojie Jiang, Yang Wang, Lin Zhang, Yanyan Xu, Yu Hou, Junling Liu, Xuemei Fan

Blood (2022) 139 (19): 2958–2971.

https://doi.org/10.1182/blood.2022015620

Published: 2022

Includes: Supplemental data

Journal Articles

ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells

Shuo Yang, Xiao-Na Zhu, Hui-Lin Zhang, Qian Yang, Yu-Sheng Wei, Di Zhu, Meng-Di Liu, Shao-Ming Shen, Li Xia, Ping He, Meng-Kai Ge, Yi-Lian Pan, Meng Zhao, Ying-Li Wu, Jun-Ke Zheng, Guo-Qiang Chen, Yun Yu

Blood (2021) 138 (24): 2485–2498.

https://doi.org/10.1182/blood.2020010400

Published: 2021

Includes: Supplemental data

Journal Articles

Identification of Chemo-Resistant Residual Cell Population in Pediatric AML of Complete Remission By Single Cell RNA Sequencing

Shuting Jiang, Fuhong He, PhD, Li Gao, MD, Aili Chen, PhD, Yixin Hu, MD, Liyan Fan, MD, Lin Zhang, MS, Yongping Zhang, Haiyang Hu, Dan Liu, MS, Zihan Zhou, Yanxun Su, Lei Qin, Jun Lu, MD, Peifang Xiao, MD, Raul Ribeiro, MD, Shaoyan Hu, MD PhD, Qian-fei Wang, PhD

Blood (2020) 136 (Supplement 1): 25–26.

https://doi.org/10.1182/blood-2020-141139

Published: 2020

Journal Articles

Chimeric Antigen Receptor T Cell Therapy in the Relapsed or Refractory Multiple Myeloma with Extramedullary Disease--a Single Institution Observation in China

Baiyan Wang, MD PhD, Jie Liu, MD, Wan-Hong Zhao, MD PhD, Yin-Xia Chen, MD, Xing-Mei Cao, MD, Yun Yang, MD, Yi-Lin Zhang, MD, Fang-Xia Wang, MD PhD, Peng-Yu Zhang, MD PhD, Bo Lei, MD, Liu-Fang Gu, MD PhD, Jian-Li Wang, MD PhD, Frank Xiao-Hu Fan, MD PhD, Wang-Gang Zhang, MD PhD, Ai-Li He, MD PhD

Blood (2020) 136 (Supplement 1): 6.

https://doi.org/10.1182/blood-2020-140243

Published: 2020

Journal Articles

The role of AGK in thrombocytopoiesis and possible therapeutic strategies

Haojie Jiang, Zhuo Yu, Nan Ding, Mina Yang, Lin Zhang, Xuemei Fan, Yuan Zhou, Qiang Zou, Jian Hou, Junke Zheng, Lei Zhang, Yanyan Xu, Junling Liu

Blood (2020) 136 (1): 119–129.

https://doi.org/10.1182/blood.2019003851

Published: 2020

Includes: Supplemental data

Journal Articles

Long-Term Follow-up of a Phase 1, First-in-Human Open-Label Study of LCAR-B38M, a Structurally Differentiated Chimeric Antigen Receptor T (CAR-T) Cell Therapy Targeting B-Cell Maturation Antigen (BCMA), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)

Blood (2019) 134 (Supplement_1): 579.

https://doi.org/10.1182/blood-2019-124953

Published: 2019

Journal Articles

Efficacy and Adverse Reactions of Gemcitabine Combined with Cyclophosphamide, Vinblastine and Prednisone Hydrogenation Regiments in Relapse and/or Refractory Non-Hodgkin's Lymphoma

Baiyan Wang, MD PhD, Jie Liu, MD, Yin-Xia Chen, MD, Xing-Mei Cao, MD, Wan-Hong Zhao, MD PhD, Jian-Li Wang, MD PhD, Xiao-Rong Ma, MD PhD, Yun Yang, MD, Peng-Yu Zhang, MD PhD, Fang-Xia Wang, MD PhD, Liu-Fang Gu, MD PhD, Bo Lei, MD, Jin Wang, MD PhD, Ju Bai, PhD, Yi-Lin Zhang, MD, Yan Xu, Ai-Li He, MD PhD, Wang-Gang Zhang, MD PhD

Blood (2018) 132 (Supplement 1): 5393.

https://doi.org/10.1182/blood-2018-99-116600

Published: 2018

Journal Articles

Updated Analysis of a Phase 1, Open-Label Study of LCAR-B38M, a Chimeric Antigen Receptor T Cell Therapy Directed Against B-Cell Maturation Antigen, in Patients with Relapsed/Refractory Multiple Myeloma

Blood (2018) 132 (Supplement 1): 955.

https://doi.org/10.1182/blood-2018-99-110548

Published: 2018

Journal Articles

Early Enrichment and Subsequent Dysfunction of Marrow ILC Subsets in Monoclonal Gammopathy: Target for IMiD Therapy

Jithendra Kini Bailur, PhD, Sameet Mehta, PhD, Lin Zhang, Natalia Neparidze, MD, Terri L Parker, MD, Noffar Bar, MD, Tara Anderson, PA, Mina Xu, MD, Kavita Dhodapkar, MBBS, Madhav V Dhodapkar, MBBS

Blood (2017) 130 (Supplement 1): 4370.

https://doi.org/10.1182/blood.V130.Suppl_1.4370.4370

Published: 2017

Journal Articles

Two Dose Series of High-Dose Influenza Vaccine Is Associated with Longer Duration of Serologic Immunity in Patients with Plasma Cell Disorders

Andrew Branagan, MD, Eamon Duffy, Connor Foster, Rakesh Verma, PhD, Lin Zhang, PhD, Geliang Gan, PhD, Fangyong Li, PhD, Madhav V Dhodapkar, MBBS

Blood (2017) 130 (Supplement 1): 438.

https://doi.org/10.1182/blood.V130.Suppl_1.438.438

Published: 2017

Journal Articles

In Vivo CRISPR/Cas9-Targeted Genome Editing Recovers Factor IX Expression Restoring Haemostasis in a Mouse Model

Qiang Wang, MD, Lin Zhang, PhD, Zhu Chen, PhD, Sai-Juan Chen, PhD

Blood (2017) 130 (Supplement 1): 5562.

https://doi.org/10.1182/blood.V130.Suppl_1.5562.5562

Published: 2017

Journal Articles

Lower Rates of Influenza Infection Following Two Dose Series of High Dose Vaccination in Plasma Cell Disorders: Results of a Randomized, Double-Blind, Placebo-Assisted Clinical Trial

Andrew R Branagan, MD, Eamon Duffy, Terri L Parker, MD, Stuart Seropian, MD, Connor Foster, Lin Zhang, Rakesh Verma, PhD(MDcal Oncology), MBA, MS, BCA, BS, Daniel Zelterman, PhD, Geliang Gan, PhD, Debra S. Brandt, DO, Jeremy Kortmansky, David H Witt, MD, Thomas M Ferencz, RPh, Madhav V Dhodapkar, MD

Blood (2016) 128 (22): 2139.

https://doi.org/10.1182/blood.V128.22.2139.2139

Published: 2016

Journal Articles

Identification of a First in Class GSK3-Alpha Selective Inhibitor As a New Differentiation Therapy for AML

Lina Benajiba, Florence Wagner, PhD, Linda Ross, PhD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Jennifer Gale, Jen Pan, PhD, Yan-Lin Zhang, PhD, Joshua Sacher, PhD, Michel Weiwer, PhD, Richard M. Stone, MD, Edward Holson, PhD, Kimberly Stegmaier, MD

Blood (2015) 126 (23): 870.

https://doi.org/10.1182/blood.V126.23.870.870

Published: 2015

Journal Articles

Identification of a Cereblon-Independent Protein Degradation Pathway in Residual Myeloma Cells Treated with Immunomodulatory Drugs

Rakesh Verma, PhD, Zifeng Mai, MS, Mina Xu, MD, Lin Zhang, Kavita Dhodapkar, MBBS, Madhav V Dhodapkar, MD

Blood (2015) 126 (23): 913.

https://doi.org/10.1182/blood.V126.23.913.913

Published: 2015

Journal Articles

Fluzone® High-Dose Influenza Vaccine with a Booster Is Associated with Low Rates of Influenza Infection in Patients with Plasma Cell Disorders

Andrew R Branagan, MD, Eamon Duffy, Chandra Sekhar Boddupall, PhD, Randy A Albrecht, PhD, Lin Zhang, Rakesh Verma, PhD, Dennis L Cooper, MD, Stuart Seropian, MD, Terri L Parker, MD, Xiaopan Yao, PhD, Thomas M Ferencz, RPh, Madhav V Dhodapkar, MD

Blood (2015) 126 (23): 3058.

https://doi.org/10.1182/blood.V126.23.3058.3058

Published: 2015

Journal Articles

Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice

Rituparna Das, PhD, Till Strowig, PhD, Rakesh Verma, PhD, Srinivas Koduru, PhD, Anja Hafemann, PhD, Stephanie Hopf, Mehmet H. Kocoglu, MD, Chiara Borsotti, PhD, Lin Zhang, Andrew R Branagan, MD, Elizabeth Eynon, PhD, Markus Manz, MD, Richard Flavell, PhD, Madhav V Dhodapkar, MD

Blood (2015) 126 (23): 120.

https://doi.org/10.1182/blood.V126.23.120.120

Published: 2015

Journal Articles

Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells

Rakesh Verma, PhD, Till Strowig, PhD, Rituparna Das, PhD, Srinivas Koduru, PhD, Anja Hafemann, PhD, Stephanie Hopf, Mehmet H. Kocoglu, MD, Chiara Borsotti, PhD, Lin Zhang, Andrew R Branagan, MD, Elizabeth Eynon, PhD, Markus Manz, MD, Richard Flavell, PhD, Madhav V Dhodapkar, MD

Blood (2015) 126 (23): 22.

https://doi.org/10.1182/blood.V126.23.22.22

Published: 2015

Journal Articles

Prospective analysis of antigen-specific immunity, stem-cell antigens, and immune checkpoints in monoclonal gammopathy

Madhav V. Dhodapkar, Rachael Sexton, Rituparna Das, Kavita M. Dhodapkar, Lin Zhang, Ranjini Sundaram, Sonal Soni, John J. Crowley, Robert Z. Orlowski, Bart Barlogie

Blood (2015) 126 (22): 2475–2478.

https://doi.org/10.1182/blood-2015-03-632919

Published: 2015

Includes: Supplemental data

Journal Articles

Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets

Kartik Sehgal, Rituparna Das, Lin Zhang, Rakesh Verma, Yanhong Deng, Mehmet Kocoglu, Juan Vasquez, Srinivas Koduru, Yan Ren, Maria Wang, Suzana Couto, Mike Breider, Donna Hansel, Stuart Seropian, Dennis Cooper, Anjan Thakurta, Xiaopan Yao, Kavita M. Dhodapkar, Madhav V. Dhodapkar

Blood (2015) 125 (26): 4042–4051.

https://doi.org/10.1182/blood-2014-11-611426

Published: 2015

Includes: Supplemental data

NARROW

Preclinical Study of DZD8586, a Non-Covalent LYN/BTK Dual Inhibitor with Excellent BBB Penetration, for the Treatment of B-Cell Non-Hodgkin Lymphoma (B-NHL)

Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis

ANP32B-mediated repression of p53 contributes to maintenance of normal and CML stem cells

Identification of Chemo-Resistant Residual Cell Population in Pediatric AML of Complete Remission By Single Cell RNA Sequencing

Chimeric Antigen Receptor T Cell Therapy in the Relapsed or Refractory Multiple Myeloma with Extramedullary Disease--a Single Institution Observation in China

The role of AGK in thrombocytopoiesis and possible therapeutic strategies

Long-Term Follow-up of a Phase 1, First-in-Human Open-Label Study of LCAR-B38M, a Structurally Differentiated Chimeric Antigen Receptor T (CAR-T) Cell Therapy Targeting B-Cell Maturation Antigen (BCMA), in Patients (pts) with Relapsed/Refractory Multiple Myeloma (RRMM)

Efficacy and Adverse Reactions of Gemcitabine Combined with Cyclophosphamide, Vinblastine and Prednisone Hydrogenation Regiments in Relapse and/or Refractory Non-Hodgkin's Lymphoma

Updated Analysis of a Phase 1, Open-Label Study of LCAR-B38M, a Chimeric Antigen Receptor T Cell Therapy Directed Against B-Cell Maturation Antigen, in Patients with Relapsed/Refractory Multiple Myeloma

Early Enrichment and Subsequent Dysfunction of Marrow ILC Subsets in Monoclonal Gammopathy: Target for IMiD Therapy

Two Dose Series of High-Dose Influenza Vaccine Is Associated with Longer Duration of Serologic Immunity in Patients with Plasma Cell Disorders

In Vivo CRISPR/Cas9-Targeted Genome Editing Recovers Factor IX Expression Restoring Haemostasis in a Mouse Model

Lower Rates of Influenza Infection Following Two Dose Series of High Dose Vaccination in Plasma Cell Disorders: Results of a Randomized, Double-Blind, Placebo-Assisted Clinical Trial

Identification of a First in Class GSK3-Alpha Selective Inhibitor As a New Differentiation Therapy for AML

Identification of a Cereblon-Independent Protein Degradation Pathway in Residual Myeloma Cells Treated with Immunomodulatory Drugs

Fluzone® High-Dose Influenza Vaccine with a Booster Is Associated with Low Rates of Influenza Infection in Patients with Plasma Cell Disorders

Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice

Humanized Mouse Model of Myeloma Reveals Clinically Occult Genomic Changes in Primary Tumor Cells

Prospective analysis of antigen-specific immunity, stem-cell antigens, and immune checkpoints in monoclonal gammopathy

Clinical and pharmacodynamic analysis of pomalidomide dosing strategies in myeloma: impact of immune activation and cereblon targets

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American Society of Hematology

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