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Journal Articles

Identification of Chemo-Resistant Residual Cell Population in Pediatric AML of Complete Remission By Single Cell RNA Sequencing

Shuting Jiang, Fuhong He, PhD, Li Gao, MD, Aili Chen, PhD, Yixin Hu, MD, Liyan Fan, MD, Lin Zhang, MS, Yongping Zhang, Haiyang Hu, Dan Liu, MS, Zihan Zhou, Yanxun Su, Lei Qin, Jun Lu, MD, Peifang Xiao, MD, Raul Ribeiro, MD, Shaoyan Hu, MD PhD, Qian-fei Wang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-141139
Published: 2020
Journal Articles

Outcome and Genomic Characteristics of Non-Down Syndrome Acute Megakaryoblastic Leukemia in Children Treated with Low-Dose Chemotherapy for Induction Remission

Yixin Hu, MD, Li Gao, MD, Aili Chen, MD, Jun Lu, MD, Jie Li, MD, Hailong He, MD, Yi Wang, MD PhD, Peifang Xiao, MD, Qianfei Wang, PhD, Raul Ribeiro, MD, Shaoyan Hu, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2613.
https://doi.org/10.1182/blood-2019-129572
Published: 2019
Journal Articles

Comparable Leukemic Cells Reduction but Improved Normal Hematopoietic Regeneration with G-CSF Priming Plus Low Dose Chemotherapy Regimen Relative to Standard Chemotherapy in AML Mice Model

Ya Zhang, MS, Xiaomin Feng, MD PhD, Aili Chen, PhD, Shaoyan Hu, MD PhD, Qianfei Wang, PhD, Gang Huang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1362.
https://doi.org/10.1182/blood-2019-129465
Published: 2019
Journal Articles

Efficacy and Safety of Decitabine in Combination with G-CSF, Low-Dose Cytarabine and Mitoxantrone in Pediatric Refractory and Relapse Acute Myeloid Leukemia and MDS-Raebt

Liyan Fan, MD, Aili Chen, MD, Yixin Hu, MD, Peifang Xiao, MD, Jun Lu, MD, Jie Li, MD, Hailong He, MD, Yi Wang, MD, Shaoyan Hu, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5175.
https://doi.org/10.1182/blood-2018-99-117850
Published: 2018
Journal Articles

Clinical Outcomes and Mutation Clearance in Children with Acute Myeloid Leukemia Treated with Low-Dose Chemotherapy Plus G-CSF for Remission Induction

Aili Chen, PhD, Yixin Hu, MD, Xinchang Zheng, Jun Lu, MD, Peifang Xiao, MD, Jin Yang, Ya Zhang, Pinpin Sui, Jingyi Yang, MD, Fuhong He, PhD, Hailong He, MD, Yi Wang, MD PhD, Chung-I Wu, PhD, Xin Liu, MD PhD, Yinmei Zhou, MS, Deqing Pei, MS, Cheng Cheng, PhD, Raul C. Ribeiro, MD, Shaoyan Hu, MD PhD, Qianfei Wang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1397.
https://doi.org/10.1182/blood.V130.Suppl_1.1397.1397
Published: 2017
Journal Articles

Global Crosstalk between Two Histone Modifications That Control Transcriptional Elongation in MLL Leukemia

Jiachen Bu, Aili Chen, PhD, Xiaomei Yan, Fuhong He, PhD, Yunzhu Dong, Yile Zhou, Jianlin He, Yoshihiro Hayashi, Di Zhan, Yanling Sun, Yue Zhang, Zhijian Xiao, Lee Grimes, Qianfei Wang, PhD, Gang Huang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2495.
https://doi.org/10.1182/blood.V130.Suppl_1.2495.2495
Published: 2017
Journal Articles

Clinical Outcome and Non-Synonymous Mutation Clearance in Chinese Children with Acute Myeloid Leukemia Treated with a Low-Intensity Induction Chemotherapy Regimen

Aili Chen, PhD, Yixin Hu, MD, Xin Liu, MD PhD, Jun Lu, MD, Peifang Xiao, MD, Xinchang Zheng, Jin Yang, Ya Zhang, Jingyi Yang, MD, Fuhong He, PhD, Pinpin Sui, Hailong He, MD, Yi Wang, MD PhD, Cheng Cheng, PhD, Raul C. Ribeiro, MD, Shaoyan Hu, MD PhD, Qianfei Wang, PhD
Journal: Blood
Blood (2016) 128 (22): 2848.
https://doi.org/10.1182/blood.V128.22.2848.2848
Published: 2016
Journal Articles

Downregulation of SETD2-H3K36me3 Tumor Suppression Axis Promotes MLL Leukemia through Activation of DOT1L-H3K79me2 Axis

Jiachen Bu, Aili Chen, PhD, Yunzhu Dong, PhD, Fuhong He, PhD, Xiaomei Yan, MD PhD, Yile Zhou, Di Zhan, Yoshihiro Hayashi, MD PhD, Qianfei Wang, PhD, Gang Huang, PhD
Journal: Blood
Blood (2016) 128 (22): 435.
https://doi.org/10.1182/blood.V128.22.435.435
Published: 2016
Journal Articles

HIF-1a Pathway, As a Signal Funnel for Genetic, Epigenetic, and Metabolic Aberrations, Is Sufficient and Essential for MDS Development

Yoshihiro Hayashi, MD PhD, Yue Zhang, MD, Xiaomei Yan, MD PhD, Kwangmin Choi, PhD, Goro Sashida, MD PhD, Yunzhu Dong, Zefeng Xu, MD, Lingyun Wu, MD PhD, Aili Chen, PhD, Xiujuan Sun, MD, Andre Olsson, PhD, Hironori Harada, MD PhD, Lee-Yung Shih, MD, William Tse, MD FACP, James Bridges, PhD, David P Witte, MD, Qianfei Wang, Michael A. Caligiuri, MD, H. Leighton Grimes, PhD, Stephen D. Nimer, MD, Zhijian Xiao, MD, Gang Huang, PhD
Journal: Blood
Blood (2015) 126 (23): 303.
https://doi.org/10.1182/blood.V126.23.303.303
Published: 2015
Journal Articles

RUNX1/CBFβ Dosage Is Critical for MLL Leukemias Development

Xiaomei Yan, MD PhD, Yoshihiro Hayashi, MD PhD, Xinghui Zhao, PhD, Aili Chen, PhD, Yue Zhang, MD, Fuhong He, Yunzhu Dong, Yalan Rao, PhD, Bo Li, Rajeana Conway, Alba Maiques-Díaz, Nuomin Huang, Shannon E Elf, Johannes Zuber, MD, Zhijian Xiao, MD, William Tse, Daniel G. Tenen, MD, Qianfei Wang, Wei Chen, James C. Mulloy, PhD, Stephen D Nimer, MD, Gang Huang, PhD
Journal: Blood
Blood (2014) 124 (21): 2187.
https://doi.org/10.1182/blood.V124.21.2187.2187
Published: 2014
Journal Articles

Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

Xinghui Zhao, Aili Chen, Xiaomei Yan, Yue Zhang, Fuhong He, Yoshihiro Hayashi, Yunzhu Dong, Yalan Rao, Bo Li, Rajeana M. Conway, Alba Maiques-Diaz, Shannon E. Elf, Nuomin Huang, Johannes Zuber, Zhijian Xiao, William Tse, Daniel G. Tenen, Qianfei Wang, Wei Chen, James C. Mulloy, Stephen D. Nimer, Gang Huang
Journal: Blood
Blood (2014) 123 (11): 1729–1738.
https://doi.org/10.1182/blood-2013-03-489575
Published: 2014
Includes: Supplemental data
Journal Articles

Modeling and Targeting MLL-PTD/RUNX1 Related MDS/AML In Mouse

Yue Zhang, MD, Xiaomei Yan, Aili Chen, Goro Sashida, MD, PhD, Zhijian Xiao, MD, Gang Huang, PhD
Journal: Blood
Blood (2013) 122 (21): 2746.
https://doi.org/10.1182/blood.V122.21.2746.2746
Published: 2013
Journal Articles

PU.1 Is Essential For MLL Leukemia Via Activation Of The Meis/HOX Pathway and A Monocytic Cytokine Mediated Anti-Apoptotic Inflammatory Program

Jing Zhou, Jun Wu, Bo Li, Dan Liu, Jian Yu, Xiaomei Yan, Si Zheng, Jiguang Wang, Lixia Zhang, Lin Zhang, Fuhong He, Qiang Li, Aili Chen, Yue Zhang, MD,, Xinghui Zhao, Yinghui Guan, Xiaohong Zhao, Jin Yan, Jun Ni, Marcelo Nobrega, Bob Löwenberg, MD, PhD, Ruud Delwel, Peter J. Valk, PhD, Ashish Kumar, MBBS, PhD, Xie Lu, Daniel G. Tenen, MD, Gang Huang, PhD, Qian-fei Wang, Ph.D
Journal: Blood
Blood (2013) 122 (21): 1276.
https://doi.org/10.1182/blood.V122.21.1276.1276
Published: 2013
Journal Articles

Whole-Genome Sequencing of a Monozygotic Twin Pair Reveals Functional Cooperative Mutations of SETD2 in Acute Leukemia

Xiaofan Zhu, Fuhong He, Huimin Zeng, Shaoping Ling, Xiaomei Yan, Yaqin Wang, Aili Chen, Wei Wei, Yue Zhang, Hui Cheng, Jun Wu, Xia Li, Lingtong Hao, Lihua Cao, Lili Dong, Wei Zou, Xuejing Yang, Xin Lu, Si Zheng, Jin Yan, Jing Zhou, Lixia Zhang, Shuangli Mi, Xiaojuan Wang, Li Zhang, Yao Zou, Yumei Chen, Zhe Geng, Jianfeng Zhou, Jianmin Wang, Xin Liu, Jianxiang Wang, Gang Huang, Weiping Yuan, Tao Cheng, Qian-fei Wang
Journal: Blood
Blood (2012) 120 (21): 781.
https://doi.org/10.1182/blood.V120.21.781.781
Published: 2012
Journal Articles

Modeling MLL-PTD Related Myelodysplastic Syndromes in Mouse.

Xiaomei Yan, Yue Zhang, MD, Goro Sashida, MD, Aili Chen, Xinghui Zhao, PhD, Susan Whitman, PhD, Qianfei Wang, Michael A. Caligiuri, M.D., Zhijian Xiao, MD, Gang Huang
Journal: Blood
Blood (2012) 120 (21): 2811.
https://doi.org/10.1182/blood.V120.21.2811.2811
Published: 2012