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Michele Dundas Macpherson
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Journal Articles

Differentiation Scoring (DS) Derived from Cellworks Computational Omics Biology Model (CBM) Predicts Response to Hypomethylating Agents (HMA) and Patient Survival in Myelodysplastic Syndrome (MDS)

Michael Castro, Shahabuddin Usmani, Ansu Kumar, Jyoti Chauhan, Shweta Kapoor, Swati Khandelwal, Vivek Patil, Subrat Mohapatra, Anuj Tyagi, Mohammed Sauban, Prashant Ramachandran Nair, Vijayashree P. Shyamasundar, Neha Dutta, Upasana Mitra, Neha Gupta, Nagendra Prasad, Ashish Kumar Agrawal, Ashokraja Balla, Rakhi Purushothaman Suseela, Veena Balakrishnan, Kishore Promod, Sanjana Patel, Michele Dundas Macpherson, James Wingrove, Scott C. Howard, Guido Marcucci
Journal: Blood
Blood (2022) 140 (Supplement 1): 4970–4971.
https://doi.org/10.1182/blood-2022-166284
Published: 2022
Journal Articles

Therapy Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Is Predictive of Individual Acute Myeloid Leukemia (AML) Patient Probability of Clinical Response (CR) and Overall Survival (OS): Mycare-023

Scott C Howard, Drew Watson, Michael Castro, Shweta Kapoor, Prashant Ramachandran Nair, Samiksha Avinash Prasad, Swaminathan Rajagopalan, Aftab Alam, Kunal Ghosh Roy, Diwyanshu Sahu, Deepak Anil Lala, Kabya Basu, Yashaswini S Ullal, Yugandhara Narvekar, Adity Ghosh, Mohammed Sauban, Poornachandra G, Ashish Kumar Agrawal, Anuj Tyagi, Rakhi Purushothaman Suseela, Karthik Sundara Raju, Anusha Pampana, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 689.
https://doi.org/10.1182/blood-2021-154023
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Genomic and Molecular Markers for Decitabine (DAC) Plus Valproic-Acid (VPA) Treatment Response in Patients with Myelodysplastic Syndromes (MDS)

Michael Castro, Ansu Kumar, Himanshu Grover, Vivek Patil, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Samiksha Avinash Prasad, Kabya Basu, Rakhi Purushothaman Suseela, Chandan Kumar, Prashant Ramachandran Nair, Pallavi Kumari, Anusha Pampana, Yashaswini S Ullal, Humera Azam, Nagendra Prasad, Anish Raju R Amara, Diwyanshu Sahu, Nithya T Raveendaran, Archana Palillam Veedu, Nirjhar Mundkur, Sanjana Patel, James Christie, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 2615.
https://doi.org/10.1182/blood-2021-153220
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM)-Based Assessment of Cytarabine (ARA-C) and Anthracycline Response and Novel Biomarker Response Criteria for the Addition of Etoposide (VP16) in Acute Myeloid Leukemia (AML)

Michael Castro, Scott C Howard, Ansu Kumar, Vivek Patil, Swati Khandelwal, Drew Watson, Shweta Kapoor, Pallavi Kumari, Samiksha Avinash Prasad, Neha Gupta, Neelesh Lunkad, Upasana Mitra, Poornachandra G, Chandan Kumar, Sayantani Roy Choudhury, Shruthi Kulkarni, Ashish Choudhary, Annapoorna Prakash, Zakir Husain, Adity Ghosh, Yugandhara Narvekar, Anish Raju R Amara, Velkuru Yuvavani, Sanjana Patel, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 1299.
https://doi.org/10.1182/blood-2021-152745
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Predicted Novel Biomarkers for Hyper-CVAD (CVAD) Treatment Response and Combination of Rituximab and Cladribine (RC) in CVAD Resistant Cases of Mantle Cell Lymphoma (MCL)

Guido Marcucci, Ansu Kumar, Michael Castro, Swati Khandelwal, Subrat Mohapatra, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Kabya Basu, Vijayashree P Shyamasundar, Deepak Anil Lala, Karthik Sundara Raju, Naga Ganesh Palaniyeppa, Yashaswini S Ullal, Vishwas Joseph, Liptimayee Behura, Diwyanshu Sahu, Annapoorna Prakash, Upasana Mitra, Ashokraja Balla, Mamatha Patil, Jharana Mohanty, Sanjana Patel, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3550.
https://doi.org/10.1182/blood-2021-152423
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Immune Modulation As a Key Pathway for Predicting Azacitidine (AZA) Response in Myelodysplastic Syndromes (MDS)

Scott C Howard, Ansu Kumar, Michael Castro, Himanshu Grover, Subrat Mohapatra, Shweta Kapoor, Anuj Tyagi, Prashant Ramachandran Nair, Rakhi Purushothaman Suseela, Anusha Pampana, Deepak Anil Lala, Divya Singh, Vijayashree P Shyamasundar, Shruthi Kulkarni, Yugandhara Narvekar, Kritika Sahni, Rahul K Raman, Veena Balakrishnan, Mamatha Patil, Naga Ganesh Palaniyeppa, Ashokraja Balla, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 3690.
https://doi.org/10.1182/blood-2021-153539
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Novel Biomarkers to Inform Mitoxantrone, Etoposide, and Cytarabine (MEC)-Based Combination Therapy in Refractory & Relapsed Acute Myeloid Leukemia (AML) Patients

Guido Marcucci, Ansu Kumar, Michael Castro, Himanshu Grover, Vivek Patil, Aftab Alam, Humera Azam, Subrat Mohapatra, Anuj Tyagi, Pallavi Kumari, Samiksha Avinash Prasad, Prashant Ramachandran Nair, Neelesh Lunkad, Vishwas Joseph, Poornachandra G, Jyoti Chauhan, Sayani Basu, Liptimayee Behura, Adity Ghosh, Zakir Husain, Rema Mandal, Rahul K Raman, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 4453.
https://doi.org/10.1182/blood-2021-153769
Published: 2021
Journal Articles

Superior Therapy Response Predictions for Patients with Myelodysplastic Syndrome (MDS) Using Cellworks Singula™: Mycare-020-02

Anthony S. Stein, MD, Drew Watson, PhD, Prashant Ramachandran Nair, B.Tech., Kabya Basu, M.Sc., Yashaswini S Ullal, M.Tech., Adity Ghosh, M.Sc., Yugandhara Narvekar, M.Sc., Himanshu Grover, M.S., Diwyanshu Sahu, M.Sc., Annapoorna Prakash, M.Tech., Liptimayee Behura, B.E., Veena Balakrishnan, M.Sc., Kunal Ghosh Roy, M.Sc., Swaminathan Rajagopalan, M.Tech., Aftab Alam, M.Sc., Rajan Parashar, B.Tech., Nirjhar Mundkur, James Christie, B.S., Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc., Guido Marcucci, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9–10.
https://doi.org/10.1182/blood-2020-142214
Published: 2020
Journal Articles

Comparative Analysis for Differential Drug Response between Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) and T-Cell Acute Lymphoblastic Leukemia (T-ALL) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-03

Scott Howard, MD, Ansu Kumar, M.Sc., Anusha Pampana, M.Sc., Yashaswini S Ullal, M.Tech., Anuj Tyagi, M.Sc., Deepak Anil Lala, B.Tech., Pallavi Kumari, M.Sc., Vishwas Joseph, M.Sc., Karthik Sundara Raju, M.Sc., Veena Balakrishnan, M.Sc., Nirjhar Mundkur, B.S., Michele Dundas Macpherson, B.A.Sc., Prashant Ramachandran Nair, B.Tech., Shweta Kapoor, M.Sc.
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-139997
Published: 2020
Journal Articles

Assessment of Cellworks Omics Biosimulation Therapy Response Predictions for Patients with Acute Myeloid Leukemia (AML) Using Cellworks Singula™: Mycare-020-01

Guido Marcucci, MD, Drew Watson, PhD, Prashant Ramachandran Nair, B.Tech., Kabya Basu, M.Sc., Yashaswini S Ullal, M.Tech., Adity Ghosh, M.Sc., Yugandhara Narvekar, M.Sc., Himanshu Grover, M.S., Diwyanshu Sahu, M.Sc., Anish Raju R Amara, B.E., Anusha Pampana, M.Sc., Kunal Ghosh Roy, M.Sc., Swaminathan Rajagopalan, M.Tech., Aftab Alam, M.Sc., Rajan Parashar, B.Tech., Nirjhar Mundkur, James Christie, B.S., Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc., Anthony S. Stein, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35.
https://doi.org/10.1182/blood-2020-142184
Published: 2020
Journal Articles

Predicting Resistance to the Combination of ATO and ATRA in APL Patients with PML-Rara Fusions, Using a Computational Biology Modeling Approach: Mycare-021-01

Scott Howard, MD, Prashant Ramachandran Nair, B.Tech., Himanshu Grover, M.S., Anuj Tyagi, M.Sc., Pallavi Kumari, M.Sc., Samiksha Avinash Prasad, M.Sc., Upasana Mitra, M.Sc., Deepak Anil Lala, B.Tech., Humera Azam, M.Sc., Neha Gupta, M.Sc., Subrat Mohapatra, M.Sc., Poornachandra G, B.Tech., Nirjhar Mundkur, Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc.
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-140617
Published: 2020
Journal Articles

Monosomy 7 and Co-Occurrent Genomic Aberrations Determine Chemotherapy Response in Acute Myeloid Leukemia (AML) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-04

Michael Castro, MD, Drew Watson, PhD, Ansu Kumar, M.Sc., Prashant Ramachandran Nair, B.Tech., Himanshu Grover, M.S., Diwyanshu Sahu, M.Sc., Subrat Mohapatra, M.Sc., Poornachandra G, B.Tech., Ashish Agarwal, B.V.Sc., Rakhi Purushothaman Suseela, B.Tech., Naga Ganesh, B.Tech., Mohammed Sauban, B.E., Chandan Kumar, M.Tech., Rahul K Raman, M.Sc., Divya Singh, M.S., Sayani Basu, M.Tech., Neelesh Lunkad, M.Tech., Nirjhar Mundkur, B.S., Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc., Scott Howard, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 9.
https://doi.org/10.1182/blood-2020-140087
Published: 2020
Journal Articles

Prediction of Clinical Response for Frontline Treatment of Acute Myeloid Leukemia (AML) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-02

Michael Castro, MD, Prashant Ramachandran Nair, B.Tech., Himanshu Grover, M.S., Ansu Kumar, M.Sc., Ashish Agarwal, B.V.Sc., Rakhi Purushothaman Suseela, B.Tech., Reshma P Gopi, M.Sc., Naga Ganesh, B.Tech., Vijayashree P Shyamasundar, M.Sc., Shruthi Kulkarni, B.E., Mohammed Sauban, B.E., Ashokraja Balla, M.Tech., Srushti P Chafekar, M.Sc., Sayantani Roy Choudhury, M.Sc., Nirjhar Mundkur, Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc., Scott Howard, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 24.
https://doi.org/10.1182/blood-2020-141479
Published: 2020