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Journal Articles

Early Post-Infusion Clearance of High-Dose Methotrexate Predicts Delayed Methotrexate Elimination and Acute Kidney Injury

Carmelo Rizzari, Nicolás Tentoni, Ryan Combs, Jennifer Lowe, Miriam Hwang, Thais Murciano, María Dolores Aumente, Teresa López-Viñau López, Scott C. Howard
Journal: Blood
Blood (2023) 142 (Supplement 1): 3763.
https://doi.org/10.1182/blood-2023-182052
Published: 2023
Journal Articles

Differentiation Scoring (DS) Derived from Cellworks Computational Omics Biology Model (CBM) Predicts Response to Hypomethylating Agents (HMA) and Patient Survival in Myelodysplastic Syndrome (MDS)

Michael Castro, Shahabuddin Usmani, Ansu Kumar, Jyoti Chauhan, Shweta Kapoor, Swati Khandelwal, Vivek Patil, Subrat Mohapatra, Anuj Tyagi, Mohammed Sauban, Prashant Ramachandran Nair, Vijayashree P. Shyamasundar, Neha Dutta, Upasana Mitra, Neha Gupta, Nagendra Prasad, Ashish Kumar Agrawal, Ashokraja Balla, Rakhi Purushothaman Suseela, Veena Balakrishnan, Kishore Promod, Sanjana Patel, Michele Dundas Macpherson, James Wingrove, Scott C. Howard, Guido Marcucci
Journal: Blood
Blood (2022) 140 (Supplement 1): 4970–4971.
https://doi.org/10.1182/blood-2022-166284
Published: 2022
Journal Articles

Research and Care Networks in Acute Leukemia As a Model for Global Healthcare Collaboration

Martin R Guscott, Stacy L Cooper, Poonam Bagai, Archie Bleyer, Randal K Buddington, Dan Douer, Tina B Chong, Ryan R Combs, Jennifer L Hylton, Gabriela Ines-Villanueva, Jennifer A Lowe, Rishabh Pandey, Aman N Patel, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 4966.
https://doi.org/10.1182/blood-2021-147876
Published: 2021
Journal Articles

Therapy Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Is Predictive of Individual Acute Myeloid Leukemia (AML) Patient Probability of Clinical Response (CR) and Overall Survival (OS): Mycare-023

Scott C Howard, Drew Watson, Michael Castro, Shweta Kapoor, Prashant Ramachandran Nair, Samiksha Avinash Prasad, Swaminathan Rajagopalan, Aftab Alam, Kunal Ghosh Roy, Diwyanshu Sahu, Deepak Anil Lala, Kabya Basu, Yashaswini S Ullal, Yugandhara Narvekar, Adity Ghosh, Mohammed Sauban, Poornachandra G, Ashish Kumar Agrawal, Anuj Tyagi, Rakhi Purushothaman Suseela, Karthik Sundara Raju, Anusha Pampana, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 689.
https://doi.org/10.1182/blood-2021-154023
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Genomic and Molecular Markers for Decitabine (DAC) Plus Valproic-Acid (VPA) Treatment Response in Patients with Myelodysplastic Syndromes (MDS)

Michael Castro, Ansu Kumar, Himanshu Grover, Vivek Patil, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Samiksha Avinash Prasad, Kabya Basu, Rakhi Purushothaman Suseela, Chandan Kumar, Prashant Ramachandran Nair, Pallavi Kumari, Anusha Pampana, Yashaswini S Ullal, Humera Azam, Nagendra Prasad, Anish Raju R Amara, Diwyanshu Sahu, Nithya T Raveendaran, Archana Palillam Veedu, Nirjhar Mundkur, Sanjana Patel, James Christie, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 2615.
https://doi.org/10.1182/blood-2021-153220
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM)-Based Assessment of Cytarabine (ARA-C) and Anthracycline Response and Novel Biomarker Response Criteria for the Addition of Etoposide (VP16) in Acute Myeloid Leukemia (AML)

Michael Castro, Scott C Howard, Ansu Kumar, Vivek Patil, Swati Khandelwal, Drew Watson, Shweta Kapoor, Pallavi Kumari, Samiksha Avinash Prasad, Neha Gupta, Neelesh Lunkad, Upasana Mitra, Poornachandra G, Chandan Kumar, Sayantani Roy Choudhury, Shruthi Kulkarni, Ashish Choudhary, Annapoorna Prakash, Zakir Husain, Adity Ghosh, Yugandhara Narvekar, Anish Raju R Amara, Velkuru Yuvavani, Sanjana Patel, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 1299.
https://doi.org/10.1182/blood-2021-152745
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Predicted Novel Biomarkers for Hyper-CVAD (CVAD) Treatment Response and Combination of Rituximab and Cladribine (RC) in CVAD Resistant Cases of Mantle Cell Lymphoma (MCL)

Guido Marcucci, Ansu Kumar, Michael Castro, Swati Khandelwal, Subrat Mohapatra, Shweta Kapoor, Ashish Kumar Agrawal, Mohammed Sauban, Kabya Basu, Vijayashree P Shyamasundar, Deepak Anil Lala, Karthik Sundara Raju, Naga Ganesh Palaniyeppa, Yashaswini S Ullal, Vishwas Joseph, Liptimayee Behura, Diwyanshu Sahu, Annapoorna Prakash, Upasana Mitra, Ashokraja Balla, Mamatha Patil, Jharana Mohanty, Sanjana Patel, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 3550.
https://doi.org/10.1182/blood-2021-152423
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Immune Modulation As a Key Pathway for Predicting Azacitidine (AZA) Response in Myelodysplastic Syndromes (MDS)

Scott C Howard, Ansu Kumar, Michael Castro, Himanshu Grover, Subrat Mohapatra, Shweta Kapoor, Anuj Tyagi, Prashant Ramachandran Nair, Rakhi Purushothaman Suseela, Anusha Pampana, Deepak Anil Lala, Divya Singh, Vijayashree P Shyamasundar, Shruthi Kulkarni, Yugandhara Narvekar, Kritika Sahni, Rahul K Raman, Veena Balakrishnan, Mamatha Patil, Naga Ganesh Palaniyeppa, Ashokraja Balla, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 3690.
https://doi.org/10.1182/blood-2021-153539
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Novel Biomarkers to Inform Mitoxantrone, Etoposide, and Cytarabine (MEC)-Based Combination Therapy in Refractory & Relapsed Acute Myeloid Leukemia (AML) Patients

Guido Marcucci, Ansu Kumar, Michael Castro, Himanshu Grover, Vivek Patil, Aftab Alam, Humera Azam, Subrat Mohapatra, Anuj Tyagi, Pallavi Kumari, Samiksha Avinash Prasad, Prashant Ramachandran Nair, Neelesh Lunkad, Vishwas Joseph, Poornachandra G, Jyoti Chauhan, Sayani Basu, Liptimayee Behura, Adity Ghosh, Zakir Husain, Rema Mandal, Rahul K Raman, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 4453.
https://doi.org/10.1182/blood-2021-153769
Published: 2021
Journal Articles

Strict Treatment Regimen and Febrile Neutropenia Guidelines Allow Favorable Outcomes for Pediatric ALL in Southern India

Neeraj Sidharthan, MD DM, Rema Ganapathy, DNB, P Gangadharan, MSc MS, Sumi Soman, BSc, Keechilet Pavithran, MD DM, Raghuveer Prabhu, MD DM, Haripriya V Raju, MSW, Ayswarya Rajan, BSc, Pavankumar Boyella, MD DM, Rajeswari Arun, MBBS FAAP, Scott C. Howard, MD, Asha Pillai, MD
Journal: Blood
Blood (2015) 126 (23): 4510.
https://doi.org/10.1182/blood.V126.23.4510.4510
Published: 2015
Journal Articles

Risk Factors For Acute Pancreatitis In Patients With Acute Lymphoblastic Leukemia

Chengcheng Liu, Deqing Pei, MS, Meenakshi Devidas, PhD, Cheng Cheng, PhD, Wenjian Yang, PhD, Scott C. Howard, MD, Mignon L. Loh, MD, Paul L. Martin, MD, PhD, Naomi J. Winick, MD, William Paul Bowman, MD, Eric C. Larsen, MD, William L. Carroll, MD, Elizabeth A. Raetz, MD, Deepa Bhojwani, MD, Sima Jeha, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Stephen P. Hunger, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2013) 122 (21): 3868.
https://doi.org/10.1182/blood.V122.21.3868.3868
Published: 2013
Journal Articles

The Impact of Epstein Bar Virus On Hodgkin Lymphoma's Histopathological Patterns in Morocco

Soumaya Anoun, MD, MSc, Sofia Marouane, MD, Meryem Kabbali, Soumia Zamiati, MD, Said Benchekroun, MD, Scott C Howard, MD, MS, Asmaa Quessar, MD
Journal: Blood
Blood (2012) 120 (21): 4781.
https://doi.org/10.1182/blood.V120.21.4781.4781
Published: 2012
Journal Articles

Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia

Clinical Trials & Observations
Jitesh D. Kawedia, Chengcheng Liu, Deqing Pei, Cheng Cheng, Christian A. Fernandez, Scott C. Howard, Dario Campana, John C. Panetta, W. Paul Bowman, William E. Evans, Ching-Hon Pui, Mary V. Relling
Journal: Blood
Blood (2012) 119 (7): 1658–1664.
https://doi.org/10.1182/blood-2011-09-381731
Published: 2012
Includes: Supplemental data
Journal Articles

Systemic Exposure to Dexamethasone and Asparaginase Affects Risk of Relapse in Children with Acute Lymphoblastic Leukemia

Jitesh D. Kawedia, PhD, RPh, Chengcheng Liu, Deqing Pei, MS, Cheng Cheng, PhD, Christian A Fernandez, PhD, Scott C Howard, MD, MS, Dario Campana, MD, PhD, John C Panetta, PhD, W. Paul Bowman, MD, William E. Evans, PharmD, Ching-Hon Pui, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2011) 118 (21): 2550.
https://doi.org/10.1182/blood.V118.21.2550.2550
Published: 2011
Journal Articles

Pharmacokinetic, pharmacodynamic, and pharmacogenetic determinants of osteonecrosis in children with acute lymphoblastic leukemia

CME
Jitesh D. Kawedia, Sue C. Kaste, Deqing Pei, John C. Panetta, Xiangjun Cai, Cheng Cheng, Geoffrey Neale, Scott C. Howard, William E. Evans, Ching-Hon Pui, Mary V. Relling
Journal: Blood
Blood (2011) 117 (8): 2340–2347.
https://doi.org/10.1182/blood-2010-10-311969
Published: 2011
Includes: Supplemental data
Journal Articles

Pharmacokinetic, Pharmacodynamic and Pharmacogenetic Determinants of Osteonecrosis In Children with Acute Lymphoblastic Leukemia.

Jitesh D. Kawedia, PhD, RPh, Sue Kaste, DO, Deqing Pei, John C Panetta, PhD, Xiangjun Cai, PhD, Cheng Cheng, Ph.D., Geoffrey A. Neale, PhD, Scott C Howard, MD, MS, William E. Evans, PharmD, Ching-Hon Pui, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2010) 116 (21): 1033.
https://doi.org/10.1182/blood.V116.21.1033.1033
Published: 2010
Journal Articles

Improved Prognosis for Older Adolescents with Acute Lymphoblastic Leukemia

Sima Jeha, MD, Deqing Pei, MS, Dario Campana, MD, PhD, W. Paul Bowman, MD, John Sandlund, MD, Sue Kaste, DO, Raul C. Ribeiro, MD, Jeffrey E. Rubnitz, MD, PhD, Elaine Coustan-Smith, MS, Cheng Cheng, Ph.D., Monika L. Metzger, MD, MS, Deepa Bhojwani, MD, Hiroto Inaba, MD, PhD, Susana C. Raimondi, PhD, Mihaela Onciu, MD, Scott C. Howard, MD, MS, Wing H. Leung, MD.PhD, James R. Downing, MD, William E. Evans, PharmD, Mary . Relling, V, PharmD, Ching-Hon Pui, MD
Journal: Blood
Blood (2010) 116 (21): 498.
https://doi.org/10.1182/blood.V116.21.498.498
Published: 2010
Journal Articles

Excellent Outcome for ETV6/RUNX1 -Positive Childhood Acute Lymphoblastic Leukemia (ALL) with Contemporary Therapy

Deepa Bhojwani, MD, Deqing Pei, John Sandlund, MD, Sima Jeha, MD, Raul C. Ribeiro, MD, Jeffrey E. Rubnitz, MD, PhD, Susana C. Raimondi, PhD, Sheila Shurtleff, PhD, Mihaela Onciu, MD, Cheng Cheng, Ph.D., Elaine Coustan-Smith, MS, W. Paul Bowman, MD, Scott C. Howard, MD, MS, Monika L. Metzger, MD, MS, Hiroto Inaba, MD, PhD, Wing H. Leung, MD.PhD, William E. Evans, PharmD, Dario Campana, MD, PhD, Mary V. Relling, PharmD, Ching-Hon Pui, MD
Journal: Blood
Blood (2010) 116 (21): 495.
https://doi.org/10.1182/blood.V116.21.495.495
Published: 2010
Journal Articles

High Incidence and Curability of Patients with Acute Myeloblastic Leukemia (AML) and t(8;21) Treated On a Uniform Protocol in Casablanca, Morocco.

Asmaa Quessar, MD, Mouna Lamchahab, MD, Siham Cherkaoui, MD, Nazha Hda, MD, Scott C Howard, MD, Mohamed Rachid, MD, Abdellah Madani, MD, Katherine K. Matthay, MD, Raul C Ribeiro, MD, Said Benchekroun, MD
Journal: Blood
Blood (2009) 114 (22): 4713.
https://doi.org/10.1182/blood.V114.22.4713.4713
Published: 2009
Journal Articles

Targeting the Bcl-2 Family of Proteins in Hodgkin Lymphoma: In Vitro Cytotoxicity, Target Modulation and Drug Combination Studies of the BH3 Mimetic ABT-737

Aarthi Jayanthan, BS, Scott C Howard, MD, Tanya Trippett, MD, Terzah M. Horton, MD, PhD, Lara Daisley, Victor A. Lewis, MD, Aru Narendran, MD., Ph.D
Journal: Blood
Blood (2008) 112 (11): 3626.
https://doi.org/10.1182/blood.V112.11.3626.3626
Published: 2008