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John C. Panetta
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Journal Articles

Zegocractin to Reduce the Severity of Asparaginase Associated Pancreatitis in Children with Acute Lymphoblastic Leukemia: Results of the Phase 1 Portion of the Crspa Study

Seth E. Karol, Haitao Pan, Zhou Yinmei, Jeffrey E. Rubnitz, Nickhill Bhakta, Sima Jeha, Mary V. Relling, Kristine R Crews, John C Panetta, Cara Morin, Cheng Cheng, Ching-Hon Pui, Hiroto Inaba, M Beth McCarville
Journal: Blood
Blood (2023) 142 (Supplement 1): 2837.
https://doi.org/10.1182/blood-2023-188357
Published: 2023
Journal Articles

Population Pharmacokinetics of Mycophenolic Acid in Haploidentical Transplant Recipients Receiving Post-Transplant Cyclophosphamide Based GvHD Prophylaxis

Aswin Anand PAI, Uday Kulkarni, Binu Susan Mathew, Nayanthara KB, John C Panetta, Sujith Karumathil, Aby Abraham, Vikram Mathews, Biju George, Poonkuzhali Balasubramanian
Journal: Blood
Blood (2022) 140 (Supplement 1): 10473–10474.
https://doi.org/10.1182/blood-2022-168894
Published: 2022
Journal Articles

Preclinical Pharmacokinetic and Pharmacodynamic Evaluation of Dasatinib and Ponatinib in Lck-Activated T-Cell Acute Lymphoblastic Leukemia

Satoshi Yoshimura, Jianzhong Hu, John C. Panetta, Guoqing Du, Lie Li, Ching-Hon Pui, Marina Konopleva, Nitin Jain, Jun J.J. Yang
Journal: Blood
Blood (2022) 140 (Supplement 1): 8840–8841.
https://doi.org/10.1182/blood-2022-169363
Published: 2022
Journal Articles

Dosing-related saturation of toxicity and accelerated drug clearance with pegaspargase treatment

Clinical Trials & Observations
Yiwei Liu, John C. Panetta, Wenjian Yang, Seth E. Karol, Cheng Cheng, Jun J. Yang, William E. Evans, Hiroto Inaba, Ching-Hon Pui, Sima Jeha, Mary V. Relling
Journal: Blood
Blood (2020) 136 (25): 2955–2958.
https://doi.org/10.1182/blood.2020006214
Published: 2020
Includes: Supplemental data
Journal Articles

Predicting success of desensitization after pegaspargase allergy

Clinical Trials & Observations
Hope D. Swanson, John C. Panetta, Patricia J. Barker, Yiwei Liu, Hiroto Inaba, Mary V. Relling, Ching-Hon Pui, Seth E. Karol
Journal: Blood
Blood (2020) 135 (1): 71–75.
https://doi.org/10.1182/blood.2019003407
Published: 2020
Includes: Supplemental data
Journal Articles

Treosulfan Metabolite (S, S-EBDM) Pharmacokinetics Influences Regimen Related Toxicity in Patients with Beta Thalassaemia Major Undergoing HSCT

Aswin Anand PAI, MSc, John C Panetta, PhD, Ezhil Pavai Mohanan, PhD, Raveen Stephen Stallon Illangeswaran, MSc, Balaji Balakrishnan, PhD, Eunice Sindhuvi Edison, PhD, Kavitha M Lakshmi, MSc, Uday Prakash Kulkarni, MD DM, Anup Joseph Devasia, MD DM, Fouzia N., Anu Korula, MD DM, Aby Abraham, MD DM, Biju George, MDDM, Vikram Mathews, MD DM, Alok Srivastava, MD,FRACP,FRCPA, Poonkuzhali Balasubramanian, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1977.
https://doi.org/10.1182/blood-2019-125604
Published: 2019
Journal Articles

Pegaspargase Allergic Reactions Are Related to Anti-Pegaspargase Antibodies and to Intensity of Intrathecal Therapy

Yiwei Liu, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Lauren Thompson, Anisha Dash, Jacob Counts, May Chung, Alejandro R Molinelli, PhD, Deqing Pei, MS, Nancy M Kornegay, Erik A Springer, John C Panetta, PhD, Kristine R Crews, PharmD, Hope Swanson, PharmD, Cheng Cheng, PhD, Seth E Karol, MD, William E. Evans, PharmD, Hiroto Inaba, MD, Ching-Hon Pui, MD, Sima Jeha, MD, Mary V Relling, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2697.
https://doi.org/10.1182/blood-2018-99-110141
Published: 2018
Journal Articles

The Effect of Asparaginase on Serum Triglycerides during Therapy for Acute Lymphoblastic Leukemia

Emily R Finch, PhD, Colton A Smith, PhD, Wenjian Yang, PhD, Nancy M Kornegay, John C Panetta, PhD, Kristine R Crews, PharmD, Alejandro R Molinelli, PhD, Cheng Cheng, PhD, Deqing Pei, MS, Laura B. Ramsey, PhD, Seth E Karol, MD, Hiroto Inaba, MD, John T. Sandlund, MD, Monika Metzger, MD, William E. Evans, PharmD, Sima Jeha, MD, Ching-Hon Pui, MD, Mary V Relling, PharmD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2665.
https://doi.org/10.1182/blood-2018-99-117093
Published: 2018
Journal Articles

A 5'UTR Polymorphism in NT5E Gene Influences Outcome in Patients with Acute Myeloid Leukemia Undergoing Hematopoietic Stem Cell Transplantation with Fludarabine Based Conditioning Regimen

Ezhilpavai Mohanan, MSc, John C Panetta, PhD, Kavitha M Lakshmi, MSc, Anup Joseph Devasia, MD DM, Nisham PN, MD DM, Anu Korula, MD DM, Fouzia NA, Dip NB, DM,, Aby Abraham, MD DM, Biju George, MD DM, Alok Srivastava, Vikram Mathews, MD DM, Poonkuzhali Balasubramanian, MSc PhD
Journal: Blood
Blood (2016) 128 (22): 984.
https://doi.org/10.1182/blood.V128.22.984.984
Published: 2016
Journal Articles

Asparaginase May Affect Mercaptopurine Tolerability in the Context of Multi-Agent Therapy for Acute Lymphoblastic Leukemia

Chengcheng Liu, PhD, Deqing Pei, Cheng Cheng, PhD, Jun J Yang, PhD, Kristine R Crews, PhD, John C Panetta, PhD, Xiangjun DeMeter, Sima Jeha, MD, John Sandlund, MD, Raul C. Ribeiro, MD, Jeffrey E Rubnitz, MD PhD, Monika L. Metzger, MD, Ching-Hon Pui, MD, William E. Evans, PharmD, Mary V. Relling, PharmD
Journal: Blood
Blood (2016) 128 (22): 179.
https://doi.org/10.1182/blood.V128.22.179.179
Published: 2016
Journal Articles

Pilot Study of Combined Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib with Sorafenib in Pediatric Patients with Relapsed/Refractory FLT3+Ve AML

Hiroto Inaba, MD PhD, John C Panetta, PhD, Daelynn R Buelow, PhD, Raul C. Ribeiro, MD, John R. Eckardt, MD, Sharyn D Baker, PharmD, PhD
Journal: Blood
Blood (2016) 128 (22): 3937.
https://doi.org/10.1182/blood.V128.22.3937.3937
Published: 2016
Journal Articles

Body Mass Index Is Not Associated with Early Treatment Response or Clinical Outcome in Children with Acute Lymphoblastic Leukemia

Hesham Eissa, MD, Yinmei Zhou, MS, John C Panetta, PhD, Emily Browne, RN, MSN, CPNP, Sima Jeha, MD, Dario Campana, MD PhD, William E. Evans, PharmD, Ching-Hon Pui, MD, Mary V. Relling, PharmD, Hiroto Inaba, MD PhD
Journal: Blood
Blood (2015) 126 (23): 1299.
https://doi.org/10.1182/blood.V126.23.1299.1299
Published: 2015
Journal Articles

Generic Intravenous Busulfan in Hematopoietic Stem Cell Transplantation: Relevance of Therapeutic Drug Monitoring

Ezhil Pavai Mohanan, MSc, Shareen Stella Backia Royan, BSc, John C Panetta, PhD, Fouzia Nambiathayil Abubacker, DM, Anu Korula, MD DM, Aby Abraham, MD DM, Auro Viswabandya, MD DM, Biju George, DM, Alok Srivastava, MD FRACP, Vikram Mathews, DM, Poonkuzhali Balasubramanian, PhD
Journal: Blood
Blood (2015) 126 (23): 4322.
https://doi.org/10.1182/blood.V126.23.4322.4322
Published: 2015
Journal Articles

Population Pharmacokinetics of Fludarabine and Treosulfan in Patients with Thalassemia Undergoing Hematopoietic Stem Cell Transplantation

Ezhil Pavai Mohanan, MSc, John C Panetta, PhD, Shareen Stella Backia Royan, BSc, Ajay Abraham, MSc, Eunice Sindhuvi Edison, PhD, Kavitha M Lakshmi, MSc, Fouzia Nambiathayil Abubacker, DM, Anu Korula, MD DM, Aby Abraham, MD DM, Auro Viswabandya, MD DM, Biju George, DM, Alok Srivastava, MD FRACP, Vikram Mathews, DM, Poonkuzhali Balasubramanian, PhD
Journal: Blood
Blood (2015) 126 (23): 3120.
https://doi.org/10.1182/blood.V126.23.3120.3120
Published: 2015
Journal Articles

Pharmacokinetics of Fludarabine in Patients with Aplastic Anemia Undergoing Hematopoietic Stem Cell Transplantation

Ezhil Pavai Mohanan, MSc, John C Panetta, PhD, Kavitha M Lakshmi, MSc, Fouzia NA, MD, Abhijeet Ganapule, MD, Aby Abraham, MD, Auro Viswabandya, MD, Alok Srivastava, MD, Vikram Mathews, MD, Biju George, MD, Poonkuzhali Balasubramanian, PhD
Journal: Blood
Blood (2014) 124 (21): 3884.
https://doi.org/10.1182/blood.V124.21.3884.3884
Published: 2014
Journal Articles

Population Pharmacokinetics of Daunorubicin in AML: Influence on Clinical Outcome

Savitha Varatharajan, M.Sc, Ajay Abraham, M.Sc, John C Panetta, PhD, Sreeja Karathedath, M.Sc, Kavitha M Lakshmi, MSc, Chepsy C Philip, MD, Fouzia NA, MD, Abhijeet Ganapule, MD, Aby Abraham, MD, Auro Viswabandya, MD, Biju George, MD, Alok Srivastava, MD, Vikram Mathews, MD, Poonkuzhali Balasubramanian, PhD
Journal: Blood
Blood (2014) 124 (21): 902.
https://doi.org/10.1182/blood.V124.21.902.902
Published: 2014
Journal Articles

Genome-wide study of methotrexate clearance replicates SLCO1B1

Clinical Trials & Observations
Laura B. Ramsey, John C. Panetta, Colton Smith, Wenjian Yang, Yiping Fan, Naomi J. Winick, Paul L. Martin, Cheng Cheng, Meenakshi Devidas, Ching-Hon Pui, William E. Evans, Stephen P. Hunger, Mignon Loh, Mary V. Relling
Journal: Blood
Blood (2013) 121 (6): 898–904.
https://doi.org/10.1182/blood-2012-08-452839
Published: 2013
Includes: Supplemental data
Journal Articles

A Genome-Wide Analysis of Variants Influencing Methotrexate Clearance Replicates SLCO1B1 .

Laura B. Ramsey, PhD, John C Panetta, PhD, Colton Smith, PhD, Wenjian Yang, PhD, Yiping Fan, PhD, Naomi Winick, MD, Paul L. Martin, MD, PhD, Cheng Cheng, PhD, Meenakshi Devidas, PhD, Ching-Hon Pui, MD, William E. Evans, PharmD, Stephen P. Hunger, MD, Mignon L. Loh, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2012) 120 (21): 2466.
https://doi.org/10.1182/blood.V120.21.2466.2466
Published: 2012
Journal Articles

Dexamethasone exposure and asparaginase antibodies affect relapse risk in acute lymphoblastic leukemia

Clinical Trials & Observations
Jitesh D. Kawedia, Chengcheng Liu, Deqing Pei, Cheng Cheng, Christian A. Fernandez, Scott C. Howard, Dario Campana, John C. Panetta, W. Paul Bowman, William E. Evans, Ching-Hon Pui, Mary V. Relling
Journal: Blood
Blood (2012) 119 (7): 1658–1664.
https://doi.org/10.1182/blood-2011-09-381731
Published: 2012
Includes: Supplemental data
Journal Articles

Systemic Exposure to Dexamethasone and Asparaginase Affects Risk of Relapse in Children with Acute Lymphoblastic Leukemia

Jitesh D. Kawedia, PhD, RPh, Chengcheng Liu, Deqing Pei, MS, Cheng Cheng, PhD, Christian A Fernandez, PhD, Scott C Howard, MD, MS, Dario Campana, MD, PhD, John C Panetta, PhD, W. Paul Bowman, MD, William E. Evans, PharmD, Ching-Hon Pui, MD, Mary V. Relling, PharmD
Journal: Blood
Blood (2011) 118 (21): 2550.
https://doi.org/10.1182/blood.V118.21.2550.2550
Published: 2011