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Journal Articles

Differentiation Scoring (DS) Derived from Cellworks Computational Omics Biology Model (CBM) Predicts Response to Hypomethylating Agents (HMA) and Patient Survival in Myelodysplastic Syndrome (MDS)

Michael Castro, Shahabuddin Usmani, Ansu Kumar, Jyoti Chauhan, Shweta Kapoor, Swati Khandelwal, Vivek Patil, Subrat Mohapatra, Anuj Tyagi, Mohammed Sauban, Prashant Ramachandran Nair, Vijayashree P. Shyamasundar, Neha Dutta, Upasana Mitra, Neha Gupta, Nagendra Prasad, Ashish Kumar Agrawal, Ashokraja Balla, Rakhi Purushothaman Suseela, Veena Balakrishnan, Kishore Promod, Sanjana Patel, Michele Dundas Macpherson, James Wingrove, Scott C. Howard, Guido Marcucci
Journal: Blood
Blood (2022) 140 (Supplement 1): 4970–4971.
https://doi.org/10.1182/blood-2022-166284
Published: 2022
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Novel Biomarkers to Inform Mitoxantrone, Etoposide, and Cytarabine (MEC)-Based Combination Therapy in Refractory & Relapsed Acute Myeloid Leukemia (AML) Patients

Guido Marcucci, Ansu Kumar, Michael Castro, Himanshu Grover, Vivek Patil, Aftab Alam, Humera Azam, Subrat Mohapatra, Anuj Tyagi, Pallavi Kumari, Samiksha Avinash Prasad, Prashant Ramachandran Nair, Neelesh Lunkad, Vishwas Joseph, Poornachandra G, Jyoti Chauhan, Sayani Basu, Liptimayee Behura, Adity Ghosh, Zakir Husain, Rema Mandal, Rahul K Raman, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Scott C Howard
Journal: Blood
Blood (2021) 138 (Supplement 1): 4453.
https://doi.org/10.1182/blood-2021-153769
Published: 2021
Journal Articles

Therapy Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Is Predictive of Individual Acute Myeloid Leukemia (AML) Patient Probability of Clinical Response (CR) and Overall Survival (OS): Mycare-023

Scott C Howard, Drew Watson, Michael Castro, Shweta Kapoor, Prashant Ramachandran Nair, Samiksha Avinash Prasad, Swaminathan Rajagopalan, Aftab Alam, Kunal Ghosh Roy, Diwyanshu Sahu, Deepak Anil Lala, Kabya Basu, Yashaswini S Ullal, Yugandhara Narvekar, Adity Ghosh, Mohammed Sauban, Poornachandra G, Ashish Kumar Agrawal, Anuj Tyagi, Rakhi Purushothaman Suseela, Karthik Sundara Raju, Anusha Pampana, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 689.
https://doi.org/10.1182/blood-2021-154023
Published: 2021
Journal Articles

Biosimulation Using the Cellworks Computational Omics Biology Model (CBM) Identifies Immune Modulation As a Key Pathway for Predicting Azacitidine (AZA) Response in Myelodysplastic Syndromes (MDS)

Scott C Howard, Ansu Kumar, Michael Castro, Himanshu Grover, Subrat Mohapatra, Shweta Kapoor, Anuj Tyagi, Prashant Ramachandran Nair, Rakhi Purushothaman Suseela, Anusha Pampana, Deepak Anil Lala, Divya Singh, Vijayashree P Shyamasundar, Shruthi Kulkarni, Yugandhara Narvekar, Kritika Sahni, Rahul K Raman, Veena Balakrishnan, Mamatha Patil, Naga Ganesh Palaniyeppa, Ashokraja Balla, Sanjana Patel, Nirjhar Mundkur, James Christie, Michele Dundas Macpherson, Guido Marcucci
Journal: Blood
Blood (2021) 138 (Supplement 1): 3690.
https://doi.org/10.1182/blood-2021-153539
Published: 2021
Journal Articles

Predicting Resistance to the Combination of ATO and ATRA in APL Patients with PML-Rara Fusions, Using a Computational Biology Modeling Approach: Mycare-021-01

Scott Howard, MD, Prashant Ramachandran Nair, B.Tech., Himanshu Grover, M.S., Anuj Tyagi, M.Sc., Pallavi Kumari, M.Sc., Samiksha Avinash Prasad, M.Sc., Upasana Mitra, M.Sc., Deepak Anil Lala, B.Tech., Humera Azam, M.Sc., Neha Gupta, M.Sc., Subrat Mohapatra, M.Sc., Poornachandra G, B.Tech., Nirjhar Mundkur, Michele Dundas Macpherson, B.A.Sc., Shweta Kapoor, M.Sc.
Journal: Blood
Blood (2020) 136 (Supplement 1): 31–32.
https://doi.org/10.1182/blood-2020-140617
Published: 2020
Journal Articles

Comparative Analysis for Differential Drug Response between Early T-Cell Precursor Acute Lymphoblastic Leukemia (ETP-ALL) and T-Cell Acute Lymphoblastic Leukemia (T-ALL) Patients Using the Cellworks Omics Biology Model (CBM): Mycare-021-03

Scott Howard, MD, Ansu Kumar, M.Sc., Anusha Pampana, M.Sc., Yashaswini S Ullal, M.Tech., Anuj Tyagi, M.Sc., Deepak Anil Lala, B.Tech., Pallavi Kumari, M.Sc., Vishwas Joseph, M.Sc., Karthik Sundara Raju, M.Sc., Veena Balakrishnan, M.Sc., Nirjhar Mundkur, B.S., Michele Dundas Macpherson, B.A.Sc., Prashant Ramachandran Nair, B.Tech., Shweta Kapoor, M.Sc.
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–19.
https://doi.org/10.1182/blood-2020-139997
Published: 2020
Journal Articles

WT1 and BCORL1 Identified By Computational Biology Modeling Analysis of Patient Genomics Are Novel Predictors of Response to Azacitidine (AZA) and Lenalidomide (LEN) Treatment in Acute Myeloid Leukemia (AML)

Brett M Stevens, PhD, Amanda Winters, MDPhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Yashaswini S Ullal, B.E, Ilu Kumari, M.Sc., Anuj Tyagi, M.Sc., Aftab Alam, M.Sc., Neelesh Lunkad, M.Tech, Leylah M. Drusbosky, PhD, Christopher R. Cogle, MD, Shireen Vali, PhD, Daniel A Pollyea, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1538.
https://doi.org/10.1182/blood-2018-99-114429
Published: 2018
Journal Articles

AraC-Daunorubicin-Etoposide (ADE) Response Prediction in Pediatric AML Patients Using a Computational Biology Modeling (CBM) Based Precision Medicine Workflow

Christopher R. Cogle, MD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Mohammed Sauban, B.E, Rahul K Raman, M.Sc., Robinson Vidva, B.Tech, Anuj Tyagi, M.Sc., Anay Ashok Talawdekar, M.Tech, Arko Das, M.Sc., Steven M. Kornblau, MD, Fieke W Hoff, BSc, Terzah M. Horton, MD PhD, Shireen Vali, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4034.
https://doi.org/10.1182/blood-2018-99-115775
Published: 2018
Journal Articles

Computational Modelling of Multiple Myeloma Patient Genomic Signatures to Predict Treatment Outcome

Aneel Paulus, MD, Prachi Jani, MD, Salman Ahmed, MD, Sonikpreet Aulakh, MD, Alak Manna, PhD, Neeraj Kumar Singh, B.Tech, Mohammed Sauban, B.E, Zakir Husain, M.Tech, Ansu Kumar, M.Sc., Pallavi Kumari, M.Sc., Anuj Tyagi, M.Sc., Taimur Sher, MD, Rami Manochakian, MD, Vivek Roy, MD, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Asher A. Chanan-Khan, MD, Sikander Ailawadhi
Journal: Blood
Blood (2018) 132 (Supplement 1): 1911.
https://doi.org/10.1182/blood-2018-99-119574
Published: 2018
Journal Articles

A Protective Role of DNA Repair Genes Against Acute Graft Versus Host Disease in Children

Patricia Huezo-Diaz, Chakradhara RS Uppugunduri, PhD, Mohamed Aziz Rezgui, MsC, Anuj Tyagi, PhD, Vid Mlakar, PhD, Laurence Lesne, MSc, Tiago Nava, MD, Yves Theoret, PhD, Yves Chalandon, MD PhD, Robbert Bredius, PhD MD, Jean-Hugues Dalle, MD PhD, Peter Bader, MD PhD, Christina Peters, MD, Henrique Bittencourt, MD PhD, Maja Krajinovic, MD PhD, Marc Ansari, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 749.
https://doi.org/10.1182/blood.V130.Suppl_1.749.749
Published: 2017
Journal Articles

Computational Biology Model of ETP-ALL Used to Accurately Classify ETP-ALL Vs Non ETP-ALL Patients with Genomic Input

Leylah M. Drusbosky, PhD, Ansu Kumar, MS, Shwetha K, BE, Sumanth Vasista, BE, Anuj Tyagi, MS, Swaminathan Rajagopalan, MT, Aftab Alam, MS, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Girish Chinnaswamy, MD MRCP, Manju Sengar, MD DM, Bijal D. Shah, MD, Christopher R. Cogle, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1449.
https://doi.org/10.1182/blood.V130.Suppl_1.1449.1449
Published: 2017
Journal Articles

Personalized Therapy Design for MPN Using Predictive Simulation Methodology with in Vitro, Ex Vivo, and in Vivo Validatio

Peter P. Sayeski, PhD, Shireen Vali, PhD, Ansu Kumar, Sung Park, PhD, Neeraj Kumar Singh, Anuj Tyagi, Taher Abbasi, MS, Christopher R. Cogle, MD
Journal: Blood
Blood (2014) 124 (21): 3212.
https://doi.org/10.1182/blood.V124.21.3212.3212
Published: 2014
Journal Articles

A Novel Simulation Method for Mapping Dysregulated Pathways and Predicting Effective Therapeutics in the Myelodysplastic Syndromes

Christopher R. Cogle, MD, Kaoru Tohyama, MD PhD, Shireen Vali, PhD, Ansu Kumar, Neeraj Kumar Singh, Krishna Kumar Tiwari, Anuj Tyagi, Taher Abbasi, MS, Peter P. Sayeski, PhD
Journal: Blood
Blood (2014) 124 (21): 5595.
https://doi.org/10.1182/blood.V124.21.5595.5595
Published: 2014
Journal Articles

Ex Vivo Patient-Specific Validation Of Personalized Therapeutic Designed For Multiple Myeloma

Nicole A Doudican, PhD, Shireen Vali, PhD, Shweta Kapoor, Anay Talawdekar, Zeba Sultana, Aftab Alam, Ansu Kumar, Neeraj Kumar Singh, Anuj Tyagi, Taher Abbasi, Amitabha Mazumder, M.D.
Journal: Blood
Blood (2013) 122 (21): 4219.
https://doi.org/10.1182/blood.V122.21.4219.4219
Published: 2013