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Journal Articles

Introduction to a review series on globin disorders

Thomas D. Coates, Irene Roberts
Journal: Blood
Blood (2024) 144 (8): 797–798.
https://doi.org/10.1182/blood.2024025678
Published: 2024
Journal Articles

Optimal, Off-the-Shelf, CAR-iNKT Cell Platform-Based Immunotherapy for Multiple Myeloma

Kanagaraju Ponnusamy, Lyra Randzavola, Hongwei Ren, Klesti Karaxhuku, Bryan Lye, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Ilia Leontari, Farah Sabrin, Mehmood Zaidi, Marco Bua, Maria Atta, Alexia Katsarou, Irene Roberts, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2023) 142 (Supplement 1): 3459.
https://doi.org/10.1182/blood-2023-189905
Published: 2023
Journal Articles

GATA1 Target Gene CSF2RB Is Functionally Coupled to MPL and Marks a TPO-Dependent Preleukemic TAM Cell Population Sustained By the Fetal Liver but Not Bone Marrow

David Cruz Hernandez, Nicolas Papadopoulos, Elise Sepulchre, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Leila Varghese, Gabriel Levy, Irene Roberts, Stefan N Constantinescu, Paresh Vyas
Journal: Blood
Blood (2023) 142 (Supplement 1): 404.
https://doi.org/10.1182/blood-2023-174449
Published: 2023
Journal Articles

Bispecific CAR-iNKT Immunotherapy for High Risk MLL-Rearranged Acute Lymphoblastic Leukemia

Hongwei Ren, Natalina Elliott, Bryan Lye, Joe Cross, Lucy Field, Kanagaraju Ponnusamy, Irene Roberts, Christina Halsey, Thomas Arthur Milne, Anindita Roy, Anastasios Karadimitris
Journal: Blood
Blood (2023) 142 (Supplement 1): 766.
https://doi.org/10.1182/blood-2023-186442
Published: 2023
Journal Articles

Development of Novel Invariant TCR-Anchored Bispecific Engagers to Enhance Anti-Cancer Activity of iNKT Cells

Klesti Karaxhuku, Kanagaraju Ponnusamy, Hongwei Ren, Bryan Lye, Ilia Leontari, Mehmood Zaidi, Farah Sabrin, Marco Bua, Maria Atta, Alexia Katsarou, Irene Roberts, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2023) 142 (Supplement 1): 4828.
https://doi.org/10.1182/blood-2023-190598
Published: 2023
Journal Articles

Introduction to a review series on pediatric hematology

Thomas L. Ortel, Irene Roberts
Journal: Blood
Blood (2022) 140 (6): 523.
https://doi.org/10.1182/blood.2022017225
Published: 2022
Journal Articles

CD34 + CD19 − CD22 + B-cell progenitors may underlie phenotypic escape in patients treated with CD19-directed therapies

Brief Report
Clara Bueno, Susana Barrera, Alex Bataller, Valentín Ortiz-Maldonado, Natalina Elliot, Sorcha O’Byrne, Guanlin Wang, Montse Rovira, Francisco Gutierrez-Agüera, Juan L. Trincado, María González-González, Mireia Morgades, Marc Sorigué, Paloma Bárcena, Samanta Romina Zanetti, Montse Torrebadell, Nerea Vega-Garcia, Susana Rives, Mar Mallo, Francesc Sole, Adam J. Mead, Irene Roberts, Supat Thongjuea, Bethan Psaila, Manel Juan, Julio Delgado, Alvaro Urbano-Ispizúa, Josep María Ribera, Alberto Orfao, Anindita Roy, Pablo Menendez
Journal: Blood
Blood (2022) 140 (1): 38–44.
https://doi.org/10.1182/blood.2021014840
Published: 2022
Includes: Supplemental data
Journal Articles

Epigenome-Wide Association Study of Acute Lymphoblastic Leukemia in Children with Down Syndrome

Shaobo Li, Pagna Sok, Keren Xu, Ivo S Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M Hansen, Libby M Morimoto, Alice Y Kang, Catherine Metayer, Xiaomei Ma, Beth A Mueller, Anindita Roy, Irene Roberts, Karen R Rabin, Austin L Brown, Philip J. Lupo, Joseph L. Wiemels, Adam J. de Smith
Journal: Blood
Blood (2021) 138 (Supplement 1): 214.
https://doi.org/10.1182/blood-2021-151454
Published: 2021
Journal Articles

The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes

Brief Report
Peng Hua, Joanna Hester, George Adigbli, Rong Li, Bethan Psaila, Anindita Roy, Carole J. R. Bataille, Graham M. Wynne, Thomas Jackson, Thomas A. Milne, Angela J. Russell, James Davies, Irene Roberts, Fadi Issa, Suzanne M. Watt
Journal: Blood
Blood (2020) 136 (21): 2410–2415.
https://doi.org/10.1182/blood.2020005357
Published: 2020
Includes: Supplemental data
Journal Articles

Single-Cell Transcriptional Landscapes of Human Bone Marrow Reveal Distinct Erythroid Phenotypes Underpinned By Genotype in Diamond-Blackfan Anemia

Deena Iskander, MD, Guanlin Wang, PhD, Elisabeth F Heuston, PhD, Chrysi Christodoulidou, Bethan Psaila, MD PhD, Mark E Robinson, PhD, Aristeidis Chaidos, MD PhD, Pritesh Trivedi, MSc, Nikolaos Trasanidis, PhD, Alexia Katsarou, MD, Richard Szydlo, PhD, NISC Comparative SequencingProgram, Qais Al-Oqaily, MD PhD, Valentina S Caputo, PhD, Kanagaraju Ponnusamy, PhD, Anindita Roy, MD PhD, Leena Karnik, FRCPath, MRCP, Kikkeri Naresh, MD, Adam J. Mead, MD PhD, Supat Thongjuea, PhD, Marjorie Brand, PhD, Josu de la Fuente, David M. Bodine, PhD, Irene Roberts, MD PhD, Anastasios Karadimitris, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 1–2.
https://doi.org/10.1182/blood-2020-141535
Published: 2020
Journal Articles

Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome

David Cruz Hernandez, Marlen Metzner, Anne Pieta de Groot, Batchimeg Usukhbayar, Natalina Elliott, Irene Roberts, Paresh Vyas
Journal: Blood
Blood (2020) 136 (12): 1460–1465.
https://doi.org/10.1182/blood.2020005610
Published: 2020
Includes: Supplemental data
Journal Articles

Single-cell analysis of bone marrow–derived CD34 + cells from children with sickle cell disease and thalassemia

Peng Hua, Noemi Roy, Josu de la Fuente, Guanlin Wang, Supat Thongjuea, Kevin Clark, Anindita Roy, Bethan Psaila, Neil Ashley, Yvonne Harrington, Claus Nerlov, Suzanne M. Watt, Irene Roberts, James O. J. Davies
Journal: Blood
Blood (2019) 134 (23): 2111–2115.
https://doi.org/10.1182/blood.2019002301
Published: 2019
Includes: Supplemental data
Journal Articles

Distinct Chromatin Accessibility Changes, Aberrant Transcription Factor Networks Combined with Novel Oncogenic Enhancers Characterise Myeloma-Initiating Genetic Events

Nikolaos Trasanidis, Jaime Alvarez-Benayas, Alexia Katsarou, Aristeidis Chaidos, Philippa C May, Kanagaraju Ponnusamy, Xiaolin Xiao, Marco Bua, MD, Maria Atta, MD, Irene Roberts, Holger W Auner, MD PhD, Evdoxia Hatjiharissi, Maria Papaioannou, Valentina S Caputo, Ian Sudbery, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 1769.
https://doi.org/10.1182/blood-2019-124761
Published: 2019
Journal Articles

Novel ZBP1-IRF3 Dependency in Multiple Myeloma Mediated By IRF3-Driven Regulation of Cell Cycle Genes

Kanagaraju Ponnusamy, Maria-Myrsini Tzioni, MS, Murshida Begum, MS, Mark E Robinson, Valentina S Caputo, Alexia Katsarou, Nikolaos Trasanidis, Xiaolin Xiao, Ioannis V. Kostopoulos, Deena Iskander, MD, Irene Roberts, Pritesh Trivedi, MSc, Holger W Auner, MD PhD, Kikkeri Naresh, MD, Aristeidis Chaidos, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 2521.
https://doi.org/10.1182/blood-2019-125768
Published: 2019
Journal Articles

Trisomy 21 Driven Pro-Inflammatory Signalling in Fetal Bone Marrow May Play a Role in Perturbed B-Lymphopoiesis and Acute Lymphoblastic Leukemia of Down Syndrome

Sorcha Isabella O'Byrne, BSc, Natalina Elliott, PhD, Gemma Buck, BSc, Siobhan Rice, David O'Connor, Jana Oswald, Hannah Fuchs, Ella-Mae Labbett, Nicholas James Fordham, MBBS, BSc, Anindita Roy, MD PhD, Irene Roberts
Journal: Blood
Blood (2019) 134 (Supplement_1): 1206.
https://doi.org/10.1182/blood-2019-130180
Published: 2019
Journal Articles

Oncogenic MAF in Co-Operation with IRF4 Confers Extensive Chromatin Re-Arrangement in Plasma Cells and Generates 'Neo-Enhancers' That Regulate Genes Critical for Myeloma Biology

Alexia Katsarou, Nikolaos Trasanidis, Jaime Alvarez-Benayas, Foteini Papaleonidopoulou, Keren Keren, Ioannis V. Kostopoulos, Kanagaraju Ponnusamy, Xiaolin Xiao, Niklas Feldhahn, Irene Roberts, Evdoxia Hatjiharissi, Maria Papaioannou, Ian Sudbery, Aristeidis Chaidos, Valentina S Caputo, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 3783.
https://doi.org/10.1182/blood-2019-122371
Published: 2019
Journal Articles

PBX1 Co-Operates with FOXM1 to Regulate Myeloma Cell Proliferation and to Define an Ultra High-Risk chr1q Gain Myeloma Patient Subgroup

Nikolaos Trasanidis, Alexia Katsarou, Bien Bergonia, Keren Keren, Ioannis V. Kostopoulos, Kanagaraju Ponnusamy, Reema Paudel, Xiaolin Xiao, Holger W Auner, MD PhD, Irene Roberts, Kikkeri Naresh, MD, Aristeidis Chaidos, Luca Magnani, Valentina S Caputo, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 3760.
https://doi.org/10.1182/blood-2019-124109
Published: 2019
Journal Articles

Myc and Bet Proteins Orchestrate the Early Regulatory Genome Changes Required for Osteoclast Lineage Commitment

Valentina S Caputo, Nikolaos Trasanidis, Xiaolin Xiao, Mark E Robinson, Alexia Katsarou, Kanagaraju Ponnusamy, Aristeidis Chaidos, Holger W Auner, MD PhD, Irene Roberts, Anastasios Karadimitris
Journal: Blood
Blood (2019) 134 (Supplement_1): 4329.
https://doi.org/10.1182/blood-2019-125047
Published: 2019
Journal Articles

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Sorcha O’Byrne, Natalina Elliott, Siobhan Rice, Gemma Buck, Nicholas Fordham, Catherine Garnett, Laura Godfrey, Nicholas T. Crump, Gary Wright, Sarah Inglott, Peng Hua, Bethan Psaila, Benjamin Povinelli, David J. H. F. Knapp, Antonio Agraz-Doblas, Clara Bueno, Ignacio Varela, Phillip Bennett, Hashem Koohy, Suzanne M. Watt, Anastasios Karadimitris, Adam J. Mead, Phillip Ancliff, Paresh Vyas, Pablo Menendez, Thomas A. Milne, Irene Roberts, Anindita Roy
Journal: Blood
Blood (2019) 134 (13): 1059–1071.
https://doi.org/10.1182/blood.2019001289
Published: 2019
Includes: Supplemental data
Journal Articles

Towards an External Quality Assessment for Next Generation Sequencing in the Diagnosis of Rare Inherited Anaemias

Noemi Roy, MBBCH, MD, Melanie Proven, PhD, Irene Roberts, MD, Hannah Tamary, MD, Dorine W. Swinkels, MD PhD, Aguilar-Martinez Patricia, MD PhD, Paola Bianchi, BSc, PhD, Raffaella Colombatti, MD PhD, Roberta Russo, Barnaby Clark, Mayka Sanchez, MD, Rafael Andres DEL Orbe Barreto, Elisa Fermo, PhD, Vip Viprakasit, MD DPhil, Jiraporn Korchuenjit, BSc, Tabita Magalhães Maia, MD, Frances Smith, BSc, Maria del Mar Manu, BSc, PhD, Lydie Da Costa, Antonio Marzollo, Anabelen Hozdelarastrollo, Beatriz Arrizabalaga, MD PhD, Delasalle Barbara, Achille Iolascon, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4936.
https://doi.org/10.1182/blood-2018-99-111609
Published: 2018