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Stuart M. Pitson
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Journal Articles

Genome-wide transcription factor–binding maps reveal cell-specific changes in the regulatory architecture of human HSPCs

Shruthi Subramanian, Julie A. I. Thoms, Yizhou Huang, Paola Cornejo-Páramo, Forrest C. Koch, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S. Woll, Diego Chacon-Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O'Brien, Annette Trickett, Jason A. Powell, Ian D. Lewis, Stuart M. Pitson, Maher K. Gandhi, Steven W. Lane, Fatemeh Vafaee, Emily S. Wong, Berthold Göttgens, Hamid Alinejad-Rokny, Jason W. H. Wong, John E. Pimanda
Journal: Blood
Blood (2023) 142 (17): 1448–1462.
https://doi.org/10.1182/blood.2023021120
Published: 2023
Includes: Supplemental data
Journal Articles

Comparative Analysis of Genome-Scale Gene Regulatory Networks in Human Hematopoietic Stem and Myeloid Progenitor Fractions

Shruthi Subramanian, Julie A.I. Thoms, Yizhou Huang, Sebastien Jacquelin, Sylvie Shen, Emma Song, Swapna Joshi, Chris Brownlee, Petter S Woll, Diego Chacon Fajardo, Dominik Beck, David J. Curtis, Kenneth Yehson, Vicki Antonenas, Tracey O' Brien, Annette Trickett, Jason Powell, Stuart M Pitson, Maher K. Gandhi, Paola Cornejo, Emily Wong, Steven W Lane, Bertie Gottgens, Hamid Alinejad Rokny, Jason W.H Wong, John E. Pimanda
Journal: Blood
Blood (2022) 140 (Supplement 1): 2846–2848.
https://doi.org/10.1182/blood-2022-165620
Published: 2022
Journal Articles

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D’Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Journal: Blood
Blood (2022) 139 (26): 3737–3751.
https://doi.org/10.1182/blood.2021013277
Published: 2022
Includes: Supplemental data
Journal Articles

Dual Sphingosine Kinase and Bcl-2 Inhibition Exhibits Synergistic Cell Death in Acute Myeloid Leukemia

Alexander C. Lewis, BSc, Richard D'Andrea, BSc,PhD, Jason A Powell, BSc, PhD, Stuart M Pitson, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2660.
https://doi.org/10.1182/blood.V130.Suppl_1.2660.2660
Published: 2017
Journal Articles

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P. Cameron, Katherine M. Hannan, Nhu-Y N. Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R. Devlin, Amee J. George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J. Harrison, James D. Rozario, Jason A. Powell, Stuart M. Pitson, Johannes Zuber, Ricky W. Johnstone, Mark A. Dawson, Mark A. Guthridge, Andrew Wei, Grant A. McArthur, Richard B. Pearson, Ross D. Hannan
Journal: Blood
Blood (2017) 129 (21): 2882–2895.
https://doi.org/10.1182/blood-2016-05-718171
Published: 2017
Includes: Supplemental data
Journal Articles

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

Jason A. Powell, Alexander C. Lewis, Wenying Zhu, John Toubia, Melissa R. Pitman, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Diana Iarossi, Saumya E. Samaraweera, Nik Cummings, Hayley S. Ramshaw, Daniel Thomas, Andrew H. Wei, Angel F. Lopez, Richard J. D’Andrea, Ian D. Lewis, Stuart M. Pitson
Journal: Blood
Blood (2017) 129 (6): 771–782.
https://doi.org/10.1182/blood-2016-06-720433
Published: 2017
Includes: Supplemental data
Journal Articles

Evaluation Of Sphingosine Kinase 1 As a Therapeutic Target In B-Lineage Acute Lymphoblastic Leukemia

Craig T Wallington-Beddoe, BSc, MBBS, PhD, FRACP, FRCPA, Stuart M Pitson, BAppSc, PhD, Jason A Powell, BSc, PhD, Kenneth F Bradstock, MBBS, PhD, FRACP, FRCPA, Linda J Bendall, BSc, PhD
Journal: Blood
Blood (2013) 122 (21): 1426.
https://doi.org/10.1182/blood.V122.21.1426.1426
Published: 2013
Journal Articles

Sphingosine-1-phosphate facilitates trafficking of hematopoietic stem cells and their mobilization by CXCR4 antagonists in mice

Julius G. Juarez, Nadia Harun, Marilyn Thien, Robert Welschinger, Rana Baraz, Aileen Dela Pena, Stuart M. Pitson, Michael Rettig, John F. DiPersio, Kenneth F. Bradstock, Linda J. Bendall
Journal: Blood
Blood (2012) 119 (3): 707–716.
https://doi.org/10.1182/blood-2011-04-348904
Published: 2012
Includes: Supplemental data
Journal Articles

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

Claudine S. Bonder, Wai Y. Sun, Tyson Matthews, Carlos Cassano, Xiaochun Li, Hayley S. Ramshaw, Stuart M. Pitson, Angel F. Lopez, P. Toby Coates, Richard L. Proia, Mathew A. Vadas, Jennifer R. Gamble
Journal: Blood
Blood (2009) 113 (9): 2108–2117.
https://doi.org/10.1182/blood-2008-07-166942
Published: 2009
Includes: Supplemental data
Journal Articles

Basal and angiopoietin-1–mediated endothelial permeability is regulated by sphingosine kinase-1

Xiaochun Li, Milena Stankovic, Claudine S. Bonder, Christopher N. Hahn, Michelle Parsons, Stuart M. Pitson, Pu Xia, Richard L. Proia, Mathew A. Vadas, Jennifer R. Gamble
Journal: Blood
Blood (2008) 111 (7): 3489–3497.
https://doi.org/10.1182/blood-2007-05-092148
Published: 2008
Includes: Supplemental data