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Richard B. Pearson
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Journal Articles

Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death

Ana Domostegui, Suresh Peddigari, Carol A. Mercer, Flavia Iannizzotto, Marta L. Rodriguez, Marta Garcia-Cajide, Virginia Amador, Sarah T. Diepstraten, Gemma L. Kelly, Ramón Salazar, Sara C. Kozma, Eric P. Kusnadi, Jian Kang, Antonio Gentilella, Richard B. Pearson, George Thomas, Joffrey Pelletier
Journal: Blood
Blood (2021) 137 (24): 3351–3364.
https://doi.org/10.1182/blood.2020007452
Published: 2021
Includes: Supplemental data
Journal Articles

A High-Throughput Screening Approach to Identify Therapeutics for the Treatment of Diamond-Blackfan Anaemia

Lorena Nunez Villacis, Sheren J Al-Obaidi, Piyush Madhamshettiwar, PhD, Nadine Hein, PhD, Jun Chen, MD PhD, Priscilla Soo, Perlita Poh, Megan Pavy, Kaylene J Simpson, PhD, Thomas John Gonda, PhD BSc, Richard B Pearson, PhD, Johan Flygare, MD PhD, Katherine M Hannan, PhD, Amee J George, PhD, Ross Hannan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3859.
https://doi.org/10.1182/blood-2018-99-114303
Published: 2018
Journal Articles

RNA Polymerase 1 Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Malignancies: Results of a Phase I First in Human Study

Amit Khot, MBBS, MD MRCP, FRCPath, FRACP, Natalie Brajanovski, BSc, Donald P Cameron, BSc, Gretchen Poortinga, PhD, Elaine Sanij, PhD, John Lim, PharmD, John Soong, MD FCAP, Nadine Hein, PhD, Emma Link, DPhil, Richard B Pearson, PhD, Ross Hannan, Grant A. McArthur, MBBS, PhD BSc, FRACP, Simon J. Harrison, MBBS,MRCP,FRCPath,FRACP,PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3835.
https://doi.org/10.1182/blood.V130.Suppl_1.3835.3835
Published: 2017
Journal Articles

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Nadine Hein, Donald P. Cameron, Katherine M. Hannan, Nhu-Y N. Nguyen, Chun Yew Fong, Jirawas Sornkom, Meaghan Wall, Megan Pavy, Carleen Cullinane, Jeannine Diesch, Jennifer R. Devlin, Amee J. George, Elaine Sanij, Jaclyn Quin, Gretchen Poortinga, Inge Verbrugge, Adele Baker, Denis Drygin, Simon J. Harrison, James D. Rozario, Jason A. Powell, Stuart M. Pitson, Johannes Zuber, Ricky W. Johnstone, Mark A. Dawson, Mark A. Guthridge, Andrew Wei, Grant A. McArthur, Richard B. Pearson, Ross D. Hannan
Journal: Blood
Blood (2017) 129 (21): 2882–2895.
https://doi.org/10.1182/blood-2016-05-718171
Published: 2017
Includes: Supplemental data
Journal Articles

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Jake Shortt, Benjamin P. Martin, Andrea Newbold, Katherine M. Hannan, Jennifer R. Devlin, Adele J. Baker, Rachael Ralli, Carleen Cullinane, Clemens A. Schmitt, Maurice Reimann, Michael N. Hall, Meaghan Wall, Ross D. Hannan, Richard B. Pearson, Grant A. McArthur, Ricky W. Johnstone
Journal: Blood
Blood (2013) 121 (15): 2964–2974.
https://doi.org/10.1182/blood-2012-08-446096
Published: 2013
Includes: Supplemental data
Journal Articles

Inhibition of RNA Polymerase I Transcription by CX-5461 As a Therapeutic Strategy for the Cancer-Specific Activation of p53 in MLL-Rearranged Acute Myeloid Leukemias

Nadine Hein, PhD, Megan J Bywater, PhD, Kim Stanley, BSc, Inge Verbrugge, PhD, Carlene Cullinane, PhD, Adele Baker, PhD, Hannes Zuber, PhD, Amy Rappaport, PhD, Denis Drygin, PhD, Nanni Huser, PhD, Josh Bliesath, PhD, David M Ryckman, PhD, William G Rice, PhD, Scott W Lowe, PhD, Ricky W Johnstone, PhD, Richard B Pearson, PhD, Grant A. McArthur, MD, PhD, FRACP, MBBS, Ross D Hannan, PhD
Journal: Blood
Blood (2011) 118 (21): 1548.
https://doi.org/10.1182/blood.V118.21.1548.1548
Published: 2011
Journal Articles

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation

Anissa M. Jabbour, Carmel P. Daunt, Benjamin D. Green, Sandra Vogel, Lavinia Gordon, Rachel S. Lee, Natasha Silke, Richard B. Pearson, Cassandra J. Vandenberg, Priscilla N. Kelly, Stephen L. Nutt, Andreas Strasser, Christoph Borner, Paul G. Ekert
Journal: Blood
Blood (2010) 115 (2): 344–352.
https://doi.org/10.1182/blood-2009-07-230730
Published: 2010
Includes: Supplemental data
Journal Articles

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Meaghan Wall, Gretchen Poortinga, Katherine M. Hannan, Richard B. Pearson, Ross D. Hannan, Grant A. McArthur
Journal: Blood
Blood (2008) 112 (6): 2305–2317.
https://doi.org/10.1182/blood-2007-09-111856
Published: 2008
Includes: Supplemental data
Journal Articles

Inhibition of mTOR Reverses the Ability of c-MYC To Block the Differentiation of Murine Granulocytes.

Meaghan Wall, Gretchen Poortinga, Richard B. Pearson, Ross D. Hannan, Grant A. McArthur
Journal: Blood
Blood (2005) 106 (11): 310.
https://doi.org/10.1182/blood.V106.11.310.310
Published: 2005