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Journal Articles

Impact of Mono- and Bi-Allelic TP53 Aberrations on Transformation of Human HSPCs

Karin Lind, Sayantanee Dutta, Marco Cosenza, Thomas Eder, Johannes Foßelteder, Gabriel Pabst, Wolfgang Schöll, Andreas Prokesch, Andreas Reinisch, Albert Woelfler, Armin Zebisch, Florian Grebien, Jan O. Korbel, Heinz Sill

Blood (2024) 144 (Supplement 1): 5631.

https://doi.org/10.1182/blood-2024-203217

Published: 2024

Journal Articles

Modeling the Development of SRSF2 Mutated Myeloid Malignancies By CRISPR/Cas9 Mediated Genome Engineering of Primary Human Hematopoietic Stem and Progenitor Cells

Gabriel Pabst, Johannes Foßelteder, Angelika Schlacher, Lisa Auinger, Daniel Martinez-Krams, Asiri Ediriwickrema, Karl Kashofer, Christine Beham-Schmid, Hildegard T. Greinix, Albert Woelfler, Peter Schlenke, Heinz Sill, Armin Zebisch, Ravi Majeti, Andreas Reinisch

Blood (2021) 138 (Supplement 1): 2160.

https://doi.org/10.1182/blood-2021-149591

Published: 2021

Journal Articles

Introduction and Genetic Correction of Calreticulin Mutations in Human Hematopoietic Stem and Progenitor Cells Sheds Light on MPN Pathogenesis

Johannes Foßelteder, Angelika Schlacher, Gabriel Pabst, Bettina Amtmann, Wolfgang Schöll, Karl Kashofer, Christine Beham-Schmid, Peter Schlenke, Hildegard T. Greinix, Heinz Sill, Albert Woelfler, Armin Zebisch, Andreas Reinisch

Blood (2021) 138 (Supplement 1): 2541.

https://doi.org/10.1182/blood-2021-147919

Published: 2021

Journal Articles

A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Denis Tvorogov, Chloe AL Thompson-Peach, Johannes Foßelteder, Mara Dottore, Frank Stomski, Kelly SY Lim, Suraiya A Onnesha, David M Ross, Andreas Reinisch, Daniel Thomas, Angel F. Lopez

Blood (2021) 138 (Supplement 1): 3597.

https://doi.org/10.1182/blood-2021-154332

Published: 2021

Journal Articles

Cytokine Rescue and Targeting of Inflammation-Sensitive RUNX1 Deficient Human CD34 + Hematopoietic Stem and Progenitor Cells

Amy Fan, Armon Azizi, BS, Kevin Nuno, BS, Yusuke Nakauchi, MD PhD, Feifei Zhao, MD, Andreas Reinisch, MD PhD, David Cruz Hernandez, MS, Ravindra Majeti, MD PhD

Blood (2020) 136 (Supplement 1): 14–15.

https://doi.org/10.1182/blood-2020-137173

Published: 2020

Journal Articles

Induction of Truncating ASXL1 Mutations in Human CD34+ HSPCs Mimics Human ASXL1-Mutated Clonal Hematopoiesis and Progression to Myeloid Malignancies

Thomas Koehnke, MD, Rajiv Sharma, PhD, Yusuke Nakauchi, MD PhD, Andreas Reinisch, MD PhD, Ravi Majeti, MD PhD

Blood (2019) 134 (Supplement_1): 820.

https://doi.org/10.1182/blood-2019-130528

Published: 2019

Journal Articles

Azacitidine and Ascorbate Inhibit the Competitive Outgrowth of Human TET2 Mutant HSPCs in a Xenograft Model of Pre-Leukemia

Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Rajiv Sharma, PhD, M. Ryan Corces, PhD, Andreas Reinisch, MD PhD, David Cruz, MS, Thomas Koehnke, MD PhD, Daiki Karigane, MDPhD, Amy Fan, BS, Ravindra Majeti, MD PhD

Blood (2018) 132 (Supplement 1): 887.

https://doi.org/10.1182/blood-2018-99-113907

Published: 2018

Journal Articles

A Novel Model of Human Hemopoiesis Based on Single Cell Functional and Transcriptional Analysis of Lympho-Myeloid Progenitors

Blood (2017) 130 (Supplement 1): 2413.

https://doi.org/10.1182/blood.V130.Suppl_1.2413.2413

Published: 2017

Journal Articles

Characterization and Targeting TET2-Mutant HSPCs and AML

Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Andreas Reinisch, MD PhD, Rajiv Sharma, PhD, David Cruz, BS, M. Ryan Corces, PhD, Ravi Majeti, MD PhD

Blood (2017) 130 (Supplement 1): 2509.

https://doi.org/10.1182/blood.V130.Suppl_1.2509.2509

Published: 2017

Journal Articles

Pluripotent Reprogramming of Human AML Resets Leukemic Behavior and Models Therapeutic Targeting of Subclones

Mark Ping Chao, MD PhD, Gentles Andrew, PhD, Chatterjee Susmita, MS, Andreas Reinisch, MDPhD, M. Ryan Corces, PhD, Jinfeng Shen, PhD, Morganti Rachel, Rahul Singha, PhD, Daniel Haag, PhD, Marius Wernig, PhD, Joseph Wu, MD PhD, Ravi Majeti, MD PhD

Blood (2016) 128 (22): 575.

https://doi.org/10.1182/blood.V128.22.575.575

Published: 2016

Journal Articles

Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

Claire Mazumdar, Ying Shen, Seethu Xavy, Feifei Zhao, Andreas Reinisch, MDPhD, Rui Li, Michael Ryan Corces-Zimmerman, PhD, Jason Buenrostro, Steven M. Chan, MD PhD, Daniel Thomas, MD PhD, Julie Koenig, Wan-Jen Hong, MD, Howard Chang, MD PhD, Ravi Majeti, MD PhD

Blood (2015) 126 (23): 841.

https://doi.org/10.1182/blood.V126.23.841.841

Published: 2015

Journal Articles

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition

Subarna Sinha, Daniel Thomas, Linda Yu, Andrew J. Gentles, Namyoung Jung, M. Ryan Corces-Zimmerman, Steven M. Chan, Andreas Reinisch, Andrew P. Feinberg, David L. Dill, Ravindra Majeti

Blood (2015) 125 (2): 316–326.

https://doi.org/10.1182/blood-2014-03-566018

Published: 2015

Includes: Supplemental data

Journal Articles

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

Blood (2015) 125 (2): 249–260.

https://doi.org/10.1182/blood-2014-04-572255

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

A Novel Humanized Bone Marrow Niche Xenotransplantation Model Allows Superior Engraftment of Human Normal and Malignant Hematopoietic Cells and Reveals Myelofibrosis-Initiating Cells in the HSC Compartment

Andreas Reinisch, MDPhD, Dita Gratzinger, MD PhD, Wan-Jen Hong, MD, Ravi Majeti, MD PhD

Blood (2014) 124 (21): 349.

https://doi.org/10.1182/blood.V124.21.349.349

Published: 2014

Journal Articles

Organotypic Epigenetic Signature Predicts Bone and Marrow Niche Forming Capacity of Stromal Progenitors in a Novel Mouse Model in Vivo .

Andreas Reinisch, MD, PhD, Nathalie Etchart, PhD, Nicole A Hofmann, MSc, Margareta Frühwirth, Anna Ortner, MSc, Daniela Thaler, Birgit Feilhauer, Udo F Hartwig, Christine Beham-Schmid, MD, Slave Trajanosky, Wolfgang Wagner, MD, PhD, Frauke Alves, Katharina Schallmoser, MD, Michael Andreeff, MD, PhD, Dirk Strunk, MD

Blood (2012) 120 (21): 2987.

https://doi.org/10.1182/blood.V120.21.2987.2987

Published: 2012

Journal Articles

Maintenance of Osteogenic Differentiation Capacity of MSPC Despite Amplified Proliferation Under Elevated Oxgen Conditions

Katharina Schallmoser, MD, Nicole A Hofmann, MSc, Andreas Reinisch, MD, PhD, Anna Ortner, MSc, Claudia Url, Nathalie Etchart, PhD, Sylvia Joussen, MSc, Wolfgang Wagner, MD, PhD, Dirk Strunk, MD

Blood (2012) 120 (21): 1916.

https://doi.org/10.1182/blood.V120.21.1916.1916

Published: 2012

Journal Articles

A Novel Role for Mesenchymal Stem/Progenitor Cells As Hypoxia Sensors During Initiation of Neo-Vasculogenesis in Vivo

Nicole A Hofmann, MSc, Anna Ortner, MSc, Rodrigo Jacamo, Ph.D, Andreas Reinisch, MD, PhD, Katharina Schallmoser, MD, Rokhsareh Rohban, Margareta Frühwirth, Nathalie Liechtenstein, Christine Beham-Schmid, MD, Werner Linkesch, Michael Andreeff, MD, PhD, Dirk Strunk, MD

Blood (2012) 120 (21): 613.

https://doi.org/10.1182/blood.V120.21.613.613

Published: 2012

Journal Articles

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

Ye Chen, Rodrigo Jacamo, Yue-xi Shi, Rui-yu Wang, Venkata Lokesh Battula, Sergej Konoplev, Dirk Strunk, Nicole A. Hofmann, Andreas Reinisch, Marina Konopleva, Michael Andreeff

Blood (2012) 119 (21): 4971–4980.

https://doi.org/10.1182/blood-2011-11-389957

Published: 2012

Includes: Multimedia, Supplemental data

Journal Articles

Dissociation of In Vivo and in Vitro Differentiation Capacity of Human Mesenchymal Stem Cells Is Reflected by a Tissue Specific Epigenetic Memory

Andreas Reinisch, MD, PhD, Nathalie Liechtenstein, Nicole A Hofmann, MSc, Anna Ortner, Margareta Frühwirth, Katharina Schallmoser, MD, Christine Beham-Schmid, MD, Dirk Strunk, MD

Blood (2011) 118 (21): 2386.

https://doi.org/10.1182/blood.V118.21.2386.2386

Published: 2011

Journal Articles

Platelet-Derived Factors Allow Human Mesenchymal Stem Cells to Spontaneously Undergo Endochondral Bone Differentiation and Provide Bone Marrow Support in a Xenogenic In Vivo Model

Nathalie Etchart, PhD, Andreas Reinisch, MD, PhD, Anna Ortner, Margareta Frühwirth, Rokhsareh Rohban, Claudia Url, Katharina Schallmoser, MD, Christine Beham-Schmid, MD, Dirk Strunk, MD

Blood (2011) 118 (21): 1322.

https://doi.org/10.1182/blood.V118.21.1322.1322

Published: 2011

NARROW

Impact of Mono- and Bi-Allelic TP53 Aberrations on Transformation of Human HSPCs

Modeling the Development of SRSF2 Mutated Myeloid Malignancies By CRISPR/Cas9 Mediated Genome Engineering of Primary Human Hematopoietic Stem and Progenitor Cells

Introduction and Genetic Correction of Calreticulin Mutations in Human Hematopoietic Stem and Progenitor Cells Sheds Light on MPN Pathogenesis

A Calreticulin Neoepitope-Directed Monoclonal Antibody Can Overcome JAK Inhibitor Resistance and Block TPO-Independent Megakaryocyte Differentation

Cytokine Rescue and Targeting of Inflammation-Sensitive RUNX1 Deficient Human CD34 + Hematopoietic Stem and Progenitor Cells

Induction of Truncating ASXL1 Mutations in Human CD34+ HSPCs Mimics Human ASXL1-Mutated Clonal Hematopoiesis and Progression to Myeloid Malignancies

Azacitidine and Ascorbate Inhibit the Competitive Outgrowth of Human TET2 Mutant HSPCs in a Xenograft Model of Pre-Leukemia

A Novel Model of Human Hemopoiesis Based on Single Cell Functional and Transcriptional Analysis of Lympho-Myeloid Progenitors

Characterization and Targeting TET2-Mutant HSPCs and AML

Pluripotent Reprogramming of Human AML Resets Leukemic Behavior and Models Therapeutic Targeting of Subclones

Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition

Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation

A Novel Humanized Bone Marrow Niche Xenotransplantation Model Allows Superior Engraftment of Human Normal and Malignant Hematopoietic Cells and Reveals Myelofibrosis-Initiating Cells in the HSC Compartment

Organotypic Epigenetic Signature Predicts Bone and Marrow Niche Forming Capacity of Stromal Progenitors in a Novel Mouse Model in Vivo .

Maintenance of Osteogenic Differentiation Capacity of MSPC Despite Amplified Proliferation Under Elevated Oxgen Conditions

A Novel Role for Mesenchymal Stem/Progenitor Cells As Hypoxia Sensors During Initiation of Neo-Vasculogenesis in Vivo

Human extramedullary bone marrow in mice: a novel in vivo model of genetically controlled hematopoietic microenvironment

Dissociation of In Vivo and in Vitro Differentiation Capacity of Human Mesenchymal Stem Cells Is Reflected by a Tissue Specific Epigenetic Memory

Platelet-Derived Factors Allow Human Mesenchymal Stem Cells to Spontaneously Undergo Endochondral Bone Differentiation and Provide Bone Marrow Support in a Xenogenic In Vivo Model

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American Society of Hematology

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ASH Publications

American Society of Hematology

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